The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

(2016) Saravanan S. Karuppagounder et al.   Science Translational Medicine

New technique of local ischemic preconditioning induction without repetitive aortic cross-clamping in cardiac surgery

(2015) Dmitry I Kurapeev et al.   Journal of Cardiothoracic Surgery

First-in-man endovascular preconditioning of the paraspinal collateral network by segmental artery coil embolization to prevent ischemic spinal cord injury

(2015) Christian D. Etz et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke

(2014) Stefan Reischl et al.   PLoS One

Hypoxia-Inducible Factor 1 is Essential for Spontaneous Recovery from Traumatic Brain Injury and is a Key Mediator of Heat Acclimation Induced Neuroprotection

(2013) Gali Umschweif et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Long-Term Post-Stroke Changes Include Myelin Loss, Specific Deficits in Sensory and Motor Behaviors and Complex Cognitive Impairment Detected Using Active Place Avoidance

(2013) Jin Zhou et al.   PLoS One

Neurocognitive outcomes after cardiac surgery

(2012) Karsten Bartels et al.   Current Opinion in Anesthesiology

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?

(2012) Saravanan S Karuppagounder et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats

(2012) Ling Wei et al.   NEUROBIOLOGY OF DISEASE

Intracellular Signaling MAPK Pathway After Cerebral Ischemia–Reperfusion Injury

(2012) Maria Kovalska et al.   NEUROCHEMICAL RESEARCH

Hypoxia-Inducible Factor 1-α-AA-Modified Bone Marrow Stem Cells Protect PC12 Cells from Hypoxia-Induced Apoptosis, Partially Through VEGF/PI3K/Akt/FoxO1 Pathway

(2012) Qian Zhong et al.   STEM CELLS AND DEVELOPMENT

HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke

(2012) Ted Weita Lai et al.   Journal of Molecular Cell Biology

Cognitive Dysfunction and Depression in Adult Kidney Transplant Recipients: Baseline Findings from the FAVORIT Ancillary Cognitive Trial (FACT)

(2011) Aron M. Troen et al.   JOURNAL OF RENAL NUTRITION

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice

(2010) Xiping Li et al.   BLOOD CELLS MOLECULES AND DISEASES

Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery

(2010) L. Ansaloni et al.   BRITISH JOURNAL OF SURGERY

Suppression of hypoxia-induced HIF-1α accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633

(2010) Hyun Seung Ban et al.   CANCER LETTERS

Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat

(2010) Weike Bao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Thrombopoietin Protects the Brain and Improves Sensorimotor Functions: Reduction of Stroke-Induced MMP-9 Upregulation and Blood—Brain Barrier Injury

(2010) Jin Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Post-stroke pharmacological intervention: Promoting brain recovery from injury in the future

(2010) Frank C. Barone   NEUROPHARMACOLOGY

Pharmacologic Preconditioning: Translating the Promise

(2010) Jeffrey M. Gidday   Translational Stroke Research

Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

(2009) Sarah K. Harten et al.   ANTIOXIDANTS & REDOX SIGNALING

A hierarchy of neurobehavioral tasks discriminates between mild and moderate brain injury in rats

(2009) Samah G. Abdel Baki et al.   BRAIN RESEARCH

Mitogen-activated protein kinase p38α and retinal ischemic preconditioning

(2009) John C. Dreixler et al.   EXPERIMENTAL EYE RESEARCH

Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response

(2009) Twan van den Beucken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

(2009) Ulrich Dirnagl et al.   LANCET NEUROLOGY

Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy

(2009) Chung-Hsin Yeh et al.   LIFE SCIENCES

Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats

(2009) Chunhua Chen et al.   NEUROBIOLOGY OF DISEASE

Neural Stem/Progenitor Cells Promote Endothelial Cell Morphogenesis and Protect Endothelial Cells against Ischemia via HIF-1α-Regulated VEGF Signaling

(2008) Tamara Roitbak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM