期刊
SEMINARS IN CANCER BIOLOGY
卷 60, 期 -, 页码 225-237出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2019.06.003
关键词
Immunosuppression; Angiogenesis; Mesenchymal stem cells; Resistance; Metastasis
类别
资金
- European Research Council [711222]
- Ministry of Science and Technology, Taiwan [MOST 105-2314-B-400018]
- Taipei Medical University [DP2-107-21121-C-04]
- Wanfang Hospital, Ministry of Health and Welfare, Taiwan [MOHW108-TDU-B-212-124020]
- Chi-Mei Medical Center, Ministry of Health and Welfare, Taiwan [MOHW108-TDU-B-212-124020]
- Hualien TzuChi Hospital Joint Cancer Center Grant, Ministry of Health and Welfare, Taiwan [MOHW108-TDU-B-212-124020]
Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.
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