Editorial Material
Biochemistry & Molecular Biology
Ansgar Bueschges, Charalampos Mantziaris
Summary: New research reveals that mechanosensitive neurons in the lateral spinal cord of adult zebrafish can sense lateral bending and inhibit neighboring neurons and central rhythm-generating networks. The tight interplay between central and peripheral neural mechanisms has never been observed before.
Article
Endocrinology & Metabolism
Daniel I. Brierley, Marie K. Holt, Arashdeep Singh, Alan de Araujo, Molly McDougle, Macarena Vergara, Majd H. Afaghani, Shin Jae Lee, Karen Scott, Calyn Maske, Wolfgang Langhans, Eric Krause, Annette de Kloet, Fiona M. Gribble, Frank Reimann, Linda Rinaman, Guillaume de Lartigue, Stefan Trapp
Summary: GLP-1 suppresses eating through independent gut-brain circuits, with PPG(NTS) neurons not being necessary for the eating suppression effects of GLP-1 receptor agonists. Concurrent activation of PPG(NTS) neurons can more effectively suppress eating than using semaglutide alone.
Article
Clinical Neurology
Karen L. Elliott, Jennifer Kersigo, Jeong Han Lee, Ebenezer N. Yamoah, Bernd Fritzsch
Summary: This study found that brain-derived neurotrophic factor (BDNF) is crucial for the survival of vestibular ganglion neurons, and its long-term loss results in a significant reduction in the number of vestibular ganglion neurons and vestibular hair cells. Despite the decrease in vestibular ganglion neurons at 6 months, the connectivity between central target cells is sufficient to prevent their loss.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Bolu Zhou, Kristin E. Claflin, Kyle H. Flippo, Andrew I. Sullivan, Arvand Asghari, Satya M. Tadinada, Sharon O. Jensen-Cody, Ted Abel, Matthew J. Potthoff
Summary: The study reveals that FGF21 is not expressed in the hypothalamus, but in the retrosplenial cortex (RSC), and it enhances spatial memory in the hippocampus without regulating energy homeostasis or sugar intake.
Article
Neurosciences
Luke Grundy, Ashlee Caldwell, Sonia Garcia-Caraballo, David Grundy, Nick J. Spencer, Xinzhong Dong, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
Summary: This study demonstrates the functional expression of MrgprA3 and MrgprC11 in bladder afferents for the first time. Activation of these receptors triggers hypersensitivity to distension, which is a critically valuable factor for therapeutic target development.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ivo Lambrichts, Esther Wolfs, Annelies Bronckaers, Pascal Gervois, Tim Vangansewinkel
Summary: This study explored the biological properties and effects of leukocyte- and platelet-rich fibrin (L-PRF) on cells from the central and peripheral nervous system. The findings showed that L-PRF had positive effects on peripheral neurons, but had detrimental effects on central neurons and their neurite outgrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ashlee Caldwell, Luke Grundy, Andrea M. Harrington, Sonia Garcia-Caraballo, Joel Castro, Nigel W. Bunnett, Stuart M. Brierley
Summary: This study identifies the expression of TGR5 receptor in the bladder and neuronal tissues in mice, and shows its interaction with receptors Trpv1 and Trpa1, which are related to neuronal sensitivity. Experiments both in vitro and in vivo suggest that the TGR5 receptor mediates bladder afferent hypersensitivity to distension, potentially contributing to the symptoms of IC/BPS and OAB.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
SeulAh Kim, Michael L. Wallace, Mahmoud El-Rifai, Alexa R. Knudsen, Bernardo L. Sabatini
Summary: This study describes a method to analyze the mechanism of glutamate/GABA co-release in the mouse brain. The results show that glutamate and GABA are co-packaged into the same synaptic vesicles, and presynaptic neuromodulators can reduce vesicular release probability without affecting the co-packaging of glutamate/GABA.
Article
Neurosciences
Claire Wyart, Kin Ki Jim, Andrew E. Prendergast
Summary: The function of sensory cells in reporting the changes of the environment and internal physiology has been extensively studied in neuroscience. Recent research has shown that sensory cells can detect polymodal cues and evidence of pathogen invasion. This highlights the importance of interdisciplinary training in immunology, microbiology, and neuroscience.
Article
Medicine, Research & Experimental
Stefanie Klima, Ilinca Suciu, Lisa Hoelting, Simon Gutbier, Tanja Waldmann, Daniel Dietrich, Marcel Leist
Summary: Microcystins (MC) are cyanobacterial toxins known for their potent hepatotoxicity, but studies suggest they may also affect the nervous system. In vitro studies with human neurons show that MC-LF can cause neurotoxicity, with potential hazards even at concentrations close to levels reached after excessive algae supplement intake. Further research is needed to fully understand the risks posed by MC-LF on human health.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2021)
Review
Biochemistry & Molecular Biology
Jae-Min Lee, You Jung Choi, Myung Chul Yoo, Seung Geun Yeo
Summary: Peripheral facial nerve injury causes changes in neuroactive substances that affect nerve cell damage, survival, growth, and regeneration. This review explores the biomolecules involved in peripheral facial nerve damage and their impact on the central nervous system (CNS), aiming to identify potential strategies for treating facial nerve injury and functional recovery. By identifying the biomolecules in the CNS that change after peripheral nerve damage, this review could contribute to the development of effective treatment strategies for peripheral facial palsy.
Article
Dermatology
Brian S. Kim, Saadet Inan, Sonja Staender, Thomas Sciascia, Jacek C. Szepietowski, Gil Yosipovitch
Summary: Modern genetic approaches have identified new neural pathways specific to itch, providing potential for drug development. Opioid receptors play a role in modulating itch, but the precise mechanisms are still being investigated. Nevertheless, several drugs have shown efficacy in clinical trials by targeting opioid receptor signaling.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan Pablo Damian, Lucia Vazquez Alberdi, Lucia Canclini, Gonzalo Rosso, Silvia Olivera Bravo, Mariana Martinez, Natalia Uriarte, Paul Ruiz, Miguel Calero, Maria Vittoria Di Tomaso, Alejandra Kun
Summary: CMT1 type 1 disease is caused by mutations in pmp22, with TrJ/+ mice serving as an animal model. Behavioral analysis showed increased anxiety levels in TrJ/+ mice, consistent with hippocampus-associated behaviors. Expression of pmp22/PMP22 in hippocampal neurons also differed between TrJ/+ and wild-type mice.
Review
Endocrinology & Metabolism
Sreekala Nampoothiri, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Summary: This review discusses the key role glial cells play in regulating energy balance, emphasizing their relevance in the pathophysiology of metabolic diseases. Glial cells, located at the interface of blood vessels and neurons, participate in integrating and transmitting peripheral signals to neuronal networks in the brain for whole-body metabolism control. Metabolic diseases like obesity and type 2 diabetes can disrupt the communication mediated by glial cells between the brain and the periphery, highlighting the importance of these cell types in the pathophysiology of such complications.
Article
Cell Biology
Sarra Djemil, Claire R. Ressel, Mai Abdel-Ghani, Amanda K. Schneeweis, Daniel T. S. Pak
Summary: The study utilized an optimized primary septal-hippocampal co-culture system to generate developmentally mature cholinergic synapses, which mimicked the molecular composition and physiological properties of in vivo counterparts. This co-culture system will facilitate research on the formation, plasticity, and dysfunction of central mammalian cholinergic synapses.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)