Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis

Statins and the Risk of Cancer After Heart Transplantation

(2012) Georg Marcus Fröhlich et al.   CIRCULATION

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

(2011) W. Zheng et al.   BLOOD

12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation

(2011) N. K. Singh et al.   BLOOD

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

(2011) Dontscho Kerjaschki et al.   JOURNAL OF CLINICAL INVESTIGATION

Statins and Prostate Cancer Diagnosis and Grade in a Veterans Population

(2011) W. R. Farwell et al.   JNCI-Journal of the National Cancer Institute

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche

(2010) M. Kim et al.   CANCER RESEARCH

Rosuvastatin, Identified From a Zebrafish Chemical Genetic Screen for Antiangiogenic Compounds, Suppresses the Growth of Prostate Cancer

(2010) Chunyang Wang et al.   EUROPEAN UROLOGY

Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium

(2010) Giorgia Jurisic et al.   EXPERIMENTAL CELL RESEARCH

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

(2010) Christophe Frémin et al.   Journal of Hematology & Oncology

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice

(2010) Mara E Pitulescu et al.   Nature Protocols

An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis

(2009) R. E. Kalin et al.   BLOOD

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

(2009) C. Iverson et al.   CANCER RESEARCH

Combination of Reverse and Chemical Genetic Screens Reveals Angiogenesis Inhibitors and Targets

(2009) Mattias Kalén et al.   CHEMISTRY & BIOLOGY

Investigating endothelial invasion and sprouting behavior in three-dimensional collagen matrices

(2009) Kayla J Bayless et al.   Nature Protocols

Angiogenesis: An Improved In Vitro Biological System and Automated Image-Based Workflow to Aid Identification and Characterization of Angiogenesis and Angiogenic Modulators

(2008) Albert Francis Santos et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

(2008) Revati J. Tatake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis

(2008) J. W. Shin et al.   BLOOD

Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways

(2008) C. M. Yoon et al.   BLOOD

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Lymphatic endothelium in health and disease

(2008) Giorgia Jurisic et al.   CELL AND TISSUE RESEARCH

Modeling lymphangiogenesis in a three-dimensional culture system

(2008) Françoise Bruyère et al.   NATURE METHODS

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

(2008) Stéphane Berghmans et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS