Review
Cell Biology
Aleksandra Twarda-Clapa, Aleksandra Olczak, Aneta M. Bialkowska, Maria Koziolkiewicz
Summary: This article focuses on the receptors of advanced glycation end-products (AGEs) and their involvement in diseases. AGEs are formed through condensation reactions and trigger signaling pathways related to inflammation and oxidative stress in the human body.
Review
Biochemistry & Molecular Biology
Klaudia Gutowska, Krzysztof Czajkowski, Alina Kurylowicz
Summary: Advanced glycation end products (AGEs) play a crucial role in cellular dysfunction caused by hyperglycemia, and their accumulation in the extracellular matrix is a key factor in obesity-related adipose tissue dysfunction. By binding to their receptor (RAGE), AGEs affect various intracellular pathways, leading to impaired adipocyte differentiation, metabolism, and secretory activity. Inhibiting AGE production and accumulation, as well as interfering with the activated metabolic pathways, may be a promising therapeutic strategy for restoring normal adipose tissue function and combating obesity-related comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Chenyang Han, Liping Zhai, Heping Shen, Jin Wang, Qiaobing Guan
Summary: This study aimed to explore the role and mechanism of advanced glycation end-products (AGEs) in inducing pyroptosis of cerebrovascular endothelial cells under oxygen glucose deprivation (OGD) condition. The results showed that AGEs induced pyroptosis in cerebral endothelial cells, increased the expression of inflammatory factors, and aggravated brain injury through the HIF-alpha-RAGE-NLRP3 pathway.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Oncology
Yu Peng, Fubin Liu, Yating Qiao, Peng Wang, Han Du, Changyu Si, Xixuan Wang, Kexin Chen, Fangfang Song
Summary: This study found that higher levels of plasma AGEs and AGEs/sRAGE-ratio were associated with an increased risk of breast cancer, but sRAGE levels were negatively associated with breast cancer risk. The study emphasized the potential of the AGE-RAGE axis as a new biomarker of breast cancer.
Review
Food Science & Technology
Yueqin Li, Yao Peng, Yingbin Shen, Yunzhen Zhang, Lianliang Liu, Xinquan Yang
Summary: Advanced glycation end products (AGEs) are formed in the reaction between reducing sugars and amino acids, and play a key role in neurodegenerative diseases. Polyphenols with multiple hydroxyl groups can inhibit the formation of AGEs and prevent neurodegenerative diseases. Regulating gut microbiota and intestinal inflammation is also a strategy for preventing neurodegenerative diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Endocrinology & Metabolism
Komal Waqas, Max Muller, Marijke Koedam, Youssra el Kadi, M. Carola Zillikens, B. C. J. van der Eerden
Summary: Treatment with MG negatively influences collagen metabolism and differentiation of BMSC-derived osteoblasts, resulting in decreased cell viability, reduced ALP activity and mineralization, with downregulation of genes involved in osteogenic differentiation.
Article
Nutrition & Dietetics
Ziling Mao, Elom K. Aglago, Zhiwei Zhao, Casper Schalkwijk, Li Jiao, Heinz Freisling, Elisabete Weiderpass, David J. Hughes, Anne Kirstine Eriksen, Anne Tjonneland, Gianluca Severi, Joseph Rothwell, Marie-Christine Boutron-Ruault, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Anna Birukov, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, H. Bas Bueno-de-Mesquita, Roel C. H. Vermeulen, Inger T. Gram, Guri Skeie, Torkjel M. Sandanger, J. Ramon Quiros, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Maria-Dolores Chirlaque, Aurelio Barricarte Gurrea, Jonas Manjer, Ingegerd Johansson, Aurora Perez-Cornago, Mazda Jenab, Veronika Fedirko
Summary: The study found that pre-diagnostic dietary intakes of AGEs were not associated with colorectal cancer (CRC) patients' specific or all-cause mortality. However, in CRC patients without diabetes, there may be a positive association between AGEs and all-cause mortality or CRC-specific mortality. Further research using AGE biomarkers and stratifying by sex, diabetes status, and timing of exposure to AGEs is warranted.
Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Advanced glycation end products (AGEs) are compounds formed by nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. These AGEs can alter protein structure and activate the receptor for advanced glycation end products (RAGE). RAGE is expressed by various cells and plays a role in chronic inflammatory autoimmune disorders. Soluble RAGE (sRAGE) acts as a decoy and inhibits pro-inflammatory processes mediated by RAGE. AGE overproduction, low sRAGE concentrations, and certain RAGE polymorphisms are associated with rheumatic diseases and cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Aditi Chopra, Thilini N. Jayasinghe, Joerg Eberhard
Summary: Periodontitis can increase the levels of AGEs, even in the absence of hyperglycemia. This explains the relationship between periodontitis and related diseases such as diabetes.
Article
Agricultural Engineering
Jinming Peng, Wenjun Wen, Guiqiang Liang, Wenye Huang, Zihui Qiu, Qin Wang, Gengsheng Xiao
Summary: The study optimized the extraction process of crude polyphenols from Cammelia oleifera shells using ultrasound-microwave synergistic extraction. The extracted polyphenols showed strong anti-glycation properties and inhibited AGEs-triggered inflammation.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Applied
Wanbin Zhao, Pengju Cai, Nan Zhang, Tongtong Wu, Aidong Sun, Guoliang Jia
Summary: Plant-based polyphenols, especially chlorogenic acid and epigallocatechin gallate, show significant inhibitory effects on glycation products, with the latter also impacting protein glycosylation in simulated glycation systems.
Article
Agriculture, Multidisciplinary
Jinming Peng, Guiqiang Liang, Wenjun Wen, Wenye Huang, Yuanxin Qiu, Gengsheng Xiao, Qin Wang
Summary: Blueberry anthocyanins extract (BAE) has shown inhibitory effects on advanced glycation endproducts (AGEs) formation and AGEs-induced inflammatory response in vitro. BAE acts through scavenging glycosylated intermediates, attenuating molecular aggregation and amyloid-like fibrils formation, and preventing conformational modification. It also dose-dependently inhibits the secretion of nitric oxide and pro-inflammatory cytokines, and downregulates critical inflammatory markers, inducible nitric oxide synthase and cyclooxygenase-2, through nuclear factor-kappa B signaling pathways inhibition.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Biochemistry & Molecular Biology
Qing Yue, Yu Song, Zi Liu, Lin Zhang, Ling Yang, Jinlong Li
Summary: RAGE, as a critical molecule in inflammatory response, binds to various ligands and initiates intracellular signal cascade. It plays a vital role in the occurrence and development of immune-related diseases and has crucial functions in different aspects of life activities. Therefore, targeted intervention in the RAGE signaling pathway may have significant therapeutic potential.
Article
Biochemistry & Molecular Biology
Jinming Peng, Guiqiang Liang, Wenjun Wen, Zihui Qiu, Wenye Huang, Qin Wang, Gengsheng Xiao
Summary: This study prepared Penta-O-galloyl-beta-D-glucose (PGG) from tannic acid methanolysis products and investigated its protective effects and mechanism on glucose-induced glycation for the first time. PGG was found to have strong anti-AGEs effects in bovine serum albumin (BSA)-glucose (Glu) and BSA-methylglyoxal (MGO) glycation systems. It inhibits AGEs formation by blocking glycated intermediates, eliminating radicals, and chelating metal ions. Mechanism analysis showed that PGG prevents BSA from glycation by hindering amyloid fibril accumulation, stabilizing BSA secondary structures, and binding partial glycation sites. PGG also displays effective trapping capacities on MGO reactive intermediate. This research suggests PGG as a potential functional ingredient in food materials for preventing diabetic syndrome.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemical Research Methods
K. Ramki, G. Thiruppathi, Selva Kumar Ramasamy, P. Sundararaj, P. Sakthivel
Summary: A chromone-based ratiometric fluorescent probe L2 was developed for the selective detection of Hg(II) in a semiaqueous solution. The probe exhibited enhanced fluorescence in its aggregated state and even higher fluorescence when chelated with Hg(II). The probe demonstrated high sensitivity and specificity for Hg(II) detection and was successfully applied for imaging Hg(II) in a living model.
Article
Biochemical Research Methods
Qun Zhang, Rui Yang, Gang Liu, Shiyan Jiang, Jiarui Wang, Juqiang Lin, Tingyin Wang, Jing Wang, Zufang Huang
Summary: This research aims to develop a cost-effective and portable method for measuring creatinine levels using the enhanced Tyndall effect phenomenon. The method offers a promising solution for monitoring renal healthcare in resource-limited settings.