A versatile post-polymerization modification method for polyglutamic acid: synthesis of orthogonal reactive polyglutamates and their use in “click chemistry”

Phase I study of XMT-1001 given IV every 3 weeks to patients with advanced solid tumors.

(2017) E. A. Sausville et al.   JOURNAL OF CLINICAL ONCOLOGY

Polymer therapeutics-prospects for 21st century: The end of the beginning

(2012) Ruth Duncan et al.   ADVANCED DRUG DELIVERY REVIEWS

Complement Activation and Cell Uptake Responses Toward Polymer-Functionalized Protein Nanocapsules

(2012) Nicholas M. Molino et al.   BIOMACROMOLECULES

Enhanced Stability of Polymeric Micelles Based on Postfunctionalized Poly(ethylene glycol)-b-poly(γ-propargyl l-glutamate): The Substituent Effect

(2012) Xiaoyong Zhao et al.   BIOMACROMOLECULES

Conjugation of hyaluronan to proteins

(2012) Anna Mero et al.   CARBOHYDRATE POLYMERS

Selective conjugation of poly(2-ethyl 2-oxazoline) to granulocyte colony stimulating factor

(2012) Anna Mero et al.   JOURNAL OF CONTROLLED RELEASE

Standing on the shoulders of Hermann Staudinger: Post-polymerization modification from past to present

(2012) Kemal Arda Günay et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: a meta-analysis

(2011) J. Cortes et al.   ANNALS OF ONCOLOGY

An In-Depth Analysis of Polymer-Analogous Conjugation using DMTMM

(2011) Jeisa M. Pelet et al.   BIOCONJUGATE CHEMISTRY

Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel

(2011) Anat Eldar-Boock et al.   BIOMATERIALS

Bioconjugation via azide–Staudinger ligation: an overview

(2011) Christine I. Schilling et al.   CHEMICAL SOCIETY REVIEWS

Polymer–drug conjugates as nano-sized medicines

(2011) Fabiana Canal et al.   CURRENT OPINION IN BIOTECHNOLOGY

Polymer therapeutics as nanomedicines: new perspectives

(2011) Ruth Duncan   CURRENT OPINION IN BIOTECHNOLOGY

The effect of dextrin–rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse

(2011) Joseph T. Hardwicke et al.   JOURNAL OF CONTROLLED RELEASE

Modulating catalytic activity of polymer-based cuAAC “click” reactions

(2011) Craig A. Bell et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Nanomedicine(s) under the Microscope

(2011) Ruth Duncan et al.   MOLECULAR PHARMACEUTICS

Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

(2011) Matthias Barz et al.   Polymer Chemistry

570 Phase 1 study of XMT-1001, a novel water soluble camptothecin conjugate, given as an IV infusion every 3 weeks to patients with advanced solid tumors

(2010) R.J. Fram et al.   EJC SUPPLEMENTS

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Functional polymers as therapeutic agents: Concept to market place

(2009) Pradeep K. Dhal et al.   ADVANCED DRUG DELIVERY REVIEWS

Highly Efficient “Grafting onto” a Polypeptide Backbone Using Click Chemistry

(2009) Amanda C. Engler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

(2009) Kido Nwe et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Enzymatically catalyzed HES conjugation using microbial transglutaminase: Proof of feasibility

(2009) Ahmed Besheer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis of Functional Polymers by Post-Polymerization Modification

(2008) Marc A. Gauthier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of sterically-hindered peptidomimetics using 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride

(2008) Wen-Chung Shieh et al.   TETRAHEDRON LETTERS

An improved process for the synthesis of DMTMM-based coupling reagents

(2008) Steven A. Raw   TETRAHEDRON LETTERS