Review
Biochemistry & Molecular Biology
Tong Lin, Lars O. Tjernberg, Sophia Schedin-Weiss
Summary: Alzheimer's disease is a common neurodegenerative disease that primarily affects memory and cognitive abilities, with no known cure. Early diagnosis and understanding of its pathology are crucial for effective management of the disease.
Review
Biochemistry & Molecular Biology
Maria Norlin, Kjell Wikvall
Summary: Vitamin D signaling plays a crucial role in maintaining calcium balance for bone health and has various functions in different tissues. Disturbances in vitamin D signaling are associated with numerous diseases. This review focuses on the identification of bioactivating enzymes and their genes involved in the production of active vitamin D metabolites. It evaluates species- and tissue-specific expression, enzyme kinetics, substrate specificity, and the consequences of gene mutations. The roles of different vitamin D receptors and alternative bioactivation pathways are also discussed. Although significant progress has been made in understanding vitamin D bioactivation enzymes, further research is needed to fully comprehend the pleiotropic effects and the mechanisms of enzymatic activation in vitamin D-induced responses.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Geriatrics & Gerontology
Jinsu Park, Meenu Madan, Srinivasulu Chigurupati, Seung Hyun Baek, Yoonsuk Cho, Mohamed R. Mughal, Amin Yu, Sic L. Chan, Jogi Pattisapu, Mark P. Mattson, Dong-Gyu Jo
Summary: AQP1 levels are elevated in the cerebral cortex during the early stages of AD, particularly in vulnerable neurons, and increase as aging progresses in AD mouse models. AQP1 appears to reduce A beta production by inhibiting the binding between BACE1 and APP.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Genetics & Heredity
Alex G. Nackenoff, Timothy J. Hohman, Sarah M. Neuner, Carolyn S. Akers, Nicole C. Weitzel, Alena Shostak, Shawn M. Ferguson, Bret Mobley, David A. Bennett, Julie A. Schneider, Angela L. Jefferson, Catherine C. Kaczorowski, Matthew S. Schrag
Summary: PLD3 is a lysosomal phospholipase D that plays a role in AD and cognition. PLD3 expression levels are associated with beta-amyloid plaque density and cognitive decline.
Article
Biochemistry & Molecular Biology
Lisa Hitschler, Thorsten Lang
Summary: Neurotoxic amyloid 11-peptides are believed to contribute to Alzheimer's disease, and this study investigates the physical interactions between amyloid precursor protein (APP) and alpha-secretases. It is found that the transmembrane domain of APP is required for association with alpha-secretases and is involved in alpha-processing, suggesting the dominant role of ADAM10 in APP cleavage. Further understanding of this interaction may aid in the development of therapeutic strategies for Alzheimer's disease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lorenzo Sanesi, Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Flavia Pugliese, Carla Columbu, Vincenzo Carnevale, Silvia Tunnera, Alfredo Scillitani, Maria Grano, Graziana Colaianni, Silvia Colucci
Summary: The study aimed to evaluate the effect of vitamin D supplementation on irisin serum levels in PHPT patients and conducted related experiments in cells. The results showed that vitamin D supplementation significantly increased irisin serum levels in PHPT patients, and in cells, vitamin D could regulate the expression of Fndc5/irisin by up-regulating Sirt1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Richard J. Elsworthy, Marianne C. King, Alastair Grainger, Emily Fisher, James A. Crowe, Sarah Alqattan, Adele Ludlam, Eric J. Hill, Sarah Aldred
Summary: The study reveals the impact of PSEN1 gene mutations on AβPP processing and cellular redox status, demonstrating the potential of iPSC-derived neuron and astrocyte co-cultures as an early human model of fAD.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Justin Lines, Andres M. Baraibar, Cenxiao Fang, Eduardo D. Martin, Juan Aguilar, Michael K. Lee, Alfonso Araque, Paulo Kofuji
Summary: Research has found that dysfunction of astrocyte networks in AD mice may dysregulate cortical electrical activity, leading to cognitive decline.
Article
Neurosciences
Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C. Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, Takeshi Ikeuchi, Taisuke Tomita, Kun Zou, Makoto Michikawa
Summary: This study found that presenilin (PS) plays an important role in the pathogenesis of sporadic AD (SAD) by regulating the secretion of apolipoprotein E (ApoE). PS deficiency leads to decreased ApoE secretion, and PS mutants affect ApoE secretion. These findings reveal a novel mechanism by which PS is involved in SAD pathogenesis.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
David W. Nauen, Juan C. Troncoso
Summary: The research examined lymph nodes resected during cancer treatment or staging and found that Aβ-labeled cells were present, with cervical lymph nodes having more labeled cells than inguinal nodes. This observation supports the hypothesis that the glymphatic system contributes to the clearance of Aβ from the human brain.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Dazhi Guo, Fei Huang, Ruijun Xue, Yuehong Ma, Lin Xiao, Huifang Lou, Shuyi Pan
Summary: ADAM10 plays a crucial role in the development and myelination of oligodendrocyte precursors (OPCs) in the central nervous system (CNS) of mice. Conditional knockout of ADAM10 resulted in significant phenotypic changes, such as hair loss, reduced weight and length, and anxiety and depression-like behaviors. The loss of ADAM10 also led to a decrease in the number of OPCs and mature oligodendrocytes, as well as the inhibition of Notch-1 signaling.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ning Li, Min Yao, Jiaxin Liu, Zhiyuan Zhu, Tsz-Lung Lam, Pingde Zhang, Karrie Mei-Yee Kiang, Gilberto Ka-Kit Leung
Summary: The study showed that VitD treatment improved hindlimb movement in rats post-TSCI, but those with prior deficiency did not benefit. Maintaining sufficient VitD levels was essential for preserving myelin integrity after injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Giuseppe Murdaca, Alessandra Gerosa, Francesca Paladin, Lorena Petrocchi, Sara Banchero, Sebastiano Gangemi
Summary: The importance of both the microbiome and vitamin D in health and disease is increasingly recognized. Microbiome studies have shown unique patterns in autoimmune diseases and dysbiosis is associated with allergies. Vitamin D deficiency affects the microbiome and immune system, highlighting the need for further research in allergic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Elin Byman, Isak Martinsson, Henriette Haukedal, Gunnar Gouras, Kristine K. Freude, Malin Wennstrom
Summary: Recent studies suggest that neuronal alpha-amylase plays a crucial role in memory formation by degrading glycogen. Alpha-amylase deficiency in Alzheimer's disease patients may contribute to disrupted memory formation. The loss of alpha-amylase, induced by Aβ pathology, may be an underlying factor in impaired memory formation seen in AD patients.
Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Neurosciences
Merve Alaylioglu, Erdinc Dursun, Gencer Genc, Busra Sengul, Basar Bilgic, Aysegul Gunduz, Hulya Apaydin, Gunes Kiziltan, Hakan Gurvit, Hasmet Hanagasi, Ozgur Oztop Cakmak, Sibel Ertan, Selma Yilmazer, Duygu Gezen-Ak
Summary: The study aimed to investigate the relevance of SNPs within the DHCR7/NADSYN1 locus and CYP2R1 gene with PD and its clinical features. The results indicated that genetic variants of these genes might be related to the clinical features of PD patients, independent from vitamin D levels.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Hande Yuceer, Duygu Gezen Ak, Gulcin Benbir Senel, Erdinc Dursun, Vuslat Yilmaz, Derya Karadeniz, Erdem Tuzun, Cem Ismail Kucukali
Summary: This study found that the activation of the classical pathway of complement is significant in narcolepsy, suggesting the involvement of immune mechanisms in its pathogenesis. The levels of complement factors and degradation products may serve as biomarkers for predicting the clinical severity of narcolepsy. Further investigation is needed to understand the role of autoantibodies in altering complement levels.
ACTA NEUROPSYCHIATRICA
(2022)
Article
Nutrition & Dietetics
William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Erdinc Dursun, Duygu Gezen-Ak, Edward B. Jude, Tatiana Karonova, Pawel Pludowski
Summary: Vitamin D-3 has important health benefits, but there is a lack of awareness among healthcare professionals and the general public, leading to suboptimal levels of serum 25-hydroxyvitamin D in most of the world's population. High-quality studies show that vitamin D may reduce the risk of cardiovascular disease, cancer, etc., but randomized controlled trials in vitamin D research have flaws.
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Fatme Al Anouti, Stefan Pilz, Pawel Pludowski, Edward Jude, Kalliopi Kotsa
Summary: Dysregulation of vitamin D-binding protein has been associated with various pregnancy complications. The effects of VDBP polymorphisms on adipokine profiles in mothers and neonates have not been fully investigated. This study found that VDBP polymorphisms had minimal impact on adiponectin, irisin, and VDBP concentrations at birth under different vitamin D status cut-offs.
Article
Clinical Neurology
Cem Ismail Kucukali, Busra Sengul, Duygu Gezen-Ak, Erdinc Dursun, Ece Erdag, Gurler Akpinar, Murat Kasap, Zerrin Karaaslan, Nermin Gorkem Sirin, Pinar Tekturk, Betul Baykan, Erdem Tuzun
Summary: A novel neuronal surface antibody to Kv5.1 was identified in patients with treatment-resistant epilepsy of unknown cause, suggesting a potential autoimmune etiology that requires further investigation.
Article
Pharmacology & Pharmacy
Burak Onal, Merve Alaylioglu, Erdinc Dursun, Duygu Gezen-Ak
Summary: In a cell line model of inflammation, vitamin D was found to decrease the expression of pro-atherosclerotic cytokines and increase the expression of anti-atherosclerotic cytokines, potentially reducing cardiovascular risks. Further verification through in vivo studies is needed.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Duygu Gezen-Ak, Zuhal Yurttas, Tugay Camoglu, Erdinc Dursun
Summary: In this review, we summarized clues of possible interactions between A beta and alpha-syn with mitochondria.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Stefan Pilz, Cedric Annweiler, Fatme Al Anouti
Summary: This study aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphism heterogeneity in conjunction with different maternal and neonatal 25(OH)D cutoffs on neonatal anthropometric profile at birth. The findings suggest a potential role for neonatal VDBP genotypes rs2298850 and rs4588, in conjunction with specific neonatal 25(OH)D cutoffs, in affecting neonatal growth and development. However, no significant effects were observed for maternal VDBP polymorphisms or maternal 25(OH)D concentrations at birth on neonatal anthropometry.
Article
Biochemistry & Molecular Biology
Duygu Gezen-Ak, Merve Alaylioglu, Zuhal Yurttas, Tugay Camoglu, Busra Sengul, Cihan Islerc, Umit Yasar Kina, Ebru Keskin, Irem Lutfiye Atasoy, Ali Metin Kafardar, Mustafa Uzan, Cedric Annweiler, Erdinc Dursun
Summary: In this study, it was found that Vitamin D receptor (VDR) may function as a mitochondrial transcription factor and regulate the transcription of mitochondrial DNA (mtDNA). The research also revealed the interaction between VDR and mitochondrial transcription factor A (TFAM), suggesting their joint involvement in the regulation of mitochondrial function. These findings not only uncover a novel role of VDR, but also highlight its indispensability for energy-demanding cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
C. Sulu, G. B. Senel, O. Koca, M. Alaylioglu, A. N. Demir, E. Durcan, D. G. Ak, E. Dursun, D. Konukoglu, H. M. Ozkaya, D. Karadeniz, P. Kadioglu
Summary: This study aimed to evaluate the sleep architecture of patients with Cushing's disease (CD) and investigate the role of agouti-related peptide (AgRP) and/or leptin in sleep alterations in patients with active CD. Polysomnography was performed on 26 patients with active CD and compared with age and sex-matched control subjects. The results showed that patients with CD had reduced sleep efficiency and increased wake after sleep onset, and their serum levels of AgRP and leptin were elevated. These findings suggest that CD is associated with impaired sleep efficiency and continuity, which may be influenced by elevated levels of AgRP and leptin.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Clinical Neurology
Zerrin Karaaslan, Busra Sengul-Yediel, Hande Yuceer-Korkmaz, Elif Sanlia, Duygu Gezen-Ak, Erdinc Dursun, Ozlem Timirci-Kahraman, Ahmet Tarik Baykal, Vuslat Yilmaz, Recai Turkoglu, Murat Kurtuncu, Tuncay Gunduz, Yasemin Gursoy-Ozdemir, Erdem Tuzun, Cem Ismail Kucukali
Summary: This study identified CLIC1-antibody in patients with multiple sclerosis (MS) and relapsing inflammatory optic neuritis (RION) for the first time, confirming anti-astrocytic autoimmunity in chronic inflammatory demyelinating disorders (CIDD). CLIC1-antibody may potentially serve as a diagnostic biomarker to differentiate between MS and NMOSD.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Pharmacology & Pharmacy
B. Onal, M. Alaylioglu, G. Yenmis, A. S. Dogan, E. Dursun, D. Gezen-Ak, M. Ugurlucan
Summary: This study compared the efficacy of atorvastatin and pitavastatin in an inflammation model. The results showed that pitavastatin had superior inhibitory effects on certain pro-inflammatory cytokines compared to atorvastatin. This suggests that pitavastatin may be more suitable for controlling cardiovascular diseases caused by atherosclerosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)