Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?

(2016) Sergio A. Jimenez et al.   MATRIX BIOLOGY

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

(2016) Sonsoles Piera-Velazquez et al.   Journal of Clinical Medicine

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

The myofibroblast, a key cell in normal and pathological tissue repair

(2015) Ian A. Darby et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

Getting to the Heart of the Matter

(2015) Andrew Leask   CIRCULATION RESEARCH

Epithelial-mesenchymal transition: An emerging target in tissue fibrosis

(2015) Meirong Li et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-  and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist

(2015) P. Cipriani et al.   JOURNAL OF RHEUMATOLOGY

Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts

(2015) M. Cutolo et al.   JOURNAL OF RHEUMATOLOGY

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease

(2015) Fabian A. Mendoza et al.   Arthritis & Rheumatology

Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway

(2014) Chih-Ming Weng et al.   BIOCHEMICAL PHARMACOLOGY

The profibrotic role of endothelin-1: Is the door still open for the treatment of fibrotic diseases?

(2014) Fernando Rodríguez-Pascual et al.   LIFE SCIENCES

Knockout of Endothelial Cell-Derived Endothelin-1 Attenuates Skin Fibrosis but Accelerates Cutaneous Wound Healing

(2014) Katsunari Makino et al.   PLoS One

Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease

(2013) Rafael Kramann et al.   JOURNAL OF PATHOLOGY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

The Interaction of Endothelin-1 and TGF-β1 Mediates Vascular Cell Remodeling

(2013) Christopher Lambers et al.   PLoS One

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells in Vitro

(2012) Zhaodong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-  Signaling in Endothelial-to-Mesenchymal Transition: The Role of Shear Stress and Primary Cilia

(2012) P. ten Dijke et al.   Science Signaling

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

(2011) Sonsoles Piera-Velazquez et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation-Induced Endothelial-to-Mesenchymal Transition

(2011) Florian Rieder et al.   AMERICAN JOURNAL OF PATHOLOGY

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro

(2011) Zhaodong Li et al.   ARTHRITIS AND RHEUMATISM

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

(2011) Qian Qin et al.   CELL RESEARCH

The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension

(2011) Dongmin Shao et al.   PHARMACOLOGICAL RESEARCH

Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis

(2010) David Lagares et al.   ARTHRITIS AND RHEUMATISM

The Role of Endothelin-1 in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2010) Jeffrey J. Swigris et al.   BIODRUGS

Endothelin

(2010) Yoshifumi Kawanabe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition

(2010) Bambang Widyantoro et al.   CIRCULATION

Fibrocytes in health and disease

(2010) Erica L. Herzog et al.   EXPERIMENTAL HEMATOLOGY

Endothelin-1 Increases Collagen Accumulation in Renal Mesangial Cells by Stimulating a Chemokine and Cytokine Autocrine Signaling Loop

(2010) Michael S. Simonson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Review Article: Review: Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis

(2010) JINHUA LI et al.   NEPHROLOGY

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis

(2009) Robert M. Strieter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transforming Growth Factor β–Induced Endothelial-to-Mesenchymal Transition: A Switch to Cardiac Fibrosis?

(2009) Marie-José Goumans et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Endothelin-1 induces connective tissue growth factor expression in cardiomyocytes

(2008) Anna Grazia Recchia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY