Cigarette toxicity triggers Leber’s hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

(2014) Raffaele Cerutti et al.   Cell Metabolism

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy

(2013) Carla Giordano et al.   BRAIN

Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment

(2013) Ahmed F. Salem et al.   CELL CYCLE

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

(2013) Haider Raza et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Identification of the variants in PARL, the nuclear modifier gene, responsible for the expression of LHON patients in Thailand

(2013) Rochmy Istikharah et al.   EXPERIMENTAL EYE RESEARCH

Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

(2012) Jeongho Kwon et al.   EMBO REPORTS

Estrogen and the regulation of mitochondrial structure and function in the brain

(2012) Susanne Arnold et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The optic nerve: A “mito-window” on mitochondrial neurodegeneration

(2012) Alessandra Maresca et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Idebenone Treatment In Leber's Hereditary Optic Neuropathy

(2011) V. Carelli et al.   BRAIN

Meta-analysis of the prevalence of Leber hereditary optic neuropathy mtDNA mutations in Europe

(2011) Barbara Mascialino et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Genetic Ablation of the Aryl Hydrocarbon Receptor Causes Cigarette Smoke-induced Mitochondrial Dysfunction and Apoptosis

(2011) Angela Rico de Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hazardous Compounds in Tobacco Smoke

(2011) Reinskje Talhout et al.   International Journal of Environmental Research and Public Health

Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium

(2010) Freya L. Sheeran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oestrogens ameliorate mitochondrial dysfunction in Leber’s hereditary optic neuropathy

(2010) Carla Giordano et al.   BRAIN

Differential inhibition of mitochondrial respiratory complexes by inhalation of combustion smoke and carbon monoxide,in vivo, in the rat brain

(2010) Heung M. Lee et al.   INHALATION TOXICOLOGY

Natural History of Leber's Hereditary Optic Neuropathy: Longitudinal Analysis of the Retinal Nerve Fiber Layer by Optical Coherence Tomography

(2010) Piero Barboni et al.   OPHTHALMOLOGY

Mitochondrial optic neuropathies – Disease mechanisms and therapeutic strategies

(2010) Patrick Yu-Wai-Man et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders

(2009) Valerio Carelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Gene–environment interactions in Leber hereditary optic neuropathy

(2009) Matthew Anthony Kirkman et al.   BRAIN

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

The Background of Mitochondrial DNA Haplogroup J Increases the Sensitivity of Leber's Hereditary Optic Neuropathy Cells to 2,5-Hexanedione Toxicity

(2009) Anna Ghelli et al.   PLoS One

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

Leber Hereditary Optic Neuropathy Presenting in a 75-Year-Old Man

(2008) Patrick Yu-Wai-Man et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Evidence for a Novel X-Linked Modifier Locus for Leber Hereditary Optic Neuropathy

(2008) Suma P. Shankar et al.   OPHTHALMIC GENETICS