Article
Biochemistry & Molecular Biology
Zhipeng Yu, Li Wang, Sijia Wu, Wenjun Xue, Wenzhu Zhao, Jianrong Li
Summary: This study used a non-targeted metabolomics approach to investigate the anti-hypertensive effects of RVPSL on SHRs. The results suggested that RVPSL potentially alleviated hypertension in SHRs mainly through integrated regulations of metabolism and production of specific metabolites.
Article
Food Science & Technology
Waqas N. Baba, Bincy Baby, Priti Mudgil, Chee-Yuen Gan, Ranjit Vijayan, Sajid Maqsood
Summary: This study investigated the ACE inhibiting potential of peptic camel whey hydrolysates under different hydrolysis conditions. Through peptide sequencing and in silico analysis, specific peptides with potential ACE and renin inhibitory activities were identified. Enzymatic hydrolysis of camel whey proteins may release peptides with potential anti-hypertensive properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Article
Plant Sciences
Ping Zhang, Dongfeng Li, Jinfang Zhu, Jianglan Hu
Summary: This study evaluates the antihypertensive effects of Pleurospermum lindleyanum aqueous extract (PLAE) in spontaneously hypertensive rats (SHRs). It is found that PLAE significantly reduces the systolic blood pressure of SHRs and has protective effects on renal and cardiac injury, reduces the levels of vasoconstrictors, increases nitric oxide and superoxide dismutase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Annina S. Vischer, Gabriela M. Kuster, Raphael Twerenbold, Otmar Pfister, Qian Zhou, Andrea Villiger, Marko Poglitsch, Stephan Krahenbuhl, Michael Mayr, Stefan Osswald, Manuel Haschke, Thilo Burkard
Summary: Different antihypertensive drugs have significant effects on angiotensin II and Ang (1-7) concentrations, with perindopril and olmesartan showing distinct alterations favoring the anti-inflammatory axis.
Article
Biochemistry & Molecular Biology
Koji Kawabeta, Masahiro Yuasa, Michihiro Sugano, Kazunori Koba
Summary: Dietary beta-conglycinin has been shown to lower blood pressure in spontaneously hypertensive rats by increasing plasma adiponectin concentration and possibly regulating the renin-angiotensin system.
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Article
Peripheral Vascular Disease
Mathias Hohl, Lucas Lauder, Oezlem Sevimli, Mert Tokcan, Lea Wagmann, Felix Goetzinger, Clara Schneider, Ulrich Huebner, Ulrike Lehnert, Markus R. Meyer, Michael Boehm, Felix Mahfoud
Summary: This study investigated the effect of different antihypertensive medications following renal denervation (RDN) on blood pressure and cardiac phenotypes in spontaneously hypertensive rats. The results showed that treatment with amlodipine and olmesartan after RDN resulted in the largest reduction in blood pressure. The antihypertensive medications also had heterogeneous effects on the renin-angiotensin-aldosterone system activity and cardiac remodeling.
Article
Chemistry, Multidisciplinary
Mohamed Abdelfattah Maky, Takeshi Zendo
Summary: Bioactive peptides were successfully produced from fish and beef skeletal muscles, showing antioxidant, angiotensin-converting enzyme inhibitory, and antimicrobial activities after hydrolysis and purification.
APPLIED SCIENCES-BASEL
(2021)
Article
Peripheral Vascular Disease
Laura Semenzato, Jeremie Botton, Jerome Drouin, Berangere Baricault, Clementine Vabre, Francois Cuenot, Laetitia Penso, Philippe Herlemont, Emilie Sbidian, Alain Weill, Rosemary Dray-Spira, Mahmoud Zureik
Summary: Recent evidence suggests that hypertensive patients treated with ACE inhibitors or ARBs may have a lower risk of COVID-19 hospitalization and intubation/death compared to those treated with CCBs. This contradicts initial hypotheses regarding the association between renin-angiotensin-aldosterone system inhibitors and COVID-19 risk, raising new questions for further research.
Article
Biochemistry & Molecular Biology
Paniz Biparva, Armin Mirzapour-Kouhdasht, Shahriyar Valizadeh, Marco Garcia-Vaquero
Summary: This study explored the extraction of protein from giant kelp using conventional and ultrasound-assisted extraction methods, and examined the biological activities of the extracted fractions. The results showed that ultrasound-assisted extraction had a higher protein recovery rate compared to conventional extraction. Low-molecular-weight hydrolysates obtained through enzymatic hydrolysis and ultrafiltration had the highest levels of ACE inhibitory, DPPH radical scavenging, reducing power, and ferrous chelating activities. The amino acid composition of the low-molecular-weight fraction was rich in amino acids associated with high biological activities. The study also determined the optimal storage conditions for the stability of the bioactive compounds.
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Shadi A. D. Mohammed, Hanxing Liu, Salem Baldi, Yu Wang, Pingping Chen, Fang Lu, Shumin Liu
Summary: Hypertension is a common chronic disease and a preventable risk factor for cardiovascular disease. Combination therapy using herbal medicine and antihypertensive agents shows positive effects in reducing blood pressure and improving vascular remodeling and renal protection. This study investigates the effects of Gedan Jiangya Decoction (GJD) combined with captopril (CAP) on spontaneously hypertensive rats (SHR) and demonstrates its antihypertensive, kidney protective, antioxidant, and vasoactive effects.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Mohamed Abdelfattah Maky, Takeshi Zendo
Summary: This study purified and characterized bioactive peptides with inhibitory action on ACE, antimicrobial and antioxidant properties from frozen chicken breast. Chicken hydrolysate showed potential as a natural preservative by reducing bacterial growth and lipid oxidation in chicken breast.
Article
Nutrition & Dietetics
Preeti Sarkar, Alessandra Pecorelli, Brittany Woodby, Erika Pambianchi, Francesca Ferrara, Raj Kumar Duary, Giuseppe Valacchi
Summary: This study found that bioactive peptides obtained from edible insect-protein had ACE-inhibitory and antioxidant properties. The enzymatic protein hydrolysates from Antheraea assama and Philosomia ricini pupae showed the highest activities. The purified sub-fractions, F4 and F6, exhibited the highest ACE inhibition and anti-inflammatory properties in endothelial cells. These peptides have the potential to be used as nutritional approaches against hypertension and related cardiovascular diseases.