Review
Biology
Hasan Safwan-Zaiter, Nicole Wagner, Kay-Dietrich Wagner
Summary: Aging is a biological process characterized by the gradual decline in cellular, tissue, organ, or organismal function due to the accumulation of environmental factors and stresses. Several factors contribute to aging, including oxidative stress, inflammatory cytokines production, DNA damage, and the presence of senescent cells. P16(INK4A), a tumor suppressor gene and cell cycle regulator, plays a crucial role in aging and cellular senescence. Extensive research has shown that p16 is not only a specific biomarker for detecting senescent cells and aging, but also has other functions outside of senescence and aging.
Article
Cardiac & Cardiovascular Systems
Gabor Czibik, Zaineb Mezdari, Dogus Murat Altintas, Juliette Brehat, Maria Pini, Thomas d'Humieres, Thais Delmont, Costin Radu, Marielle Breau, Hao Liang, Cecile Martel, Azania Abatan, Rizwan Sarwar, Ophelie Marion, Suzain Naushad, Yanyan Zhang, Maissa Halfaoui, Nadine Suffee, Didier Morin, Serge Adnot, Stephane Hatem, Arash Yavari, Daigo Sawaki, Genevieve Derumeaux
Summary: The study found that aging myocardium leads to elevated plasma levels of the essential amino acid phenylalanine, contributing to cardiac dysfunction. Inhibition of p21 gene can delay this process. Phenylalanine treatment induces premature cardiac deterioration, but this can be reversed through pharmacological or dietary interventions.
Article
Biotechnology & Applied Microbiology
Micheline Kirsch-Volders, Michael Fenech
Summary: This review discusses the impact of aneuploidy on the aging process and explores strategies for its prevention. Evidence suggests that aneuploidy is associated with cellular senescence and aging, contributing to chronic inflammation. Aneuploidy can induce senescence in vitro and may trigger inflammatory response in vivo through the release of DNA into the cytoplasm. However, the heterogeneity of cellular senescence in different tissues poses challenges in understanding the role of aneuploidy in aging. Furthermore, adequate intake of specific micronutrients is essential for preventing aneuploidy-related senescence, highlighting the importance of nutritional intervention in avoiding aneuploidy-driven diseases.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2023)
Review
Immunology
Blake L. Torrance, Laura Haynes
Summary: Aging increases the risk of adverse outcomes following respiratory infections in older adults. Cellular senescence plays a crucial role in disrupting lung function and diminishing the ability to protect against pathogens. However, most vaccines do not effectively confer protection against respiratory infections in older adults.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Mingyue Ma, Na Wei, Jieren Yang, Tingting Ding, Anping Song, Lerong Chen, Shuguo Zheng, Huanhuan Jin
Summary: This study aimed to investigate the effect of Schisandrin B (Sch B) on activated hepatic stellate cells (HSCs) senescence in hepatic fibrosis and its underlying mechanism. The results showed that Sch B could alleviate hepatic fibrosis and promote the senescence of activated HSCs, possibly through the induction of NCOA4-mediated ferritinophagy to enhance the aging process.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Cell Biology
Lu Wang, Caiyue Xu, Terje Johansen, Shelley L. Berger, Zhixun Dou
Summary: This study explores the poorly understood area of nuclear autophagy, revealing LMNB1 and SIRT1 as substrates. It also demonstrates the mechanism by which SIRT1 is degraded through nuclear SIRT1-LC3 interaction and autophagosome-lysosome degradation during senescence. Furthermore, the study suggests a potential strategy for promoting SIRT1-mediated health benefits by inhibiting its autophagic degradation.
Article
Cell Biology
Paola Sebastiani, Anthony Federico, Melody Morris, Anastasia Gurinovich, Toshiko Tanaka, Kevin B. Chandler, Stacy L. Andersen, Gerald Denis, Katherine Costello, Luigi Ferrucci, Lori Jennings, David J. Glass, Stefano Monti, Thomas T. Perls
Summary: Using samples from the New England Centenarian Study, researchers characterized the serum proteome of centenarians, their offspring, and age-matched controls. They identified protein signatures associated with longer survival in centenarians and younger individuals and found similarities in aging markers between centenarians and short-lived cohorts. The study provides specific circulating biomarkers of healthy aging and longevity, suggesting potential mechanisms to prolong health and support longevity.
Editorial Material
Biology
Auden Cote-L'Heureux, Yogesh N. K. Maithania, Melissa Franco, Konstantin Khrapko
Summary: A large-scale study on mitochondrial DNA mutations has identified a subset that does not accumulate with age.
Review
Cell Biology
Guillaume Holzer, Wolfram Antonin
Summary: Nup50 is a component of the nuclear pore complex localized to the nuclear side of the pore and in the nucleoplasm. It interacts with and stimulates RCC1, the guanine nucleotide exchange factor for Ran, potentially contributing to nuclear transport, gene expression, cell cycle regulation, and DNA damage repair.
Article
Biochemistry & Molecular Biology
Elis Cristina Araujo Eleutherio, Rayne Stfhany Silva Magalhaes, Aline de Araujo Brasil, Jose Raphael Monteiro Neto, Luan de Holanda Paranhos
Summary: During cellular respiration, radicals like superoxide can cause cell damage, but cells use the enzyme Cu/Zn Superoxide Dismutase (SOD1) to convert superoxide into oxygen and hydrogen peroxide. In addition to its primary function, SOD1 also plays other roles, such as activating gene transcription or functioning as an RNA binding protein.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Environmental Sciences
Hongze Ma, Xiaoyu Jia, Jingyi Yang, Jin Liu, Zhouping Shangguan, Weiming Yan
Summary: Farmlands receive nitrogen (N) from human activities, which increases N2O emissions and promotes crop productivity. Inhibitor or biochar applications have been effective in reducing N2O emissions and promoting crop yields globally. This study conducted a meta-analysis of 787 datasets to compare the response of N2O emissions and crop yields to inhibitor and biochar applications. The results showed that inhibitors had a larger reduction in N2O emissions (37.4%) compared to biochar applications (20.2%), but there was no difference in crop yield improvement (5.8% and 5.4% respectively). Nitrogen inhibitor applications, specifically nitrification inhibitors, were more effective in reducing N2O emissions than biochar applications under different climate and experimental conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T. Heneka, Christina Ising
Summary: The highest risk factor for the development of tauopathies is aging. Senescent microglia have been identified in the brains of tau-transgenic mice and patients suffering from tauopathies. Exposure to tau can lead to microglial senescence, suggesting the presence of a vicious circle.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Physics, Multidisciplinary
M. Baity-Jesi, E. Calore, A. Cruz, L. A. Fernandez, J. M. Gil-Narvion, I. Gonzalez-Adalid Pemartin, A. Gordillo-Guerrero, D. Iniguez, A. Maiorano, E. Marinari, V. Martin-Mayor, J. Moreno-Gordo, A. Munoz Sudupe, D. Navarro, I. Paga, G. Parisi, S. Perez-Gaviro, F. Ricci-Tersenghi, J. J. Ruiz-Lorenzo, S. F. Schifano, B. Seoane, A. Tarancon, D. Yllanes
Summary: Memory and rejuvenation effects in off-equilibrium spin glasses have been regarded as a gateway to experimental exploration of ultrametricity and temperature chaos. However, simulating these effects has been difficult until recent advancements in computing power and understanding of length scales in aging dynamics of spin glasses. A numerical study has shown that at least three different length scales play a crucial role in aging dynamics, challenging previous theories that focused on a single glassy correlation length.
Review
Biochemistry & Molecular Biology
Adam James Ferrari, Ronny Drapkin, Rajan Gogna
Summary: Cell competition allows tumor cells to outcompete adjacent less fit cells. Recent studies have identified molecular fitness fingerprint, oncogenic pathways, and cell junction stability as key factors in determining the outcome of cell competition. Understanding these features may open up possibilities for new diagnostic and therapeutic approaches in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Mengdi Yu, Hongxia Zhang, Brian Wang, Yinuo Zhang, Xiaoying Zheng, Bei Shao, Qichuan Zhuge, Kunlin Jin
Summary: Aging is a fundamental biological process with declines in tissue function, leading to cognitive impairment and other age-related diseases. Understanding the mechanisms regulating aging is critical for promoting healthy aging and combating age-related diseases, with a focus on pathways such as AMPK, SIRT1, and mTOR.
Article
Oncology
Valeria I. Segatori, Hector A. Cuello, Cynthia A. Gulino, Marina Alberto, Cecilia Venier, Marcelo D. Guthmann, Ignacio A. Demarco, Daniel F. Alonso, Mariano R. Gabri
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Review
Oncology
G. A. Cardama, D. F. Alonso, N. Gonzalez, J. Maggio, D. E. Gomez, C. Rolfo, P. L. Menna
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2018)
Article
Chemistry, Medicinal
Marina Pifano, Juan Garona, Natasha T. Sobol, Marina Alberto, Daniel F. Alonso, Giselle V. Ripoll
FUTURE MEDICINAL CHEMISTRY
(2018)
Article
Oncology
Juan Garona, Natasha T. Sobol, Marina Pifano, Valeria Segatori, Daniel E. Gomez, Giselle Ripoll, Daniel F. Alonso
CANCER RESEARCH AND TREATMENT
(2019)
Article
Ophthalmology
Ana V. Torbidoni, Claudia Sampor, Viviana E. Laurent, Rosario Aschero, Saipriya Iyer, Jorge Rossi, Daniel Alderete, Daniel F. Alonso, Irene Szijan, Guillermo L. Chantada
BRITISH JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Romina Gabriela Armando, Diego Luis Mengual Gomez, Ezequiel Ivan Juritz, Pablo Lorenzano Menna, Daniel Eduardo Gomez
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biotechnology & Applied Microbiology
Merari T. Chevalier, Juan Garona, Natasha T. Sobol, Hernan G. Farina, Daniel F. Alonso, Vera A. Alvarez
Review
Genetics & Heredity
Romina G. Armando, Diego L. Mengual Gomez, Julian Maggio, Maria C. Sanmartin, Daniel E. Gomez
Article
Oncology
Rosario Aschero, Ana Torbidoni, Claudia Sampor, Viviana Laurent, Santiago Zugbi, Ursula Winter, Fabiana Lubieniecki, Daniel Alonso, Paula Schaiquevich, Guillermo L. Chantada
PEDIATRIC BLOOD & CANCER
(2019)
Letter
Surgery
Juan Garona, Natasha T. Sobol, Luisina M. Solerno, Daniel F. Alonso
JOURNAL OF SURGICAL RESEARCH
(2019)
Article
Genetics & Heredity
Cintia N. Parsza, Diego L. M. Gomez, Jorge A. Simonin, Mariano Nicolas Belaich, Pablo D. Ghiringhelli
Summary: The study demonstrated that the budded virions of Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) can transduce and support the expression of delivered genes in mammalian cells but do not replicate. Therefore, AgMNPV has the potential to be used as an alternative to non-infectious viruses in humans for exploring new approaches in gene therapy and other applications based on the use of mammalian cells.
CURRENT GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Julian Maggio, Maia Cabrera, Romina Armando, Patricio Chinestrad, Marina Pifano, Pablo Lorenzano Menna, Daniel E. Gomez, Diego L. Mengual Gomez
Summary: PIN1 is an enzyme that is unique in its ability to isomerize proline residues in certain peptide sequences, playing a crucial role in regulating protein function, cell signaling, and potentially cancer treatment. Through structural characterization, a druggable pocket around residue Trp34 was identified, leading to the discovery of novel drug candidates with high affinity and potential inhibitory activity against PIN1.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Virology
Valeria Ines Segatori, Juan Garona, Lorena Grisel Caligiuri, Juan Bizzotto, Rosario Lavignolle, Ayelen Toro, Pablo Sanchis, Eduardo Spitzer, Alejandro Krolewiecki, Geraldine Gueron, Daniel Fernando Alonso
Summary: Nuclear transport and vesicle trafficking play a crucial role in the pathogenesis of RNA viruses. This study found that COVID-19 patients exhibit gene expression alterations in importins and Rho GTPases compared to non-COVID-19 patients. Ivermectin (IVM) and atorvastatin (ATV) have the potential to inhibit viral infection-induced NF-kappa B activation and affect the gene expression of importins and Rho GTPases. Through confocal microscopy, it was observed that IVM and ATV can significantly inhibit importin alpha nuclear accumulation, suggesting them as potential drugs to impair the nuclear localization of importin alpha during SARS-CoV-2 infection at clinically-relevant concentrations.
Article
Cell Biology
Maria Cecilia Lira, Francisco Damian Rosa, Laura Carolina Panelo, Monica Alejandra Costas, Maria Fernanda Rubio
CELL DEATH DISCOVERY
(2018)