Review
Biochemistry & Molecular Biology
Wen Kin Lim, Prameet Kaur, Huanyan Huang, Richard Shim Jo, Anupriya Ramamoorthy, Li Fang Ng, Jahnavi Suresh, Fahrisa Islam Maisha, Ajay S. Mathuru, Nicholas S. Tolwinski
Summary: Aging organisms experience a decrease in stem cells, leading to impaired tissue repair and the development of cellular and neurodegenerative diseases. Optogenetics, a technique using photosensitive molecules and genetic engineering, provides a precise way to study homeostasis and degeneration mechanisms.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alice Lippi, Anita Krisko
Summary: Protein quality control mechanisms are involved in various stages of protein lifetime. Protein aggregates, formed when proteins lose their solubility, play a role in aging and protein folding diseases, but may also serve as an adaptive mechanism for stress survival. This review discusses the different roles of protein aggregation and their potential implications in stress, aging, and disease.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lisa J. Lapidus
Summary: The Free Energy Landscape theory of Protein Folding suggests that proteins have multiple paths to reach the folded conformation with the lowest free energy, but detecting these pathways has been challenging. Recent technical advancements and the use of multiple experimental probes have revealed multiple folding pathways in various proteins that were previously described with a single path.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2021)
Article
Chemistry, Physical
Frederico Campos Freitas, Michelli Maldonado, Antonio Bento Oliveira Junior, Jose Nelson Onuchic, Ronaldo Junio de Oliveira
Summary: Biotin-labeled proteins are commonly used to study protein-protein interactions and proximity in living cells. However, the influence of biotinylation on aspects such as folding, binding, stability, and kinetics needs to be investigated further.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Victor V. Dyakin, Vladimir N. Uversky
Summary: The paper discusses the universal phenomenon of chirality and its connection to protein aging and organism aging. It emphasizes the importance of non-equilibrium thermodynamics and the role of phosphorylation in maintaining and reshaping the system. The broader understanding of protein folding, including the impact of spontaneous racemization, has implications for experimental design in chiral proteomics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Balamurugan Dhayalan, Deepak Chatterjee, Yen-Shan Chen, Michael A. Weiss
Summary: Analysis of diabetes-associated mutations in the human insulin gene has provided insights into the folding mechanisms of proinsulin, revealing the impact of mutations on pancreatic beta-cell dysfunction and insulin secretion. Studies suggest that conserved residues play a crucial role in folding efficiency and the susceptibility of proinsulin to impaired foldability can contribute to the development of diseases. This highlights the molecular links between biophysical principles and the impact on diseases such as diabetes and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kaushik Bhattacharya, Didier Picard
Summary: The Hsp70 and Hsp90 molecular chaperone systems in eukaryotes are crucial for protein homeostasis under normal and stressed conditions, exhibiting both physical and functional interactions to maintain cellular proteostasis. Co-chaperones like Hop and Sti1 play a key role in facilitating substrate transfer from Hsp70 to Hsp90. Interestingly, while eukaryotes rely on the canonical Hsp70-Hop-Hsp90 ternary chaperone complex for optimal maturation and stability of specific clients, prokaryotes can form a binary chaperone complex without Hop, displaying enhanced protein folding and anti-aggregation activities.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Paola Turina, Piero Fariselli, Emidio Capriotti
Summary: The study of protein folding is crucial for understanding protein function and the relationship between genetics and phenotypes. K-Pro is a new database that collects experimental kinetic data on monomeric proteins with a two-state folding mechanism. It provides a user-friendly interface for browsing and downloading relevant data.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
R. Charlotte Eccleston, David D. Pollock, Richard A. Goldstein
Summary: Epistasis and cooperativity in protein folding are both influenced by networks of energetic interactions within proteins, and their selection can affect each other. Selection for cooperativity may be crucial for predicting protein structure using epistasis measurements.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Tae-Eun Kim, Kotaro Tsuboyama, Scott Houliston, Cydney M. Martell, Claire M. Phoumyvong, Alexander Lemak, Hugh K. Haddox, Cheryl H. Arrowsmith, Gabriel J. Rocklin
Summary: Designing new protein structures remains challenging, and our study successfully designed stable aPPa proteins through large-scale design and test cycles, shedding light on the biophysical determinants of folding.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Rafayel Petrosyan, Abhishek Narayan, Michael T. Woodside
Summary: Single-molecule force spectroscopy (SMFS) is a powerful tool for studying protein folding dynamics, uncovering energy landscapes of folding, complex folding pathways, mechanisms of chaperones in assisting folding, effects of ribosomes on co-translational folding, and monitoring membrane protein folding.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Irina Sorokina, Arcady R. Mushegian, Eugene V. Koonin
Summary: The prevailing thermodynamic hypothesis of protein folding is called into question due to the lack of strong empirical evidence. Physical theory-based approaches in predicting protein folds have largely failed, except for small proteins. Recent successes in protein structure prediction have been achieved through evolutionary modeling and deep learning methods, but provide no insights into protein folding mechanisms and pathways. An alternative view suggests that most proteins do not occupy the global minimum of free energy, but instead a local minimum on a fluctuating landscape. This view also argues that the majority of proteins require energy-dependent cellular processes for folding, such as interactions with the translation system and chaperones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Rebeca San Martin, Priyojit Das, Jacob T. Sanders, Ashtyn M. Hill, Rachel Patton McCord
Summary: The expression of a mutant Lamin A, progerin, in Hutchinson-Gilford Progeria Syndrome leads to various alterations in cells, such as changes in genome architecture, nuclear morphology, epigenetic states, and altered phenotypes. This study comprehensively analyzed the transcriptional status of patient-derived HGPS fibroblasts and found abnormal transcriptional signatures, related to DNA maintenance, bone development, blood vessel maturation, lipid management, and muscle growth. The study also revealed misregulation of genes involved in endochondral ossification and chondrogenic commitment in children aged 4-7 years old. Hi-C measurements indicated changes in genome compartmentalization and TAD strength in patient fibroblasts.
Review
Biochemistry & Molecular Biology
Awa Diop, Daniele Santorelli, Francesca Malagrino, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Lucia Marcocci, Paola Pietrangeli, Stefano Gianni, Angelo Toto
Summary: This review summarizes the latest research on the structure, function, pathogenic role, and regulation of SH2 domains. The findings suggest that pharmacological interest in SH2 domains and a deeper understanding of their binding properties are crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Louise Laursen, Stefano Gianni, Per Jemth
Summary: This study investigates the folding of a three-domain supramodule from the protein PSD-95, revealing that the PDZ domain folds faster and independently from the SH3-GK tandem. However, concurrent folding of the PDZ domain slows down folding of SH3-GK, resulting in an off-pathway folding intermediate. This contributes to the understanding of multidomain protein folding where individual domains cannot be viewed as separate folding units.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ron Mittler, Merav Darash-Yahana, Yang Sung Sohn, Fang Bai, Luhua Song, Ioav Z. Cabantchik, Patricia A. Jennings, Jose N. Onuchic, Rachel Nechushtai
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Biochemistry & Molecular Biology
Jasmine H. Lee, Kendra L. Hailey, Steven A. Vitorino, Patricia A. Jennings, Timothy D. Bigby, Ellen C. Breen
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Article
Psychology, Educational
Ezgi Ayturk, Heining Cham, Patricia A. Jennings, Joshua L. Brown
EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT
(2020)
Article
Multidisciplinary Sciences
Colin H. Lipper, Jason T. Stofleth, Fang Bai, Yang-Sung Sohn, Susmita Roy, Ron Mittler, Rachel Nechushtai, Jose N. Onuchic, Patricia A. Jennings
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Dominique T. Capraro, David J. Burban, Patricia A. Jennings
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Mathematics, Interdisciplinary Applications
Ezgi Ayturk, Heining Cham, Patricia A. Jennings, Joshua L. Brown
Summary: The study found that LMS-cat is excellent at estimating structural parameters but may produce highly biased measurement parameters. The performance of LMS-cat varies under different conditions, as revealed by the simulation study.
STRUCTURAL EQUATION MODELING-A MULTIDISCIPLINARY JOURNAL
(2021)
Article
Physiology
Cynthia S. Indralingam, Alma K. Gutierrez-Gonzalez, Scott C. Johns, Tzuhan Tsui, Daniel T. Cannon, Mark M. Fuster, Timothy D. Bigby, Patricia A. Jennings, Ellen C. Breen
Summary: Pulmonary arterial hypertension (PAH) is a severe disease characterized by pulmonary artery remodeling, elevated right ventricular pressure, and cardiac failure. Pulmonary endothelial cells play a crucial role in PAH by sensing danger or damage and triggering cell proliferation through alarmin cytokines. This study found that IL-33/ST2 signaling is essential for the proliferative response of pulmonary artery endothelial cells in PAH.
PHYSIOLOGICAL REPORTS
(2022)
Article
Psychology, Educational
Polina P. Mischenko, Pamela Nicholas-Hoff, Deborah L. Schussler, Jessica Iwu, Patricia A. Jennings
Summary: This study provides an overarching analysis on the barriers and facilitators that implementers experienced in delivering a mindfulness-based social-emotional learning program. It emphasizes the importance of relational trust between implementers and actors within various ecological levels. The study applies a framework of relational trust to understand the relationships that influence the effectiveness of program delivery.
PSYCHOLOGY IN THE SCHOOLS
(2022)
Editorial Material
Psychology, Clinical
Patricia A. Jennings
Summary: There is a growing interest in studying the impacts of mindfulness-based programs in PreK-12 school settings, but the research lacks rigor and the results have been mixed. Baelen et al. present a conceptual framework for implementing school-based mindfulness programs, which will contribute to building a more solid evidence base. It is important to simultaneously focus on implementation practice to bridge the gap between knowledge and practice.
Article
Education & Educational Research
Holly E. Brophy-Herb, Ahnalee Brincks, Jody L. Cook, Ann Stacks, Claire D. Vallotton, Cynthia Frosch, Russell Carson, Rebecca Wheeler, Haiden A. Perkins, Patricia A. Jennings
Summary: This study examined the perceptions of stress and exhaustion among infant/toddler teachers. The findings revealed that workload and personal life stressors were associated with stress and exhaustion. Teachers used fewer than two coping strategies per day, and reframing was the only strategy negatively associated with stress and emotional exhaustion. The study highlights the need for professional development supports and workload reduction for infant/toddler teachers.
EARLY EDUCATION AND DEVELOPMENT
(2023)
Article
Education & Educational Research
Holly E. Brophy-Herb, Ann M. Stacks, Cynthia Frosch, Ahnalee M. Brincks, Jody L. Cook, Claire D. Vallotton, Haiden A. Perkins, Loria E. Kim, Russell Carson, Maria Muzik, Katherine Rosenblum, Patricia A. Jennings
Summary: The study focused on a relationship-based professional development intervention for infant and toddler teachers to enhance their use of mindfulness-based strategies for coping. While the intervention did not have an impact on stress and exhaustion trajectories, teachers in the intervention group reported increased use of mindfulness-based coping strategies over time.
EARLY CHILDHOOD EDUCATION JOURNAL
(2022)
Review
Psychology, Clinical
Patricia A. Jennings, Helen H. Min
Summary: Teachers' social and emotional competence and well-being are crucial for creating and maintaining supportive learning environments. However, teachers often lack the necessary support to provide trauma-sensitive care to students who have experienced adversity. This review explores the concept of empathy-based stress and proposes that shifting towards compassionate responding can help teachers effectively meet students' needs while protecting their own well-being.
Article
Psychology, Clinical
Sebrina L. Doyle L. Fosco, Deborah L. Schussler, Patricia A. Jennings
Summary: This research investigated how school and district leaders perceive and respond to an adapted version of the CARE program. The study found that acceptability of the program was inconsistent among educational leaders, with those with prior mindfulness experience benefiting the most. The format of the program also influenced acceptability, with many leaders finding it too long. However, all leaders reported using CARE practices and saw improvements in intrapersonal and interpersonal aspects.
Article
Education & Educational Research
Vanessa Rodriguez, S. Lynneth Solis, Bryan Mascio, Kathleen Kiely Gouley, Patricia A. Jennings, Laurie M. Brotman
EARLY EDUCATION AND DEVELOPMENT
(2020)
Article
Psychology, Educational
Damira Rasheed, Joshua Brown, Sebrina L. Doyle, Patricia A. Jennings
