Article
Neurosciences
Gloria Brunori, Oliver B. Pelletier, Anna M. Stauffer, Janet D. Robishaw
Summary: The study reveals the importance of Gaolfb2c7/cAMP signaling in specific populations of MSNs in regulating motor behaviors, acting through D1R and A2AR to coordinate behavior. Additionally, the loss of Gaolfb2c7 in A2AR/D2R-MSNs leads to a hyperlocomotor phenotype and enhanced locomotor response to amphetamine.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ornela Kljakic, Helena Janickova, Miguel Skirzewski, Amy Reichelt, Sara Memar, Salah El Mestikawy, Yulong Li, Lisa M. Saksida, Timothy J. Bussey, Vania F. Prado, Marco A. M. Prado
Summary: In the striatum, cholinergic interneurons can release both acetylcholine and glutamate, and their individual and combined contributions to behavior regulation were assessed in mice using reward-based touchscreen tests. Changes in VAChT and VGLUT3 levels have different effects on reward responses, and the simultaneous loss of both vesicular transporters affects dopamine signaling and behavior in a more severe way than the loss of VAChT alone. This shows that the ability of CINs to secrete two different neurotransmitters allows for complex modulation of various behaviors.
Article
Biology
Ali Mohebi, Val L. Collins, Joshua D. Berke
Summary: This study investigates the role of cholinergic interneurons (CINs) in the regulation of dopamine (DA) release and its impact on motivated behavior. The findings highlight the crucial influence of CINs on DA dynamics and provide insights into the underlying mechanisms of motivation.
Article
Clinical Neurology
Fernando Caravaggio, Alexander J. Barnett, Shinichiro Nakajima, Yusuke Iwata, Julia Kim, Carol Borlido, Wanna Mar, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrero
Summary: This study investigated the effects of AMPT-induced dopamine depletion on resting-state functional connectivity of the basal ganglia and canonical resting-state networks in healthy individuals. The results showed reduced connectivity between the caudate and the medial prefrontal cortex, as well as decreased connectivity between several brain regions and the occipital cortex, while increased connectivity was observed between the dorsal caudate and the sensorimotor network. AMPT also significantly decreased self-reported motivation and increased fatigue. Moreover, greater fatigue was associated with reduced connectivity between the substantia nigra and the medial prefrontal cortex, and decreased motivation was correlated with decreased connectivity between the ventral tegmental area and the left sensorimotor cortex.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hongfei Ji, Anthony D. Fouad, Zihao Li, Andrew Ruba, Christopher Fang-Yen
Summary: This study describes the proprioception-mediated homeostatic control of undulatory movement in C. elegans. The worm responds to decreases in midbody bending amplitude by increasing anterior amplitude and vice versa. The neural circuit underlying this compensatory postural response involves dopamine signaling from PDE neurons to AVK interneurons, which release FLP-1 to regulate SMB head motor neurons for anterior bending. This homeostatic control optimizes locomotor efficiency.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Olivier Rampin, Audrey Saint Albin Deliot, Christian Ouali, Jasmine Burguet, Elisa Gry, Gaelle Champeil Potokar, Nathalie Jerome, Olga Davidenko, Nicolas Darcel, Vincent Bombail, Philippe Andrey, Isabelle Denis
Summary: Food odour coding is crucial for food intake, and dopamine plays a regulatory role in food odour information processing in the ventral striatum.
Article
Multidisciplinary Sciences
Wouter van Elzelingen, Jessica Goedhoop, Pascal Warnaar, Damiaan Denys, Tara Arbab, Ingo Willuhn
Summary: Dopamine signals in the striatum play a critical role in motivated behavior. The release and modulation of dopamine in different regions of the striatum vary, while prediction-error signals are limited to specific regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Morgane M. Moss, Peter Zatka-Haas, Kenneth D. Harris, Matteo Carandini, Armin Lak
Summary: Research suggests that dopamine in the striatum plays a critical role in visual decision-making, encoding visual stimuli and rewarded actions in a lateralized fashion. Contrary to previous beliefs, dopamine signals in the DMS respond to contralateral stimuli and rewarded actions, facilitating associations between specific visual stimuli and actions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Noorya Yasmin Ahmed, Rhys Knowles, Lixinyu Liu, Yiming Yan, Xiaohan Li, Ulrike Schumann, Yumeng Wang, Yovina Sontani, Nathan Reynolds, Riccardo Natoli, Jiayu Wen, Isabel Del Pino, Da Mi, Nathalie Dehorter
Summary: Interneurons play a fundamental role in maintaining the balance between excitation and inhibition in the brain. This study focused on understanding the molecular and physiological changes in developing interneurons in the striatum of Cntnap2 knockout mouse model. The findings revealed alterations in cell proliferation and cell loss, as well as specific changes in the firing properties of cholinergic interneurons during early postnatal development. These findings provide insights into the mechanisms underlying the pathogenesis of autism spectrum disorder (ASD).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Stephanie Kullmann, Dominik Blum, Benjamin Assad Jaghutriz, Christoph Gassenmaier, Benjamin Bender, Hans-Ulrich Haering, Gerald Reischl, Hubert Preissl, Christian la Fougere, Andreas Fritsche, Matthias Reimold, Martin Heni
Summary: This study demonstrates that central administration of insulin can impact dopaminergic activity in the striatum, which in turn affects regional brain activity and connectivity. The interaction between insulin and dopamine and the regulation of whole-body metabolism through a complex network are further elucidated by our findings.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Vladimir M. Pogorelov, Michael L. Martini, Jian Jin, William C. Wetsel, Marc G. Caron
Summary: L-DOPA is the main treatment for Parkinson's disease, but it can lead to dyskinesia over time. In this study, dopamine-depleted dopamine-transporter KO (DDD) mice were used as an acute PD model to screen novel compounds for anti-parkinsonian and L-DOPA-induced dyskinesia. The researchers found that oral stereotypies could be used as an index for LID in DDD mice.
Article
Biochemistry & Molecular Biology
Subramaniam Jayanthi, Bruce Ladenheim, Patricia Sullivan, Michael T. McCoy, Irina N. Krasnova, David S. Goldstein, Jean Lud Cadet
Summary: Perturbations in striatal dopamine homeostasis may contribute to METH use disorder. Rats exposed to footshocks after long-term METH intake showed decreased intake when given a DA D1 receptor antagonist. Compulsive METH takers exhibited abnormal DA metabolism and decreased protein levels. These findings are consistent with studies on human METH users.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Alexander Soutschek, Susanna C. Weber, Thorsten Kahnt, Boris B. Quednow, Philippe N. Tobler
Summary: The study found that pharmacological manipulations can affect human desires for rewards rather than preferences, with stronger neural connectivity. Opioid receptors impact reward motivation, whereas dopamine receptors do not affect behavior or neural activity.
Article
Environmental Sciences
Muhammad Badruzzaman, Md Shahjahan, Prodip Kumar Roy, Md Taimur Islam
Summary: The study revealed that rotenone exposure led to significant reductions in dopamine, DOPAC, and TH-positive neurons in the Indian freshwater catfish's brain. This was accompanied by decreased movement and feeding behavior, increased mature vitellogenic oocytes in the ovaries, and decreased dopaminergic activity.
Article
Biology
Kelly M. Martyniuk, Arturo Torres-Herraez, Daniel C. Lowes, Marcelo Rubinstein, Marie A. Labouesse, Christoph Kellendonk
Summary: In the striatum, the activity of acetylcholine neurons is regulated by dopamine release, and this regulation is mediated by dopamine D2 receptors. Through experiments on mice, it was found that D2 receptors affect the duration of acetylcholine level changes and regulate the temporal correlation between the two signals. These results suggest an important role of D2 receptors in motivation to initiate actions.
Review
Pharmacology & Pharmacy
Matthew Hearing, Nicholas Graziane, Yan Dong, Mark J. Thomas
TRENDS IN PHARMACOLOGICAL SCIENCES
(2018)
Article
Multidisciplinary Sciences
Brian M. Sweis, A. David Redish, Mark J. Thomas
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Brian M. Sweis, Mark J. Thomas, A. David Redish
Article
Neurosciences
Michael A. Benneyworth, Matthew C. Hearing, Anders J. Asp, Aric Madayag, Anna E. Ingebretson, Clare E. Schmidt, Keelia A. Silvis, Erin B. Larson, Stephanie R. Ebner, Mark J. Thomas
JOURNAL OF NEUROSCIENCE
(2019)
Article
Anatomy & Morphology
Aric C. Madayag, Devan Gomez, Eden M. Anderson, Anna E. Ingebretson, Mark J. Thomas, Matthew C. Hearing
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Cell Biology
Michelle Corkrum, Patrick E. Rothwell, Mark J. Thomas, Paulo Kofuji, Alfonso Araque
Article
Biochemistry & Molecular Biology
Carey E. Lyons, Maria Razzoli, Erin Larson, Daniel Svedberg, Andrea Frontini, Saverio Cinti, Lucy Vulchanova, Mark Sanders, Mark Thomas, Alessandro Bartolomucci
Article
Neurosciences
Michelle Corkrum, Ana Covelo, Justin Lines, Luigi Bellocchio, Marc Pisansky, Kelvin Loke, Ruth Quintana, Patrick E. Rothwell, Rafael Lujan, Giovanni Marsicano, Eduardo D. Martin, Mark J. Thomas, Paulo Kofuji, Alfonso Araque
Article
Neurosciences
Katherine R. Tonn Eisinger, Andrew D. Chapp, Samuel P. Swanson, Daniel Tam, Natalie M. Lopresti, Erin B. Larson, Mark J. Thomas, Lorene M. Lanier, Paul G. Mermelstein
PSYCHOPHARMACOLOGY
(2020)
Article
Neurosciences
Andrew D. Chapp, Paul G. Mermelstein, Mark J. Thomas
Summary: The study suggests that acetic acid may play a role in neurophysiological changes in medium spiny neurons of the nucleus accumbens, potentially influencing behaviors and physiological responses associated with ethanol consumption. This raises the interesting possibility that ethanol may act as a prodrug generating acetic acid as a metabolite, altering neurophysiological function to influence behaviors and physiological responses related to ethanol consumption.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Biology
Erin B. Lind, Brian M. Sweis, Anders J. Asp, Manuel Esguerra, Keelia A. Silvis, A. David Redish, Mark J. Thomas
Summary: An optogenetic spatial self-stimulation task in mice reveals how different excitatory inputs to the nucleus accumbens shell integrate information and drive behavioral responses during reinforcement learning. Each input provides distinct information, reflecting reinforcement of different credit assignment functions, and contributes to driving situationally appropriate behavioral responses.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Neurosciences
Michelle Corkrum, Mark Thomas, Paulo Kofuji, Alfonso Araque
NEUROPSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Neurosciences
Brian Sweis, Jazmin Camchong, Samantha Abram, Ann Haynos, Sheila Specker, Kelvin Lim, Angus MacDonald, Mark Thomas, David Redish
NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Neurosciences
Brian M. Sweis, Mark J. Thomas, A. David Redish
Meeting Abstract
Neurosciences
Shamsudheen Moidunny, David J. Titus, Michael A. Benneyworth, Joyce Meintz, Mark J. Thomas, Sundaram Ramakrishnan, Coleen M. Atkins, Sabita Roy
JOURNAL OF NEUROVIROLOGY
(2018)