Editorial Material
Hematology
Cha Han, Jing-fei Dong
Summary: The study reveals a noncoagulation role of TM in maintaining placental growth and healthy embryogenesis, with IL-1 beta playing a key role in regulating TM synthesis and shedding. Solulin shows potential in preventing TM shedding and related abnormalities.
Review
Biochemistry & Molecular Biology
Carolin Brombach, Wen Tong, Dino A. Giussani
Summary: The prevalence of maternal obesity is increasing rapidly, posing a major challenge for obstetric practice. Adverse effects on maternal and fetal health are mediated by complex interactions in the placenta. Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) may be key mediators in the pathogenesis of placental dysfunction. This article summarizes the current literature on placental changes in obese women, with a special focus on ER stress in obese pregnancy.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kaituo Wang, Robert Dagil, Thomas Lavstsen, Sandeep K. Misra, Charlotte B. Spliid, Yong Wang, Tobias Gustavsson, Daniel R. Sandoval, Elena Ethel Vidal-Calvo, Swati Choudhary, Mette O. Agerbaek, Kresten Lindorff-Larsen, Morten A. Nielsen, Thor G. Theander, Joshua S. Sharp, Thomas Mandel Clausen, Pontus Gourdon, Ali Salanti
Summary: The study presents cryo-EM structures of VAR2CSA and placental CS, identifying molecular interactions that could guide the design of placental malaria vaccines.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Gabriele Orlando, Daniele Raimondi, Ramon Duran-Romana, Yves Moreau, Joost Schymkowitz, Frederic Rousseau
Summary: Structural bioinformatics lacks interfaces connecting with machine learning methods, hindering the application of modern neural network architectures. PyUUL is introduced as a library that translates biological structures into 3D tensors, enabling the application of state-of-the-art deep learning algorithms. The library also supports GPU and sparse calculation, and can be used to address typical bioinformatics problems.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Hee Jin Park, Hee Young Cho, Dong Hyun Cha
Summary: Analysis of cell-free mRNA in amniotic fluid is important for understanding fetal health, placental development, and diagnosing potential diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rohan M. Lewis, Harikesan Baskaran, Jools Green, Stanimir Tashev, Eleni Palaiologou, Emma M. Lofthouse, Jane K. Cleal, Anton Page, David S. Chatelet, Patricia Goggin, Bram G. Sengers
Summary: This article reports the existence of trans-syncytial nanopores (TSNs) on the placental syncytiotrophoblast, which connect the maternal and fetal facing sides and provide a pathway for paracellular diffusion between the mother and fetus.
Article
Microbiology
Saumya Ramanayake, Dale A. Moulding, Yuetsu Tanaka, Abhyudai Singh, Charles R. M. Bangham
Summary: We studied the kinetics of Tax expression in two naturally-infected, non-malignant T-cell clones using live-cell imaging and mathematical modeling. Single-cell analysis revealed five patterns of Tax expression, with most Tax-positive cells expressing continuously over a 30-hour period. The average duration of Tax expression in the two clones was 94 and 417 hours, respectively, as estimated by mathematical modeling. Tax expression was associated with transiently decreased proliferation, increased apoptosis, enhanced activation of DNA damage response pathways, and delayed progression through the cell cycle. Extended observation showed that as cells ceased Tax expression, there was an increase in the proportion of proliferating cells and a decrease in the percentage of apoptotic cells, resulting in a greater net growth of the initially Tax-positive population. Tax-expressing cells also formed cell clumps and exhibited reduced cell movement. These findings help reconcile previous conflicting observations regarding the impact of Tax on the host cell.
Article
Pharmacology & Pharmacy
Laura Goetzl, Nune Darbinian, Nana Merabova, Lindsay C. Devane, Sammanda Ramamoorthy
Summary: Patient and providers' fear of fetal exposure to medications may lead to discontinuation of treatment, disease relapse, and maternal morbidity. Placental drug transporters play a critical role in fetal exposure through active transport but the majority of data are limited to the 3rd trimester, when the majority of organogenesis has already occurred. Our objective was to define gestational age (GA) dependent changes in protein activity, expression and modifications of five major placental drug transporters: SERT, P-gp, NET, BCRP and MRP3.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Developmental Biology
Arsenio Spinillo, Irene De Maggio, Beatrice Ruspini, Camilla Bellingeri, Chiara Cavagnoli, Serena Giannico, Anna Boschetti, Flavia Magri, Elisabetta Lovati, Fausta Beneventi
Summary: The study found that women with TPO Ab positivity and isolated hypothyroidism during pregnancy had placental pathologic features, with more prominent features in cases with TSH >= 2.5mU/L. These cases also had higher rates of FGR/SGA, placental pathological features suggesting decidual vasculopathy, and severe maternal vascular malperfusion. The increased risk of defective placentation and FGR associated with TPO Ab was independent of simultaneous presence of antinuclear antibodies (ANA) and TSH concentration.
Article
Microbiology
Birgitta Lindqvist, Bianca B. Jutte, Luca Love, Wlaa Assi, Julie Roux, Anders Sonnerborg, Tugsan Tezil, Eric Verdin, J. Peter Svensson
Summary: This study developed a method to assess the microenvironment of the integrated HIV-1 promoter in single cells, revealing how T cell stimulation modulates the proviral activity and the subsequent fate of the infected cell depends on the chromatin context. Using small molecules, they also analyzed the effect of modifying chromatin marks on HIV-1 latency.
Article
Multidisciplinary Sciences
Muhammad Sharif, Yeong-Bin Baek, Thu Ha Nguyen, Mahmoud Soliman, Kyoung-Oh Cho
Summary: Sapoviruses, a type of calicivirus, are common causes of severe acute gastroenteritis in humans and animals. This study shows that infection with porcine sapovirus induces RIPK1-dependent necroptosis, which promotes viral replication, while PSaV-induced apoptosis has an antiviral effect. These findings contribute to understanding and developing therapies against PSaV and other calicivirus infections.
Article
Multidisciplinary Sciences
Maru Jaime-Garza, Carlos A. Nowotny, Daniel Coutandin, Feng Wang, Mariano Tabios, David A. Agard
Summary: PP5 requires Hsp90 to dephosphorylate CRaf kinase and Cdc37. Hsp90 acts as a platform to facilitate targeted dephosphorylation by PP5 and collaborates with phosphorylated Cdc37 for the folding and activation of client kinases. The cryo-EM structure reveals how Hsp90 activates and scaffolds PP5 to dephosphorylate nearby phosphorylation sites of CRaf, showing the role of Hsp90 in post-translational modification of client kinases goes beyond folding and activation.
NATURE COMMUNICATIONS
(2023)
Article
Acoustics
J. J. Dyhr, I. R. Linderoth, D. N. Hansen, J. B. Frokjaer, D. A. Peters, M. Sinding, A. Sorensen
Summary: This study aimed to compare placental function between CPM and non-CPM pregnancies prenatally and at birth. The results showed that CPM pregnancies have abnormal placental function, which is related to their chromosomal subtype.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sokrates Stein, Julien Weber, Stefanie Nusser-Stein, Juergen Pahla, Hui E. Zhang, Shafeeq A. Mohammed, Sara Oppi, Daniel S. Gaul, Francesco Paneni, Anne Tailleux, Bart Staels, Ferdinand von Meyenn, Frank Ruschitzka, Mark D. Gorrell, Thomas F. Luescher, Christian M. Matter
Summary: Fibroblast activation protein (FAP) is upregulated in tissues undergoing remodeling, including atherosclerotic plaques. This study found that deletion of the Fap gene decreased plaque formation in atherosclerosis-prone mouse models, indicating a potential therapeutic target for atherosclerosis and cancer therapies.
CARDIOVASCULAR RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jakob T. Rostol, Wei Xie, Vitaly Kuryavyi, Pascal Maguin, Kevin Kao, Ruby Froom, Dinshaw J. Patel, Luciano A. Marraffini
Summary: The type III CRISPR system utilizes CARF domain proteins to provide immune defense, with Card1 serving as an activated nucleic acid enzyme that induces infected hosts into dormancy to provide immunity by cleaving single-stranded RNA and DNA. This strategy highlights the diversity of methods used by CRISPR systems in providing immune defense.
Review
Biology
George Kassiotis, Jonathan P. Stoye
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2017)
Article
Biophysics
William R. Taylor, Jonathan P. Stoye, Ian A. Taylor
BMC STRUCTURAL BIOLOGY
(2017)
Article
Microbiology
Jan Attig, George R. Young, Jonathan P. Stoye, George Kassiotis
FRONTIERS IN MICROBIOLOGY
(2017)
Letter
Virology
Mart Krupovic, Jonas Blomberg, John M. Coffin, Indranil Dasgupta, Hung Fan, Andrew D. Geering, Robert Gifford, Balazs Harrach, Roger Hull, Welkin Johnson, Jan F. Kreuze, Dirk Lindemann, Carlos Llorens, Ben Lockhart, Jens Mayer, Emmanuelle Muller, Neil E. Olszewski, Hanu R. Pappu, Mikhail M. Pooggin, Katja R. Richert-Poeggeler, Sead Sabanadzovic, Helene Sanfacon, James E. Schoelz, Susan Seal, Livia Stavolone, Jonathan P. Stoye, Pierre-Yves Teycheney, Michael Tristem, Eugene V. Koonin, Jens H. Kuhn
JOURNAL OF VIROLOGY
(2018)
Article
Multidisciplinary Sciences
George R. Young, Melvyn W. Yap, Johan R. Michaux, Scott J. Steppan, Jonathan P. Stoye
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Virology
Robert J. Gifford, Jonas Blomberg, John M. Coffin, Hung Fan, Thierry Heidmann, Jens Mayer, Jonathan Stoye, Michael Tristem, Welkin E. Johnson
Article
Oncology
Eleonora Ottina, Prisca Levy, Urszula Eksmond, Julia Merkenschlager, George R. Young, Juliette Roels, Jonathan P. Stoye, Thomas Tueting, Dinis P. Calado, George Kassiotis
CANCER IMMUNOLOGY RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Jeremy R. Keown, Moyra M. Black, Aaron Ferron, Melvyn Yap, Michael J. Barnett, F. Grant Pearce, Jonathan P. Stoye, David C. Goldstone
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Jan Attig, George R. Young, Louise Hosie, David Perkins, Vesela Encheva-Yokoya, Jonathan P. Stoye, Ambrosius P. Snijders, Nicola Ternette, George Kassiotis
Article
Multidisciplinary Sciences
Christopher Monit, Elizabeth R. Morris, Christopher Ruis, Bart Szafran, Grant Thiltgen, Ming-Han Chloe Tsai, N. Avrion Mitchison, Kate N. Bishop, Jonathan P. Stoye, Ian A. Taylor, Ariberto Fassati, Richard A. Goldstein
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Oliver Acton, Tim Grant, Giuseppe Nicastro, Neil J. Ball, David C. Goldstone, Laura E. Robertson, Kasim Sader, Andrea Nans, Andres Ramos, Jonathan P. Stoye, Ian A. Taylor, Peter B. Rosenthal
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Matthew A. Cottee, Suzanne C. Letham, George R. Young, Jonathan P. Stoye, Ian A. Taylor
Article
Genetics & Heredity
Melvyn W. Yap, George R. Young, Renata Varnaite, Serge Morand, Jonathan P. Stoye
Article
Biochemistry & Molecular Biology
George R. Young, Aaron K. W. Ferron, Veera Panova, Urszula Eksmond, Peter L. Oliver, George Kassiotis, Jonathan P. Stoye
Summary: Inbred mice genomes contain around 50 endogenous murine leukemia virus (MLV) loci, with the Gv1 locus being important for controlling MLV transcription and cell-surface presentation of the G(IX) antigen. Zfp998 gene is identified as Gv1 and is essential for determining the G(IX)(+) phenotype, highlighting its role in epigenetic suppression of endogenous MLVs and control of endogenous retroviruses.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Matthew A. Cottee, Sean L. Beckwith, Suzanne C. Letham, Sarah J. Kim, George R. Young, Jonathan P. Stoye, David J. Garfinkel, Ian A. Taylor
Summary: Excessive replication of Saccharomyces cerevisiae Ty1 retrotransposons is regulated by Copy Number Control, with p22/p18 protein interrupting Gag function to block retrotransposition. The authors present structural, biophysical and genetic analyses of p18m, a minimal fragment of Gag that restricts transposition, revealing insights into Ty1 Gag structure and the mechanism of action of p22/p18 in restriction.
NATURE COMMUNICATIONS
(2021)
