The age of anxiety: role of animal models of anxiolytic action in drug discovery

Caffeine, Mental Health, and Psychiatric Disorders

(2017) Diogo R. Lara   JOURNAL OF ALZHEIMERS DISEASE

Temporary disruption of fear-potentiated startle following PKMζ inhibition in the amygdala

(2011) Ryan G Parsons et al.   NATURE NEUROSCIENCE

Predatory Stress as an Experimental Strategy to Measure Fear and Anxiety-related Behaviors in Non-human Primates

(2011) M. Barros et al.   REVIEWS IN THE NEUROSCIENCES

Resistance to Early-Life Stress in Mice: Effects of Genetic Background and Stress Duration

(2011) Hélène M. Savignac et al.   Frontiers in Behavioral Neuroscience

Susceptibility of a potential animal model for pathological anxiety to chronic mild stress

(2010) Amber R. Salomons et al.   BEHAVIOURAL BRAIN RESEARCH

Acute pharmacological modulation of mGluR8 reduces measures of anxiety

(2010) Robert M. Duvoisin et al.   BEHAVIOURAL BRAIN RESEARCH

General and social anxiety in the BTBR T+ tf/J mouse strain

(2010) Roger L.H. Pobbe et al.   BEHAVIOURAL BRAIN RESEARCH

Maternal separation with early weaning: a novel mouse model of early life neglect

(2010) Elizabeth D George et al.   BMC NEUROSCIENCE

Behavioral and genetic investigations of low exploratory behavior in Il18r1−/− mice: We can’t always blame it on the targeted gene

(2010) Amy F. Eisener-Dorman et al.   BRAIN BEHAVIOR AND IMMUNITY

Pharmacological enhancement of fear reduction: preclinical models

(2010) Bronwyn M Graham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Using Functional Neuroimaging to Investigate the Mechanisms of Action of Selective Serotonin Reuptake Inhibitors (SSRIs)

(2010) Susannah E. Murphy   CURRENT PHARMACEUTICAL DESIGN

Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder

(2010) Vladimir Coric et al.   DEPRESSION AND ANXIETY

Metabotropic glutamate receptor 7: At the interface of cognition and emotion

(2010) Richard M. O'Connor et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice

(2010) Samantha J. Line et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactate-induced acute panic-like responses

(2010) Anantha Shekhar et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Anxiolytic Effects of the MCH1R Antagonist TPI 1361-17

(2010) Cheol Lee et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Transient Early-Life Forebrain Corticotropin-Releasing Hormone Elevation Causes Long-Lasting Anxiogenic and Despair-Like Changes in Mice

(2010) B. J. Kolber et al.   JOURNAL OF NEUROSCIENCE

MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans

(2010) JR Atack et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Genetic dissection of an amygdala microcircuit that gates conditioned fear

(2010) Wulf Haubensak et al.   NATURE

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems

(2010) Joanna M. Wierońska et al.   NEUROPHARMACOLOGY

Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear

(2010) Demetrio Sierra-Mercado et al.   NEUROPSYCHOPHARMACOLOGY

Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague–Dawley rats: Effects of anxiolytic and anxiogenic agents

(2010) Amanda A. Braun et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear

(2010) Hans-Christian Pape et al.   PHYSIOLOGICAL REVIEWS

Associations between personality traits and CCK-4-induced panic attacks in healthy volunteers

(2010) Innar Tõru et al.   PSYCHIATRY RESEARCH

The Trier Social Stress Test for Groups (TSST-G): A new research tool for controlled simultaneous social stress exposure in a group format

(2010) Bernadette von Dawans et al.   PSYCHONEUROENDOCRINOLOGY

Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours

(2010) Beate C. Finger et al.   PSYCHOPHARMACOLOGY

Maternal separation as a model of brain–gut axis dysfunction

(2010) Siobhain M. O’Mahony et al.   PSYCHOPHARMACOLOGY

Proposed Revisions to Psychiatry's Canon Unveiled

(2010) G. Miller et al.   SCIENCE

Behavioral Addictions Debut in Proposed DSM-V

(2010) C. Holden   SCIENCE

Overlapping neural systems mediating extinction, reversal and regulation of fear

(2010) Daniela Schiller et al.   TRENDS IN COGNITIVE SCIENCES

A Reverse-Translational Study of Dysfunctional Exploration in Psychiatric Disorders

(2009) William Perry et al.   ARCHIVES OF GENERAL PSYCHIATRY

Behavioral abnormality and pharmacologic response in social isolation-reared mice

(2009) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Wistar–Kyoto rats as an animal model of anxiety vulnerability: Support for a hypervigilance hypothesis

(2009) J.D. McAuley et al.   BEHAVIOURAL BRAIN RESEARCH

The modified Geller–Seifter test in rats was insensitive to GABAB receptor positive modulation or blockade, or 5-HT1A receptor activation

(2009) Neil E. Paterson et al.   BEHAVIOURAL BRAIN RESEARCH

Pitfalls in the interpretation of genetic and pharmacological effects on anxiety-like behaviour in rodents

(2009) Jan Adriaan Bouwknecht et al.   BEHAVIOURAL PHARMACOLOGY

Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission

(2009) Katarzyna Stachowicz et al.   BEHAVIOURAL PHARMACOLOGY

Anxiolytic-like effects of the neurokinin 1 receptor antagonist GR-205171 in the elevated plus maze and contextual fear-potentiated startle model of anxiety in gerbils

(2009) Scott A. Heldt et al.   BEHAVIOURAL PHARMACOLOGY

Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E

(2009) Kazunari Sekiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intraneuronal β-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice

(2009) Judit España et al.   BIOLOGICAL PSYCHIATRY

Tachykinin Receptors as Therapeutic Targets in Stress-Related Disorders

(2009) Karl Ebner et al.   CURRENT PHARMACEUTICAL DESIGN

Freezing reaction in panic disorder patients associated with anticipatory anxiety

(2009) Fabiana L. Lopes et al.   DEPRESSION AND ANXIETY

Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain

(2009) M. Camp et al.   GENES BRAIN AND BEHAVIOR

Identifying emotional adaptation: behavioural habituation to novelty and immediate early gene expression in two inbred mouse strains

(2009) A. R. Salomons et al.   GENES BRAIN AND BEHAVIOR

Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice

(2009) CK Thoeringer et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Preventing the return of fear in humans using reconsolidation update mechanisms

(2009) Daniela Schiller et al.   NATURE

Amygdala Inhibitory Circuits and the Control of Fear Memory

(2009) Ingrid Ehrlich et al.   NEURON

Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety

(2009) Michael Davis et al.   NEUROPSYCHOPHARMACOLOGY

Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3α,5α-tetrahydrodeoxycorticosterone concentrations

(2009) Peter Zwanzger et al.   PSYCHONEUROENDOCRINOLOGY

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

(2009) Alexia Thomas et al.   PSYCHOPHARMACOLOGY

Time course of attentional bias in anxiety: Emotion and gender specificity

(2009) Sarah M. Sass et al.   PSYCHOPHYSIOLOGY

Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

(2009) Rainer Rupprecht et al.   SCIENCE

Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression

(2009) Shunsuke Hasegawa et al.   Molecular Brain

GABA homeostasis contributes to the developmental programming of anxiety-related behavior

(2008) Amaicha Mara Depino et al.   BRAIN RESEARCH

Translational aspects of pharmacological research into anxiety disorders: The stress-induced hyperthermia (SIH) paradigm

(2008) Christiaan H. Vinkers et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: A comparison to other agents

(2008) Mauricette Brocco et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Anxiety disorders and comorbid medical illness

(2008) Peter P. Roy-Byrne et al.   GENERAL HOSPITAL PSYCHIATRY

Impaired Fear Extinction Learning and Cortico-Amygdala Circuit Abnormalities in a Common Genetic Mouse Strain

(2008) K. Hefner et al.   JOURNAL OF NEUROSCIENCE

CCK-4-induced anxiety but not panic is associated with serum brain-derived neurotrophic factor in healthy subjects

(2008) E Maron et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Central Nervous System-Specific Knockout of Steroidogenic Factor 1 Results in Increased Anxiety-Like Behavior

(2008) Liping Zhao et al.   MOLECULAR ENDOCRINOLOGY

Anxiety disorders: a comprehensive review of pharmacotherapies

(2008) Ellen J. Hoffman et al.   MOUNT SINAI JOURNAL OF MEDICINE

Switching on and off fear by distinct neuronal circuits

(2008) Cyril Herry et al.   NATURE

The regular and light–dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents

(2008) Allan V Kalueff et al.   Nature Protocols

Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice

(2008) Hannelore Goddyn et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry and Government Settings

(2008) P Jeffrey Conn et al.   NEUROPSYCHOPHARMACOLOGY

Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models

(2008) Athina Markou et al.   NEUROPSYCHOPHARMACOLOGY

Ultrasonic vocalizations: A tool for behavioural phenotyping of mouse models of neurodevelopmental disorders

(2008) Maria Luisa Scattoni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine

(2008) Inge Sillaber et al.   PSYCHOPHARMACOLOGY

Direct effects of diazepam on emotional processing in healthy volunteers

(2008) S. E. Murphy et al.   PSYCHOPHARMACOLOGY

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

(2008) Anne Dekeyne et al.   PSYCHOPHARMACOLOGY