Article
Medicine, General & Internal
Huanrui Wang, Weiyu Zhang, Zehua Ding, Tao Xu, Xiaopeng Zhang, Kexin Xu
Summary: This study preliminarily investigated the transcriptional expression, survival data, and immune infiltration of AQPs in ccRCC patients. The results showed that the expression levels of multiple AQPs were decreased in ccRCC, and they were associated with clinical stage, pathological grade, and overall survival of patients. AQP mutations did not have a significant impact on patient survival. Furthermore, the expression of certain AQPs was correlated with immune cell infiltration, suggesting the involvement of AQPs in the immunomodulatory state of ccRCC. Further research is needed to explore AQPs as potential biomarkers for ccRCC.
Article
Biotechnology & Applied Microbiology
Zuhu Yu, Chong Lu, Bin Lu, Hong Gao, Rongfang Liang, Wuxing Xiang
Summary: This study identified necroptosis-related microRNAs (miRNAs) associated with the prognosis of clear cell renal cell carcinoma (ccRCC), and developed a prognostic signature to predict overall survival in ccRCC patients. The targeted genes of these miRNAs were predicted using miRNA databases, and their functional and pathway associations with ccRCC prognosis were investigated. The differential expression of the three miRNAs in the signature was validated in ccRCC tissues.
Article
Cell Biology
Lei Yao, Juanni Li, Zhijie Xu, Yuanliang Yan, Kuan Hu
Summary: This study evaluated the roles of the GSDM family in patients with clear cell renal cell carcinoma (ccRCC) in terms of expression, prognostic value, functional enrichment analysis, genetic alterations, immune infiltration, and DNA methylation using various bioinformatics databases. The findings suggest that GSDME may serve as a potential clinical target and prognostic biomarker for ccRCC patients.
Article
Oncology
Di Zheng, Jinzhuo Ning, Yuqi Xia, Yuan Ruan, Fan Cheng
Summary: In this study, the researchers analyzed the expression profiles and prognostic value of HOX genes in ccRCC using datasets from TCGA and ICGC databases. They developed a prognostic signature comprising eight HOX genes for overall survival prediction in ccRCC and found that HOXD8 might be a tumor suppressor gene and a potential predictor of tumor progression in ccRCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Gang Wang, Panhong Liu, Jiangfeng Li, Ke Jin, Xiangyi Zheng, Liping Xie
Summary: This study constructed an immune-related long non-coding RNA (irlncRNA) prognosis model for clear cell renal cell carcinoma (ccRCC) that is independent of gene expression levels. The paired irlncRNA model showed promising clinical prediction value, allowing for better prediction of patient survival, pathological characteristics, and immune-related factors.
Article
Oncology
Gui Mal, Zirui Wang, Junyao Liu, Shengjun Fu, Lili Zhang, Duo Zheng, Panfeng Shang, Zhongjin Yue
Summary: The study revealed a sophisticated metabolic reprogramming in ccRCC, with upregulation of rate-limiting enzymes in glycolysis and mitochondrial impairment. FMNL1 was identified as a potential prognostic marker in ccRCC, and knockdown of FMNL1 inhibited cell proliferation, migration, and invasion.
Article
Oncology
Joanna Wesoly, Natalia Pstrag, Kamil Derylo, Barbara Michalec-Wawiorka, Natalia Derebecka, Hanna Nowicka, Arkadiusz Kajdasz, Katarzyna Kluzek, Malgorzata Srebniak, Marek Tchorzewski, Zbigniew Kwias, Hans Bluyssen
Summary: Recent studies have shown that Transmembrane Proteins (TMEMs) play a significant role in the development of various cancers. In clear cell Renal Cell Carcinoma (ccRCC), TMEM213, 207, 116, 72, and 30B are downregulated on the mRNA level, particularly in advanced ccRCC tumors. Experimental validation confirmed the membrane-bound status of selected TMEMs and their potential involvement in cellular processes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Immunology
Mancheng Gong, Yongxiang Li, Erlin Song, Miaoyuan Li, Shaopeng Qiu, Wenjing Dong, Runqiang Yuan
Summary: Our study found a correlation between OIP5 expression and immune cell infiltration level in ccRCC. Analysis based on RNA-seq data showed that OIP5 has an impact on immune activity. Additionally, OIP5 was associated with several immunomodulators and involved in multiple immune signaling pathways. We constructed a multiple-gene risk prediction signature, providing a potential target for immunotherapy in ccRCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yuxiong Jiang, Dongxu Han, Yifan Zhao, Chen Zhang, Xiujuan Shi, Wenyu Gu
Summary: The TRPV ion channel family, including TRPV1-6, has been found to have a profound impact on a wide range of pathological processes in various cancers. However, the biological function and prognostic value of TRPVs in clear cell renal cell carcinoma (ccRCC) remain largely unknown. In this study, we analyzed gene expression data and clinical information of ccRCC patients and found that TRPV2/3 expression was upregulated while TRPV5/6 expression was downregulated in ccRCC tumor tissues. This study provides insights into the role of TRPV channels in the development and progression of ccRCC and suggests that TRPV family members may serve as diagnostic and prognostic markers and potential therapeutic targets for ccRCC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tengda Wang, Wengang Jian, Wei Xue, Yuyang Meng, Zhinan Xia, Qinchen Li, Shenhao Xu, Yu Dong, Anli Mao, Cheng Zhang
Summary: This study demonstrates the important role of MYBL1 in renal cancer, showing its correlation with tumor progression, prognosis, and immunotherapy response. It provides insights into precision medicine for renal cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Youlong Huili, Shiwen Nie, Liguo Zhang, Anliang Yao, Jian Liu, Yong Wang, Lei Wang, Fenghong Cao
Summary: This study identified five cuproptosis-associated lncRNAs as potential prognostic markers for ccRCC. The developed prognostic model showed high accuracy in predicting ccRCC patients' prognosis. Differences were observed in immune therapy and drug sensitivity among different risk categories and subtypes.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Fan Zhang, Junyu Lin, Dechao Feng, Jiayu Liang, Yiping Lu, Zhihong Liu, Xianding Wang
Summary: This study explored the correlation between cuprotosis and clear cell renal cell carcinoma (ccRCC) and developed a cuprotosis-related signature to predict the prognosis of patients with ccRCC. The signature risk score was significantly associated with tumor stage, histological grade, and immune cell infiltrates in ccRCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Fan Zhang, DongBo Yuan, JuKun Song, WeiMing Chen, Wei Wang, GuoHua Zhu, Bin Hu, Xiaoyue Chen, Jianguo Zhu
Summary: HJURP is upregulated in ccRCC, associated with poor pathological features and poor prognosis in patients. It serves as a high-risk factor for ccRCC patients and is closely linked to multiple immune-related signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fanni Annamaria Boros, Rita Maszlag-Torok, Monika Szucs, Adam Annus, Peter Klivenyi, Laszlo Vecsei
Summary: This study highlights the importance of genetic background in the occurrence, etiology, and clinical parameters of ischemic stroke. Significant differences in frequencies related to ischemic stroke were detected in seven out of ten studied polymorphisms. Changes in expression levels of IDO1 and TPH1 genes during the disease course suggest a potential causal relationship with stroke etiology.
Article
Cell Biology
Huanrui Wang, Weiyu Zhang, Zehua Ding, Hanwei Ke, Dongyu Su, Qi Wang, Kexin Xu
Summary: This study analyzed the expression of SEMA3G in renal cell cancer (RCC) and found that it was significantly lower in ccRCC tissues, and was highly associated with clinical stage and pathological grade. Low expression of SEMA3G was associated with poorer prognosis, while overexpression inhibited the motility, invasion, and proliferation of renal cancer cells. The study also suggested that SEMA3G may affect tumorigenesis and progression of ccRCC through the Wnt signaling pathway.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Wenbin Liu, Hongxiang Ji, Jun Zhao, Jiahui Song, Shaoling Zheng, Lei Chen, Peng Li, Xiaojie Tan, Yibo Ding, Rui Pu, Jianhua Yin, Xue Han, Guangwen Cao
Summary: APOBEC3-related mutations are associated with biliary tract cancers. The functional polymorphisms of APOBEC3A and APOBEC3B play important roles in the development of cholangiocarcinoma and gallbladder cancer. TNF-alpha regulates the levels of APOBEC3A and APOBEC3B by affecting transcriptional repressors and promoter accessibility.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Rui Pu, Wenbin Liu, Xinyu Zhou, Xi Chen, Xiaomei Hou, Shiliang Cai, Liping Chen, Jianfeng Wu, Fan Yang, Xiaojie Tan, Jianhua Yin, Xin Wang, Guangwen Cao
Summary: The study aimed to explore the mechanism by which hepatitis B virus X mutations increase the occurrence of hepatocellular carcinoma (HCC) and identify potential therapeutic targets. The results showed that M3-HBx and Ct-HBx mutants had a higher HCC incidence compared to wild-type HBx. M3-HBx had a stronger capacity to upregulate inflammatory cytokines and promote cell proliferation in HepG2 and HeLa cells. Plasminogen activator inhibitor-1 (PAI1) and cell division cycle 20 (CDC20) were identified as novel effectors, and their expression was significantly upregulated by M3-HBx and Ct-HBx in both cells and mouse livers. Silencing PAI1 attenuated the effects of M3-HBx and Ct-HBx on cell growth. PAI1 could be a promising prognostic biomarker and therapeutic target in HBV-related HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Ruihua Wang, Qiaoyuan Fei, Shan Liu, Xueqiong Weng, Huanzhu Liang, Yingying Wu, Lin Wen, Guang Hao, Guangwen Cao, Chunxia Jing
Summary: This study assessed the effects of bisphenol F (BPF) and bisphenol S (BPS) as substitutes for bisphenol A (BPA) in the US population. The results suggest that BPS may increase the risk of cardiovascular disease (CVD) and coronary heart disease, especially in the 50-80 age group.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Oncology
Donghong Liu, Wenbin Liu, Xi Chen, Jianhua Yin, Longteng Ma, Mei Liu, Xinyu Zhou, Linfeng Xian, Peng Li, Xiaojie Tan, Jun Zhao, Yong Liao, Guangwen Cao
Summary: In this study, circKCNN2 was identified as a potential predictive biomarker and therapeutic agent for the recurrence of hepatocellular carcinoma (HCC). Through multi-omics analyses, circKCNN2 was found to suppress the recurrence of HCC via the miR-520c-3p/MBD2 axis. These findings suggest that circKCNN2 may hold promise for predicting HCC recurrence and improving therapeutic outcomes.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Agronomy
Xiaojie Jin, Dawn Chi, Danielle Wolfe, Colin Hiebert, Tom Fetch, Wenguang Cao, Allen Xue, Gavin Humphreys, George Fedak
Summary: By using marker-assisted selection and doubled haploid technology, five stem rust resistance genes were stacked to produce 13 desired combinations. The wheat cultivar Hoffman was improved by stacking Sr35 and Sr36. The pyramided lines with three or four genes and improved Hoffman with Sr35+Sr36 were all immune to TTKSK.
CANADIAN JOURNAL OF PLANT SCIENCE
(2022)
Article
Oncology
Jiansheng Lin, Hongwei Zhang, Hongping Yu, Xinyu Bi, Weilu Zhang, Jianhua Yin, Pei Zhao, Xiumei Liang, Chunfeng Qu, Minjie Wang, Ming Hu, Kun Liu, Yuting Wang, Zihan Zhou, Junqi Wang, Xiaojie Tan, Wenbin Liu, Zhongjun Shao, Jianqiang Cai, Weizhong Tang, Guangwen Cao
Summary: This study investigated the contribution of HBV and HCV to primary liver cancer and their association with cancer aggressiveness in China. The results showed that HBV accounted for 84.4% of HCC cases in China and was associated with clinical characteristics of the tumor. Early screening and preoperative prognosis prediction models are important in clinical decision-making.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Feijun Ye, Siwei Zhang, Qing Qi, Jing Zhou, Yan Du, Ling Wang
Summary: This study found an association between MTHFR genetic polymorphism rs1801133 and BMI, but not with pregnancy outcomes. Additionally, MTHFR 677C>T was not associated with preterm delivery. The results suggest that using less expensive and readily available folic acid supplementation may be appropriate in women undergoing IVF/ICSI-ET with adequate synthetic folic acid supplementation.
Article
Oncology
Hao Feng, Ling Qiu, Zixiao Shi, Yao Sheng, Peipei Zhao, Di Zhou, Fei Li, Hailin Yu, Yanan You, Hui Wang, Ming Li, Shurong Zhu, Yan Du, Jun Cui, Jingwei Sun, Yarong Liu, Hua Jiang, Xin Wu
Summary: Modulating the PI3K-AKT signaling pathway has been found to enhance the stemness and cytotoxicity of tumor-infiltrating lymphocytes (TIL) and improve the clinical outcome of solid tumor therapy.
Article
Oncology
Zhi Wei, Jianfeng Gan, Xuan Feng, Mo Zhang, Zhixian Chen, Hongbo Zhao, Yan Du
Summary: This study found that A3B is overexpressed in cervical cancer and progressively activated during its development. The results also suggest that A3B promotes cell proliferation, migration, and cell cycle, and inhibits apoptosis in cervical cancer cells through the p53 pathway. Additionally, A3B may contribute to chemoresistance in cervical cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaopan Li, Mo Zhang, Yichen Chen, Huihui Lv, Yan Du
Summary: This study aimed to characterize the long-term trends in mortality, survival and disease burden of ovarian cancer in Shanghai, China. The results showed that the survival rates of ovarian cancer patients did not improve and more efforts in targeted prevention and treatment are needed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
Gang Chen, Mengwei Wang, Peiguang Wang, Bo Liang
Summary: We report a Chinese patient with Ichthyosis follicularis with atrichia and photophobia (IFAP) syndrome, presenting with the classic triad of follicular ichthyosis, alopecia, and photophobia, along with painful palmoplantar keratoderma, recurrent infections, periorificial keratotic plaques, nail dystrophy, and pachyonychia. Whole-exome sequencing identified an intronic variant (NM_015884.3: exon7:c.970+5G>A) in the MBTPS2 gene, which was confirmed to segregate with phenotype in the family. cDNA sequencing showed that the variant introduced a new splice donor site, leading to partial skipping of exon 7 (r.951_970del). An in vitro mini-gene assay demonstrated abnormal splicing of exon 7. This study highlights the importance of validation assays in determining the pathogenicity of intronic variants in MBTPS2.
JOURNAL OF DERMATOLOGY
(2023)
Review
Oncology
Zheyun Niu, Dongming Jiang, Jiaying Shen, Wenbin Liu, Xiaojie Tan, Guangwen Cao
Summary: Tumor development follows an evolutionary pattern of mutation-selection-adaptation, and FHIT plays a crucial role in this process by regulating gene expression and promoting retro-differentiation during cancer evolution and development. This article provides evidence on how FHIT is inactivated in cancer and highlights its importance in bridging macroevolution and microevolution.
Review
Biochemistry & Molecular Biology
Jiayi Zhao, Yiwei Shi, Guangwen Cao
Summary: The initiation and progression of tumors are complex, with the inflammation tumor microenvironment playing a crucial role. Single-cell RNA sequencing (scRNA-seq) can detect the transcription levels of cells, revealing the heterogeneity and evolutionary trajectory of infiltrated immune cells and cancer cells, providing insights into the composition and function of cells in the inflammatory tumor microenvironment.
Article
Oncology
Hui-Chao Zheng, Jing Zhou, Yi-Chen Chen, Ying Yu, Wei Dai, Yan Han, Xiao-Pan Li, Sun-Fang Jiang
Summary: Studies on liver metastases-related mortality are rare. This study aimed to analyze the burden and trend of liver metastases in Pudong, Shanghai. The results showed that liver metastases accounted for a significant proportion of all metastases, and the mortality rates of liver metastases decreased over the years, but there was a significant upward trend in aging patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Public, Environmental & Occupational Health
Xiaopan Li, Ru Liu, Yichen Chen, Yan Han, Qizhe Wang, Yaxin Xu, Jing Zhou, Sunfang Jiang
Summary: This study assessed the trends and burden of diabetes mellitus (DM) mortality in Shanghai's Pudong district, and analyzed the impact of aging and multimorbidity. The findings highlight the increasing disease burden among young and middle-aged individuals, emphasizing the need for greater attention to these groups.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
