期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 39, 期 3, 页码 276-294出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2017.12.004
关键词
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资金
- NATIONAL INSTITUTE ON DRUG ABUSE [R21DA044538, R00DA038706, R01DA019666, R01DA034856, R01DA040620] Funding Source: NIH RePORTER
- NIDA NIH HHS [R21 DA044538, R01 DA040620, R21 DA024570, R01 DA034856, R01 DA019666, R00 DA038706] Funding Source: Medline
Commonalities in addictive behavior, such as craving, stimuli-driven drug seeking, and a high propensity for relapse following abstinence, have pushed for a unified theory of addiction that encompasses most abused substances. This unitary theory has recently been challenged - citing distinctions in structural neural plasticity, biochemical signaling, and neural circuitry to argue that addiction to opioids and psychostimulants is behaviorally and neurobiologically distinct. Recent more selective examination of drug-induced plasticity has highlighted that these two drug classes promote an overall reward circuitry signaling overlap through modifying excitatory synapses in the nucleus accumbens - a key constituent of the reward system. We discuss adaptations in presynaptic/postsynaptic and extrasynaptic glutamate signaling produced by opioids and psychostimulants, and their relevance to circuit remodeling and addiction-related behavior - arguing that these core neural adaptations are important targets for developing pharmacotherapies to treat addiction to multiple drugs.
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