Phosphatidlyinositol-3-kinase C2 beta (PI3KC2β) is a potential new target to treat IgE mediated disease

New Developments in Mast Cell Biology

(2016) Greer Arthur et al.   CHEST

Targeting mast cells: Uncovering prolific therapeutic role in myriad diseases

(2016) Jatinder Singh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression

(2016) Anissa Chikh et al.   Oncotarget

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

(2015) Laura Braccini et al.   Nature Communications

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function

(2015) Jessica K. Mountford et al.   Nature Communications

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

(2015) Samira Alliouachene et al.   Cell Reports

New insight into the intracellular roles of class II phosphoinositide 3-kinases

(2014) Tania Maffucci et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

(2014) Irene Franco et al.   DEVELOPMENTAL CELL

Targeting mast cells in inflammatory diseases

(2014) Laurent L. Reber et al.   PHARMACOLOGY & THERAPEUTICS

Involvement of Class II Phosphoinositide 3-Kinase α-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells

(2014) Kiyomi Nigorikawa et al.   PLoS One

Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy

(2013) Emilie Collmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation and cellular functions of class II phosphoinositide 3-kinases

(2012) Marco Falasca et al.   BIOCHEMICAL JOURNAL

Widespread Immunological Functions of Mast Cells: Fact or Fiction?

(2012) Hans-Reimer Rodewald et al.   IMMUNITY

Phosphatidylinositol-3-Kinase C2  and TRIM27 Function To Positively and Negatively Regulate IgE Receptor Activation of Mast Cells

(2012) S. Srivastava et al.   MOLECULAR AND CELLULAR BIOLOGY

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

(2012) Kazuaki Yoshioka et al.   NATURE MEDICINE

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2 

(2011) X. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3

(2010) Irina M. Zemtsova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nucleoside Diphosphate Kinase B Knock-out Mice Have Impaired Activation of the K+Channel KCa3.1, Resulting in Defective T Cell Activation

(2010) Lie Di et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis

(2010) L. Di et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Class II Phosphatidylinositol 3 kinase C2β Is Required for the Activation of the K+ Channel KCa3.1 and CD4 T-Cells

(2009) Shekhar Srivastava et al.   MOLECULAR BIOLOGY OF THE CELL

PI3K  Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells

(2009) T. Bohnacker et al.   Science Signaling