Article
Endocrinology & Metabolism
Sara Csiha, Istvan Molnar, Sandor Halmi, David Hutkai, Hajnalka Lorincz, Sandor Somodi, Monika Katko, Mariann Harangi, Gyorgy Paragh, Endre V. Nagy, Eszter Berta, Miklos Bodor
Summary: The levels of advanced glycation end products (AGEs) in the serum of patients with Hashimoto thyroiditis (HT) are lower, and soluble RAGE (sRAGE) can reduce the interaction between AGEs and their receptor in a competitive manner, which is beneficial for thyroid function balance in patients. Further research is needed to confirm these results.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tommaso Aversa, Rosaria Maddalena Ruggeri, Domenico Corica, Maria Teresa Cristani, Giorgia Pepe, Teresa Manuela Vicchio, Angela Alibrandi, Francesco Trimarchi, Salvatore Cannavo, Giovanni Battista Pajno, Malgorzata Gabriela Wasniewska
Summary: This study found that serum sRAGE levels were significantly decreased in euthyroid children with HT, while no significant differences were observed in AGEs and AOPPs levels. This suggests that children with HT may have increased susceptibility to oxidative damage even when their thyroid function is normal.
HORMONE RESEARCH IN PAEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Biochemistry & Molecular Biology
Raphael S. Pinto, Carlos A. Minanni, Aecio Lopes de Araujo Lira, Marisa Passarelli
Summary: This review focuses on the role of advanced glycation end products (AGEs) in cardiovascular disease (CVD). Clinical trials and experimental evidence are used to revisit the mechanisms by which AGEs contribute to CVD, including enhanced oxidative stress, inflammation, endoplasmic reticulum stress, and impairment in reverse cholesterol transport (RCT). AGEs promote cholesterol accumulation in the arterial wall through these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Akinobu Suzuki, Akito Yabu, Hiroaki Nakamura
Summary: The global aging population and the increase in diabetes cases have led to a high prevalence of musculoskeletal disorders in elderly and diabetic patients, which are associated with advanced glycation end products (AGEs). AGEs accumulate in tissues and contribute to various aging and diabetes-related conditions such as osteoporosis, osteoarthritis, and neuropathy. Understanding the mechanisms of AGEs can potentially lead to the development of novel prevention and therapy methods for these disorders, improving patients' quality of life.
Review
Nutrition & Dietetics
Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
Summary: Diabetes is a chronic disease with a high health burden primarily caused by mortality or morbidity from vascular complications. Prolonged hyperglycemia leads to abnormal metabolism and the formation of advanced glycation end products (AGEs). The interaction between AGEs and their receptors promotes oxidative stress and inflammation through multiple pathways.
Review
Nutrition & Dietetics
Melpomeni Peppa, Ioanna Mavroeidi
Summary: Research indicates that dietary advanced glycation end products play a significant role in health and disease, contributing to the pathogenesis of various diseases and their complications in animal models. They are also involved in changes related to the aging process.
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Endocrinology & Metabolism
Tian Jiang, Yi Zhang, Fang Dai, Chao Liu, Honglin Hu, Qiu Zhang
Summary: This study aimed to explore the role of non-invasive detection of advanced glycation end products (AGEs) in the early screening of diabetes mellitus (DM) in the Chinese community and investigate the moderating effect of body mass index (BMI) and metabolic indexes. The results indicate that in Chinese participants with high AGE accumulation, priority should be given to the quality of metabolic-related indicators such as BMI, TG, and TC to effectively reduce fasting blood glucose levels.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Agriculture, Multidisciplinary
Hong Sun, Juan Chen, Lili Sun, Bimin Shi, Jianzhong Li
Summary: Research found that silencing TXNIP can reduce renal lipid deposition, inhibit cholesterol uptake and synthesis through regulating SCAP, and may be a potential therapeutic target for treating a diabetic fatty kidney.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Liu Gao, Chang Liu, Pan Hu, Na Wang, Xiaoxue Bao, Bin Wang, Ke Wang, Yukun Li, Peng Xue
Summary: The objective of this study was to analyze the quantitative association between advanced glycation end products (AGEs) and adjusted FRAX by rheumatoid arthritis (FRAX-RA) in postmenopausal type 2 diabetic (T2D) patients. The optimal cutoff value of AGEs was also explored, which was aimed at demonstrating the potential value of AGEs on evaluating osteoporotic fracture risk in postmenopausal T2D patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hayahide Ooi, Ryuto Nasu, Ayako Furukawa, Masayoshi Takeuchi, Yoshiki Koriyama
Summary: Diabetes mellitus (DM) is a risk factor for Alzheimer's disease (AD). Inhibitors of advanced glycation end-product (AGE) formation can improve neuronal dysfunction caused by diabetes and reduce abnormal aggregation and phosphorylation of Alzheimer's disease-related markers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tomoka Nakamura, Tetsuro Tsujimoto, Kazuki Yasuda, Kohjiro Ueki, Hiroshi Kajio
Summary: This study aimed to determine whether a long-time shift in the levels of serum AGEs is associated with cardiovascular events in patients with poorly controlled type 2 diabetes. The study found that continuous low serum AGEs levels are associated with a low frequency of cardiovascular events in patients with poorly controlled type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Pediatrics
Panagiota Markopoulou, Eleni Papanikolaou, Sofia Loukopoulou, Paraskevi Galina, Aimilia Mantzou, Tania Siahanidou
Summary: Circulating EPCs were significantly increased in prepubertal preterm-born children compared to controls, with prematurity and maternal gestational diabetes being recognized as independent predictors of EPCs.
PEDIATRIC RESEARCH
(2021)
Article
Rheumatology
Maria G. Tektonidou, Evrydiki Kravvariti, Nikolaos Vlachogiannis, Georgios Georgiopoulos, Aimilia Mantzou, Petros P. Sfikakis, Konstantinos Stellos, Kimon Stamatelopoulos
Summary: In patients with Antiphospholipid Syndrome (APS), elevated plasma levels of Aβ40 are associated with adverse thrombo-inflammatory profile, and independently correlated with recurrent arterial events. Aβ40 levels provide additional value in improving the discrimination ability for recurrent arterial thromboses over the validated risk score aGAPSS in APS.
Article
Neurosciences
Kalliopi Tournikioti, Maria Alevizaki, Ioannis Michopoulos, Aimilia Mantzou, Constantin Soldatos, Athanasios Douzenis, Dimitris Dikeos, Panagiotis Ferentinos
Summary: This study is the first to assess the impact of DHEA-S and cortisol to DHEA-S ratio on memory and executive function in bipolar disorder. The results suggest that bipolar patients perform poorly in planning and attentional set shifting.
NEUROPSYCHOBIOLOGY
(2021)
Review
Medicine, General & Internal
Maria G. Filippa, Maria G. Tektonidou, Aimilia Mantzou, Gregory A. Kaltsas, George P. Chrousos, Petros P. Sfikakis, Maria P. Yavropoulou
Summary: Iatrogenic adrenal insufficiency due to long-term use of exogenous glucocorticoids is common in rheumatoid arthritis patients, with a proportion needing small doses of glucocorticoids for clinical remission. Inadequate production of endogenous cortisol relative to enhanced clinical needs associated with the systemic inflammatory response may operate in RA, with the underlying mechanisms still unknown. Further research is needed on the pathogenetic role of compromised adrenal reserve in RA.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Christos Vassileiou, Stefania Kalantzi, Eleanna Vachlioti, Constantinos M. Athanassopoulos, Christos Koutsakis, Zoi Piperigkou, Nikos Karamanos, Theodora Stivarou, Peggy Lymberi, Konstantinos Avgoustakis, Dionissios Papaioannou
Summary: This study demonstrates that the structure of both the head group and the polyamine (PA) chain play a critical role in determining the strength of the antiproliferative activity of polyamine toxins (PATs) and their selectivity towards different cells.
Article
Psychiatry
Kalliopi Tournikioti, Maria Alevizaki, Ioannis Michopoulos, Aimilia Mantzou, Constantin R. Soldatos, Athanasios Douzenis, Dimitris Dikeos, Panagiotis Ferentinos
Summary: This study found that cortisol is associated with hippocampal-related visual memory/learning but not with prefrontal lobe-related executive function in Bipolar Disorder.
PSYCHIATRY RESEARCH
(2022)
Article
Pediatrics
Eirini V. Christaki, Panagiota Pervanidou, Ioannis Papassotiriou, Despoina Bastaki, Eleni Valavani, Aimilia Mantzou, Giorgos Giannakakis, Dario Boschiero, George P. Chrousos
Summary: The aim of this study was to examine the associations between multiple indices of stress, inflammation, and metabolism with body composition parameters in children and adolescents. The study found that obesity was associated with stress, inflammation, and insulin resistance, while heart rate variability could be used as a screening tool for obesity-related health risks in this population.
Article
Pharmacology & Pharmacy
Kyriaki Hatziagapiou, Kostas Bethanis, Eleni Koniari, Elias Christoforides, Olti Nikola, Athena Andreou, Aimilia Mantzou, George P. Chrousos, Christina Kanaka-Gantenbein, George I. Lambrou
Summary: Phytocannabinoids, such as CBD, have anticancer properties, but their high lipophilicity limits their solubility, stability, and bioavailability. This study investigates the in vitro effects of CBD and its inclusion complexes with cyclodextrins (CDs) on cancer cell lines. The study demonstrates that CBD complexed with methylated beta-CDs exhibits enhanced solubility and improved efficacy against cancer cells, suggesting the potential of cannabinoids as inhibitors of cancer growth.
Article
Pediatrics
Eirini Christaki, Panagiota Pervanidou, Ioannis Papassotiriou, Aimilia Mantzou, Giorgos Giannakakis, Dario Boschiero, George P. Chrousos
Summary: This study investigates the relationship between FGF21 and stress indices in girls and their caregivers, suggesting a correlation between them.
Article
Sport Sciences
Gregory C. Bogdanis, George Mastorakos, Spyridon Tsirigkakis, Pinelopi S. Stavrinou, Athanasios Kabasakalis, Aimilia Mantzou, Vassilis Mougios
Summary: This study compared hematologic, metabolic, and antioxidant responses between different bout durations of high-intensity interval exercise (HIIE) and continuous exercise. Despite equal total work, duration, and work-to-recovery ratio, shorter bouts of HIIE (30 s or 10 s) induced lower blood cell perturbations, metabolic stress, and antioxidant responses.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2022)
Article
Pediatrics
Anna Agapaki, Fenia Papagianni, Dimitra Metallinou, Eleni Valavani, Aimilia Mantzou, Stamatia Kanelli, Makarios Eleftheriades, Areti C. Spyropoulou, Ioannis Zervas, George P. Chrousos, Panagiota Pervanidou
Summary: Maternal perinatal mental disorders (PMD) may have an impact on children's development and behavior, possibly mediated by the programming of the hypothalamic-pituitary-adrenal (HPA) axis. The study found that cortisol concentrations in both mothers and children were associated with children's behavior and stress response. In the PMD group, children's cortisol concentrations were significantly associated with anxiety/depression symptoms.
Article
Medicine, General & Internal
Aikaterini Giannouli, Charikleia Stefanaki, Christos Kouskoutis, Marianna Konidari, Iliana Mani, Konstantina Konidari, Sophia L. Markantonis, Aimilia Mantzou, Spyridon P. Dourakis, Efthymios Deligeoroglou, Flora Bacopoulou
Summary: The current guidelines recommend routine screening for non-alcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS). This study aimed to investigate the serum profile of hepatokines in adolescent PCOS patients and their association with metabolic and hormonal parameters. The results showed that selenoprotein P and sex hormone-binding globulin (SHBG) concentrations were decreased in PCOS patients, while fibroblast growth factor 21 (FGF21) concentrations were higher in PCOS patients with NAFLD. FGF21 may serve as a potential biomarker for hepatic disease in adolescent females with PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Arsinoi Koutroumpa, Christina Kanaka Gantenbein, Aimilia Mantzou, Artemis Doulgeraki, Flora Bacopoulou, Helen Bouza, George Chrousos, Tania Siahanidou
Summary: Prematurely born children have lower levels of irisin, as well as slightly unhealthy adiposity and cardiometabolic patterns, compared to full-term born peers.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Maria P. Yavropoulou, Maria G. Filippa, Aimilia Mantzou, Fotinie Ntziora, Maria Mylona, Maria G. Tektonidou, Nikolaos I. Vlachogiannis, Dimitrios Paraskevis, Gregory A. Kaltsas, George P. Chrousos, Petros P. Sfikakis
Summary: This study investigated the cortisol secretion in COVID-19 patients and found higher levels of evening and nocturnal cortisol secretion, but no significant difference in morning cortisol levels. The study also observed a strong correlation between IL-6 levels and nocturnal cortisol levels in patients.
Article
Dermatology
Nikolena Repousi, Stavroula Fotiadou, Eleftheria Chaireti, Gerasimos Makris, Giorgos Chouliaras, Aimilia Mantzou, Charitomeni Vavouli, George P. Chrousos, Alexandros Stratigos, Panagiota Pervanidou
Summary: There is evidence of bidirectional interaction between stress and psoriasis. Stress may act as a precipitating factor for the onset or exacerbation of psoriasis. Patients with psoriasis showed higher prevalence of self-reported anxiety, stress, and depressive symptoms. Blunted salivary cortisol diurnal rhythm was observed in psoriatic patients, with a positive correlation of salivary cortisol concentration with state anxiety and psoriasis severity. Hair cortisol concentrations did not show any associations with disease presence or severity.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)