Article
Medical Laboratory Technology
Yoshifumi Umemori, Ryosei Murai, Koichi Asanuma, Yusuke Takahashi, Yoshika Kuno, Tsuyoshi Saito, Satoshi Takahashi
Summary: An investigation into a 30-year-old woman with significantly elevated luteinizing hormone (LH) levels revealed the presence of macro-LH, LH, and anti-LH-IgG autoantibody complex, which possibly caused the falsely high LH values in the absence of specific symptoms.
CLINICAL BIOCHEMISTRY
(2021)
Article
Reproductive Biology
Ashley N. Lindo, Jennifer F. Thorson, Michelle N. Bedenbaugh, Richard B. McCosh, Justin A. Lopez, Samantha A. Young, Lanny J. Meadows, Elizabeth C. Bowdridge, Chrysanthi Fergani, Bradley A. Freking, Michael N. Lehman, Stanley M. Hileman, Clay A. Lents
Summary: In pigs, Kisspeptin and NKB neurons are mainly located in the arcuate nucleus, while NK3R cells are distributed in the preoptic area and other hypothalamic regions but not in the arcuate nucleus. Treatment with altrenogest decreases LH secretion without affecting the expression of Kisspeptin and NKB.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Clara Lazzaretti, Valentina Secco, Elia Paradiso, Samantha Sperduti, Claudia Rutz, Annika Kreuchwig, Gerd Krause, Manuela Simoni, Livio Casarini
Summary: The study focused on identifying key residues in LHCGR that are likely evolved in humans to discriminate between specific binding of LH and hCG. Mutations within the receptor's leucine reach repeat 9 and 10 were found to lead to loss of discrimination ability, resembling the modulation of Lhr-mediated signaling patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Sofwatul Mokhtarah Maluin, Khairul Osman, Farah Hanan Fathihah Jaffar, Siti Fatimah Ibrahim
Summary: Exposure to radiofrequency electromagnetic radiation from mobile phones and Wi-Fi devices can have negative effects on male reproductive hormones, potentially leading to a reduction in testosterone levels. However, the impact on gonadotrophic hormones is still inconclusive, with studies showing conflicting results influenced by various factors such as energy absorption and duration of device use. Therefore, limiting the use of wireless devices is recommended to minimize potential risks to male reproductive function.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
And Demir, Matti Hero, Elina Holopainen, Anders Juul
Summary: Most ovulation prediction kits currently available only provide a rough estimation of ovulation time and do not track the post-ovulation period. This exploratory study found that non-intact LH immunoreactivity derived from degradation products remains detectable at peak levels from LH surge until ovulation and during the early postovulatory period. This suggests that non-intact U-LH-ir could be a promising marker for evaluating the post-surge segment of the fertility window.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Robert Porteous, Patricia Haden, Eleni C. R. Hackwell, Aaron Singline, Michel K. Herde, Reena Desai, David J. Handelsman, David R. Grattan, Allan E. Herbison
Summary: Recent research has utilized the tail-tip bleeding approach in mice to analyze the pulsatile and surge profiles of luteinizing hormone secretion. The PULSAR algorithm has been reformulated to operate on modern computer systems, allowing for more accurate analysis of pulsatile LH secretion in mice and the establishment of a realistic model of estrogen negative feedback.
Article
Endocrinology & Metabolism
Robert Porteous, Patricia Haden, Eleni C. R. Hackwell, Aaron Singline, Michel K. Herde, Reena Desai, David J. Handelsman, David R. Grattan, Allan E. Herbison
Summary: The recent use of the tail-tip bleeding approach in mice has allowed researchers to generate detailed pulse and surge profiles of luteinizing hormone (LH) secretion, leading to the reformulation of the PULSAR algorithm for analyzing pulsatile LH secretion and establishing an accurate model of estrogen negative feedback in mice.
Article
Biochemistry & Molecular Biology
Elena Yu. Gorbacheva, Konstantin A. A. Toniyan, Yulia A. A. Biriukova, Nadezhda A. A. Lukicheva, Oleg I. I. Orlov, Valery V. V. Boyarintsev, Irina V. V. Ogneva
Summary: The impact of weightlessness on the female reproductive system is not well understood. This study examined the effects of a 5-day dry immersion on the reproductive system of female subjects. Results showed that after immersion, there was an increase in inhibin B and a decrease in luteinizing hormone and progesterone. The size of the uterus and the thickness of the endometrium did not change. However, the average diameters of the antral follicles and the dominant follicle were higher after immersion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Zhuo Liu, Ke-Hua Wang
Summary: This study aimed to evaluate the impact of basal luteinizing hormone (bLH) levels on the outcomes of In Vitro Fertilization/Intra-Cytoplasmic Injections (IVF/ICSI) in polycystic ovary syndrome (PCOS) patients. The study found that basal LH levels do not affect pregnancy outcomes in PCOS patients, but LH levels on the day of antagonist addition can impact the number of good quality embryos for PCOS patients undergoing IVF/ICSI.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Endocrinology & Metabolism
Klara Beitl, Didier Dewailly, Rudolf Seemann, Marlene Hager, Jakob Buenker, Daniel Mayrhofer, Iris Holzer, Johannes Ott
Summary: Polycystic ovary syndrome (PCOS) and functional hypothalamic amenorrhea (FHA) are the two most frequent causes of secondary amenorrhea, and distinguishing between them remains challenging. A retrospective case-control study found significant differences in hormone levels and protein binding globulin between PCOS-D patients and FHA-PCOM patients. The authors proposed a model including serological parameters as a reliable tool to distinguish between the two conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sergi Ferre, Francisco Ciruela, Carmen W. Dessauer, Javier Gonzalez-Maeso, Terence E. Hebert, Ralf Jockers, Diomedes E. Logothetis, Leonardo Pardo
Summary: The study proposes the concept of GPCR-effect assemblies (GEMMAs), which are pre-assembled before receptor activation and allow more efficient interactions between specific signaling components. This offers an alternative model to the conventional collision coupling model and explains the differential properties of GPCRs in different cellular environments.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Endocrinology & Metabolism
Colin M. Clay, Brian D. Cherrington, Amy M. Navratil
Summary: Gonadotropes cells in the anterior pituitary gland play a critical role in reproductive health by generating the LH surge required for ovulation through increasing sensitivity to GnRH, elevating GnRHR expression, and altering cellular morphology.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, Research & Experimental
Kanyada Koysombat, Waljit S. Dhillo, Ali Abbara
Summary: Reproductive conditions caused by disorders of the HPG axis have significant health implications and psychosocial impact. Basal and dynamic tests are useful in diagnosing and understanding the pathophysiology of reproductive disorders. Differentiating pubertal and reproductive disorders can be challenging due to similar clinical presentations and hormonal profiles. This review aims to describe the various disorders affecting the HPG axis and the challenges faced in clinical practice, as well as the utility of endocrine tests in investigating specific components of the HPG axis.
Article
Endocrinology & Metabolism
Ruiqiong Zhou, Mei Dong, Li Huang, Xiulan Zhu, Jinyan Wei, Qianyu Zhang, Dun Liu, Xiqian Zhang, Fenghua Liu
Summary: This study aims to investigate the association between serum LH levels and live birth rate (LBR) after fresh embryo transfer with GnRH antagonist regimen in different populations. The results suggest that high serum LH levels are associated with increased LBR, possibly due to higher implantation rate. Therefore, LH may serve as a predictor for scheduling fresh embryo transfer in IVF cycles to achieve better clinical outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Veterinary Sciences
Tamako Miyazaki, Reiko Uenoyama, Takashi Matsuzaki, Tetsuro Yamashita, Toh-ichi Hirata, Masao Miyazaki
Summary: This study investigated the changes in urinary LH concentrations in six Japanese black cows after administration of GnRH. The results showed abrupt rises in both plasma and urinary LH levels after GnRH administration, with peak levels reached at 2 and 5 hours respectively. Additionally, a positive correlation was observed between plasma LH concentrations and urinary LH amounts, and ovulation in the cows was confirmed 48 hours post-GnRH administration.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)