Review
Microbiology
Darshika J. Udawatte, Alan L. Rothman
Summary: RIPK1 serves as a key regulator of cell death and inflammation, affecting the outcome of virus infections through activation of different signaling pathways. Viruses manipulate host immune responses by targeting RIPK1, highlighting potential directions for future research.
Article
Immunology
Fan Mao, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Jingchen Song, Shiwei Fu, Zhiming Xiang, Shu Xiao, Yongbo Bao, Ziniu Yu, Yang Zhang
Summary: This study reveals the regulatory mechanisms of the Hippo pathway in immune responses of Crassostrea hongkongensis hemocytes, highlighting its importance in maintaining immune homeostasis and orchestrating hemocytic functions. It also demonstrates the divergence of the Hippo pathway's roles in marine invertebrate immunity from mammalian observations, indicating the need for further comparative studies across species.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Floriana Mulas, Xu Wang, Shanshan Song, Gopala Nishanth, Wenjing Yi, Anna Brunn, Pia-Katharina Larsen, Berend Isermann, Ulrich Kalinke, Antonio Barragan, Michael Naumann, Martina Deckert, Dirk Schlueter
Summary: OTUB1 is identified as a potent novel regulator of DCs during infectious and inflammatory diseases. It promotes NF-kappa B activity, regulates cytokine production, and impacts the response to pathogens.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Yi Guo, Xia-Nan Zhang, Shan Su, Zi-Lun Ruan, Ming-Ming Hu, Hong-Bing Shu
Summary: Upon viral infection, the levels of beta-adrenergic hormones and their receptors decrease, inhibiting the innate antiviral response. Increased levels of beta-adrenergic hormones activate PKA kinase, which phosphorylates MITA and VISA, suppressing the innate immune response to DNA and RNA viruses. These findings provide insights into the regulatory mechanisms of innate antiviral responses and the increased susceptibility to viral infection in stressful situations.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patrick Haider, Julia B. Kral-Pointner, Manuel Salzmann, Florian Moik, Sonja Bleichert, Waltraud C. Schrottmaier, Christoph Kaun, Mira Brekalo, Michael B. Fischer, Walter S. Speidl, Christian Hengstenberg, Bruno K. Podesser, Kurt Huber, Ingrid Pabinger, Sylvia Knapp, Frank Brombacher, Christine Brostjan, Cihan Ay, Johann Wojta, Philipp J. Hohensinner
Summary: IL-4R alpha plays a homeostatic role in regulating the lifespan of monocytes, and its absence leads to a reduction in monocyte numbers and affects the occurrence of inflammatory responses.
Review
Allergy
Timothy N. Perkins, Mason L. Donnell, Tim D. Oury
Summary: Asthma affects nearly 400 million people worldwide, with the majority of patients exhibiting a type 2-high phenotype and severe asthma often being associated with a type 2-low phenotype. The receptor for advanced glycation endproducts (RAGE) plays a significant role in asthma pathogenesis and allergic airway disease, especially in severe neutrophilic asthma.
Article
Multidisciplinary Sciences
Yu-Lin Yang, Li -Bo Cao, Wen-Rui He, Li Zhong, Yi Guo, Qing Yang, Hong -Bing Shu, Ming-Ming Hu
Summary: The current understanding of nucleic acid-mediated innate immunity is that the binding of intracellular sensors to nucleic acids is enough to activate them. However, this study reveals that the endocytosis of viruses or foreign DNA provides a priming signal for the activation of the DNA sensor cGAS in the innate immune response. This finding demonstrates that the activation of cGAS following endocytosis requires tyrosine phosphorylation mediated by the V-ATPase-SYK pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Shangran Zhang, Runan Zheng, Yanhong Pan, Hongbin Sun
Summary: The stimulator of interferon genes (STING) is a critical protein that activates the immune system and participates in the inflammatory response. It can modulate the inflammation-preferred translation program or induce the secretion of type I interferons and proinflammatory factors through different pathways. This review summarizes the potential value of STING inhibitors in preventing and treating infectious diseases, psoriasis, systemic lupus erythematosus, non-alcoholic fatty liver disease, and other inflammatory and autoimmune diseases, based on the structure, location, function, genotype, and regulatory mechanism of STING.
Review
Pharmacology & Pharmacy
Aleksandra Kusiak, Gareth Brady
Summary: The human innate immune response can be activated by various stimuli, such as PAMPs and DAMPs. These stimuli trigger intracellular signaling pathways that activate transcription factors from the NF-kappa B and IRF families, which play crucial roles in inflammation and antiviral response.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Piet Nuijten, Natalie Cleton, Jeroen van der Loop, Birgit Makoschey, Wilco Pulskens, Geert Vertenten
Summary: Intranasal vaccination with live attenuated BRSV and BPIV3 virus strains can provide early protection against bovine respiratory disease in young calves. Vaccination induced gene expression profiles reflecting an antiviral state, early activation of innate immune and antiviral responses, and specific cellular immune pathways. The vaccinated animals were protected against nasal shedding of the challenge virus and clinical symptoms, and gene expression levels returned to values before vaccination.
Article
Veterinary Sciences
Elisabetta Razzuoli, Chiara Grazia De Ciucis, Barbara Chirullo, Katia Varello, Roberto Zoccola, Lisa Guardone, Paola Petrucci, Danja Rubini, Elena Bozzetta, Maria Goria, Floriana Fruscione, Paola Modesto
Summary: Canine mammary cancer shares many similarities with human breast cancer in terms of risk factors, behavior, and clinical course. These breast tumors are resistant to conventional therapies, making the study of alternative treatments necessary. The CF33 cell line can serve as an in vitro model for evaluating innovative therapeutic approaches involving bacteria.
VETERINARY SCIENCES
(2022)
Article
Fisheries
Xiaohao Li, Yanyun Liu, Jianxin Cheng, Yuqing Xia, Kunpeng Fan, Ying Liu, Peng-fei Liu
Summary: This study cloned a fibrinogen alpha chain-like gene from Atlantic salmon, analyzed its expression pattern after infection by the bacterium Aeromonas salmonicida, and found that it may play important roles in the innate immune responses to bacterial invasion in Atlantic salmon. The study highlighted the significance of Ss-FGA in the immune system of Atlantic salmon.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Livio Ruzzante, Romain Feron, Maarten J. M. F. Reijnders, Antonin Thiebaut, Robert M. Waterhouse
Summary: The study explores the roles of constraints in shaping evolutionary outcomes in the contexts of developmental biology, population genetics, and comparative genomics. It suggests that gene roles in immune responses limit the range of possible evolutionary scenarios they exhibit.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Mengling Huang, Ying Zhang, Ying Wang, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Xiao Yu, Bo Li
Summary: Active DNA demethylation plays a critical role in MAMP-triggered immune response in plants, with flg22-induced DNA demethylation tightly associated with the expression of salicylic acid signaling-related and phytoalexin biosynthesis-related genes. Lack of active DNA demethylation compromises immune response.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Chemistry, Multidisciplinary
Rui Zhang, Xianteng Hou, Changwan Wang, Jiaxin Li, Junyan Zhu, Yingbo Jiang, Fajian Hou
Summary: This study identifies ATP13A1 as an important regulator of the stability and activation of RIG-I pathway, highlighting its crucial role in antiviral innate immune response.
Review
Biochemistry & Molecular Biology
Umberto Tosi, Christopher S. Marnell, Raymond Chang, William C. Cho, Richard Ting, Uday B. Maachani, Mark M. Souweidane
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Oncology
Y. Linda Wu, Uday Bhanu Maachani, Melanie Schweitzer, Ranjodh Singh, Melinda Wang, Raymond Chang, Mark M. Souweidane
TRANSLATIONAL ONCOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Umberto Tosi, Harikrishna Kommidi, Vanessa Bellat, Christopher S. Marnell, Hua Guo, Oluwaseyi Adeuyan, Melanie E. Schweitzer, Nandi Chen, Taojunfeng Su, Guoan Zhang, Uday B. Maachani, David J. Pisapia, Benedict Law, Mark M. Souweidane, Richard Ting
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Medicine, Research & Experimental
Hua Guo, Harikrishna Kommidi, Uday B. Maachani, Julia C. Voronina, Weiqi Zhang, Rajiv S. Magge, Jana Ivanidze, Amy P. Wu, Mark M. Souweidane, Omer Aras, Richard Ting
MOLECULAR PHARMACEUTICS
(2019)
Article
Oncology
Uday B. Maachani, Umberto Tosi, David J. Pisapia, Sushmita Mukherjee, Christopher S. Marnell, Julia Voronina, Daniel Martinez, Mariarita Santi, Nadia Dahmane, Zhiping Zhou, Cynthia Hawkins, Mark M. Souweidane
TRANSLATIONAL ONCOLOGY
(2020)
Article
Biology
Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Taiki Saito, Tokiro Ishikawa, Tetsushi Sakuma, Takashi Yamamoto, Koshi Imami, Yasushi Ishihama, Koichi Kato, Tetsuya Okada, Kazutoshi Mori
Article
Multidisciplinary Sciences
Umberto Tosi, Harikrishna Kommidi, Oluwaseyi Adeuyan, Hua Guo, Uday Bhanu Maachani, Nandi Chen, Taojunfeng Su, Guoan Zhang, David J. Pisapia, Nadia Dahmane, Richard Ting, Mark M. Souweidane
Article
Biology
Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P. Mamahit, Yuta Maki, Yasuhiro Kajihara, Koichi Kato, Tetsuya Okada, Kazutoshi Mori
Summary: The sequential mannose trimming process in N-glycan modification involves EDEM2, EDEM3, and EDEM1 at different stages, with each enzyme playing a specific role in the endoplasmic reticulum-associated degradation of misfolded glycoproteins. The study establishes the entire route of oligosaccharide processing and confirms the Golgi localization of MAN1B, highlighting the essential enzymes involved in glycoprotein ERAD.
Article
Biology
Shunsuke Saito, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Kazutoshi Mori, David Ron
Summary: This study provides new evidence that aggregation-prone non-glycosylated Seipin activates ER stress and apoptosis through inactivating the major ER calcium pump SERCA2b, shedding light on the causal relationship between ER stress and neurodegenerative diseases.
Article
Oncology
Prajwal Rajappa, Kenneth W. Eng, Rohan Bareja, Evan D. Bander, Melissa Yuan, Alisha Dua, Uday Bhanu Maachani, Matija Snuderl, Heng Pan, Tuo Zhang, Umberto Tosi, Iryna Ivasyk, Mark M. Souweidane, Olivier Elemento, Andreas Sboner, Jeffrey P. Greenfield, David J. Pisapia
Summary: This study explored the clinical utility of wide-breadth assays, including whole-exome sequencing, RNA sequencing, and methylation array profiling, as an addition to conventional diagnostic tools for pediatric CNS tumors. The results showed that RNA sequencing and methylation profiling frequently provided clinically relevant information orthogonal to conventional methods, while whole-exome sequencing primarily added value through copy number assessment. Longitudinal cohorts comparing different molecular pathology workup strategies will be necessary to further evaluate the clinical benefits of these modalities in practice.
NEURO-ONCOLOGY ADVANCES
(2022)
Article
Cell Biology
Byungseok Jin, Tokiro Ishikawa, Mai Taniguchi, Satoshi Ninagawa, Tetsuya Okada, Shigehide Kagaya, Kazutoshi Mori
CELL STRUCTURE AND FUNCTION
(2020)
Article
Cell Biology
Hibiki Koba, Shengyu Jin, Nanami Imada, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Tetsushi Sakuma, Takashi Yamamoto, Kazutoshi Mori
CELL STRUCTURE AND FUNCTION
(2020)
Article
Oncology
Raymond Chang, Umberto Tosi, Julia Voronina, Oluwaseyi Adeuyan, Linda Y. Wu, Melanie E. Schweitzer, David J. Pisapia, Oren J. Becher, Mark M. Souweidane, Uday B. Maachani
NEURO-ONCOLOGY ADVANCES
(2019)
Article
Cell Biology
Takehiro Sugimoto, Satoshi Ninagawa, Shimpei Yamano, Tokiro Ishikawa, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
CELL STRUCTURE AND FUNCTION
(2017)
Article
Oncology
Susanne Kossatz, Brandon Carney, Melanie Schweitzer, Giuseppe Carlucci, Vesselin Z. Miloushev, Uday B. Maachani, Prajwal Rajappa, Kayvan R. Keshari, David Pisapia, Wolfgang A. Weber, Mark M. Souweidane, Thomas Reiner