Article
Medicine, General & Internal
Bhavana Katta, Chellappa Vijayakumar, Souradeep Dutta, Biswajit Dubashi, Vishnu Prasad Nelamangala Ramakrishnaiah
Summary: Understanding and managing patients’ self-reported chemotherapy side effects is crucial for improving patients’ quality of life and treatment compliance. However, the current knowledge of chemotherapy side effects is limited in terms of external validity and lack of focus on various cancers and associated side effects. This observational study aimed to assess the frequency and prevalence of chemotherapy side effects in patients with gastric, periampullary, colorectal, and breast cancer over a six-month period. The study found a high incidence of side effects, with fatigue, loss of appetite, and diarrhea being the most common. The frequency of side effects varied significantly between cancer types, highlighting the importance of integrating patient-reported side effects into clinical practice.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Dermatology
R. Kjaersgaard Andersen, I. C. Loft, T. Hansen, H. Hjalgrim, K. Rostgaard, K. Banasik, M. Bruun, K. Nielsen, K. M. Dinh, E. Sorensen, K. Burgdorff, C. Erikstrup, H. Ullum, D. M. Saunte, O. B. Pedersen, G. B. E. Jemec
Summary: The incidence and remission rates of self-reported HS are high, with factors such as gender, smoking, and BMI affecting both the development and recovery of HS. Females with BMI above 25, active smokers, and individuals with symptoms in multiple areas are more likely to develop self-reported HS, while weight loss and smoking cessation can significantly impact the remission rate.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Medicine, General & Internal
Jirapitcha Boonpor, Frederick K. Ho, Stuart R. Gray, Carlos A. Celis-Morales
Summary: The study found that self-reported average and slow walking pace were associated with a higher risk of developing type 2 diabetes. This association was consistent across different physical activity levels and walking time.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Infectious Diseases
Philippine Eloy, Coralie Tardivon, Guillaume Martin-Blondel, Margaux Isnard, Paul Le Turnier, Marion Le Marechal, Andre Cabie, Odile Launay, Pierre Tattevin, Eric Senneville, Severine Ansart, Francois Goehringer, Catherine Chirouze, Laurane Bousson, Cedric Laouenan, Manuel Etienne, Duc Nguyen, Jade Ghosn, Xavier Duval
Summary: At six months post-hospital discharge for COVID-19, 58% of patients reported experiencing at least one symptom, but less than 7% considered any symptom severe. Female gender was associated with moderate/severe symptom reporting. Anxiety, depression, and physical health-related quality of life were common among patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Obstetrics & Gynecology
Siwen Wang, Audrey J. Gaskins, Leslie V. Farland, Dan Zhang, Brenda M. Birmann, Janet W. Rich-Edwards, Yi-Xin Wang, Rulla M. Tamimi, Stacey A. Missmer, Jorge E. Chavarro
Summary: This prospective cohort study examined the association between infertility and the incidence of invasive cancer in women. It found that women who reported infertility had a higher risk of developing cancer, especially obesity-related reproductive cancers. The risk was also higher for women who first reported infertility at a younger age.
FERTILITY AND STERILITY
(2023)
Article
Clinical Neurology
Steven J. Warach, Adrienne N. Dula, Truman J. Milling, Samantha Miller, Leigh Allen, Nathan D. Zuck, Collin Miller, Christine A. Jesser, Lotika R. Misra, Jefferson T. Miley, Manzure Mawla, Ming-Chieh Ding, John A. Bertelson, Annie Y. Tsui, John R. Jefferson, Holly M. Davison, Darshan N. Shah, Kent T. Ellington, Matthew M. Padrick, Alan S. Nova, Vivek R. Krishna, Lisa A. Davis, David Paydarfar
Summary: Switching to tenecteplase as the standard thrombolytic treatment for stroke in a regional network of 10 hospitals resulted in reduced workflow times, noninferior clinical outcomes, and reduced hospital costs.
Article
Geriatrics & Gerontology
Yara van Holstein, Floor J. van Deudekom, Stella Trompet, Iris Postmus, Anna Uit den Boogaard, Marjan J. T. van der Elst, Nienke A. de Glas, Diana van Heemst, Geert Labots, Mariette Altena, Marije Slingerland, Gerrit Jan Liefers, Frederiek van den Bos, Jessica M. van der Bol, Gerard J. Blauw, Johanneke E. A. Portielje, Simon P. Mooijaart
Summary: The paper describes the implementation of a routine clinical care pathway and the design of the TENT study for older patients in need of intensive treatment. The TENT study aims to study associations between geriatric characteristics and treatment outcomes, supporting individualized treatment for future patients.
Article
Multidisciplinary Sciences
Philippe Halfon, Christelle Ansaldi, Guillaume Penaranda, Laurent Chiche, Patrick Dukan, Chloe Stavris, Anne Plauzolles, Frederique Retornaz, Marc Bourliere
Summary: This study aimed to evaluate the interest of utilizing FIB-4 for liver fibrosis screening in primary care population during routine blood analysis. The results demonstrated that FIB-4 index can effectively screen high-risk advanced fibrosis patients, particularly identifying those who have not received treatment before.
Article
Health Care Sciences & Services
Yi-Chun Tsai, Pei-Ni Hsiao, Mei-Chuan Kuo, Shu-Li Wang, Tzu-Hui Chen, Lan-Fang Kung, Shih-Ming Hsiao, Ming-Yen Lin, Shang-Jyh Hwang, Hung-Chun Chen, Yi-Wen Chiu
Summary: The study investigated the impact of mHealth on disease knowledge and self-care behavior in CKD patients. Patients using iCKD had higher disease knowledge scores, especially among those with higher education levels.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zhaozhong Zhu, Yijun Li, Robert J. Freishtat, Juan C. Celedon, Janice A. Espinola, Brennan Harmon, Andrea Hahn, Carlos A. Camargo, Liming Liang, Kohei Hasegawa
Summary: This study investigates the role of DNA methylation in the severity of bronchiolitis in infants. The authors analyze blood DNA methylation data from hospitalized infants and identify differentially methylated CpGs associated with disease severity. These CpGs are found to be differentially methylated in blood immune cells and enriched in various tissues, cells, and pathways. Additionally, they are also associated with respiratory and immune traits. The study highlights the importance of DNA methylation in understanding the pathobiology of bronchiolitis and its severity.
NATURE COMMUNICATIONS
(2023)
Article
Critical Care Medicine
Chiara Abbruzzese, Amedeo Guzzardella, Dario Consonni, Gloria Turconi, Claudia Bonetti, Matteo Brioni, Mauro Panigada, Giacomo Grasselli
Summary: CRTs are common in ICU population but rarely symptomatic. Obesity and ECMO were identified as protective factors, while pulmonary artery catheter, internal jugular vein, and left-side positioning were risk factors for CRT.
ANNALS OF INTENSIVE CARE
(2023)
Article
Public, Environmental & Occupational Health
Maria Elena Camacho Moll, Ana Maria Salinas Martinez, Benjamin Tovar Cisneros, Juan Ignacio Garcia Onofre, Gloria Navarrete Floriano, Mario Bermudez de Leon
Summary: This study compared the extension and severity of self-reported side effects of seven COVID-19 vaccines in the Mexican population and evaluated the association of vaccine type, sex, age, comorbidity, and history of allergies with the extent and severity of side effects. The results showed that ChAdOx1 and Gam-COVID-Vac had the highest rate of side effects in the first dose, while mRNA-1273 had the highest rate of side effects in the second dose. Young age, female sex, comorbidity, and history of allergies were associated with greater extension and severity of side effects.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Lotte E. Terwindt, Jaap Schuurmans, Bjorn J. P. van der Ster, Carin A. G. C. L. Wensing, Marijn P. Mulder, Marije Wijnberge, Thomas G. Cherpanath, Wim K. Lagrand, Alain A. Karlas, Mark H. Verlinde, Markus W. Hollmann, Bart F. Geerts, Denise P. Veelo, Alexander P. J. Vlaar
Summary: This study observed the incidence and severity of hypotension in ICU patients and found that the incidence of hypotension is remarkably high with a certain level of severity. Age, sex, BMI, and cardiogenic shock are associated clinical factors for hypotension.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Jordi Merino, Amit D. Joshi, Long H. Nguyen, Emily R. Leeming, Mohsen Mazidi, David A. Drew, Rachel Gibson, Mark S. Graham, Chun-Han Lo, Joan Capdevila, Benjamin Murray, Christina Hu, Somesh Selvachandran, Alexander Hammers, Shilpa N. Bhupathiraju, Shreela Sharma, Carole Sudre, Christina M. Astley, Jorge E. Chavarro, Sohee Kwon, Wenjie Ma, Cristina Menni, Walter C. Willett, Sebastien Ourselin, Claire J. Steves, Jonathan Wolf, Paul W. Franks, Timothy D. Spector, Sarah Berry, Andrew T. Chan
Summary: The study found that a diet characterized by healthy plant-based foods was associated with a lower risk and severity of COVID-19. This association was particularly evident in areas with higher socioeconomic deprivation.
Article
Multidisciplinary Sciences
Laila Salameh, Bassam Mahboub, Amar Khamis, Mouza Alsharhan, Syed Hammad Tirmazy, Youssef Dairi, Qutayba Hamid, Rifat Hamoudi, Saba Al Heialy
Summary: This study suggests that asthma patients are at a higher risk of developing different types of cancers, with asthma severity and goiter being the main factors associated with increased cancer risk among asthmatic patients.
Article
Economics
Kathleen Manipis, Brendan Mulhern, Philip Haywood, Rosalie Viney, Stephen Goodall
Summary: Lost productivity is a significant cost associated with foodborne illness. A study was conducted to examine preferences for avoiding different illnesses and to estimate the effect of work ability, paid sick leave, and health-related quality of life on willingness-to-pay (WTP). The results showed that factors such as work ability and paid sick leave influenced the WTP to avoid both acute and chronic conditions.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Pediatrics
Serena Yu, Kei Lui, Denzil G. Fiebig, Javeed Travadi, Caroline S. E. Homer, Lynn Sinclair, Vanessa Scarf, Rosalie Viney
Summary: This study investigates the relationship between preterm birth and healthcare utilization and costs in the first 5 years of life. The findings suggest that preterm infants have significantly higher healthcare utilization and costs compared to term infants, highlighting the need for increased access to care and appropriate resource allocation.
JOURNAL OF PEDIATRICS
(2023)
Article
Economics
Richard Norman, Brendan Mulhern, Emily Lancsar, Paula Lorgelly, Julie Ratcliffe, Deborah Street, Rosalie Viney
Summary: This paper reports on a study that developed an EQ-5D-5L value set for Australia using a discrete choice experiment (DCE) that included both duration and death as attributes. The study used a large Australian panel of internet respondents and generated an Australian adult utility model for use in cost-utility analysis through a DCE with 500 choice triplets.
Article
Economics
Cathrine Mihalopoulos, Gang Chen, James G. Scott, Jessica Bucholc, Cassandra Allen, David Coghill, Peter Jenkins, Richard Norman, Julie Ratcliffe, Jeffrey Richardson, Stephen Stathis, Rosalie Viney
Summary: This study aimed to compare the validity and sensitivity of 5 multiattribute utility instruments (MAUIs) with 3 routinely collected outcome measures in Australian mental health services for children and adolescents with different mental disorders. The results showed that there were significant correlations between MAUIs and self-reported clinical measures, but weak correlations with clinician/proxy-reported measures.
Article
Health Care Sciences & Services
Kees van Gool, Jane Hall, Philip Haywood, Dan Liu, Serena Yu, Samuel B. G. Webster, Bahare Moradi, Sanchia Aranda
Summary: This study examines the recent trends in funding for radiotherapy services from 2009-10 to 2021-22 and provides policy implications. The research reveals a 78% increase in demand for radiotherapy services while funding has increased by 137%. Despite the main driver of funding growth being the Extended Medicare Safety Net, patients are facing increasing financial barriers. Therefore, there is a need to review policies on funding radiotherapy services to ensure easy and affordable access for all patients in need of treatment, while maintaining reasonable costs for the government.
AUSTRALIAN HEALTH REVIEW
(2023)
Article
Pharmacology & Pharmacy
Sarah N. Hilmer, Sarita Lo, Patrick J. Kelly, Rosalie Viney, Fiona M. Blyth, David G. Le Couteur, Andrew J. McLachlan, Sheena Arora, Lutfun Hossain, Danijela Gnjidic
Summary: This study comprehensively investigates the prescribing practices for hospitalized older people, focusing on polypharmacy, potentially inappropriate medications (PIMs) based on Beers criteria, and cumulative exposure to anticholinergic and sedative medications using the Drug Burden Index (DBI). The study aims to quantify the exposure to these measures on admission, analyze changes between admission and discharge, and assess the associations with adverse outcomes and medication costs. The findings show an increase in the number of medications during hospitalization and slight reductions in PIMs and DBI, with varying associations with adverse outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Phyllis Butow, Mona F. Faris, Joanne Shaw, Patrick Kelly, Sharon He, Marnie Harris, Jessica M. Cuddy, Lindy Masya, Liesbeth Geerligs, Brian Kelly, Afaf Girgis, Nicole Rankin, Philip Beale, Thomas Hack, Laura Kirsten, Haryana Dhillon, Peter Grimison, Rosalie Viney, Josephine L. Clayton, Timothy Schlub, Heather L. Shepherd
Summary: This study evaluated two implementation strategies (Core versus Enhanced) to facilitate the implementation of a clinical pathway for anxiety and depression management in cancer patients. The results showed that the implementation strategy did not have a significant effect on adherence to the clinical pathway, but anxiety/depression severity level did have a significant impact on adherence.
IMPLEMENTATION SCIENCE
(2023)
Article
Medicine, General & Internal
Dan Liu, Serena Yu, Samuel B. G. Webster, Bahare Moradi, Philip Haywood, Jane Hall, Sanchia Aranda, Kees van Gool
Summary: This study aimed to analyze patients' out-of-pocket costs for radiation oncology services and their variation by geographic location. The results showed that there was a significant variation in out-of-pocket costs for radiation therapy among different areas, with some patients facing high costs, and this situation changed over time.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Health Care Sciences & Services
Brendan J. Mulhern, Tianxin Pan, Richard Norman, An Tran-Duy, Janel Hanmer, Rosalie Viney, Nancy J. Devlin
Summary: This study aims to assess the measurement relationship between EQ-5D-5L, PROMIS-29, and PROPr. The findings suggest a high correlation between the measurement dimensions of these instruments, but PROMIS-29 assesses additional health concepts not covered by EQ-5D. Both instruments are able to detect differences between those with and without a condition, but PROPr can more precisely detect varying levels of self-reported health.
QUALITY OF LIFE RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Maryam Naghsh-Nejad, Serena Yu, Philip Haywood
Summary: This study examines how providers responded to the expansion of public subsidies for innovative oral chemotherapy treatment in 2015, in a health system where providers set their own prices. While the new treatment was preferred by patients for its at-home administration, the potential misalignment between patient and provider preferences raised concerns for policymakers. Our study used national administrative data on services and chemotherapy medications prescribed to 1850 patients in Australia to analyze the impact of the subsidies. The results highlight the importance of understanding provider responses to financial incentives in policy changes.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Health Care Sciences & Services
Rachel Milte, Matthew Crocker, Kiri Lay, Julie Ratcliffe, Brendan Mulhern, Richard Norman, Rosalie Viney, Jyoti Khadka
Summary: This study applied eye-tracking technology to assess self-reported health-related quality of life (HRQoL) in older people receiving aged care services. The findings suggest that participants with mild or moderate cognitive impairment had different patterns of eye gaze during HRQoL assessment compared to those without cognitive impairment, although these differences were not statistically significant.
QUALITY OF LIFE RESEARCH
(2023)
Article
Medicine, General & Internal
Alice Yu, Yiting Luo, Mina Bahrampour, Richard Norman, Deborah Street, Rosalie Viney, Nancy Devlin, Brendan James Mulhern
Summary: This paper describes a protocol for a qualitative study that aims to explore the decision-making process of adults and adolescents when completing DCE valuation tasks. The study will also investigate the impact of methodological choices in the design of DCE studies on participants' thinking process.
Article
Economics
Madeleine T. King, D. A. Revicki, R. Norman, F. Mueller, R. C. Viney, A. S. Pickard, D. Cella, J. W. Shaw
Summary: This study aims to develop a value set that reflects the preferences of the US general population for health states described by the FACT-8D, a multi-attribute utility instrument derived from the FACT-General questionnaire. A discrete choice experiment was conducted to value these health states using a representative sample of the US general population.
PHARMACOECONOMICS-OPEN
(2023)
Article
Health Care Sciences & Services
Julie Ratcliffe, Kiri Lay, Matthew Crocker, Lidia Engel, Rachel Milte, Claire Hutchinson, Jyoti Khadka, David G. T. Whitehurst, Brendan Mulhern, Rosalie Viney, Richard Norman
Summary: This study examines the effect of cognitive threshold on the reliability of self-reported quality of life using EQ-5D-5L in older people. The findings suggest that most older residents with an MMSE score of 24 or higher have sufficient cognitive capacity to complete the EQ-5D-5L self-report.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)
