Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

Targeting acid ceramidase sensitises head and neck cancer to cisplatin

(2016) Jong-Lyel Roh et al.   EUROPEAN JOURNAL OF CANCER

Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies

(2015) Kazuyuki Kitatani et al.   MOLECULES AND CELLS

Targeting (cellular) lysosomal acid ceramidase by B13: Design, synthesis and evaluation of novel DMG-B13 ester prodrugs

(2014) Aiping Bai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Export of sphingosine-1-phosphate and cancer progression

(2014) Kazuaki Takabe et al.   JOURNAL OF LIPID RESEARCH

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

(2013) Joseph C. Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization

(2011) Duska Separovic et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IRF8 Regulates Acid Ceramidase Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia

(2011) X. Hu et al.   CANCER RESEARCH

Identification of Cystatin SA as a Novel Inhibitor of Acid Ceramidase

(2011) Efrat Eliyahu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine

(2011) Carmen Bedia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes

(2010) Ruijuan Xu et al.   FASEB JOURNAL

Differential Effects of Ceramide and Sphingosine 1-Phosphate on ERM Phosphorylation

(2010) Daniel Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and bioevaluation of ω-N-amino analogs of B13

(2009) Aiping Bai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats

(2008) Z NAHAS et al.   BEHAVIOURAL BRAIN RESEARCH

Novel analogs of d-e-MAPP and B13. Part 1: Synthesis and evaluation as potential anticancer agents

(2007) Zdzislaw M. Szulc et al.   BIOORGANIC & MEDICINAL CHEMISTRY