Article
Multidisciplinary Sciences
Tao Yue, Xiaoming Zhan, Duanwu Zhang, Ruchi Jain, Kuan-Wen Wang, Jin Huk Choi, Takuma Misawa, Lijing Su, Jiexia Quan, Sara Hildebrand, Darui Xu, Xiaohong Li, Emre Turer, Lei Sun, Eva Marie Y. Moresco, Bruce Beutler
Summary: ROS in activated T cells triggers an oxidative stress response leading to translation repression, which is countered by SLFN2 binding tRNAs. SLFN2 deficiency results in tRNA fragment accumulation, inhibiting translation and promoting stress-granule formation.
Review
Biochemistry & Molecular Biology
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann
Summary: IL-4 and IL-13 are pleiotropic Th2 cytokines involved in immune responses and have been found to play a role in oncogenesis and tumor progression. Their effects on tumor cells are mediated through specific receptors, with IL-4R alpha/IL-13R alpha 1 being the main target in tumors. Understanding the implications of these cytokines and their receptors in pancreatic cancer helps in developing potential new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann
Summary: IL-4 and IL-13 are structurally and functionally related cytokines that regulate immune responses and are involved in the pathogenesis of various human neoplasms. They can mediate tumor cell proliferation, survival, and metastasis in solid tumors through different receptors. This review summarizes their role in gastric and colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
B. Szymanska, E. Sawicka, K. Jurkowska, M. Matuszewski, J. Dembowski, A. Piwowar
Summary: The study found that plasma levels of IL-13 and ANG were significantly higher in BC patients and subgroups than in controls, with a negative correlation between ANG and IL-13 levels in BC patients. IL-13 showed good diagnostic value in BC according to the ROC curves.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Amirala Bakhshian Nik, Santiago Alvarez-Argote, Caitlin C. O'Meara
Summary: IL4 and IL13 play a significant role in cardiac regeneration and repair following injury, leading to beneficial outcomes. However, there is still a lack of comprehensive understanding about their molecular and cellular actions in the heart.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cell Biology
Chu-Yen Chien, Ying-Chen Chen, Chia-Chen Hsu, Yu-Ting Chou, Shine-Gwo Shiah, Shyun-Yeu Liu, Alexander Cheng-Ting Hsieh, Ching-Yu Yen, Chien-Hsing Lee, Yi-Shing Shieh
Summary: Nicotine induces the expression of BiP in oral squamous cell carcinoma cells through the activation of the YAP-TEAD transcriptional complex, leading to increased malignancy. Inhibition of BiP expression can suppress nicotine-induced malignant behaviors, including epithelial-mesenchymal transition, migration, and invasion.
Article
Immunology
H. Takahashi, H. Nomura, H. Iriki, A. Kubo, K. Isami, Y. Mikami, M. Mukai, T. Sasaki, J. Yamagami, J. Kudoh, H. Ito, A. Kamata, Y. Kurebayashi, H. Yoshida, A. Yoshimura, H. W. Sun, M. Suematsu, J. J. O'Shea, Y. Kanno, M. Amagai
Summary: IL-27 induces the expression of Ch25h gene in CD4+ T cells, limiting immune responses and affecting the growth and survival of neighboring cells at the same time.
SCIENCE IMMUNOLOGY
(2021)
Article
Biology
Nil Vanli, Jinghao Sheng, Shuping Li, Zhengping Xu, Guo-Fu Hu
Summary: RNASE4 serves as a biomarker for prostate cancer and can predict aggressiveness of the disease and enhance diagnosis accuracy. It also promotes tumor cell proliferation and angiogenesis.
COMMUNICATIONS BIOLOGY
(2022)
Review
Medicine, General & Internal
Fangyuan Chen, Yiman Wang, Xinyi Chen, Nan Yang, Li Li
Summary: This review aims to discuss the role of IL-4/13 in the pathogenesis of BP and the potential of using IL-4/13 antagonists for treatment. The study found that IgE, eosinophils, IL-4, and IL-13 may interact with each other in the pathogenesis of BP, providing clues for finding targets for molecular treatment.
ANNALS OF MEDICINE
(2023)
Article
Cell Biology
Philippe Godin, Mayra F. Tsoi, Martin Morin, Nicolas Gevry, Derek Boerboom
Summary: This study found that LH hormone activates the Hippo signaling pathway in murine granulosa cells through protein kinase A. Yap1 and Taz play important roles in regulating the LH signaling pathway, as they are involved in the induction of multiple LH target genes and the activation of the ERK1/2 pathway. The collaboration between the Hippo signaling pathway and the cAMP/PKA and ERK1/2 pathways ensures the precise regulation of the LH cascade, and YAP1 directly targets Areg to mediate its actions in the ovary.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Immunology
Zachary J. J. Bernstein, Anjali Shenoy, Amy Chen, Nicola M. M. Heller, Jamie B. B. Spangler
Summary: IL-4 and IL-13 cytokines play important roles in immune activity, especially in T helper 2 cell-mediated inflammation, immune regulation, antibody production, and fibrosis. Manipulating the IL-4/IL-13 axis through cytokine engineering, fusion protein formulation, antagonist development, cell engineering, and biosensor design can lead to the discovery of new immunotherapies targeting allergy, autoimmune diseases, and cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Immunology
Christian Behm, Alice Blufstein, Johannes Gahn, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov
Summary: Human periodontal ligament-derived mesenchymal stromal cells (hPDL-MSCs) have bi-directional interaction with CD4(+) T lymphocytes, and their immunomodulatory abilities are enhanced by 25-hydroxyvitamin D-3 (25(OH)D-3) through boosting the expression of immunomediators. The influence of 25(OH)D-3 on this interaction is still unknown.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Cen Jiang, Beiying Wu, Minghui Xue, Jiafei Lin, Zhenli Hu, Xiaomeng Nie, Gang Cai
Summary: The study revealed that patients with various pulmonary diseases have elevated levels of copper in sputum, and inflammation affects copper uptake in the lung. IL-17 and TNF-α were found to regulate copper homeostasis through the upregulation of STEAP4, a metalloreductase that facilitates copper uptake and contributes to copper-mediated oxidative damage.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Immunology
Haiyu Hong, Kai Sen Tan, Yan Yan, Fenghong Chen, Hsiao Hui Ong, Yukei Oo, Jing Liu, Yew Kwang Ong, Mark Thong, Richard Sugrue, Vincent T. Chow, De Yun Wang
Summary: This study confirmed elevated levels of IL-25 in CRSwNP tissues, which correlated with type 2 inflammatory cytokines. Influenza virus infection was identified as a potential contributor of IL-25 in both control and CRSwNP epithelium, with IFN-alpha pretreatment shown to diminish IL-25 induction by active influenza infection.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jesus Amo-Aparicio, Joana Garcia-Garcia, Isaac Francos-Quijorna, Andrea Urpi, Anna Esteve-Codina, Marta Gut, Albert Quintana, Ruben Lopez-Vales
Summary: The study found that while IL-13 induced anti-inflammatory markers in microglia and macrophages after SCI, it did not promote functional recovery as effectively as IL-4. IL-13 and IL-4 induced different gene signatures in these cells after SCI, with IL-4 shifting metabolism towards oxidative phosphorylation. This metabolic shift is important for minimizing cytotoxic responses of microglia and macrophages.
Article
Environmental Sciences
Mustafa Mahfuz, Mohammed Ashraful Alam, Shah Mohammad Fahim, Md Amran Gazi, Mohammad Jyoti Raihan, Muttaquina Hossain, Patricia A. Egner, Pascal Obong Bessong, William A. Petri, John D. Groopman, Tahmeed Ahmed
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2019)
Article
Nutrition & Dietetics
Stephanie A. Richard, Benjamin J. J. McCormick, Laura E. Murray-Kolb, Gwyneth O. Lee, Jessica C. Seidman, Mustafa Mahfuz, Tahmeed Ahmed, Richard L. Guerrant, William A. Petri, Elizabeth T. Rogawski, Eric Houpt, Gagandeep Kang, Estomih Mduma, Margaret N. Kosek, Aldo Am Lima, Sanjaya K. Shrestha, Ram K. Chandyo, Zulfiqar Bhutta, Pascal Bessong, Laura E. Caulfield, Angel Mendez Acosta, Rosa Rios de Burga, Cesar Banda Chavez, Julian Torres Flores, Maribel Paredes Olortegui, Silvia Rengifo Pinedo, Mery Siguas Salas, Dixner Rengifo Trigoso, Angel Orbe Vasquez, Imran Ahmed, Didar Alam, Asad Ali, Zulfiqar A. Bhutta, Shahida Qureshi, Muneera Rasheed, Sajid Soofi, Ali Turab, Aisha Yousafzai, Anita K. M. Zaidi, Ladaporn Bodhidatta, Sudhir Babji, Anuradha Bose, Ajila TGeorge, Dinesh Hariraju, M. Steffi Jennifer, Sushil John, Shiny Kaki, Gagandeep Kang, Priyadarshani Karunakaran, Beena Koshy, Robin P. Lazarus, Jayaprakash Muliyil, Preethi Ragasudha, Mohan Venkata Raghava, Sophy Raju, Anup Ramachandran, Rakhi Ramadas, Karthikeyan Ramanujam, Anuradha Rose, Reeba Roshan, Srujan L. Sharma, Shanmuga E. Sundaram, Rahul J. Thomas, William K. Pan, Ramya Ambikapathi, J. Daniel Carreon, Vivek Charu, Viyada Doan, Jhanelle Graham, Christel Hoest, Stacey Knobler, Dennis R. Lang, Benjamin J. J. McCormick, Monica McGrath, Mark A. Miller, Archana Mohale, Gaurvika Nayyar, Stephanie Psaki, Zeba Rasmussen, Stephanie A. Richard, Jessica C. Seidman, Vivian Wang, Rebecca Blank, Michael Gottlieb, Karen H. Tountas, Caroline Amour, Eliwaza Bayyo, Estomih R. Mduma, Regisiana Mvungi, Rosemary Nshama, John Pascal, Buliga Mujaga Swema, Ladislaus Yarrot, Tahmeed Ahmed, A. M. Shamsir Ahmed, Md Ashraful Alam, Rashidul Haque, Umma Haque, Iqbal Hossain, Munirul Islam, Mustafa Mahfuz, Dinesh Mondal, Baitun Nahar, Fahmida Tofail, Carl J. Mason, Ram Krishna Chandyo, Prakash Sunder Shrestha, Rita Shrestha, Manjeswori Ulak, Aubrey Bauck, Robert E. Black, Laura E. Caulfield, Margaret N. Kosek, Gwenyth O. Lee, Kerry Schulze, Pablo Penataro Yori, William Checkley, Laura E. Murray-Kolb, Catharine Ross, Sam Scott, Suzanne Simons, Barbara Schaefer, Laura Pendergast, Claudia B. Abreu, Hilda Costa, Alessandra Di Moura, Alexandre Havt, Alvaro M. Leite, Aldo A. M. Lima, Noelia L. Lima, Ila F. Lima, Bruna L. L. Maciel, Pedro H. Q. S. Medeiros, Milena Moraes, Francisco S. Mota, Rosa M. S. Mota, Reinaldo B. Oria, Josiane Quetz, Alberto M. Soares, Jose Quirino Filho, Crystal L. Patil, Pascal Bessong, Cloupas Mahopo, Angelina Maphula, Emanuel Nyathi, Amidou Samie, Leah Barrett, Rebecca Dillingham, Jean Gratz, Richard L. Guerrant, Eric Houpt, James Platts-Mills, Elizabeth T. Rogawski, Rebecca Scharf, Binob Shrestha, Bishnu Bahadur Rayamajhi, Sanjaya Kumar Shrestha, Tor Strand, Erling Svensen
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Editorial Material
Immunology
Kevin L. Steiner, Mamun Kabir, Jeffrey W. Priest, Biplob Hossain, Carol A. Gilchrist, Heather Cook, Jennie Z. Ma, Poonum S. Korpe, Tahmeed Ahmed, A. S. G. Faruque, Rashidul Haque, William A. Petri
CLINICAL INFECTIOUS DISEASES
(2020)
Review
Immunology
Mahmoud M. Saleh, William A. Petri
INFECTION AND IMMUNITY
(2020)
Article
Medicine, General & Internal
Wanze Xie, Sarah K. G. Jensen, Mark Wade, Swapna Kumar, Alissa Westerlund, Shahria H. Kakon, Rashidul Haque, William A. Petri, Charles A. Nelson
Article
Nutrition & Dietetics
Mustafa Mahfuz, Mohammed Ashraful Alam, Subhasish Das, Shah Mohammad Fahim, Md Shabab Hossain, William A. Petri, Per Ashorn, Ulla Ashorn, Tahmeed Ahmed
JOURNAL OF NUTRITION
(2020)
Article
Microbiology
Genevieve L. Wojcik, Poonum Korpe, Chelsea Marie, Alexander J. Mentzer, Tommy Carstensen, Josyf Mychaleckyj, Beth D. Kirkpatrick, Stephen S. Rich, Patrick Concannon, A. S. G. Faruque, Rashidul Haque, William A. Petri, Priya Duggal
Article
Gastroenterology & Hepatology
Alexandra Donlan, William A. Petri
CLINICS IN COLON AND RECTAL SURGERY
(2020)
Article
Neurosciences
Ted Turesky, Wanze Xie, Swapna Kumar, Danielle D. Sliva, Borjan Gagoski, Jennifer Vaughn, Lilla Zollei, Rashidul Haque, Shahria Hafiz Kakon, Nazrul Islam, William A. Petri, Charles A. Nelson, Nadine Gaab
Review
Biochemistry & Molecular Biology
Humaira Rashid, Biplob Hossain, Towfida Siddiqua, Mamun Kabir, Zannatun Noor, Mamun Ahmed, Rashidul Haque
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Public, Environmental & Occupational Health
Md Amran Gazi, Subhasish Das, Md Abdullah Siddique, Md Ashraful Alam, Shah Mohammad Fahim, Md Mehedi Hasan, Farzana Hossaini, Md Mamun Kabir, Zannatun Noor, Rashidul Haque, Mustafa Mahfuz, Tahmeed Ahmed
Summary: The study demonstrated a correlation between KT ratio and linear growth as well as inflammatory biomarkers in Bangladeshi children. Following nutrition intervention, stunted children showed significant reductions in KYN concentration and KT ratio. These findings suggest that KT ratio may play a role in the pathophysiology of stunting and inflammation in this population.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biochemistry & Molecular Biology
Humaira Rashid, Towfida J. Siddiqua, Biplob Hossain, Abdullah Siddique, Mamun Kabir, Zannatun Noor, Masud Alam, Mamun Ahmed, Rashidul Haque
Summary: This study investigated the expression levels of miRNA-122 and miR-21 in stool samples of Bangladeshi children with altered intestinal permeability, finding that they were upregulated in children with IIP. Significant correlations were observed between stool levels of miR-122 and miR-21 and inflammatory cytokines. Additionally, IIP children were frequently infected with various pathogens, showing significant correlations with miR-122.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Virology
Parag Palit, Rina Das, Md Ahshanul Haque, Md Mehedi Hasan, Zannatun Noor, Mustafa Mahfuz, Abu Syed Golam Faruque, Tahmeed Ahmed
Summary: The prevalence of norovirus infections and their association with childhood diarrhea in different geographical locations is well established. However, there are no reports on the relationship between different norovirus genogroups and subsequent childhood malnutrition. In this study, we found a potential association between asymptomatic norovirus infections and childhood growth faltering, highlighting the need for accelerated development of vaccines to minimize the long-term impact on child growth.
Article
Nutrition & Dietetics
Parag Palit, Md Amran Gazi, Subhasish Das, Md Mehedi Hasan, Zannatun Noor, Jafrin Ferdous, Md Ashraful Alam, Sharika Nuzhat, Md Ridwan Islam, Mustafa Mahfuz, Rashidul Haque, Tahmeed Ahmed
Summary: This study aimed to investigate the relationship between childhood malnutrition and aberrations in the mTOR pathway. The results showed that phosphorylation of mTORC1 was reduced, LAMTOR2 gene expression was decreased, and TSC1 gene expression was increased in malnourished children. Deregulation in the activity of the TSC1 and LAMTOR2 gene was significantly associated with all forms of childhood malnutrition.
Article
Multidisciplinary Sciences
Sarah K. G. Jensen, Swapna Kumar, Wanze Xie, Fahmida Tofail, Rashidul Haque, William A. Petri, Charles A. Nelson
SCIENTIFIC REPORTS
(2019)
