Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors

(2017) Daniel Blanco-Melo et al.   eLife

On the classification and evolution of endogenous retrovirus: human endogenous retroviruses may not be ‘human’ after all

(2016) Marina Escalera-Zamudio et al.   APMIS

Utility of next-generation RNA-sequencing in identifying chimeric transcription involving human endogenous retroviruses

(2016) Martin Sokol et al.   APMIS

PMS2 inactivation by a complex rearrangement involving an HERV retroelement and the inverted 100-kb duplicon on 7p22.1

(2016) Julia Vogt et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Discovery of unfixed endogenous retrovirus insertions in diverse human populations

(2016) Julia Halo Wildschutte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

The human endogenous retrovirus K(HML-2) has a broad envelope-mediated cellular tropism and is prone to inhibition at a post-entry, pre-integration step

(2016) Philipp Kramer et al.   VIROLOGY

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

(2015) I. Scarfo et al.   BLOOD

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

(2015) Michael S. Rooney et al.   CELL

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death

(2015) U Beyer et al.   CELL DEATH AND DIFFERENTIATION

Genetic Engineering of T Cells to Target HERV-K, an Ancient Retrovirus on Melanoma

(2015) J. Krishnamurthy et al.   CLINICAL CANCER RESEARCH

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

(2015) Adam D. Ewing et al.   GENOME RESEARCH

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer

(2015) Thomas Wiesner et al.   NATURE

Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma

(2015) Nemanja Rodić et al.   NATURE MEDICINE

Onco-exaptation of an endogenous retroviral LTR drives IRF5 expression in Hodgkin lymphoma

(2015) A Babaian et al.   ONCOGENE

LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma

(2015) Tara T. Doucet-O'Hare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human endogenous retroviruses sustain complex and cooperative regulation of gene-containing loci and unannotated megabase-sized regions

(2015) Martin Sokol et al.   Retrovirology

Somatic mutation in cancer and normal cells

(2015) I. Martincorena et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

HERV-K(HML-2) rec and np9 transcripts not restricted to disease but present in many normal human tissues

(2015) Katja Schmitt et al.   Mobile DNA

Induction of Immunoregulatory CD271+ Cells by Metastatic Tumor Cells That Express Human Endogenous Retrovirus H

(2014) C. Kudo-Saito et al.   CANCER RESEARCH

Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?

(2014) Ronan F. Downey et al.   INTERNATIONAL JOURNAL OF CANCER

Recent developments linking retroviruses to human breast cancer: infectious agent, enemy within or both?

(2014) B. Salmons et al.   JOURNAL OF GENERAL VIROLOGY

Endogenous Retroviruses and the Development of Cancer

(2014) G. Kassiotis   JOURNAL OF IMMUNOLOGY

Unfixed Endogenous Retroviral Insertions in the Human Population

(2014) E. Marchi et al.   JOURNAL OF VIROLOGY

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma

(2014) F. E. Lock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

(2014) J. M. C. Tubio et al.   SCIENCE

Processed pseudogenes acquired somatically during cancer development

(2014) Susanna L. Cooke et al.   Nature Communications

5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies

(2014) A O Gang et al.   Blood Cancer Journal

Larger Mammalian Body Size Leads to Lower Retroviral Activity

(2014) Aris Katzourakis et al.   PLoS Pathogens

Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis

(2013) George R. Young et al.   BIOESSAYS

Human endogenous retroviruses and cancer prevention: evidence and prospects

(2013) Luca Cegolon et al.   BMC CANCER

On the concept and elucidation of endogenous retroviruses

(2013) R. A. Weiss   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation

(2013) C. Lavialle et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Transmembrane Protein of the Human Endogenous Retrovirus - K (HERV-K) Modulates Cytokine Release and Gene Expression

(2013) Vladimir A. Morozov et al.   PLoS One

Endogenous retroviruses: acquisition, amplification and taming of genome invaders

(2013) Marie Dewannieux et al.   Current Opinion in Virology

Retrotransposition of gene transcripts leads to structural variation in mammalian genomes

(2013) Adam D Ewing et al.   GENOME BIOLOGY

Association of Endogenous Retroviruses and Long Terminal Repeats with Human Disorders

(2013) Iyoko Katoh et al.   Frontiers in Oncology

HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease

(2013) Oliver Hohn et al.   Frontiers in Oncology

Endogenous Retroviruses as Targets for Antitumor Immunity in Renal Cell Cancer and Other Tumors

(2013) Elena Cherkasova et al.   Frontiers in Oncology

Transposable Elements: An Abundant and Natural Source of Regulatory Sequences for Host Genes

(2012) Rita Rebollo et al.   Annual Review of Genetics

Human Transposon Tectonics

(2012) Kathleen H. Burns et al.   CELL

Active human retrotransposons: variation and disease

(2012) Dustin C Hancks et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The cancer antigenome

(2012) Bianca Heemskerk et al.   EMBO JOURNAL

Nucleic Acid-Sensing Toll-like Receptors Are Essential for the Control of Endogenous Retrovirus Viremia and ERV-Induced Tumors

(2012) Philipp Yu et al.   IMMUNITY

Immunotherapeutic Potential of Anti-Human Endogenous Retrovirus-K Envelope Protein Antibodies in Targeting Breast Tumors

(2012) Feng Wang-Johanning et al.   JNCI-Journal of the National Cancer Institute

Resurrection of endogenous retroviruses in antibody-deficient mice

(2012) George R. Young et al.   NATURE

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Studies of endogenous retroviruses reveal a continuing evolutionary saga

(2012) Jonathan P. Stoye   NATURE REVIEWS MICROBIOLOGY

Landscape of Somatic Retrotransposition in Human Cancers

(2012) E. Lee et al.   SCIENCE

Endogenous retrovirus sequences as a novel class of tumor-specific antigens: an example of HERV-H env encoding strong CTL epitopes

(2011) Christina S. Mullins et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals

(2011) R. Contreras-Galindo et al.   JOURNAL OF VIROLOGY

Repetitive DNA and next-generation sequencing: computational challenges and solutions

(2011) Todd J. Treangen et al.   NATURE REVIEWS GENETICS

Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes

(2011) Ulrike Beyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

(2011) Ravi P Subramanian et al.   Retrovirology

SINEs

(2011) Dmitri A. Kramerov et al.   Wiley Interdisciplinary Reviews-RNA

A revised nomenclature for transcribed human endogenous retroviral loci

(2011) Jens Mayer et al.   Mobile DNA

Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia

(2010) O. Goodyear et al.   BLOOD

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

(2010) Björn Lamprecht et al.   NATURE MEDICINE

SVA retrotransposons: Evolution and genetic instability

(2010) Dustin C. Hancks et al.   SEMINARS IN CANCER BIOLOGY

Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer

(2010) M.T. Romanish et al.   SEMINARS IN CANCER BIOLOGY

A Compendium of the Mouse Mammary Tumor Biologist: From the Initial Observations in the House Mouse to the Development of Genetically Engineered Mice

(2010) R. D. Cardiff et al.   Cold Spring Harbor Perspectives in Biology

Treatment of Chronic Lymphocytic Leukemia with a Hypomethylating Agent Induces Expression of NXF2, an Immunogenic Cancer Testis Antigen

(2009) J. A. Dubovsky et al.   CLINICAL CANCER RESEARCH

Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements

(2009) Sebastian Szpakowski et al.   GENE

Classification and nomenclature of endogenous retroviral sequences (ERVs)

(2009) Jonas Blomberg et al.   GENE

Segmental duplications mediate novel, clinically relevant chromosome rearrangements

(2009) M. Katharine Rudd et al.   HUMAN MOLECULAR GENETICS

Beneficial and detrimental effects of human endogenous retroviruses

(2009) Reinhard Kurth et al.   INTERNATIONAL JOURNAL OF CANCER

Role of human noncoding RNAs in the control of tumorigenesis

(2009) L. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serological Response to Human Endogenous Retrovirus K in Melanoma Patients Correlates with Survival Probability

(2008) Silvia Hahn et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Effects of Retroviruses on Host Genome Function

(2008) Patric Jern et al.   Annual Review of Genetics

Human Endogenous Retrovirus K Triggers an Antigen-Specific Immune Response in Breast Cancer Patients

(2008) F. Wang-Johanning et al.   CANCER RESEARCH

Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

(2008) John L. Goodier et al.   CELL

Endogenous retroviruses

(2008) K. Ruprecht et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells

(2008) Yoshiyuki Takahashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Human RNA "Rumor" Viruses: the Search for Novel Human Retroviruses in Chronic Disease

(2008) C. Voisset et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS