Design of a superior cytokine antagonist for topical ophthalmic use

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

(2014) G. L. Stritesky et al.   JOURNAL OF IMMUNOLOGY

Efficacy of Topical Blockade of Interleukin-1 in Experimental Dry Eye Disease

(2012) Andre Okanobo et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Dry Eye Disease

(2012) William Stevenson   ARCHIVES OF OPHTHALMOLOGY

Structure of the activating IL-1 receptor signaling complex

(2012) Christoph Thomas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

 -Bulge triggers route-switching on the functional landscape of interleukin-1 

(2012) D. T. Capraro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Interleukin-1 as a Phenotypic Immunomodulator in Keratinizing Squamous Metaplasia of the Ocular Surface in Sjögren's Syndrome

(2010) Ying-Ting Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome

(2010) Ioannis Mitroulis et al.   European Journal of Internal Medicine

Chronic blockade of interleukin-1 (IL-1) prevents and attenuates neuropathic pain behavior and spontaneous ectopic neuronal activity following nerve injury

(2010) Eran Gabayl et al.   EUROPEAN JOURNAL OF PAIN

Autoimmunity at the ocular surface: pathogenesis and regulation

(2010) M E Stern et al.   Mucosal Immunology

Accessory to inflammation

(2010) John E Sims   NATURE IMMUNOLOGY

Structural insights into the assembly and activation of IL-1β with its receptors

(2010) Dongli Wang et al.   NATURE IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Denaturant-Dependent Conformational Changes in a β-Trefoil Protein: Global and Residue-Specific Aspects of an Equilibrium Denaturation Process

(2009) Ramil F. Latypov et al.   BIOCHEMISTRY

Anakinra for Rheumatoid Arthritis: A Systematic Review

(2009) M. MERTENS et al.   JOURNAL OF RHEUMATOLOGY

Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: Results from two sequential placebo-controlled studies

(2008) Hal M. Hoffman et al.   ARTHRITIS AND RHEUMATISM

IL-1β signaling initiates inflammatory hypernociception

(2008) Fletcher A. White et al.   BRAIN BEHAVIOR AND IMMUNITY

The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation

(2008) F. Annunziato et al.   INTERNATIONAL IMMUNOLOGY

Nociceptors Are Interleukin-1  Sensors

(2008) A. M. Binshtok et al.   JOURNAL OF NEUROSCIENCE

Extracting function from a  -trefoil folding motif

(2008) S. Gosavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA