Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist

A splice site mutation combined with a novel missense mutation ofLHCGRcause male pseudohermaphroditism

(2009) Jie Qiao et al.   HUMAN MUTATION

Drug development and the cellular quality control system

(2009) P. Michael Conn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor

(2008) R. van de Lagemaat et al.   HUMAN REPRODUCTION

A new LH receptor splice mutation responsible for male hypogonadism with subnormal sperm production in the propositus, and infertility with regular cycles in an affected sister

(2008) M. Bruysters et al.   HUMAN REPRODUCTION

Asp330and Tyr331in the C-terminal Cysteine-rich Region of the Luteinizing Hormone Receptor Are Key Residues in Hormone-induced Receptor Activation

(2008) Martijn Bruysters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor

(2008) Chris J. van Koppen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY