A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits
出版年份 2016 全文链接
标题
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits
作者
关键词
DNA methylation, Adipose tissue, Consortia, Genome-wide association studies, Genetic loci, Obesity, Gene expression, Genetics of disease
出版物
PLoS One
Volume 11, Issue 6, Pages e0157776
出版商
Public Library of Science (PLoS)
发表日期
2016-06-21
DOI
10.1371/journal.pone.0157776
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
- (2015) Anubha Mahajan et al. PLoS Genetics
- Metabolic heritability at birth: implications for chronic disease research
- (2014) Kelli K. Ryckman et al. HUMAN GENETICS
- DNA methylation and body-mass index: a genome-wide analysis
- (2014) Katherine J Dick et al. LANCET
- Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets
- (2014) Anders H. Olsson et al. PLoS Genetics
- Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion
- (2014) Tasnim Dayeh et al. PLoS Genetics
- CHRNA5-A3-B4genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users
- (2013) Andy Z. X. Zhu et al. ADDICTION
- Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements
- (2013) Elin Grundberg et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
- (2013) T. A. Dayeh et al. DIABETOLOGIA
- Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
- (2013) Yi-an Chen et al. Epigenetics
- Genetics of diabetes – Are we missing the genes or the disease?
- (2013) Leif Groop et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
- (2013) Yun Liu et al. NATURE BIOTECHNOLOGY
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013
- (2013) Jing Wang et al. NUCLEIC ACIDS RESEARCH
- The Presence of Methylation Quantitative Trait Loci Indicates a Direct Genetic Influence on the Level of DNA Methylation in Adipose Tissue
- (2013) Alexander W. Drong et al. PLoS One
- A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue
- (2013) Tina Rönn et al. PLoS Genetics
- Matrix eQTL: ultra fast eQTL analysis via large matrix operations
- (2012) A. A. Shabalin BIOINFORMATICS
- What model organisms and interactomics can reveal about the genetics of human obesity
- (2012) Michael J. Williams et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes
- (2012) M. D. Nitert et al. DIABETES
- Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men
- (2012) S. C. Jacobsen et al. DIABETOLOGIA
- First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle
- (2012) T. Elgzyri et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes
- (2012) Beatrice T. Yang et al. MOLECULAR ENDOCRINOLOGY
- FTO genotype is associated with phenotypic variability of body mass index
- (2012) Jian Yang et al. NATURE
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
- (2012) Robert A Scott et al. NATURE GENETICS
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- (2012) Alisa K Manning et al. NATURE GENETICS
- Functions of DNA methylation: islands, start sites, gene bodies and beyond
- (2012) Peter A. Jones NATURE REVIEWS GENETICS
- Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population
- (2012) Anthony G. Comuzzie et al. PLoS One
- Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women
- (2012) Caroline S. Fox et al. PLoS Genetics
- Epigenetics and obesity: the devil is in the details
- (2011) Paul W Franks et al. BMC Medicine
- Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
- (2011) Abbas Dehghan et al. CIRCULATION
- High density DNA methylation array with single CpG site resolution
- (2011) Marina Bibikova et al. GENOMICS
- Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
- (2011) Tuomas O Kilpeläinen et al. NATURE GENETICS
- DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
- (2011) Jordana T Bell et al. GENOME BIOLOGY
- Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain
- (2010) Dandan Zhang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A framework for oligonucleotide microarray preprocessing
- (2010) Benilton S. Carvalho et al. BIOINFORMATICS
- Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
- (2010) Pan Du et al. BMC BIOINFORMATICS
- Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham Heart Study data
- (2010) Li Ma et al. BMC Medical Genetics
- Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
- (2010) N. Soranzo et al. DIABETES
- Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets
- (2010) B. T. Yang et al. DIABETOLOGIA
- Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC
- (2010) Yee Him Cheung et al. HUMAN GENETICS
- DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome
- (2010) Miina Ollikainen et al. HUMAN MOLECULAR GENETICS
- Deoxyribonucleic Acid Methylation and Gene Expression ofPPARGC1Ain Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner
- (2010) Charlotte Brøns et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- (2010) Iris M Heid et al. NATURE GENETICS
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- (2010) Elizabeth K Speliotes et al. NATURE GENETICS
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- (2010) Josée Dupuis et al. NATURE GENETICS
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- (2010) Benjamin F Voight et al. NATURE GENETICS
- Genomics, Type 2 Diabetes, and Obesity
- (2010) Mark I. McCarthy NEW ENGLAND JOURNAL OF MEDICINE
- Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain
- (2010) J. Raphael Gibbs et al. PLoS Genetics
- Disentangling molecular relationships with a causal inference test
- (2009) Joshua Millstein et al. BMC GENETICS
- Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density
- (2009) Romain Barrès et al. Cell Metabolism
- Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes
- (2009) Charlotte Ling et al. DIABETES
- The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
- (2009) Rafael A Irizarry et al. NATURE GENETICS
- DNA methylation profiles in monozygotic and dizygotic twins
- (2009) Zachary A Kaminsky et al. NATURE GENETICS
- Epigenetic mechanisms that underpin metabolic and cardiovascular diseases
- (2009) Peter D. Gluckman et al. Nature Reviews Endocrinology
- Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae
- (2009) Jennifer K. Lowe et al. PLoS Genetics
- SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
- (2008) A. D. Johnson et al. BIOINFORMATICS
- lumi: a pipeline for processing Illumina microarray
- (2008) P. Du et al. BIOINFORMATICS
- Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
- (2008) C. Ling et al. DIABETOLOGIA
- Mitochondrial Function in Skeletal Muscle Is Normal and Unrelated to Insulin Action in Young Men Born with Low Birth Weight
- (2008) Charlotte Brøns et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57
- (2008) Deborah J G Mackay et al. NATURE GENETICS
- Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
- (2008) Chiara Sabatti et al. NATURE GENETICS
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
- (2008) Eleftheria Zeggini et al. NATURE GENETICS
- Common genetic variation near MC4R is associated with waist circumference and insulin resistance
- (2008) John C Chambers et al. NATURE GENETICS
- Revealing the architecture of gene regulation: the promise of eQTL studies
- (2008) Yoav Gilad et al. TRENDS IN GENETICS
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