Review
Biochemistry & Molecular Biology
Pedro Borges de Souza, Laura de Araujo Borba, Louise Castro de Jesus, Ana Paula Valverde, Joana Gil-Mohapel, Ana Lucia S. Rodrigues
Summary: Major depressive disorder (MDD) is a significant contributor to the global burden of disease, with a complex interaction between environmental and genetic factors. Recent studies have shown that dysbiosis of the gut microbiota may contribute to the development of depression through dysregulation of the gut-brain axis. Physical exercise has been recognized as a potential therapeutic strategy for modulating the gut microbiota and alleviating MDD-related symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Mingyang Wu, Junqing Xie, Ziyi Zhou, Lulin Wang, Yonghua Hu, Yu Sun, Youjie Wang, Yaohua Tian
Summary: The study found that high levels of vitamin D and physical activity may attenuate the relationship between PM2.5 and major depressive disorder among elderly adults.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Esra Goerguelue, Miriam Bieber, Tobias Engeroff, Kirsten Zabel, Semra Etyemez, David Prvulovic, Andreas Reif, Viola Oertel
Summary: The study highlights the importance of physical activity in reducing medical complications and depressive symptoms in patients with major depressive disorder. It suggests that promoting habitual moderate-to-vigorous-intensity physical activity may help alleviate depression symptoms in outpatients. Additionally, it indicates that well-being and self-esteem may mediate the relationship between physical activity levels and depression symptoms in these patients.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Neuroimaging
M. K. Schwefel, C. Kaufmann, G. Gutmann, R. Henze, T. Fydrich, M. A. Rapp, A. Stroehle, A. Heissel, S. Heinzel
Summary: This study examined MDD patients and healthy controls using functional magnetic resonance imaging, and found that MDD patients showed poor cognitive abilities and longer reaction times in a working memory task. Compared to the healthy controls, MDD patients exhibited reduced neural activity in frontoparietal regions during medium to high loads of the working memory task. Additionally, physical fitness in MDD patients was associated with activity in the parietal lobules, suggesting a potential link between exercise and cognitive functioning in MDD.
NEUROIMAGE-CLINICAL
(2023)
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Caroline Swoboda, Lena Deloch, Claudia von Zimmermann, Tanja Richter-Schmidinger, Bernd Lenz, Johannes Kornhuber, Christiane Muehle
Summary: This study investigated the potential of MIF at genetic, expression, and protein levels as a risk factor and biomarker for diagnosing, monitoring, or predicting MDD. The results suggest a genetic effect of MIF in women but do not provide strong evidence for its utility as a biomarker for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Yolanda Sanchez-Carro, Maria J. Portella, Itziar Leal-Leturia, Neus Salvat-Pujol, Mikel Etxandi, Aida de Arriba-Arnau, Mikel Urretavizcaya, Esther Pousa, Alba Toll, Pilar Alvarez, Virginia Soria, Pilar Lopez-Garcia
Summary: The study found that patients with MDD have cognitive deficits compared to healthy controls, and these deficits are significantly associated with years of education, job status, age of onset of the disease, and physical activity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Chih-Chiang Chiu, Hsing-Cheng Liu, Wei-Hsin Li, Shang-Ying Tsai, Chiao-Chicy Chen, Chian-Jue Kuo
Summary: A study conducted in a large-scale Asian cohort found that patients with major depression have higher suicide mortality rates. The study estimated the standardised mortality ratio (SMR) and identified risk and protective factors for suicide in these patients. Findings revealed that agitation, restlessness, and previous suicide attempts were associated with increased suicide risk, while employment and loss of interest were associated with lower risk.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Meisheng Wang, Deju Yin, Lijun Liu, Shuzhe Zhou, Qi Liu, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Tianmei Si, Xin Yu, Xiaozhen Lv, Nan Zhang
Summary: This study found that cognitive impairment is common in patients with major depressive disorder, and it is associated with male sex and younger age of first onset, while comorbid anxiety disorders are protective against cognitive impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medical Laboratory Technology
Masoomeh Dadkhah, Mohsen Jafarzadehgharehziaaddin, Soheila Molaei, Morteza Akbari, Negin Gholizadeh, Farzaneh Fathi
Summary: Depressive disorders, characterized by loss of interest in previously enjoyed activities and a depressed mood, are highly heterogeneous psychiatric diseases. Diagnosis and treatment of major depressive disorder (MDD) remain challenging due to significant clinical presentation heterogeneity and lack of applicable biomarkers. Identification of relevant biomarkers would enhance disease classification and personalized treatment strategies. In this review, we discuss the current state of these biomarkers and diagnostic techniques specifically targeting these analytes using state-of-the-art biosensor technology.
CLINICA CHIMICA ACTA
(2023)
Article
Psychiatry
Robyn Cody, Johannes Beck, Serge Brand, Lars Donath, Oliver Faude, Martin Hatzinger, Christian Imboden, Jan-Niklas Kreppke, Undine E. Lang, Sebastian Ludyga, Sarah Mans, Thorsten Mikoteit, Anja Oswald, Nina Schweinfurth, Lukas Zahner, Markus Gerber
Summary: A physical activity counseling intervention based on a motivation-volition model was developed and delivered to in-patients with Major Depressive Disorders in Swiss psychiatric clinics. According to the study, the intervention group showed a decrease in step count and moderate-to-vigorous physical activity compared to the control group. However, there were no significant changes observed in motivation, volition determinants, and implicit attitudes towards physical activity.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Jixiang Yuan, Hua Yu, Minglan Yu, Xuemei Liang, Chaohua Huang, Rongfang He, Wei Lei, Jing Chen, Jianning Chen, Youguo Tan, Kezhi Liu, Tao Zhang, Huairong Luo, Bo Xiang
Summary: This meta-analysis study revealed that major depressive disorder (MDD) is associated with significant abnormalities in spontaneous neural activity during resting state, particularly in brain regions associated with visual processing such as the cuneus and middle occipital gyrus. Dysfunction in these regions may contribute to the pathogenesis of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: The study compared patients diagnosed with DSM-5 type II bipolar disorder (BD2) and major depressive disorder (MDD). The results showed significant differences between BD2 and MDD patients in terms of symptoms, morbidity, and treatment, which can contribute to better differentiation and treatment planning for the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Hao Tang, Tingting Xiong, Jiabo Shi, Yu Chen, Xiaoxue Liu, Siqi Zhang, Huan Wang, Qing Lu, Zhijian Yao
Summary: The study aimed to investigate the relationship between rumination and suicide attempts, finding that both global rumination levels and reflection were higher in suicide attempters than non-suicide attempters; the results suggest that rumination may be a risk factor for suicide attempts.
Article
Cell Biology
Jaeyoon Kim, Elisabetta Dare, Subu Surendran Rajasekaran, Sung Ho Ryu, Per-Olof Berggren, Christopher J. Barker
CELLULAR SIGNALLING
(2019)
Article
Biochemistry & Molecular Biology
Minchul Lee, Hae-Sung Cho, Kyeong Jin Yoon, WonSang Lee, Hyo Youl Moon
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Hyo Youl Moon, Kyeong Jin Yoon, Won Sang Lee, Hae-Sung Cho, Yeon Kim, Ji-Seok Kim
SCIENTIFIC REPORTS
(2020)
Article
Biochemical Research Methods
Kang Uk Kim, Kyeong Jin Yoon, Suhong Park, Jong Cheol Lee, Hyo Youl Moon, Myeong Hee Moon
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Cell Biology
Kyeong Jin Yoon, Aram Ahn, Soo Hong Park, Seung Hee Kwak, Seong Eun Kwak, Wonsang Lee, Yong Ryoul Yang, Minji Kim, Hyun Mu Shin, Hang-Rae Kim, Hyo Youl Moon
Summary: This study confirmed that 4 weeks of treadmill exercise can significantly improve metabolic function in aged mice, including increased lean mass and decreased fat mass, while decreasing the expression level of the senescence marker p16 in white adipose tissue. Exercise also induced changes in immune-cell subsets in the stromal vascular fraction of WAT, as well as activating pathways involved in the interaction between WAT and immune cells, particularly NK cells, in aged mice. These results suggest that exercise has a profound effect on immune-cell distribution and senescent-cell scavenging in WAT of aged mice, ultimately affecting overall energy metabolism towards a more youthful state.
Article
Biochemistry & Molecular Biology
Na-Oh Yunn, Mangeun Park, Seongeun Park, Jimin Lee, Jeongeun Noh, Euisu Shin, Sung Ho Ryu
Summary: Aptamers are single-stranded oligonucleotides that can bind to a specific target with high affinity. In this study, researchers discovered that aptamers can also act as positive allosteric modulators to enhance receptor activation. By developing a novel aptamer, IR-A43, they demonstrated that it could potentiate insulin receptor activation by binding to the receptor and stabilizing ligand binding.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Environmental Sciences
Seiyeong Park, Junhye Kwon, Chiyoung Ahn, Hae-Sung Cho, Hyo Youl Moon, Chung Gun Lee
Summary: This study found that dopamine receptor D2 (DRD2) influences the behavior of male university students in sports participation, with male students carrying the A1 allele of DRD2 participating in sports for a longer duration. Within the framework of the Integrated Behavioral Model (IBM), DRD2 can alter the impact of intention on sports participation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Julian M. Gaitan, Hyo Youl Moon, Matthew Stremlau, Dena B. Dubal, Dane B. Cook, Ozioma C. Okonkwo, Henriette van Praag
Summary: Research suggests that aerobic exercise training can increase plasma CTSB levels, and changes in CTSB are correlated with cognitive performance. BDNF levels decreased with exercise training, while klotho levels remained unchanged but were closely related to changes in VO(2)peak. Metabolomic analysis showed an increase in PUFAs, reductions in ceramides, sphingo- and phospholipids, as well as changes in gut microbiome metabolites and redox homeostasis with exercise training.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Kyeong Jin Yoon, Suhong Park, Seung Hee Kwak, Hyo Youl Moon
Summary: Anxiety disorders are commonly diagnosed psychological conditions that are often treated with drugs, but these medications can have side effects. Exercise is an effective treatment for anxiety, and it has been found to release extracellular vesicles (EVs) that may help reduce anxiety. Research suggests that exercise-derived EVs may have anti-anxiety effects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Immunology
Hyung Sik Kim, Min Young Park, Nam Joo Yun, Hye Sun Go, Mi Young Kim, Je Kyung Seong, Minyoung Lee, Eun Seok Kang, Jaewang Ghim, Sung Ho Ryu, Brian A. Zabel, Ara Koh, Yoe-Sik Bae
Summary: Kim et al. found that deficiency of phospholipase D2 enhances thermogenic program and enhances mitochondrial quality in adipose tissues, leading to resistance to high fat diet-induced obesity and insulin resistance. Targeting PLD2 may offer potential therapeutics for obese and/or type 2 diabetic patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Harim Choe, Hoyong Sung, Geon Hui Kim, On Lee, Hyo Youl Moon, Yeon Soo Kim
Summary: The study found a significant association between lower grip strength and poor glycemic control in male patients with diabetes mellitus. Further research is needed to confirm the causal relationship between grip strength and glycemic control.
EPIDEMIOLOGY AND HEALTH
(2021)
Article
Multidisciplinary Sciences
Minhyeok Chang, O-Chul Lee, Gayun Bu, Jaeho Oh, Na-Oh Yunn, Sung Ho Ryu, Hyung-Bae Kwon, Anatoly B. Kolomeisky, Sang-Hee Shim, Junsang Doh, Jae-Hyung Jeon, Jong-Bong Lee
Summary: The study discovered that membrane nanotubes are formed from double filopodial bridges through physical contact and helical deformation. The transition of a double filopodial bridge to a closed-end membrane nanotube is likely triggered by the disruption of adhesion between two filopodia due to accumulated mechanical energy in the twisted double filopodial bridge.
Article
Physiology
Suhong Park, Hyo Youl Moon
Summary: The study found that the number of urinary EVs significantly increased after exercise and returned to baseline levels after 1-hour rest. miRNA sequencing revealed alterations in four miRNAs pre- and post-exercise, suggesting that urinary EVs could potentially serve as a novel biomarker for acute exercise-induced fatigue.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Junhong Kim, Na-Oh Yunn, Mangeun Park, Jihan Kim, Seongeun Park, Yoojoong Kim, Jeongeun Noh, Sung Ho Ryu, Yunje Cho
Summary: Here, the authors determine the structures of insulin receptor bound to aptamers and provide a basis for the selective activation or allosteric regulation of the insulin receptor.
NATURE COMMUNICATIONS
(2022)
Article
Geriatrics & Gerontology
Hyung Eun Shin, Seong Eun Kwak, Di Di Zhang, Jihyun Lee, Kyeong Jin Yoon, Hae Sung Cho, Hyo Youl Moon, Wook Song
EXPERIMENTAL GERONTOLOGY
(2020)