Article
Immunology
Youngae Lee, Jang-Hee Oh, Na Li, Hyun-Jae Jang, Kyung-Seop Ahn, Sei-Ryang Oh, Dong Hun Lee, Jin Ho Chung
Summary: SFII demonstrated anti-inflammatory effects in atopic dermatitis therapy, effectively suppressing inflammation, cytokine production, and cell infiltration, indicating therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Dimitra Koumaki, Stamatios Gregoriou, George Evangelou, Konstantinos Krasagakis
Summary: Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by intense itchiness that affects both children and adults. This review analyzes the underlying causes of itchiness in AD, including histamine-dependent and histamine-independent pruritogens. Various mediators, such as substance P, secreted molecules, chemokines, and cytokines, are involved in chronic itch. Additionally, emerging antipruritic drugs for AD are summarized.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tobias Weihrauch, Maren M. Limberg, Natalie Gray, Martin Schmelz, Ulrike Raap
Summary: Allergic diseases can cause various symptoms such as itching, coughing, sneezing, and watery eyes, leading to severe physiological and psychological impairments. The mechanisms of these conditions are still not fully understood, but recent studies have shown the high relevance of neurotrophins in allergic inflammation. Neurotrophins induce cytokine release, facilitate interactions between immune cells and neurons, and show different expression levels in health and disease. In this review, the role of neurotrophins in atopic disorders like atopic dermatitis, allergic asthma, and allergic rhinitis is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Pei-Yi Sun, Hua-Guo Li, Qian-Yue Xu, Zhen Zhang, Jia-Wen Chen, Yi-Hang Shen, Xin Qi, Jian-Fei Lu, Yi-Dong Tan, Xiao-Xiao Wang, Chun-Xiao Li, Meng-Ying Yang, Yu-Zhi Ma, Ying Lu, Tian-Le Xu, Jin-Wen Shen, Wei-Guang Li, Yi-Feng Guo, Zhi-Rong Yao
Summary: This study found that lidocaine can alleviate itch and skin lesions in atopic dermatitis by blocking certain subpopulations of sensory neurons. It also suggests that lidocaine may be a potential treatment for atopic dermatitis.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Franz J. Legat
Summary: Atopic dermatitis is a common inflammatory skin disease affecting up to 20% of children and 10% of adults in higher income countries, with chronic pruritus as a major symptom causing significant impact on quality of life. New systemic and topical treatments targeting specific cytokines and receptors have ushered in a new era in atopic dermatitis and pruritus therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Allergy
Ester Del Duca, Helen He, Ying Liu, Angel D. D. Pagan, Eden David, Julia Cheng, Britta Carroll, Yael Renert-Yuval, Jonathan Bar, Yeriel D. D. Estrada, Catherine Maari, Etienne Saint-Cyr Proulx, James G. G. Krueger, Robert Bissonnette, Emma Guttman-Yassky
Summary: Tape-strips and biopsies capture overlapping but distinct features of the AD molecular signature. Tape-strips are more sensitive to dysregulation of innate immunity and Th2/Th17-associated genes, while biopsies are more sensitive to Th22 and dermal cytokines. Both techniques detect epidermal barrier abnormalities, with tape-strips better representing terminal differentiation defects and biopsies better detecting epidermal hyperplasia changes.
Review
Dermatology
Shuyun Yang, Tingting Zhu, Joan S. S. Wakefield, Theodora M. M. Mauro, Peter M. M. Elias, Mao-Qiang Man
Summary: Two serious health conditions, obesity and atopic dermatitis (AD), share pathological features and evidence suggests a link between them. Obesity can predispose and worsen AD, while AD increases the risk of obesity. Cytokines, chemokines, and immune cells mediate the interactions between obesity and AD. Weight loss can alleviate AD, but obese individuals with AD are more resistant to anti-inflammatory therapy. Effective management and further studies are needed to validate the connection and explore mitigation strategies.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ashley Vander Does, Teresa Ju, Noreen Mohsin, Divya Chopra, Gil Yosipovitch
Summary: Itch can be caused by various factors, including skin diseases, neuropathy, systemic conditions, and psychogenic factors. The underlying etiologies involve different pathways, and there are identified itch mediators and receptors that present potential targets for therapy. Recent research has focused on targeting inflammatory cytokines, Janus kinase signaling, protease-activated receptors, substance P and neurokinin, transient receptor potential-vanilloid ion channels, Mas-related G-protein-coupled receptors (MRGPRX2 and MRGPRX4), the endogenous opioid and cannabinoid balance, and phosphodiesterase 4. Further exploration of periostin as a pruritogen through clinical trials is needed. Drugs targeting neural sensitization, such as the gabergic system and P2X3, may also be potential treatments for chronic itch. There is a need for more targeted therapies to improve clinical outcomes and minimize side effects.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Dermatology
Youkyung S. Roh, Amy H. Huang, Nishadh Sutaria, Una Choi, Shannon Wongvibulsin, Justin Choi, Zachary A. Bordeaux, Varsha Parthasarathy, Junwen Deng, Deepa P. Patel, Joseph K. Canner, Anna L. Grossberg, Shawn G. Kwatra
Summary: Adult atopic dermatitis is associated with various psychiatric and systemic comorbidities, emphasizing the systemic nature of the disease and the need for collaborative management of these patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Sheena Chatrath, Donald Lei, Muhammad Yousaf, Rajeev Chavda, Sylvie Gabriel, Jonathan I. Silverberg
Summary: Depressive symptoms in adults with atopic dermatitis are closely related and fluctuate with the severity of the skin condition. Improved control of atopic dermatitis, particularly reducing itchiness, may indirectly improve mental health.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Allergy
Chia-Yu Chu
Summary: Atopic dermatitis (AD) is a T helper type 2-dominated disease, with pediatric patients possibly presenting as moderate to severe lesions inadequately managed by current treatments. Emerging therapeutics for AD target the inflammatory pathway by intervening in specific cytokines/chemokines or their receptors.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
WenDi Fei, JunLin Wu, MengDie Gao, Qian Wang, Ya Yu Zhao, ChunLi Shan, Yu Shen, Gang Chen
Summary: The study demonstrated that Muse cells can alleviate scratching symptoms, reduce epidermal inflammation, and promote wound healing in a mouse model of atopic dermatitis. Additionally, Muse cells showed anti-inflammatory effects on human HaCat cells and promoted keratinocyte proliferation and wound healing.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Yoshie Umehara, Chanisa Kiatsurayanon, Juan Valentin Trujillo-Paez, Panjit Chieosilapatham, Ge Peng, Hainan Yue, Hai Le Thanh Nguyen, Pu Song, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: Itch or pruritus is a hallmark of atopic dermatitis and is believed to be a signal of danger from various environmental factors or physiological abnormalities. While histamine is a well-known substance inducing itch, H-1-antihistamines may not be fully effective against intractable itch in patients with atopic dermatitis. Treatment of the underlying conditions that cause itch is necessary to improve the quality of life of patients with atopic dermatitis.
Article
Pharmacology & Pharmacy
Yubin Xu, Saizhen Chen, Lingling Zhang, Guirong Chen, Jinguang Chen
Summary: The study indicates that Huanglian Jiedu decoction can treat atopic dermatitis by regulating the antigen presentation function of dendritic cells, weakening T-lymphocyte activation, and subsequently exerting anti-inflammatory and anti-pruritus effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Jason Pearson, Renato Leon, Haley Starr, Sujung Jun Kim, Jonathan E. Fogle, Frane Banovic
Summary: Intradermal administration of IL-31 to healthy dogs caused delayed itch responses, which were reduced by oclacitinib, an oral JAK inhibitor.
VETERINARY SCIENCES
(2023)
Article
Anesthesiology
Rafael Taeho Han, Hyunkyoung Lee, JaeHee Lee, Sat-Byol Lee, Hee Jin Kim, Seung Keun Back, Heung Sik Na
Article
Multidisciplinary Sciences
Rafael Taeho Han, Seung Keun Back, JaeHee Lee, Hye Young Kim, Hee Jin Kim, Heung Sik Na
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Dermatology
Rafael Taeho Han, Hye Young Kim, Hyun Ryu, Wooyoung Jang, Seung Ha Cha, Hyo Young Kim, JaeHee Lee, Seung Keun Back, Hee Jin Kim, Heung Sik Na
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Article
Pharmacology & Pharmacy
Rafael Taeho Han, Han-Byul Kim, Young-Beom Kim, Kyungmin Choi, Gi Yeon Park, Pa Reum Lee, JaeHee Lee, Hye Young Kim, Chul-Kyu Park, Youngnam Kang, Seog Bae Oh, Heung Sik Na
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2018)
Article
Neurosciences
Rafael T. Han, Young-Beom Kim, Eui-Ho Park, Jin Yong Kim, Changhyeon Ryu, Hye Y. Kim, JaeHee Lee, Kisoo Pahk, Cui Shanyu, Hyun Kim, Seung K. Back, Hee J. Kim, Yang In Kim, Heung S. Na
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Phi T. Nguyen, Leah C. Dorman, Simon Pan, Ilia D. Vainchtein, Rafael T. Han, Hiromi Nakao-Inoue, Sunrae E. Taloma, Jerika J. Barron, Ari B. Molofsky, Mazen A. Kheirbek, Anna Molofsky
Article
Neurosciences
Stephan Raiders, Taeho Han, Nicole Scott-Hewitt, Sarah Kucenas, Deborah Lew, Mary A. Logan, Aakanksha Singhvi
Summary: The phagocytic activity of glial cells is crucial for proper nervous system development, maintenance, and health, with remarkably conserved pathways governing this engulfment process across different species and cell types.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Immunology
Rafael T. Han, Rachel D. Kim, Anna Molofsky, Shane A. Liddelow
Summary: This article reviews the various functions of astrocytes and their changes in reactive states, emphasizing interactions between astrocytes and microglia, vasculature, and protective barriers in the CNS, as well as discussing recent insights into different sub-states of astrocytes identified by transcriptional profiling. The goal is to stimulate research on how molecular identifiers link to specific functional changes in astrocytes and to define the implications of these heterogeneous molecular and functional changes in brain function and pathology, with the potential to lead to new therapies in CNS injury, infection, and disease.
Article
Immunology
Rafael T. T. Han, Ilia D. D. Vainchtein, Johannes C. M. Schlachetzki, Frances S. S. Cho, Leah C. C. Dorman, Eunji Ahn, Dong Kyu Kim, Jerika J. J. Barron, Hiromi Nakao-Inoue, Ari B. B. Molofsky, Christopher K. K. Glass, Jeanne T. T. Paz, Anna V. V. Molofsky
Summary: Using epigenomics, transcriptomics, and functional studies, this research explains the mechanisms by which IL-33 promotes microglial synapse engulfment and reduces seizure susceptibility during brain development, including the induction of pattern recognition receptors like MARCO.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Allergy
Rafael Taeho Han, Sewon Kim, Kyungmin Choi, Hyeonseok Jwa, JaeHee Lee, Hye Young Kim, Hee Jin Kim, Hang-Rae Kim, Seung Keun Back, Heung Sik Na
JOURNAL OF ASTHMA AND ALLERGY
(2017)