Article
Multidisciplinary Sciences
Navid Manouchehri, Rehana Z. Hussain, Petra D. Cravens, Ekaterina Esaulova, Maxim N. Artyomov, Brian T. Edelson, Gregory F. Wu, Anne H. Cross, Richard Doelger, Nicolas Loof, Todd N. Eagar, Thomas G. Forsthuber, Laurent Calvier, Joachim Herz, Olaf Stueve
Summary: Selective deletion of alpha 4-integrin in CD11c(+) cells delays disease onset and reduces specific cell numbers in the central nervous system in experimental autoimmune encephalomyelitis (EAE).
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Lohmeier, Rafaela Silva, Anna Tietze, Matthias Taupitz, Takaaki Kaneko, Harald Pruss, Friedemann Paul, Carmen Infante-Duarte, Bernd Hamm, Peter Caravan, Marcus R. Makowski
Summary: This study demonstrated for the first time the visualization and quantification of CNS fibrin deposition using molecular imaging, revealing its correlation with neuroinflammatory pathology and disease monitoring. The molecular imaging biomarker showed a higher signal-to-noise ratio compared to clinically used contrast media, enhancing the diagnostic imaging of neurological diseases.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Immunology
Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li, Zizhen Kang
Summary: This study identified STEAP4 as a Th17-specific effector molecule that plays a key role in the pathogenesis of neuroinflammation. STEAP4 knockout mice showed delayed onset and reduced severity of EAE induced by active immunization. Notably, STEAP4 was only induced in the spinal cord of EAE mice that received Th17 cells, indicating its specific role in Th17-mediated neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Pavan Bhargava, Sol Kim, Arthur A. Reyes, Roland Grenningloh, Ursula Boschert, Martina Absinta, Carlos Pardo, Peter Van Zijl, Jiangyang Zhang, Peter A. Calabresi
Summary: Leptomeningeal inflammation in multiple sclerosis is associated with poor clinical outcomes and severe cortical pathology. By utilizing ultra-high field MRI in experimental autoimmune encephalomyelitis mouse models, researchers have identified a novel therapeutic approach to target meningeal inflammation.
Article
Multidisciplinary Sciences
Anna S. Thomann, Courtney A. McQuade, Katarina Pinjusic, Anna Kolz, Rosa Schmitz, Daisuke Kitamura, Hartmut Wekerle, Anneli Peters Ab
Summary: In multiple sclerosis, pathogenic T cell responses play a major role in autoimmune inflammation, but B cells may also contribute to the pathogenesis through antigen presentation and the production of proinflammatory cytokines. This study developed a new model to study the roles of pathogenic B cells in the development of multiple sclerosis, providing insights into the disease's pathogenic processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Lacey B. Sell, Christina C. Ramelow, Hannah M. Kohl, Kristina Hoffman, Jasleen K. Bains, William J. Doyle, Kevin D. Strawn, Theresa Hevrin, Trevor O. Kirby, K. Michael Gibson, Jean-Baptiste Roullet, Javier Ochoa-Reparaz
Summary: Farnesol treatment delays disease onset and reduces severity in EAE, potentially through modulation of gut microbiota composition.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Aaron H. S. Heng, Caleb W. Han, Caitlin Abbott, Shaun R. McColl, Iain Comerford
Summary: Pro-inflammatory CD4(+) T helper cells play a crucial role in autoimmune diseases. Recent research has revealed the heterogeneity of chemokine receptors expressed by these cells, which are responsible for recruiting different subsets of pro-inflammatory Th cells in autoimmune inflammation. Understanding these receptors may lead to potential therapeutic targets for intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Theresa L. Montgomery, Korin Eckstrom, Katarina H. Lile, Sydney Caldwell, Eamonn R. Heney, Karolyn G. Lahue, Angelo D'Alessandro, Matthew J. Wargo, Dimitry N. Krementsov
Summary: The study found that gut commensal, such as the potential probiotic species Lactobacillus reuteri, can unexpectedly enhance autoimmunity through tryptophan metabolism, leading to broad shifts in the metabolome and immunological repertoire.
Article
Neurosciences
Tal Ganz, Omri Zveik, Nina Fainstein, Marva Lachish, Ariel Rechtman, Lihi Sofer, Livnat Brill, Tamir Ben-Hur, Adi Vaknin-Dembinsky
Summary: Pushing OPC into differentiation program may help overcome remyelination failure, but creating a permissive environment for OPC activation, migration, and differentiation is also crucial.
Article
Immunology
Javad Rasouli, Giacomo Casella, Larissa L. W. Ishikawa, Rodolfo Thome, Alexandra Boehm, Adam Ertel, Carolina R. Melo-Silva, Elisabeth R. Mari, Patrizia Porazzi, Weifeng Zhang, Dan Xiao, Luis J. Sigal, Paolo Fortina, Guang-Xian Zhang, Abdolmohamad Rostami, Bogoljub Ciric
Summary: The study reveals that IFN-beta therapy reduces GM-CSF production by Th cells indirectly through its effects on monocytes, and increases IL-10 expression in monocytes to suppress IL-1 beta secretion, thereby disrupting a proinflammatory loop involving several molecules derived from Th cells and monocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tessa Peck, Connor Davis, Georgia Lenihan-Geels, Maddie Griffiths, Sam Spijkers-Shaw, Olga V. Zubkova, Anne Camille La Flamme
Summary: This study investigates the use of a novel HS-mimetic, Tet-29, in an animal model of MS. Tet-29 significantly reduced lymphocyte accumulation in the central nervous system and decreased disease severity in experimental autoimmune encephalomyelitis. The disease-modifying effect of Tet-29 was associated with a rescue of BBB integrity and inhibition of activated lymphocyte migration across the BBB and choroid plexus.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Magdalena Dubik, Joanna Marczynska, Marlene T. Morch, Gill Webster, Kirstine Nolling Jensen, Agnieszka Wlodarczyk, Reza Khorooshi, Trevor Owens
Summary: This study developed a novel focal EAE model to study the effect of innate signaling on demyelinating pathology, finding that intrathecal administration of a specific innate ligand reduced focal lesions and upregulated various factors associated with immune responses. The study also showed changes in the composition of early CNS infiltrates. The research contributes to understanding how innate immune responses can play a protective role in diseases like multiple sclerosis.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Immunology
Shen-zhao Lu, Yue Wu, Yong-shun Guo, Pei-zhou Liang, Shu Yin, Yan-qing Yin, Xiu-li Zhang, Yan-Fang Liu, Hong-yan Wang, Yi-chuan Xiao, Xin-miao Liang, Jia-wei Zhou
Summary: This study reveals a previously unknown role for dopamine D2 receptor (DRD2) in astrocyte activation during central nervous system inflammation associated with experimental autoimmune encephalomyelitis (EAE). Blocking astrocytic DRD2 can inhibit the inflammatory response.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Patrick O'Connell, Maja K. Blake, Sarah Godbehere, Andrea Amalfitano, Yasser A. Aldhamen
Summary: This study identifies novel roles for SLAMF7 in CNS immune regulation and B cell function, and sheds light on the genetic association between SLAMF7 and MS.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Emanuela Colombo, Marco Di Dario, Ramesh Menon, Maria Maddalena Valente, Claudia Bassani, Nicole Sarno, Davide Mazza, Federico Montini, Lucia Moiola, Giancarlo Comi, Vittorio Martinelli, Cinthia Farina
Summary: Hepatocyte nuclear factor 4 a (HNF4a), an essential transcription factor for embryonic development, has been found to regulate the expression of inflammatory genes. Blocking HNF4a reduces immune activation and disease severity in multiple sclerosis (MS). Studies on human immune transcriptomes have identified HNF4a, SP1 and c-myc as master transcription factors regulating differential gene expression in MS. These transcription factors are activated by immune cell activation and regulated by environmental risk factors for MS. Targeting their expression or function may provide a potential therapeutic approach for MS and other inflammatory disorders.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Oncology
Mirco Friedrich, Markus Hahn, Julius Michel, Roman Sankowski, Michael Kilian, Niklas Kehl, Manina Guenter, Theresa Bunse, Stefan Pusch, Andreas von Deimling, Wolfgang Wick, Stella E. Autenrieth, Marco Prinz, Michael Platten, Lukas Bunse
Summary: The study reveals that glioma-associated dendritic cells are abundant in human IDHwt and mutant tumors, interacting with other immune cells in the tumor microenvironment. IDH mutations in gliomas result in specifically educated, dysfunctional dendritic cells through paracrine reprogramming of infiltrating monocytes, laying the foundation for combinatorial immunotherapy concepts against IDH mutant gliomas.
Review
Biochemistry & Molecular Biology
Marvin Korff, Ruben Steigerwald, Elena Bechthold, Dirk Schepmann, Julian A. Schreiber, Sven G. Meuth, Guiscard Seebohm, Bernhard Wuensch
Summary: GluN2B-NMDA receptors play a key role in neurological and neurodegenerative disorders. A new GluN2B-NMDA receptor modulator was developed with promising affinity and pharmacological activity, which could be suitable for human application.
BIOLOGICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Theresia Sarabhai, Lucia Mastrototaro, Sabine Kahl, Gidon J. Boenhof, Marc Jonuscheit, Pavel Bobrov, Hisayuki Katsuyama, Rainer Guthoff, Martin Wolkersdorfer, Christian Herder, Sven G. Meuth, Sven Dreyer, Michael Roden
Summary: This study aimed to examine the effects of hyperbaric oxygen therapy on whole-body glucose metabolism in individuals with type 2 diabetes. The results showed that hyperbaric oxygen therapy decreased fasting blood glucose, improved whole-body insulin sensitivity, and achieved this improvement through decreasing endoplasmic reticulum stress and increasing mitochondrial function.
Article
Clinical Neurology
Sofia Doubrovinskaia, Christoph M. Mooshage, Corinna Seliger, Hanns-Martin Lorenz, Simon Nagel, Pascal Lehnert, Jan Purrucker, Brigitte Wildemann, Martin Bendszus, Wolfgang Wick, Silvia Schoenenberger, Leon D. Kaulen
Summary: This study reports the long-term clinical, laboratory, and imaging characteristics of patients with neurological autoimmunity diagnosed in temporal association (<= 6 weeks) with SARS-CoV-2 vaccinations. The condition of most patients improved following therapy, and re-vaccinations were well tolerated. The results suggest that re-vaccinations should be considered based on individual risk-benefit analysis.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Correction
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schueller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Henri Bogumil, Martin Sill, Daniel Schrimpf, Britta Ismer, Christina Blume, Ramin Rahmanzade, Felix Hinz, Asan Cherkezov, Rouzbeh Banan, Dennis Friedel, David E. Reuss, Florian Selt, Jonas Ecker, Till Milde, Kristian W. Pajtler, Jens Schittenhelm, Jürgen Hench, Stephan Frank, Henning B. Boldt, Bjarne Winther Kristensen, David Scheie, Linea C. Melchior, Viola Olesen, Astrid Sehested, Daniel R. Boue, Zied Abdullaev, Laveniya Satgunaseelan, Ina Kurth, Annekatrin Seidlitz, Christine L. White, Ho-Keung Ng, Zhi-Feng Shi, Christine Haberler, Martina Deckert, Marco Timmer, Roland Goldbrunner, Arnault Tauziede-Espariat, Pascale Varlet, Sebastian Brandner, Sanda Alexandrescu, Matija Snuderl, Kenneth Aldape, Andrey Korshunov, Olaf Witt, Christel Herold-Mende, Andreas Unterberg, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, David T. W. Jones, Felix Sahm, Philipp Sievers
Summary: This study identified a new type of glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features. The molecular characteristics of these tumors suggest potential targeted therapies, such as NTRK inhibition.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Hira Altunbueker, Felix Hinz, Felix Sahm, Stefanie Brehmer, Holger Wenz
Summary: Rosette-forming glioneuronal tumors (RGNT) are rare benign tumors of the central nervous system, with limited clinical and radiological knowledge. In this study, we observed the entire growth process of a RGNT on subsequent MRI examinations in a typical case, preventing potential clinical complications.
NEUROLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Denis Abu Sammour, James L. Cairns, Tobias Boskamp, Christian Marsching, Tobias Kessler, Carina Ramallo Guevara, Verena Panitz, Ahmed Sadik, Jonas Cordes, Stefan Schmidt, Shad A. Mohammed, Miriam F. Rittel, Mirco Friedrich, Michael Platten, Ivo Wolf, Andreas von Deimling, Christiane A. Opitz, Wolfgang Wick, Carsten Hopf
Summary: Mass spectrometry imaging utilizes traditional ion images for metabolite visualization and analysis, but lacks consideration for nonlinearities and statistical significance. The computational framework moleculaR aims to improve signal reliability by Gaussian-weighting ion intensities and introduces probabilistic molecular mapping for statistically significant spatial abundance analysis. It allows cross-tissue comparisons and spatial statistical significance evaluation, facilitating the investigation of ion milieus, lipid remodeling pathways, and complex scores within the same image.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Verena Turco, Kira Pfleiderer, Jessica Hunger, Natalie K. Horvat, Kianush Karimian-Jazi, Katharina Schregel, Manuel Fischer, Gianluca Brugnara, Kristine Jaehne, Volker Sturm, Yannik Streibel, Duy Nguyen, Sandro Altamura, Dennis A. Agardy, Shreya S. Soni, Abdulrahman Alsasa, Theresa Bunse, Matthias Schlesner, Martina U. Muckenthaler, Ralph Weissleder, Wolfgang Wick, Sabine Heiland, Philipp Vollmuth, Martin Bendszus, Christopher B. Rodell, Michael O. Breckwoldt, Michael Platten
Summary: Glioblastoma, the most aggressive brain tumor type, can be treated by reprogramming myeloid cells using CDNP-R848 nanoparticles. CDNP-R848 induces tumor regression by targeting blood-borne macrophages independently of adaptive immunity.
NATURE COMMUNICATIONS
(2023)
Review
Clinical Neurology
Stefan Bittner, Katrin Pape, Luisa Klotz, Frauke Zipp
Summary: Worsening clinical symptoms in patients with multiple sclerosis (MS) are caused by inflammation specifically occurring within the CNS. This chronic and non-relapsing immune-mediated mechanism of disease progression, called "smouldering inflammation," is sustained by local factors in the CNS and explains why current MS treatments do not adequately target it. This review summarizes the current understanding of the local inflammatory microenvironment in smouldering inflammation, its interaction with immune cell metabolism, and potential treatments for preventing neurodegenerative damage.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Oncology
Anna S. Kolodziejczak, Lea Guerrini-Rousseau, Julien Masliah Planchon, Jonas Ecker, Florian Selt, Martin Mynarek, Denise Obrecht, Martin Sill, Robert J. Autry, Eric Stutheit-Zhao, Steffen Hirsch, Elsa Amouyal, Christelle Dufour, Olivier Ayrault, Jacob Torrejon, Sebastian M. Waszak, Vijay Ramaswamy, Virve Pentikainen, Haci Ahmet Demir, Steven C. Clifford, Ed C. Schwalbe, Luca Massimi, Matija Snuderl, Kristyn Galbraith, Matthias A. Karajannis, Katherine Hill, Bryan K. Li, Mike Walsh, Christine L. White, Shelagh Redmond, Loizou Loizos, Marcus Jakob, Uwe R. Kordes, Irene Schmid, Julia Hauer, Claudia Blattmann, Maria Filippidou, Gianluca Piccolo, Wolfram Scheurlen, Ahmed Farrag, Kerstin Grund, Christian Sutter, Torsten Pietsch, Stephan Frank, Denis M. Schewe, David Malkin, Myriam Ben-Arush, Astrid Sehested, Tai-Tong Wong, Kuo-Sheng Wu, Yen-Lin Liu, Fernando Carceller, Sabine Mueller, Schuyler Stoller, Michael D. Taylor, Uri Tabori, Eric Bouffet, Marcel Kool, Felix Sahm, Andreas von Deimling, Andrey Korshunov, Katja von Hoff, Christian P. Kratz, Dominik Sturm, David T. W. Jones, Stefan Rutkowski, Cornelis M. van Tilburg, Olaf Witt, Gaelle Bougeard, Kristian W. Pajtler, Stefan M. Pfister, Franck Bourdeaut, Till Milde
Summary: This retrospective cohort study investigated medulloblastoma in Li-Fraumeni syndrome (LFS) patients and found poor prognosis. The results showed that patients who received radiotherapy and chemotherapy had better clinical outcomes, while chemotherapy intensity did not affect their prognosis.
Meeting Abstract
Oncology
Erin R. Rudzinski, Marc Ladanyi, Lauren L. Ritterhouse, Felix Sahm, Ricarda Norenberg, Hong Zheng, Chi Chen, Vadim Bernard-Gauthier, Nicoletta Brega, Cornelis M. Van Tilburg, Jessica J. Lin, Marcia S. Brose, Ulrik N. Lassen, Ray McDermott, Theodore W. Laetsch, David S. Hong, Alexander Drilon, Sinchita Roy-Chowdhuri
Meeting Abstract
Oncology
Anna Kolodziejczak, Lea Guerrini-Rousseau, Julien Masliah Planchon, Martin Mynarek, Martin Sill, Robert Autry, Eric Zhao, Steffen Hirsch, Christelle Dufour, Olivier Ayrault, Sebastian Waszak, Vijay Ramaswamy, Virve Pentikainen, Steven Clifford, Ed Schwalbe, Luca Massimi, Matija Snuderl, Matthias Karajannis, Christine White, Shelagh Redmond, Loizou Loizos, Marcus Jakob, Irene Schmid, Julia Hauer, Claudia Blattmann, Maria Filippidou, Christian Sutter, Torsten Pietsch, Stephan Frank, Denis Schewe, David Malkin, Astrid Sehested, Tai-Tong Wong, Fernando Carceller, Sabine Mueller, Michael Taylor, Uri Tabori, Eric Bouffet, Marcel Kool, Felix Sahm, Christian Kratz, Dominik Sturm, David Jones, Stefan Rutkowski, Olaf Witt, Gaelle Bougeard, Kristian Pajtler, Stefan Pfister, Franck Bourdeaut, Till Milde
Article
Clinical Neurology
Antonios Bayas, Achim Berthele, Norbert Blank, Peter Dreger, Simon Faissner, Manuel A. Friese, Lisa-Ann Gerdes, Oliver Martin Grauer, Vivien Haeussler, Christoph Heesen, Dietlinde Janson, Mirjam Korporal-Kuhnke, Markus Kowarik, Nikolaus Kroeger, Jan D. Luenemann, Roland Martin, Uwe Meier, Sven Meuth, Paolo Muraro, Michael Platten, Lucas Schirmer, Klarissa Hanja Stuerner, Jan Patrick Stellmann, Christof Scheid, Florian Then Bergh, Clemens Warnke, Brigitte Wildemann, Tjalf Ziemssen
Summary: Autologous hematopoietic stem cell transplantation (AHSCT) has shown high efficacy in controlling inflammatory disease activity in multiple sclerosis (MS), and the safety profile of the treatment has improved in recent years. Further clinical trials and registry-based analyses are needed to better define patient characteristics, evaluate the efficacy and safety of AHSCT, and position it as an optimal treatment option for different stages of MS.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
H. Kapell, L. Fazio, J. Dyckow, A. Cruz-Herranz, J. Campos, C. Mayer, E. d'Este, S. Schwarz, W. Mobius, C. Cordano, A. Probstel, M. Gharagozloo, A. Zulji, V. Naik, A. Delank, M. Cerina, T. Muntefering, C. Lerma-Martin, J. Sonner, J. Sin, K. Sabeur, M. Chavali, R. Srivastava, M. Heidenreich, K. Fitzgerald, C. Stadelmann, B. Hemmer, M. Platten, T. J. Jentsch, M. Engelhardt, T. Budde, K. Nave, P. Calabresi, M. Friese, A. Green, C. Acuna, D. H. Rowitch, S. Meuth, L. Schirmer
MULTIPLE SCLEROSIS JOURNAL
(2023)