Article
Cardiac & Cardiovascular Systems
Xin Jin, Anna Meletiou, Joshua Chung, Agne Tilunaite, Kateryna Demydenko, Eef Dries, Rosa Donate Puertas, Matthew Amoni, Ashutosh Tomar, Guillaume Gilbert, Piet Claus, Christian Soeller, Vijay Rajagopal, Karin Sipido, H. Llewelyn Roderick
Summary: Efficient Ca2+ coupling between sarcolemmal Ca2+ channels and sarcoplasmic reticulum (SR) ryanodine receptor Ca2+ channels (RyR) is necessary for Ca2+ transients (CaT) and cardiomyocyte (CM) contraction. In addition to RyRs, Ca2+ can also be released via inositol 1,4,5-trisphosphate receptors (InsP3R) in CM. InsP3R-RyR crosstalk plays a role in altered Ca2+ dynamics and arrhythmogenic Ca2+ release in disease. This mechanism is demonstrated in a porcine model of ischemic heart disease (IHD), highlighting the importance of InsP3R-RyR channel crosstalk in Ca2+ release and post-MI remodelling-induced arrhythmia.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Randall Clark, Lawson Fuller, Jason A. Platt, Henry D. I. Abarbanel
Summary: This article introduces how to use methods from nonlinear dynamics and interpolation techniques from applied mathematics to construct discrete time dynamical rules that forecast observed neuron properties accurately, which is crucial for the development of neural network models and biological networks.
NEURAL COMPUTATION
(2022)
Article
Biochemistry & Molecular Biology
Laura Marongiu, Francesca Mingozzi, Clara Cigni, Roberta Marzi, Marco Di Gioia, Massimiliano Garre, Dario Parazzoli, Laura Sironi, Maddalena Collini, Reiko Sakaguchi, Takashi Morii, Mariacristina Crosti, Monica Moro, Stephane Schurmans, Tiziano Catelani, Rany Rotem, Miriam Colombo, Stephen Shears, Davide Prosperi, Ivan Zanoni, Francesca Granucci
Summary: Recognition of LPS by DCs involves the receptor complex CD14 and TLR4, and subsequent Ca2+ mobilization and NFAT activation require IP3R3 and ITPKB. Targeting ITPKB may offer a promising approach for anti-inflammatory therapies aimed at inhibiting specific DC functions.
Article
Cardiac & Cardiovascular Systems
Rebecca A. Capel, Samuel J. Bose, Thomas P. Collins, Skanda Rajasundaram, Thamali Ayagama, Manuela Zaccolo, Rebecca-Ann Beatrice Burton, Derek A. Terrar
Summary: The study showed that the interaction between IP3 receptor pathways and Ca2+-stimulated adenylyl cyclases plays a crucial role in modulating cardiac function, particularly in the atria and sinoatrial node. Activation of IP3 receptors leads to increased Ca2+ transients through cAMP signaling, which is essential for initiation of atrial arrhythmias.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biology
Alberto Coccarelli, Sanjay Pant
Summary: Agonist-induced Ca2+ signaling plays a vital role in regulating endothelial cell functions. This study establishes a minimalistic modeling framework based on data from isolated endothelial cells to quantitatively capture the cytosolic Ca2+ response to IP3 stimulation. The Ca2+-regulatory function of IP3Rs and parameter space are identified through experimental fitting and validation. This minimalistic model can serve as a reference framework for quantifying EC Ca2+ dynamics induced by IP3Rs activation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nagendra Babu Thillaiappan, Holly A. Smith, Peace Atakpa-Adaji, Colin W. Taylor
Summary: The study demonstrates that the KRas-induced KRAP protein tethers a subset of IP3 receptors to actin, enabling them to evoke calcium signals. Loss of KRAP results in the disappearance of Ca2+ puffs and a global response to increased cytosolic Ca2+ concentration from more intense stimulation.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Ana M. Rossi, Andrew M. Riley, Genevieve Dupont, Taufiq Rahman, Barry V. L. Potter, Colin W. Taylor
Summary: Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are intracellular Ca2+ channels linking extracellular stimuli to Ca2+ signals. Research shows that quantal responses to low IP3 concentrations do not require heterogeneous Ca2+ stores, and IP(3)Rs exhibit incremental responses to IP3 stimulation. This suggests that Ca2+ signals evoked by IP3 pulses arise from rapid activation and inactivation of a small fraction of IP(3)Rs.
Review
Neurosciences
Pragnya Chakraborty, Gaiti Hasan
Summary: Key components of endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) are expressed in all metazoan cells. This review presents evidence on how these two mechanisms impact neuronal physiology and their interaction with ion channels in neurons. The careful regulation of neural SOCE is essential due to the detrimental effects of Ca2+ imbalance on neurons. The study also discusses different mechanisms of SOCE regulation in Drosophila and mammalian neurons, and their significance in human neurodegenerative diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Multidisciplinary Sciences
Roberto Ornelas-Guevara, Diana Gil, Valerie Voorsluijs, Genevieve Dupont
Summary: Inositol 1,4,5-trisphosphate (IP3) plays a key role in calcium signaling. Previous studies overestimated the diffusion coefficient of IP3 in vivo, but new computational analysis shows that the effective diffusion coefficient is close to 100 μm(2)s(-1), significantly lower than previous estimations. This moderate reduction can be explained by the buffering effect of non-fully bound inactive IP3 receptors.
SCIENTIFIC REPORTS
(2023)
Article
Biophysics
Victor Nicolai Friedhoff, Benjamin Lindner, Martin Falcke
Summary: This article investigates the randomness and properties of Ca2+ signaling in cells. The researchers found that the generation of Ca2+ spikes follows certain patterns and can be described as a process from one state to another. They proposed a theoretical model to explain the differences in spike behavior between different cell types and stimulating agonists, as well as the variability observed in experiments.
BIOPHYSICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Nicolas Rosa, Hristina Ivanova, Larry E. Wagner, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W. Andrews, Jan B. Parys, David Yule, Geert Bultynck
Summary: The study shows that Bcl-xL and Bcl-2 have similar anti-apoptotic effects in controlling endoplasmic reticulum Ca2+ release, challenging the current understanding of their divergent functions in Ca2+ signaling modulation.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Cell Biology
Jens Loncke, Allen Kaasik, Ilya Bezprozvanny, Jan B. Parys, Martijn Kerkhofs, Geert Bultynck
Summary: Organelles cooperate through membrane contact sites to regulate cellular homeostasis and function. Particularly, the communication between the endoplasmic reticulum and mitochondria enables efficient transmission of Ca2+ signals, tightly controlling mitochondrial functions at a microdomain level.
TRENDS IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Valerio Farfariello, Dmitri Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan B. Parys, Loic Lemonnier, Natalia Prevarskaya
Summary: This study reveals the mechanism of how alterations in mitochondrial function and calcium signaling contribute to cellular senescence and tumor growth. The downregulation of TRPC3 protein in senescent fibroblasts leads to increased mitochondrial calcium load and oxidative phosphorylation, promoting cellular senescence. The downregulation of TRPC3 in stromal cells also affects secretome and tumor progression, highlighting its importance in cancer development.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Kyle E. Harvey, Shiqi Tang, Emily K. LaVigne, Evan P. S. Pratt, Gregory H. Hockerman
Summary: In this study, the researchers found that RyR2 is required for the regulation of insulin content and glucose-stimulated insulin secretion in INS-1 cells, partly through its interaction with IRBIT. The experiments showed that the absence of RyR2 led to a decrease in store-operated Ca2+ entry and PLC activity, as well as an increase in cellular PIP2 levels. Furthermore, RyR2 was found to regulate beta-cell electrical activity by controlling Ca-v current density and SK channel activation.
Article
Microbiology
Yu Tang, Ramesh Rijal, David E. Zimmerhanzel, Jacquelyn R. McCullough, Louis A. Cadena, Richard H. Gomer
Summary: Research has found that the inhibitory mechanism induced by polyphosphate can be achieved through the IP3/Ca2+ signaling pathway in Dictyostelium discoideum.
Review
Cell Biology
Don-On Daniel Mak, J. Kevin Foskett
Letter
Cell Biology
Horia Vais, Jessica E. Tanis, Marioly Mueller, Riley Payne, Karthik Mallilankaraman, J. Kevin Foskett
Article
Behavioral Sciences
Michael G. Tordoff, Tiffany R. Aleman, Hillary T. Ellis, Makoto Ohmoto, Ichiro Matsumoto, Val I. Shestopalov, Claire H. Mitchell, J. Kevin Foskett, Rachel L. Poole
Correction
Biochemistry & Molecular Biology
Patrick J. Doonan, Harish C. Chandramoorthy, Nicholas E. Hoffman, Xueqian Zhang, Cesar Cardenas, Santhanam Shanmughapriya, Sudarsan Rajan, Sandhya Vallem, Xiongwen Chen, J. Kevin Foskett, Joseph Y. Cheung, Steven R. Houser, Muniswamy Madesh
Review
Cardiac & Cardiovascular Systems
J. Kevin Foskett, Benjamin Philipson
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2015)
Correction
Cell Biology
Karthik Mallilankaraman, Cesar Cardenas, Patrick J. Doonan, Harish C. Chandramoorthy, Krishna M. Irrinki, Tuende Golenar, Gyoergy Csordas, Priyanka Madireddi, Jun Yang, Marioly Mueller, Russell Miller, Jill E. Kolesar, Jordi Molgo, Brett Kaufman, Gyoergy Hajnoczky, J. Kevin Foskett, Muniswamy Madesh
NATURE CELL BIOLOGY
(2015)
Review
Physiology
Zhongming Ma, Jessica E. Tanis, Akiyuki Taruno, J. Kevin Foskett
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2016)
Article
Biochemical Research Methods
Don-On Daniel Mak, King-Ho Cheung, Patrick Toglia, J. Kevin Foskett, Ghanim Ullah
PLOS COMPUTATIONAL BIOLOGY
(2015)
Article
Cell Biology
Horia Vais, Karthik Mallilankaraman, Don-On Daniel Mak, Henry Hoff, Riley Payne, Jessica E. Tanis, J. Kevin Foskett
Article
Biochemistry & Molecular Biology
Russell A. Miller, Yuji Shi, Wenyun Lu, David A. Pirman, Aditi Jatkar, Matthew Blatnik, Hong Wu, Cesar Cardenas, Min Wan, J. Kevin Foskett, Junyoung O. Park, Yiyi Zhang, William L. Holland, Joshua D. Rabinowitz, Morris J. Birnbaum
Correction
Biochemistry & Molecular Biology
Russell A. Miller, Yuji Shi, Wenyun Lu, David A. Pirman, Aditi Jatkar, Matthew Blatnik, Hong Wu, Cesar Cardenas, Min Wan, J. Kevin Foskett, Junyoung O. Park, Yiyi Zhang, William L. Holland, Joshua D. Rabinowitz, Morris J. Birnbaum
Review
Physiology
Akiyuki Taruno, Kengo Nomura, Tsukasa Kusakizako, Zhongming Ma, Osamu Nureki, J. Kevin Foskett
Summary: Recent research has made significant progress in understanding the molecular mechanisms behind taste transduction, including the identification of specific taste sensors and components for each taste sensation. The discovery of unconventional chemical synapses and insights into the structures of ion channels have provided new perspectives in the field of taste sensation and neurotransmission.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Horia Vais, Riley Payne, Usha Paudel, Carmen Li, J. Kevin Foskett
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Oncology
Cristina Aguirre-Portoles, Riley Payne, Aspen Trautz, J. Kevin Foskett, Christopher A. Natale, John T. Seykora, Todd W. Ridky
Summary: Testosterone signaling through ZIP9 mediates some of the sex differences in melanoma, and drugs that target AR can be repurposed to block ZIP9 and inhibit melanoma in males.
Article
Cell Biology
Zhongming Ma, Usha Paudel, J. Kevin Foskett
Summary: The intensity of taste is strongly influenced by temperature, but there is a lack of comprehensive understanding about the physiological, hedonic, and commercial implications of this relationship. This study used patch-clamp electrophysiology to investigate the effects of temperature on taste-bud cell electrical excitability, revealing that temperature significantly affects the electrical activity of type II taste-bud cells. These findings provide a mechanism for understanding how temperature influences taste sensitivity and perception.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)