Article
Pharmacology & Pharmacy
Himangshu Sonowal, Hongying Zhang, William Rice, Stephen B. Howell
Summary: The multikinase inhibitor Luxeptinib demonstrates the ability to inhibit the release of IL-1 beta, IL-6, and TNF alpha from monocytes and macrophages, making it a potential treatment for inflammatory diseases and inflammation-associated resistance in cancer. The mechanism involves disabling caspase-1 and inhibiting multiple kinases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Article
Cell & Tissue Engineering
Lingli Qi, Jing Wu, Shan Zhu, Xue Wang, Xinping Lv, Chunyan Liu, Yong-Jun Liu, Jingtao Chen
Summary: Mesenchymal stem cells (MSCs) have been shown to effectively alleviate inflammatory bowel disease (IBD) by increasing the proportion of type 1 regulatory T (Tr1) cells and decreasing the proportion of T helper (Th)-1 and Th17 cells. The upregulation of Tr1 cells by MSCs is mediated by blocking indoleamine-2,3-dioxygenase (IDO) and is associated with the inhibition of Tr1 cell apoptosis and promotion of proliferation.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Irene Soleto, Samuel Fernandez-Tome, Irene Mora-Gutierrez, Montserrat Baldan-Martin, Cristina Ramirez, Cecilio Santander, Jose Andres Moreno-Monteagudo, Maria Jose Casanova, Fernando Casals, Sergio Casabona, Irene Becerro, Maria Chaparro, David Bernardo, Javier P. Gisbert
Summary: Inflammatory bowel disease (IBD) is a chronic condition characterized by uncontrolled intestinal immune response. This study focuses on the role of dendritic cells (DCs) in IBD and explores the mechanisms governing their migration. The results suggest that DC migration towards the intestinal mucosa plays a key role in IBD and may have potential diagnostic and immunomodulatory implications.
Article
Biochemistry & Molecular Biology
Xiangli Zhao, Ronghan Liu, Yuehong Chen, Aubryanna Hettinghouse, Chuanju Liu
Summary: Fexofenadine, a commonly used antihistamine, has been found to be therapeutic in murine models of chemically-induced IBD, with its anti-inflammatory effects depending on cPLA2 rather than histamine H1 receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Irene Marafini, Giovanni Monteleone
Summary: Recent advances in understanding the pathogenic mechanisms of inflammatory bowel diseases (IBD) have led to an expansion in therapeutic options, including monoclonal antibodies and small molecule inhibitors. However, treatment efficacy varies and some patients may lose response over time due to the complex and evolving nature of the disease. Personalized approaches to identify the most suitable treatment for individual patients at specific time points may improve drug efficacy and minimize adverse reactions, ultimately benefiting patients' quality of life and reducing costs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Valeria Dipasquale, Giuseppe Cicala, Edoardo Spina, Claudio Romano
Summary: This study reviewed the use of biosimilars in pediatric inflammatory bowel disease (IBD) patients and found that the effectiveness of CT-P13, a biosimilar of anti-TNF-alpha, was similar to that of the originator drug IFX in terms of clinical response and remission rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Jose M. Ferro, Miguel Oliveira Santos
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that not only affect the digestive system but can also cause neurological manifestations in the central and peripheral nervous system. The pathophysiology of neurological complications in IBD involves immune mediated processes as well as other mechanisms such as thromboembolism, infections, and nutritional deficiencies. There is a bidirectional association between multiple sclerosis and IBD, and caution is needed when treating patients with both conditions.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Immunology
Junjun Zhao, Qiliang Lu, Yang Liu, Zhan Shi, Linjun Hu, Zhi Zeng, Yifeng Tu, Zunqiang Xiao, Qiuran Xu
Summary: Autoimmune diseases are complex and closely related to CD4+ T helper cells. Th17 cells play a key role in the pathogenesis of autoimmune bowel disease.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hetal Bhadricha, Vainav Patel, Amit Kumar Singh, Lalita Savardekar, Anushree Patil, Suchitra Surve, Meena Desai
Summary: The study indicates that the increase in Th17 cell frequency and IL-17 levels in postmenopausal women may be associated with decreased bone density, possibly due to estrogen deficiency. Th17 cells and IL-17 could be potential targets for immunotherapy in the treatment of osteoporosis.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Alberto Signore, Rita Bonfiglio, Michela Varani, Filippo Galli, Giuseppe Campagna, Manuel Desco, Lorena Cusso, Maurizio Mattei, Andreas Wunder, Filippo Borri, Maria T. Lupo, Elena Bonanno
Summary: Imaging using radiolabelled monoclonal antibodies can provide molecular information for treatment planning and monitoring therapeutic response in cancer and chronic inflammatory diseases. The study aimed to evaluate if a pre-therapy scan with radiolabelled anti-alpha(4)beta(7) integrin or anti-TNF alpha mAb could predict therapeutic outcome with unlabelled counterparts.
Review
Medicine, Research & Experimental
Yaoyao Chang, Lixiang Zhai, Jiao Peng, Haiqiang Wu, Zhaoxiang Bian, Haitao Xiao
Summary: IBD is a chronic inflammatory intestinal disorder with limited treatment options, and correcting the imbalance of Th17/Treg has been shown to be effective in preventing and treating IBD. Phytochemicals derived from natural products have been recognized as potent regulators of Th17/Treg and may offer protective benefits against colonic inflammation, showing great potential for the development of new drugs for IBD treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ranit Das, Navneet Khurana, Neha Sharma
Summary: In this study, a new animal model was developed to investigate the causal relationship between inflammatory bowel disease (IBD) and isotretinoin. The results showed that isotretinoin caused significant damage to the intestinal mucosa and worsened the symptoms of IBD, especially at the dose of 35 mg/kg.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Gastroenterology & Hepatology
Yuri Gorelik, Shay Freilich, Shiran Gerassy-Vainberg, Sigal Pressman, Chagit Friss, Alexandera Blatt, Gili Focht, Yiska Loewenberg Weisband, Shira Greenfeld, Revital Kariv, Nathan Lederman, Iris Dotan, Naama Geva-Zatorsky, Shai Shlomo Shen-Orr, Yechezkel Kashi, Yehuda Chowers
Summary: This study found that antibiotic treatments can affect the risk of developing anti-drug antibodies (ADA) to anti-TNF therapy in patients with inflammatory bowel disease. The use of cephalosporins and penicillins with beta-lactamase inhibitors increased the risk of ADA development, while macrolides and fluoroquinolones reduced the risk.
Article
Environmental Sciences
Fallah Hashemi, Farahnaz Soleimani Hamidinejad, Lori Hoepner, Ata Rafiee, Alireza Abbasi, Mohammad Hoseini
Summary: This study investigated the exposure of pregnant women living near the Ilam petrochemical complex to BTEX and its associations with pro-inflammatory cytokines IL-6 and TNF-alpha. Results showed higher levels of BTEX and increased pro-inflammatory cytokine levels in the exposed group, with benzene having the most significant correlation. Long-term residence near petrochemical industries may pose health risks for pregnant women due to exposure to BTEX and elevated cytokine levels.
AIR QUALITY ATMOSPHERE AND HEALTH
(2022)
Review
Immunology
Ourania Kolliniati, Eleftheria Ieronymaki, Eleni Vergadi, Christos Tsatsanis
Summary: Macrophages, as central mediators of innate immune responses, adapt to different environments and nutritional resources by utilizing energy at both normoxic and hypoxic conditions and modulating signaling pathways to shape different activation phenotypes. Systemic changes in diseases can also affect macrophage metabolism, resulting in altered activation phenotypes in adipose tissue or in the periphery.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Endocrinology & Metabolism
Kalliopi G. Gkouskou, Georgios Georgiopoulos, Ioannis Vlastos, Evgenia Lazou, Dimitrios Chaniotis, Theodore G. Papaioannou, Christos S. Mantzoros, Despina Sanoudou, Aristides G. Eliopoulos
Summary: This study found that the rs762551 polymorphism in the CYP1A2 gene modifies the association between habitual coffee consumption and BMI, partly by influencing appetite, energy intake, and circulating levels of the orexigenic hormone asprosin. This association is more evident in individuals with a high genetic predisposition to obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Nutrition & Dietetics
Kalliopi K. Gkouskou, Maria G. Grammatikopoulou, Evgenia Lazou, Despina Sanoudou, Dimitrios G. Goulis, Aristides G. Eliopoulos
Summary: This study assessed the effects of genetically-guided vs. conventional MNT on patients with pre-diabetes or T2DM through n-of-1 trials. The results showed that genetically-guided precision MNT intervention led to improvements in body weight, fasting plasma glucose, blood pressure, and glycemic control. Additionally, remission of pre-diabetes was observed in two patients.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Maria Vougioukalaki, Konstantina Georgila, Emmanouil Athanasiadis, Aristides G. Eliopoulos
Summary: This study reveals that detached carcinoma cells and immortalized fibroblasts exhibit defects in signaling pathways induced by TNF and CD40L, leading to increased sensitivity to death-inducing receptor ligands. The findings suggest a new mode of regulation of TNF family signal transduction by adhesion-related molecules, which may have significant implications for cancer therapy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Eleftherios E. Deiktakis, Eleftheria Ieronymaki, Peter Zaren, Agnes Hagsund, Elin Wirestrand, Johan Malm, Christos Tsatsanis, Ilpo T. Huhtaniemi, Aleksander Giwercman, Yvonne Lundberg Giwercman
Summary: This study explores the direct effects of adding FSH on prostate size and gene expression after androgen ablation with a GnRH antagonist. The results indicate that supplementing FSH can partially restore prostate weight and increase the expression of specific genes in mice. However, in humans, FSH has no effect on PSA production.
ENDOCRINE CONNECTIONS
(2022)
Article
Biochemistry & Molecular Biology
Evangelos Karatzas, Fotis A. Baltoumas, Ioannis Kasionis, Despina Sanoudou, Aristides G. Eliopoulos, Theodosios Theodosiou, Ioannis Iliopoulos, Georgios A. Pavlopoulos
Summary: Darling is a web application that helps users find and explore the associations between diseases and biomedical entities in PubMed literature.
Review
Health Care Sciences & Services
Ioannis Stouras, Theodore G. Papaioannou, Konstantinos Tsioufis, Aristides G. Eliopoulos, Despina Sanoudou
Summary: Despite the availability of numerous drugs for cardiovascular disease, challenges remain in ensuring their safe and effective use. Dietary elements and genetic variation can impact the absorption, distribution, and action of drugs, highlighting the importance of personalized cardiovascular healthcare.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Zacharias Christoforakis, Eirini Dermitzaki, Eleni Paflioti, Marianna Katrinaki, Michail Deiktakis, Theodoros H. Tosounidis, Konstantine Ballalis, Christos Tsatsanis, Maria Venihaki, George Kontakis
Summary: This study found that knee osteoarthritis patients with metabolic syndrome had higher concentrations of interleukin 6, and demonstrated the critical role of infrapatellar fat pad in knee joint homeostasis and progression of KOA.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Retraction
Multidisciplinary Sciences
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Dimitrios Chioureas, Janina Beck, George Baltatzis, Ioulia Vardaki, Pedro Fonseca, Nikolaos Tsesmetzis, Francisco Vega, Vasiliki Leventaki, Aristides G. Eliopoulos, Elias Drakos, George Z. Rassidakis, Theocharis Panaretakis
Summary: ALK+ anaplastic large cell lymphoma (ALK+ ALCL) is an aggressive non-Hodgkin lymphoma characterized by overexpression and activation of ALK kinase due to chromosomal translocations. This study demonstrates that ALK+ ALCL cells secrete exosomes containing critical components of ALK signaling which can be taken up by other cells, influencing tumor microenvironment and possibly contributing to treatment resistance. The interactions between ALK signaling and the microenvironment in ALK+ ALCL are not fully understood, but this research shows that exosome-mediated activation of stromal cells can alter the cytokine profile of the microenvironment, potentially impacting tumor aggressiveness and resistance to treatment.
Article
Immunology
Ahmed A. Al-Qahtani, Ioanna Pantazi, Fatimah S. Alhamlan, Hani Alothaid, Sabine Matou-Nasri, George Sourvinos, Eleni Vergadi, Christos Tsatsanis
Summary: The study found that the S protein of SARS-CoV-2 suppresses inflammatory responses in alveolar epithelial type II cells at early stages of infection by activating the PI3K/AKT pathway. Additionally, when combined with TLR2 signals, the S protein enhances PAI-1 expression, potentially affecting the local coagulation cascade.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Mohamed A. A. Tammam, Maria G. G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou
Summary: The chemical investigation of the organic extract of the red alga Laurencia majuscula resulted in the isolation of several new natural products with significant anti-inflammatory activity. The structures and configurations of these natural products were determined through NMR, MS, and single-crystal X-ray diffraction analysis. The most prominent anti-inflammatory activity was exhibited by compounds 5 and 18.
Article
Chemistry, Medicinal
Aristides G. Eliopoulos, Apostolis Angelis, Anastasia Liakakou, Leandros A. Skaltsounis
Summary: Non-polar Primula veris L. subsp. veris extracts have been found to exhibit anti-influenza virus activity, providing prophylactic and therapeutic effects against influenza virus-induced cytolysis in vitro. These extracts contain terpenes, flavones, tocopherols, and other phytochemicals with known or putative anti-influenza properties. Combining P. veris subsp. veris with extracts of medicinal plants such as Echinacea purpurea (L.) Moench and Cistus creticus L. subsp. creticus enhances the protective effect against influenza virus infection and reduces virus production by infected cells. Further studies are needed to evaluate the clinical efficacy of non-polar P. veris flower extracts.
Article
Endocrinology & Metabolism
Christos Tsatsanis, Angel Elenkov, Irene Leijonhufvud, Katerina Vaporidi, Asa Tivesten, Aleksander Giwercman
Summary: Sex hormones and sex chromosomes have different impacts on cytokines involved in sex-dependent inflammatory response. The concentration of BAFF and LPS-stimulated TNF secretion depends on sex hormone levels, while basal TNF is regulated by both sex hormone-dependent and -independent factors.
ENDOCRINE CONNECTIONS
(2023)
Article
Nutrition & Dietetics
Maria G. Grammatikopoulou, Kalliopi K. Gkouskou, Konstantinos Gkiouras, Dimitrios P. Bogdanos, Aristides G. Eliopoulos, Dimitrios G. Goulis
Summary: n-of-1 clinical trials are considered the epitome of individualized healthcare, providing evidence-based personalized obesity treatment through trial and error, reducing non-responders, and tailoring the best intervention for each patient.
CURRENT NUTRITION REPORTS
(2022)