Article
Cell Biology
Zhaohui Wei, Qiang Hong, Zijiao Ding, Jingwen Liu
Summary: The study generated mutant lines for cxcl12a and cxcr4b using the CRISPR/Cas9 system. Results showed that Cxcl12a is crucial for pharyngeal cartilage formation by promoting the proliferation of craniofacial neural crest cells. Additionally, Cxcl12a and Cxcl12b were found to have a synergistic influence on pharyngeal arch and pouch formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Gang Feng, Yuhua Sun
Summary: The study reveals that the PRC1 complex plays an important role in the development of the central nervous system and enteric nervous system in vertebrates. Loss of function of the rnf2 gene, which encodes the enzymatic component of PRC1, leads to abnormal migration and differentiation of neural precursor cells, as well as defective development of ENS and CNS in zebrafish.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biology
Anjali Goswami, Eve Noirault, Ellen J. Coombs, Julien Clavel, Anne-Claire Fabre, Thomas J. D. Halliday, Morgan Churchill, Abigail Curtis, Akinobu Watanabe, Nancy B. Simmons, Brian L. Beatty, Jonathan H. Geisler, David L. Fox, Ryan N. Felice
Summary: The evolution of the skull's major skeletal elements was assessed in this study, using a dataset of 322 living and extinct placental mammals and their relatives. The results revealed distinct macroevolutionary patterns across different cranial elements and highlighted the influence of ecological adaptations. Elements derived from neural crest showed the fastest rates of evolution, while developmental origin had an impact on evolutionary tempo but not specialization capacity.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zachary T. Olmsted, Janet L. Paluh
Summary: Researchers have successfully studied the co-development of the central and peripheral nervous systems with trunk mesendoderm in elongating multi-lineage organized (EMLO) gastruloids. They identified NCCs that differentiate to form peripheral neurons integrated with an upstream spinal cord region after day 8.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Tamas Kovacs, Viktoria Halasy, Csongor Petho, Emoke Szocs, Adam Soos, David Dora, Pascal de Santa Barbara, Sandrine Faure, Rhian Stavely, Allan M. Goldstein, Nandor Nagy, Nicolas Pilon
Summary: The enteric nervous system (ENS) is derived from vagal neural crest cells and plays a crucial role in gastrointestinal development. This study shows that the avian ceca, located at the junction of the midgut and hindgut, are necessary for hindgut ENS development. It also highlights the importance of bone morphogenetic protein-4 (BMP4) and glial cell line-derived neurotrophic factor (GDNF) signaling pathways in the migration of enteric neural crest-derived cells (ENCDC) and the formation of enteric ganglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Apurva Gahankari, Chunmin Dong, Garrett Bartoletti, Maria Galazo, Fenglei He
Summary: The study found that abnormal elevation of Rac1 activity can lead to abnormal development of neural crest cells and have a significant impact on normal brain tissue development. The experimental results showed that enhanced Rac1 activity leads to enlargement of the midbrain, changes in cell density, increased NCCs proliferation rate, and misrouted cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Hiroyuki Yamaguchi, Matthew D. Meyer, Li He, Lakmini Senavirathna, Sheng Pan, Yoshihiro Komatsu
Summary: Intramembranous ossification is a characteristic process in skull development, where ciliary and golgin proteins play a crucial role in regulating collagen trafficking. The molecular complex of IFT20 and GMAP210 is essential for proper intramembranous ossification during skull development, as shown through mutant mouse models.
Review
Cardiac & Cardiovascular Systems
Shannon Erhardt, Mingjie Zheng, Xiaolei Zhao, Tram P. Le, Tina O. Findley, Jun Wang
Summary: The neural crest cells play a crucial role in cardiovascular development, with the loss or dysregulation of cardiac neural crest cells potentially leading to cardiac defects. This review discusses the contributions of cardiac neural crest cells in cardiovascular development, as well as the regulatory factors and signaling pathways associated with cardiac defects.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Weiwei Wu, Shuo Liu, Hao Wu, Meishan Chen, Lili Gao, Bosheng Zhao, Baohua Liu, Qiuxiang Pang
Summary: This study identified the essential role of DjPtpn11 gene in planarian regeneration and its potential involvement in the migration and differentiation of stem cells through the ERK and Wnt signaling pathways. It provides insights into the molecular mechanisms underlying regeneration in planarians.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Developmental Biology
Elias H. Barriga, Delan N. Alasaadi, Chiara Mencarelli, Roberto Mayor, Franck Pichaud
Summary: This study reveals the essential role of RanBP1 in neural crest cell collective migration, which is involved in establishing front-to-rear polarity and promoting directed chemotaxis. This finding has important implications for our understanding of cell migration and various pathological conditions.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Developmental Biology
Makoto Abe, Timothy C. Cox, Anthony B. Firulli, Stanley M. Kanai, Jacob Dahlka, Kim-Chew Lim, James Douglas Engel, David E. Clouthier
Summary: Neural crest cells in the mandibular and maxillary prominences initially respond to signals from both regions, with GATA3 playing a crucial role in separating the upper and lower jaw domains during development by influencing BMP4 and FGF8 gene regulatory networks.
Article
Cell Biology
Maike Krenz
Summary: Regulation of protein tyrosine phosphorylation is crucial for cellular processes in the heart. Understanding the roles and mechanisms of protein tyrosine phosphatases in cardiac pathology can provide insights for future research and potential therapeutic targets.
CELLULAR SIGNALLING
(2022)
Article
Multidisciplinary Sciences
Malcolm Maden, Trey Polvadore, Arod Polanco, W. Brad Barbazuk, Edward Stanley
Summary: Osteoderms are bony plates found in the skin of vertebrates, mostly reptiles, and are rarely observed in mammals and birds. However, in one subfamily of rodents, osteoderms have been discovered in the skin of their tails. RNA sequencing has revealed the gene networks involved in their differentiation and comparing them with reptilian osteoderms may provide insights into their evolution and rarity in mammals.
Article
Multidisciplinary Sciences
Emi Murayama, Catherine Vivier, Anne Schmidt, Philippe Herbomel
Summary: Mesenchymal stromal cells in hematopoietic niches are derived from the sclerotome section of somites and express Alcam and Pdgfr-alpha markers. These cells are crucial for the development of hematopoiesis, including the formation of the vascular component of the CHT niche and the emergence of HSPCs from the aorta.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Hyun-Jee Kim, Sungho Shin, Seon-Yeong Jeong, Sun-Ung Lim, Dae-Won Lee, Yunhee-Kim Kwon, Jiyeon Kang, Sung-Won Kim, Chan-Kwon Jung, Cheolju Lee, Il-Hoan Oh
Summary: TB-MSCs derived from the turbinate exhibit unique characteristics compared to BM-MSCs, showing higher neural crest-like properties and a distinct secretome profile. While TB-MSCs have potential for neurogenic differentiation, they also display comparable immunosuppressive effects as BM-MSCs, but with a stronger stimulatory effect on breast cancer cell growth and metastasis.
JOURNAL OF CLINICAL MEDICINE
(2021)