Review
Immunology
Yang Xu, Huikai Zhang, Qian Sun, Rongxin Geng, Fanen Yuan, Baohui Liu, Qianxue Chen
Summary: Gliomas, the most common primary malignant tumor in adults' central nervous system, still lack breakthroughs in long-term treatment. Abnormalities in the immune regulatory mechanism in the tumor microenvironment are crucial for tumor cell survival, with alterations in amino acid metabolism impacting tumor cells and immune regulation mechanisms. Studying immune regulation of tryptophan metabolism in the tumor microenvironment of gliomas can help identify potential targets for treatment and enhance the efficacy of immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Danna Wang, Jianbin Wu, Peilin Zhu, Hanqi Xie, Lianxiao Lu, Wanting Bai, Weixi Pan, Renjie Shi, Jin Ye, Bing Xia, Zhenting Zhao, Yutang Wang, Xuebo Liu, Beita Zhao
Summary: Tryptophan can regulate depression-like behavior through modulating gut microbiota and metabolic pathways, improving neuroinflammation and energy metabolism.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Erica E. Alexeev, Alexander S. Dowdell, Morkos A. Henen, Jordi M. Lanis, J. Scott Lee, Ian M. Cartwright, Rachel E. M. Schaefer, Alfredo Ornelas, Joseph C. Onyiah, Beat Vogeli, Sean P. Colgan
Summary: Microbiota-derived indoles have been discovered as potent inhibitors of MPO, reducing MPO-associated tissue damage and potentially acting as endogenous immunomodulatory compounds. These findings suggest a symbiotic association between the gut microbiota and host innate immune system.
Review
Oncology
Nikita Choudhary, Robert C. Osorio, Jun Y. Oh, Manish K. Aghi
Summary: Glioblastoma (GBM) is an aggressive brain tumor with limited prognosis despite multimodal treatment approaches. Various immunotherapies have been investigated to address the need for novel therapeutic options in GBM with limited success. Recently, alterations in the metabolism of cancer cells which allow for tumor proliferation, but simultaneously alter immune populations leading to an immunosuppressive tumor microenvironment, have been investigated as contributory to therapeutic resistance.
Article
Chemistry, Multidisciplinary
Li-juan Wang, Yuan-ling Jin, Wen-long Pei, Jia-cong Li, Rui-lin Zhang, Jia-ju Wang, Wei Lin
Summary: In this study, the researchers found that pretreatment with the protein Amuc_1100 can alleviate acute pancreatitis (AP) and reduce pancreatic injury and inflammation. This is achieved by inhibiting the NF-kappa B signaling pathway, reducing inflammatory cell infiltration, and regulating the composition of gut microbiota and tryptophan metabolism.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Benatti Cristina, Rivi Veronica, Alboni Silvia, Grilli Andrea, Castellano Sara, Pani Luca, Brunello Nicoletta, Blom M. C. Johanna, Bicciato Silvio, Tascedda Fabio
Summary: Dysregulation of the kynurenine pathway is involved in various human diseases and disorders. Lymnaea stagnalis (LS), an invertebrate model, is a valuable tool for studying the complexity of this pathway. The researchers characterized the kynurenine pathway in LS, confirming the sequence conservation of key enzymes and identifying several compounds in the LS hemolymph.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Tingting Wang, Yonggui Song, Zhifu Ai, Yali Liu, Huizhen Li, Weize Xu, Liling Chen, Genhua Zhu, Ming Yang, Dan Su
Summary: This study reveals for the first time the antidepressant effect of Pulsatilla chinensis saponins and further demonstrates its potential therapeutic targets. Additionally, it clarifies that the tryptophan/kyurenine pathway is the crosstalk between inflammatory bowel disease and depression, providing a new choice for depression treatment. Moreover, it provides an important basis for the follow-up development and exploration of anti-intestinal antidepressants.
Article
Chemistry, Medicinal
Haitao Xiao, Jinxiu Feng, Jiao Peng, Peigen Wu, Yaoyao Chang, Xianqian Li, Jinhui Wu, Haifeng Huang, Huan Deng, Miao Qiu, Yuedong Yang, Bin Du
Summary: This study discovered a polysaccharide called Fuc-S that can alleviate chronic colitis. The experiment showed that Fuc-S significantly improved clinical manifestations and tissue injury associated with colitis, regulated the gut microbiota, and modulated the host-microbe tryptophan metabolism. This research provides useful information for the development of functional food and pharmaceutical candidates for treating inflammatory bowel disease.
Article
Immunology
Ting Liu, Zunxi Ning, Pengyu Liu, Huiyuan Gao
Summary: This study investigated the bioactivity of caesaldekarin e (CA), a cassane diterpenoid isolated from C. bonduc, in dextran sulfate sodium (DSS)-induced experimental colitis. The results showed that CA could ameliorate colitis symptoms, suppress inflammation, maintain intestinal barrier integrity, restore gut microbiota imbalance, and regulate tryptophan metabolism. Thus, CA has the potential to be used as a treatment option for ulcerative colitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Benedict Herhaus, Niklas Joisten, Inga Wessels, Philipp Zimmer, Katja Petrowski
Summary: Psychological stress and physical stress both affect the kynurenine pathway and inflammatory mediators, but the metabolic response is more pronounced after physical stress, suggesting an exercise-induced neuroprotective mechanism.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Immunology
Ronan Thibaut, Lucie Orliaguet, Tina Ejlalmanesh, Nicolas Venteclef, Fawaz Alzaid
Summary: Macrophages are innate immune cells with high phenotypic plasticity that can polarize on a spectrum from pro- to anti-inflammatory. Cellular metabolism is recognized as a key factor influencing macrophage function, but the directionality between metabolism and phenotype is still under investigation. By modulating metabolic pathways in macrophages, it has been shown that disruption of cellular metabolism does influence macrophage phenotype and function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Yao Yao, Xiaoyu Cai, Weidong Fei, Yiqing Ye, Mengdan Zhao, Caihong Zheng
Summary: Short-chain fatty acids (SCFAs) are important metabolites of gut microbiome and play a vital role in host health. They are key energy sources for colon and ileum cells, regulate intestinal epithelial barrier and defense functions, modulate the function of innate immune cells, regulate the differentiation of T cells and B cells, and also inhibit tumor cell proliferation and promote apoptosis.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Oncology
Johanna A. Seier, Julia Reinhardt, Kritika Saraf, Susanna S. Ng, Julian P. Layer, Dillon Corvino, Kristina Althoff, Frank A. Giordano, Alexander Schramm, Matthias Fischer, Michael Hoelzel
Summary: The study identified epigenetic drivers EHMT2 and EHMT1 as effectors of the MYCN-driven malignant phenotype and suppressors of IFN-gamma transcriptional responses in neuroblastoma cells. Inhibitors of EHMT enhanced T-cell recruitment into the tumor microenvironment through increased expression of Th1-type chemokines, which was further potentiated by co-inhibition of EZH2 in MYCN-amplified high-risk neuroblastomas.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Gioacchino Natoli, Francesco Pileri, Francesco Gualdrini, Serena Ghisletti
Summary: Macrophages respond to microbial and endogenous danger signals by activating various effector and homeostatic responses. This involves rapid changes in gene expression programs and metabolic rewiring, with chromatin modifications integrating transcriptional and metabolic regulation. The mutual influences between signal-induced metabolic changes and gene expression are not fully understood yet, and further research is needed to explore these interactions.
Article
Oncology
Yanqing Liu, Wei Gu
Summary: The metabolic regulation of p53 in tumor suppression is complex and diverse. It inhibits tumor development through regulating glucose, lipid, amino acid, nucleotide, iron metabolism, and ROS production.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Michael Timaner, Kelvin K. Tsai, Yuval Shaked
SEMINARS IN CANCER BIOLOGY
(2020)
Article
Oncology
Nai-Jung Chiang, Kelvin K. Tsai, Chin-Fu Hsiao, Shih-Hung Yang, Hui-Hua Hsiao, Wen-Chi Shen, Chiun Hsu, Yu-Lin Lin, Jen-Shi Chen, Yan-Shen Shan, Li-Tzong Chen
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Cell & Tissue Engineering
Wen-Ying Liao, Chung-Chi Hsu, Tze-Sian Chan, Chia-Jui Yen, Wei-Yu Chen, Hung-Wei Pan, Kelvin K. Tsai
Article
Oncology
Chung-Chi Hsu, Wen-Ying Liao, Kwang-Yu Chang, Tze-Sian Chan, Po-Jui Huang, Chun-Ting Chiang, Yan-Shen Shan, Lin-Hsin Cheng, Tai-Yan Liao, Kelvin K. Tsai
Summary: The study identified the crucial roles of ASPM and FOXM1 in GC progression, forming a regulatory module for Wnt activity and stemness. This has significant implications for the prognosis of GC patients.
Correction
Oncology
Chung-Chi Hsu, Wen-Ying Liao, Kwang-Yu Chang, Tze-Sian Chan, Po-Jui Huang, Chun-Ting Chiang, Yan-Shen Shan, Lin-Hsin Cheng, Tai-Yan Liao, Kelvin K. Tsai
Summary: A correction to the paper has been published.
Article
Multidisciplinary Sciences
Elisa Saccon, Xi Chen, Flora Mikaeloff, Jimmy Esneider Rodriguez, Laszlo Szekely, Beatriz Sa Vinhas, Shuba Krishnan, Siddappa N. Byrareddy, Teresa Frisan, Akos Vegvari, Ali Mirazimi, Ujjwal Neogi, Soham Gupta
Summary: The study assessed the tropism and cytopathogenicity of the first Swedish isolate of SARS-CoV-2 in six different human cell lines, comparing their growth characteristics and performing quantitative proteomics for susceptible cell lines. The protein abundance profile during SARS-CoV-2 infection revealed cell-type-specific regulation of cellular pathways. The data showed cell-type specific variability for cytopathogenicity, susceptibility, and cellular response to SARS-CoV-2, offering important clues for future studies.
Article
Infectious Diseases
Sreenivasulu B. Reddy, Noemi Nagy, Caroline Ronnberg, Francesca Chiodi, Allan Lugaajju, Frank Heuts, Laszlo Szekely, Mats Wahlgren, Kristina E. M. Persson
Summary: The study presents a new method for co-culturing P. falciparum parasites and human B-cells in vitro, showing that direct contact between the cells enhances parasite growth. The presence of parasites leads to changes in the proportion of different types of B-cells, highlighting the potential impact of the interaction between the parasites and B-cells on immune response and vaccine research.
Article
Oncology
Shenq-Shyang Huang, Wen-Ying Liao, Chung-Chi Hsu, Tze-Sian Chan, Tai-Yan Liao, Pei-Ming Yang, Li-Tzong Chen, Shian-Ying Sung, Kelvin K. Tsai
Summary: This study found specific expression of ENO1 on the invadopodial surface of a subset of highly invasive and pro-metastatic CSCs in human gastric and prostate adenocarcinomas. The ENO1(+) CSCs exhibited stronger mesenchymal properties compared to their ENO1(-) counterparts. Inhibiting the surface localization of ENO1 compromised invadopodia biogenesis, proteolysis, and CSC invasiveness, suggesting that sENO1 may be a potential target for improving outcomes in aggressive and metastatic cancers.
FRONTIERS IN ONCOLOGY
(2021)
Correction
Oncology
Shenq-Shyang Huang, Wen-Ying Liao, Chung-Chi Hsu, Tze-Sian Chan, Tai-Yan Liao, Pei-Ming Yang, Li-Tzong Chen, Shian-Ying Sung, Kelvin K. Tsai
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Isabel Pablos, Yoan Machado, Hugo C. Ramos de Jesus, Yasir Mohamud, Reinhild Kappelhoff, Cecilia Lindskog, Marli Vlok, Peter A. Bell, Georgina S. Butler, Peter M. Grin, Quynh T. Cao, Jenny P. Nguyen, Nestor Solis, Srinivas Abbina, Wioletta Rut, John C. Vederas, Laszlo Szekely, Attila Szakos, Marcin Drag, Jayachandran N. Kizhakkedathu, Karen Mossman, Jeremy A. Hirota, Eric Jan, Honglin Luo, Arinjay Banerjee, Christopher M. Overall
Summary: Research on the main viral protease of SARS-CoV-2 and its relationship with human protein substrates has revealed a large group of substrates, accelerating the exploration of pathophysiology and drug design. The study also demonstrates the interactions between 3CL(pro) and the Hippo pathway and other key effector proteins in human cells.
Article
Oncology
Benedek Bozoky, Carlos Fernandez Moro, Carina Strell, Natalie Geyer, Rainer L. Heuchel, J. Matthias Lohr, Ingemar Ernberg, Laszlo Szekely, Marco Gerling, Bela Bozoky
Summary: PDAC tumor cells integrated into the duodenal epithelium show a reversal to non-destructive growth and adopt the traits of intestinal cell differentiation, leading to phenotypical stabilization of the classical subtype. This phenomenon is conserved across species, highlighting the influence of microenvironmental cues on pancreatic cancer plasticity.
Article
Oncology
Li-Hsin Cheng, Chung-Chi Hsu, Hung-Wen Tsai, Wen-Ying Liao, Pei-Ming Yang, Tai-Yan Liao, Hsiao-Yen Hsieh, Tze-Sian Chan, Kelvin K. Tsai
Summary: Small cell lung cancer (SCLC) is a highly aggressive and deadly tumor. The upregulation of neurogenesis-associated protein ASPM-I1 is found in SCLC cells and is associated with poor patient prognosis. ASPM-I1 plays a crucial role in maintaining SCLC stemness and tumorigenesis through the regulation of multiple pathways and the Wnt signaling pathway.
Review
Oncology
Kelvin K. Tsai, Byoung-Il Bae, Chung-Chi Hsu, Li-Hsin Cheng, Yuval Shaked
Summary: Despite recent advances in targeted therapies and immunotherapies, effective treatment for advanced-stage cancers is still a clinical need. Identifying the driver mechanisms of cancer aggressiveness is crucial for developing breakthrough therapeutic strategies. ASPM has been found to play a critical role in regulating cancer stemness and aggressiveness in various malignant tumor types. This review summarizes the domain compositions, expression patterns, and prognostic significance of ASPM in cancers, as well as its role as a regulatory hub in development- and stemness-associated signaling pathways and DNA repair in cancer cells. The review highlights the potential utility of ASPM as a prognostic biomarker and therapeutic target.
Article
Oncology
Kelvin K. Tsai, Shenq-Shyang Huang, Jason J. Northey, Wen-Ying Liao, Chung-Chi Hsu, Li-Hsin Cheng, Michael E. Werner, Chih-Pin Chuu, Chandrima Chatterjee, Jonathon N. Lakins, Valerie M. Weaver
Summary: The study demonstrates the inhibitory role of nuclear repressor NCOR2 in chemotherapy response and antitumor immunity using breast cancer patient-derived organoids and mouse models. Blocking NCOR2-HDAC3 interaction provides a potential therapeutic target. The findings highlight the importance of targeting stress and inflammatory-repressor complexes, such as NCOR2-HDAC3, to overcome treatment resistance and improve outcomes for cancer patients.
Article
Multidisciplinary Sciences
Laszlo Szekely, Bela Bozoky, Matyas Bendek, Masih Ostad, Pablo Lavignasse, Lars Haag, Jieyu Wu, Xu Jing, Soham Gupta, Elisa Saccon, Anders Sonnerberg, Yihai Cao, Mikael Bjornstedt, Attila Szakos
Summary: The main pathology of COVID-19 was found in the lung parenchyma, with a massive accumulation of CD163+ macrophages and the disappearance of other immune cells being the dominant inflammatory response. Lung consolidations were caused by regenerative response, proliferation, and neovascularization.