Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

(2015) Patrick Ejlerskov et al.   CELL

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions

(2015) Rowan Radford et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats

(2015) Sonu Singh et al.   MOLECULAR NEUROBIOLOGY

N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution

(2015) Stephen D. Skaper et al.   MOLECULAR NEUROBIOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

(2015) Markus Mandler et al.   Molecular Neurodegeneration

A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy

(2015) Brian Spencer et al.   Molecular Neurodegeneration

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

The relation between α-synuclein and microglia in Parkinson’s disease: Recent developments

(2015) V. Sanchez-Guajardo et al.   NEUROSCIENCE

Multiple-System Atrophy

(2015) Alessandra Fanciulli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Propagation of prions causing synucleinopathies in cultured cells

(2015) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elusive roles for reactive astrocytes in neurodegenerative diseases

(2015) Lucile Ben Haim et al.   Frontiers in Cellular Neuroscience

Contra-Directional Expression of Serum Homocysteine and Uric Acid as Important Biomarkers of Multiple System Atrophy Severity: A Cross-Sectional Study

(2015) Dan Chen et al.   Frontiers in Cellular Neuroscience

Relevance of chronic stress and the two faces of microglia in Parkinson’s disease

(2015) Antonio J. Herrera et al.   Frontiers in Cellular Neuroscience

Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease

(2014) Poonam Thakur et al.   MOLECULAR NEUROBIOLOGY

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Transcellular degradation of axonal mitochondria

(2014) Chung-ha O. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease

(2014) Sandra Tenreiro et al.   PLoS Genetics

Multiple System Atrophy and Amyotrophic Lateral Sclerosis in a Family With Hexanucleotide Repeat Expansions inC9orf72

(2014) Jill S. Goldman et al.   JAMA Neurology

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

(2013) Maria Xilouri et al.   BRAIN

Alpha-synuclein transfers from neurons to oligodendrocytes

(2013) Juan F. Reyes et al.   GLIA

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 Inhibits α-Synuclein Aggregation by Interacting with Soluble Oligomers

(2013) Soumya Daturpalli et al.   JOURNAL OF MOLECULAR BIOLOGY

The natural history of multiple system atrophy: a prospective European cohort study

(2013) Gregor K Wenning et al.   LANCET NEUROLOGY

Innate Immunity and Neuroinflammation

(2013) Abhishek Shastri et al.   MEDIATORS OF INFLAMMATION

Role and Mechanism of Microglial Activation in Iron-Induced Selective and Progressive Dopaminergic Neurodegeneration

(2013) Wei Zhang et al.   MOLECULAR NEUROBIOLOGY

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

Screening of Toll-Like Receptors Expression in Multiple System Atrophy Brains

(2013) Tomasz Brudek et al.   NEUROCHEMICAL RESEARCH

Microglia are the major source of TNF-α and TGF-β1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin

(2013) Jennifer V. Welser-Alves et al.   NEUROCHEMISTRY INTERNATIONAL

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Astrocyte loss and astrogliosis in neuroinflammatory disorders

(2013) Stephanie Hostenbach et al.   NEUROSCIENCE LETTERS

Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies

(2013) Elvira Valera et al.   PHARMACOLOGY & THERAPEUTICS

Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life

(2013) Lu-Tai Tien et al.   TOXICOLOGY

A randomized trial of mesenchymal stem cells in multiple system atrophy

(2012) Phil Hyu Lee et al.   ANNALS OF NEUROLOGY

α-synuclein fate

(2012) Simone Engelender   Autophagy

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

(2012) Jörg Scheffel et al.   GLIA

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

The Role of Glia in Alpha-Synucleinopathies

(2012) Lisa Fellner et al.   MOLECULAR NEUROBIOLOGY

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

(2012) Masatoshi Konno et al.   Molecular Neurodegeneration

SUMO-1 is Associated with a Subset of Lysosomes in Glial Protein Aggregate Diseases

(2012) Mathew B. Wong et al.   NEUROTOXICITY RESEARCH

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

MAPT H1 haplotype is a risk factor for essential tremor and multiple system atrophy

(2011) C. Vilarino-Guell et al.   NEUROLOGY

The neuropathology, pathophysiology and genetics of multiple system atrophy

(2011) Z. Ahmed et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Mesenchymal Stem Cells in a Transgenic Mouse Model of Multiple System Atrophy: Immunomodulation and Neuroprotection

(2011) Sylvia Stemberger et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple system atrophy: a clinical and neuropathological perspective

(2011) Kiren Ubhi et al.   TRENDS IN NEUROSCIENCES

Neuroprotective Effect of Human Mesenchymal Stem Cells in an Animal Model of Double Toxin-Induced Multiple System Atrophy Parkinsonism

(2010) Hyun-Jung Park et al.   CELL TRANSPLANTATION

Microglia dynamics and function in the CNS

(2010) Christopher N Parkhurst et al.   CURRENT OPINION IN NEUROBIOLOGY

Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions

(2010) Ara Jang et al.   JOURNAL OF NEUROCHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection

(2010) He-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Defining “Neuroinflammation”

(2009) James P. O'Callaghan et al.   Annals of the New York Academy of Sciences

Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

(2009) Junchao Tong et al.   BRAIN

Degeneration in Different Parkinsonian Syndromes Relates to Astrocyte Type and Astrocyte Protein Expression

(2009) Yun Ju C. Song et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Proposed neuroimaging criteria for the diagnosis of multiple system atrophy

(2009) David J. Brooks et al.   MOVEMENT DISORDERS

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Multiple system atrophy: A primary oligodendrogliopathy

(2008) Gregor K. Wenning et al.   ANNALS OF NEUROLOGY

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

(2008) Marta Martinez-Vicente et al.   JOURNAL OF CLINICAL INVESTIGATION

Second consensus statement on the diagnosis of multiple system atrophy

(2008) S. Gilman et al.   NEUROLOGY

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

(2007) Jacques De Keyser et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES