TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model

Cell Contact-Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response

(2014) P. Bartholomaeus et al.   JOURNAL OF IMMUNOLOGY

Delayed onset of graft-versus-host disease in immunodeficent human leucocyte antigen-DQ8 transgenic, murine major histocompatibility complex class II-deficient mice repopulated by human peripheral blood mononuclear cells

(2013) S. M. Büchner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08

(2013) Paula Tabares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation

(2012) S. Weissmuller et al.   BLOOD

A humanised mouse model of cytokine release: Comparison of CD3-specific antibody fragments

(2012) S.L. Malcolm et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412

(2011) P. S. Romer et al.   BLOOD

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

(2010) D Eastwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

(2010) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Monoclonal antibody-induced cytokine-release syndrome

(2009) Peter J Bugelski et al.   Expert Review of Clinical Immunology

A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

(2008) Nora Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies

(2008) Zoe Waibler et al.   PLoS One