Article
Chemistry, Multidisciplinary
Jinyoung Hwang, Phuong Le Thi, Simin Lee, Eun-Hye Park, Eunmi Lee, Eunmin Kim, Kiyuk Chang, Ki Dong Park
Summary: Although numerous poly(ethylene glycol) (PEG)-based bioadhesives have been developed and commercialized, their biocompatibility and bioactivity performances are generally lacking. To address these issues, chemically crosslinked gelatin-PEG adhesive hydrogels (GP) were designed through the enzymatic crosslinking reaction of horseradish peroxidase (HRP). The GP hydrogels exhibited adjustable mechanical and adhesive properties and effectively improved tissue adhesiveness and bioactivity. They also showed promising potential for hemostatic and wound healing treatments.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Adam Kasinski, Monika Zielinska-Pisklak, Sebastian Kowalczyk, Andrzej Plichta, Anna Zgadzaj, Ewa Oledzka, Marcin Sobczak
Summary: The paper developed injectable, thermosensitive smart hydrogel local drug delivery systems releasing the model antitumour drug 5-fluorouracil (5-FU). The biodegradable triblock copolymers synthesized through ring opening polymerization showed a sharp sol-gel transition at physiological temperature, with good mechanical properties at 37°C. In vitro release kinetics characterization indicated good control, with a total drug release time of approximately 12 hours.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Laura Brelle, Agustin Rios de Anda, Teoman Ozturk, Nathalie Didier, Estelle Renard, Valerie Langlois
Summary: Biocompatible gels based on PHAs were developed using radical polymerization in the presence of PEGDA. The microscopic structure varied depending on the mass proportions between the two polymers, and chemical crosslinking was observed between unsaturated PHA and PEGDA.
Article
Polymer Science
Naofumi Naga, Mitsusuke Satoh, Tomoyuki Magara, Kumkum Ahmed, Tamaki Nakano
Summary: Michael-addition reaction between multifunctional-acetoacetate, meso-erythritol tetra-acetoacetate (ETAA) or dsorbitol hexa-acetoacetate (SHAA), and poly(ethylene glycol) diacrylate (PEGDA) has been investigated to obtain porous polymers with controllable diameter and morphology. The porous polymers are soft, flexible, and have high affinity with various solvents.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Elaine Halligan, Billy Shu Hieng Tie, Declan Mary Colbert, Mohamad Alsaadi, Shuo Zhuo, Gavin Keane, Luke M. Geever
Summary: This study presents the preparation of hydrogels based on Poly (N-vinylcaprolactam) with diethylene glycol diacrylate using the photopolymerization technique. The structure of the polymers is investigated using FTIR spectroscopy, and their characteristics are further examined using DSC and swelling analysis. The study aims to determine the properties of the polymer and its effects on the phase transition.
Article
Polymer Science
Ionela Alice Podaru, Paul O. Stanescu, Raluca Ginghin, Stefania Stoleriu, Bogdan Tric, Raluca Somoghi, Mircea Teodorescu
Summary: This study investigates the synthesis and properties of nanocomposite hydrogels obtained by the aqueous solution free radical polymerization of N-vinylpyrrolidone (NVP) in the presence of Laponite XLG (XLG) as a crosslinker, and compares them with hydrogels prepared using conventional crosslinking agents. The results show that XLG is a better crosslinking agent than the conventional agent, leading to larger gel fractions and more homogeneous network hydrogels. Adding XLG as a second crosslinker significantly enhances the material properties.
Article
Materials Science, Composites
Hatice Karaer Yagmur, Ismet Kaya
Summary: In this study, PU/Ag composites were synthesized in DMF without extra reducing agents, with DMF serving as both diluent and reducing agent for silver particles. Various analyses confirmed the formation of PU/Ag composites and showed that the composites have higher thermal stability compared to polyurethane. Conductivity measurements revealed different conductivity values for undoped PU and PU/Ag composites.
POLYMER COMPOSITES
(2021)
Article
Biochemistry & Molecular Biology
Yuan Xu, Zhicheng Deng, Yun Chen, Chao Huang, Yong Hu
Summary: A novel mussel-inspired adhesive hydrogel, composed of methacrylated catechol-chitosan (MCCS) and dopamine methacrylate (DMA), was synthesized through photopolymerization. The structure and morphology of the MCCS/DMA adhesive hydrogel were characterized by FTIR, NMR, XRD, TG, and SEM. Rheological and texture properties, swelling and degradation characteristics, as well as the adhesion mechanism of the hydrogels were investigated. The results demonstrated the potential applications of the MCCS/DMA adhesive hydrogel in medical bioadhesives.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Analytical
Luca Burratti, Michele Sisani, Irene Di Guida, Fabio De Matteis, Roberto Francini, Paolo Prosposito
Summary: This study describes an innovative approach to integrate silver nanoparticles (AgNPs) into poly(ethylene glycol) diacrylate (PEGDA) hydrogels. The composite material can detect and eliminate Hg(II) ions from water. The sensing properties of Hg(II) and removal efficiency were investigated, showing linear dependence and enhanced removal efficiency of the doped material. The interaction between Hg(II) ions and the modified hydrogel adhered to the Langmuir isotherm model, suggesting chemisorption as the driving mechanism.
Article
Nanoscience & Nanotechnology
Shohei Ishikawa, Yuki Yoshikawa, Hiroyuki Kamata, Ung-il Chung, Takamasa Sakai
Summary: Injectable hydrogels are promising artificial extracellular matrix materials that can be administered minimally invasively in liquid form. This study proposes a simple material design approach to introduce phase-separated structures to injectable hydrogels by adding inorganic salts. These phase-separated structures enhance the fracture toughness of the hydrogel and do not compromise the proliferative activity of encapsulated cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Andrew Chung, Burak Tavsanli, Elizabeth R. Gillies
Summary: Hydrogels have diverse applications, and OPF has attracted attention for its tunable degradation. By introducing protected amines into OPF, the degradation rate can be controlled by triggering the cleavage of the polymer backbone. This approach can be applied to other stimuli, providing a versatile method to control OPF degradation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Ana Catarina Sousa, Sara Biscaia, Rui Alvites, Mariana Branquinho, Bruna Lopes, Patricia Sousa, Joana Valente, Margarida Franco, Jose Domingos Santos, Carla Mendonca, Luis Atayde, Nuno Alves, Ana Colette Mauricio
Summary: This study explores a new approach to produce synthetic bone grafts and successfully manufactures three different composition scaffolds. Through in vitro evaluation, it is demonstrated that these scaffolds, especially the one with PEGDA, show promising effects on bone regeneration, including higher cell viability and increased cell adhesion and proliferation.
Article
Polymer Science
Balakondareddy Sana, Nancy Ferrentino, Taha Behroozi Kohlan, Yaqun Liu, Valdas Pasiskevicius, Anna Finne-Wistrand, Daniela Pappalardo
Summary: We have designed a light-sensitive polymer material that self-assembles into core-shell nanoparticles and releases encapsulated fluorescent dye upon light irradiation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Nam Duc Vu, Julien Crozzolo, Amandine Guerinot, Renaud Nicolay
Summary: In this study, a novel thiazolidine-based polyacrylamide hydrogel with self-healing and shear-thinning behavior was synthesized. The hydrogel exhibited highly pH-dependent stability, making it a potential candidate for drug encapsulation and controlled release.
Article
Biochemistry & Molecular Biology
Mathilde Grosjean, Edouard Girard, Audrey Bethry, Gregory Chagnon, Xavier Garric, Benjamin Nottelet
Summary: This study designed degradable bioadhesives based on PEG-PLA star-shaped hydrogels and investigated the performance of acrylate, methacrylate, and catechol functional copolymers as bioadhesive hydrogels. The results showed that these bioadhesives reached adhesion strength comparable to commercial glues and exhibited low cytotoxicity, indicating their potential as surgical adhesives.
