Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function

(2016) Sandra Milasta et al.   IMMUNITY

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

(2016) Aldo Vacaflores et al.   PLoS One

The impact of cryopreservation on human peripheral blood leucocyte bioenergetics

(2015) Kevin N. Keane et al.   CLINICAL SCIENCE

Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions

(2015) Kathrin Renner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

(2015) Veronica De Rosa et al.   NATURE IMMUNOLOGY

Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production

(2015) Blanche Ip et al.   Obesity

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

(2014) Tracey McLaughlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes

(2014) Elise Dalmas et al.   DIABETES

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus

(2014) Mor-Li Hartman et al.   VASCULAR MEDICINE

Methods for Assessing Mitochondrial Function in Diabetes

(2013) C. G. R. Perry et al.   DIABETES

Association Between Specific Adipose Tissue CD4+ T-Cell Populations and Insulin Resistance in Obese Individuals

(2013) Elisa Fabbrini et al.   GASTROENTEROLOGY

Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes and neutrophils and the oxidative burst from human blood

(2013) Balu K Chacko et al.   LABORATORY INVESTIGATION

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death

(2010) A Garedew et al.   CELL DEATH AND DIFFERENTIATION

B cells as under-appreciated mediators of non-auto-immune inflammatory disease

(2010) Barbara S. Nikolajczyk   CYTOKINE

Toll-like receptors regulate B cell cytokine production in patients with diabetes

(2010) M. Jagannathan et al.   DIABETOLOGIA

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

(2010) M. Jagannathan-Bogdan et al.   JOURNAL OF IMMUNOLOGY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

B cells from periodontal disease patients express surface Toll-like receptor 4

(2009) H. Shin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE