Review
Cell Biology
Min Chen, Xiangchen Gu
Summary: Endocytosis plays a crucial role in kidney diseases, particularly in renal fibrosis, and is affected by other diseases and factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jeroen R. Huyghe, Tabitha A. Harrison, Stephanie A. Bien, Heather Hampel, Jane C. Figueiredo, Stephanie L. Schmit, David Conti, Sai Chen, Conghui Qu, Yi Lin, Richard Barfield, John A. Baron, Amanda J. Cross, Brenda Diergaarde, David Duggan, Sophia Harlid, Liher Imaz, Hyun Min Kang, David M. Levine, Vittorio Perduca, Aurora Perez-Cornago, Lori C. Sakoda, Fredrick R. Schumacher, Martha L. Slattery, Amanda E. Toland, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Antonio Agudo, Demetrius Albanes, M. Henar Alonso, Kristin Anderson, Coral Arnau-Collell, Volker Arndt, Barbara L. Banbury, Michael C. Bassik, Sonja Berndt, Stephane Bezieau, D. Timothy Bishop, Juergen Boehm, Heiner Boeing, Marie-Christine Boutron-Ruault, Hermann Brenner, Stefanie Brezina, Stephan Buch, Daniel D. Buchanan, Andrea Burnett-Hartman, Bette J. Caan, Peter T. Campbell, Prudence R. Carr, Antoni Castells, Sergi Castellvi-Bel, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Keith R. Curtis, Albert de la Chapelle, Douglas F. Easton, Dallas R. English, Edith J. M. Feskens, Manish Gala, Steven J. Gallinger, W. James Gauderman, Graham G. Giles, Phyllis J. Goodman, William M. Grady, John S. Grove, Andrea Gsur, Marc J. Gunter, Robert W. Haile, Jochen Hampe, Michael Hoffmeister, John L. Hopper, Wan-Ling Hsu, Wen-Yi Huang, Thomas J. Hudson, Mazda Jenab, Mark A. Jenkins, Amit D. Joshi, Temitope O. Keku, Charles Kooperberg, Tilman Kuhn, Sebastien Kury, Loic Le Marchand, Flavio Lejbkowicz, Christopher Li, Li Li, Wolfgang Lieb, Annika Lindblom, Noralane M. Lindor, Satu Mannisto, Sanford D. Markowitz, Roger L. Milne, Lorena Moreno, Neil Murphy, Rami Nassir, Kenneth Offit, Shuji Ogino, Salvatore Panico, Patrick S. Parfrey, Rachel Pearlman, Paul D. P. Pharoah, Amanda Phipps, Elizabeth A. Platz, John D. Potter, Ross L. Prentice, Lihong Qi, Leon Raskin, Gad Rennert, Hedy S. Rennert, Elio Riboli, Clemens Schafmayer, Robert E. Schoen, Daniela Seminara, Mingyang Song, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Antonia Trichopoulou, Cornelia M. Ulrich, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Korbinian Weigl, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Goncalo R. Abecasis, Deborah A. Nickerson, Peter C. Scacheri, Anshul Kundaje, Graham Casey, Stephen B. Gruber, Li Hsu, Victor Moreno, Richard B. Hayes, Polly A. Newcomb, Ulrike Peters
Summary: Understanding the etiologic heterogeneity of colorectal cancer is crucial for precision prevention efforts. By performing GWAS meta-analyses, we identified 13 loci that reached genome-wide significance for specific colorectal cancer subsites, with evidence of heterogeneity between anatomical subsites. This suggests that the genetic architectures of proximal and distal CRC are partly distinct, highlighting the importance of considering tumour subsite in studies of risk factors and prevention strategies.
Article
Urology & Nephrology
Lihe Chen, Chun-Lin Chou, Mark A. Knepper
Summary: Single-cell transcriptomics analysis revealed unexpected diversity among the cells of the distal nephron in mice, identifying differences between DCT1 and DCT2 cells, as well as subtypes of CTAL cells.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Physiology
Ryan J. Cornelius, Jonathan W. Nelson, Xiao-Tong Su, Chao-Ling Yang, David H. Ellison
Summary: Cullin-RING ligases are a type of E3 ubiquitin ligases that control cellular processes by regulating degradation. Genetic deletion of renal-specific genes results in a reduction of NCC due to hypoplasia of the DCT, which coincides with cortical kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Oncology
Samuel Rasmussen, Jia Xiang Jin, Lissett R. Bickford, Andrew D. Woods, Felix Sahm, Kenneth A. Crawford, Kiyo Nagamori, Hiroaki Goto, Keila E. Torres, Angelo Sidoni, Erin R. Rudzinski, Khin Thway, Robin L. Jones, Alessio Ciulli, Hollis Wright, Melvin Lathara, Ganapati Srinivasa, Kavya Kannan, Paul H. Huang, Thomas G. P. Grunewald, Noah E. Berlow, Charles Keller
Summary: This study used a functional genomics approach to identify key signaling pathway vulnerabilities in EPS patient samples, revealing subtle differences between distal, pediatric/young adult-associated EPS and proximal, adult-associated EPS. These differences highlight the need to approach the two subtypes as molecularly and clinically distinct diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Cynthia Dela Cruz, Cassandra A. Horton, Kelsey N. Sanders, Nathan D. Andersen, Pei-San Tsai
Summary: The study found that Fgfr1 signaling directly supports reproductive axis function to some extent in GnRH neurons, but is not critically required for pubertal onset or reproductive maintenance in sexually mature animals.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Paula de Oliveira Leite, Xiao C. Li, Sarah M. Nwia, Rumana Hassan, Jia L. Zhuo
Summary: Contrary to public perception, hypertension remains a major public health issue in the United States, affecting a significant proportion of adults and increasing the risk of cardiovascular diseases. Recent advancements in genetic modification techniques have provided new insights into the role of proximal tubule angiotensin II (Ang II) and its receptors in blood pressure control and the development of hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
David J. Lin, Richard Hardstone, Julie A. DiCarlo, Sydney Mckiernan, Samuel B. Snider, Hannah Jacobs, Kimberly S. Erler, Kelly Rishe, Pierce Boyne, Jeff Goldsmith, Jessica Ranford, Seth P. Finklestein, Lee H. Schwamm, Leigh R. Hochberg, Steven C. Cramer
Summary: The study investigates the distinct patterns of upper extremity motor deficits after acute stroke, showing that separate proximal and distal upper extremity clinical syndromes can be distinguished, and the patterns of neuroanatomical injury leading to these syndromes reflect their distinct organization in the healthy central nervous system. The results reveal that patients with relatively preserved distal motor control have better outcomes in the first week and at 90 days poststroke. Deficits in proximal motor control are associated with widespread injury to subcortical white and gray matter, while deficits in distal motor control are associated with injury restricted to the posterior aspect of the precentral gyrus.
Article
Cell Biology
Matthew J. Ford, Keerthana Harwalkar, Alain S. Pacis, Helen Maunsell, Yu Chang Wang, Dunarel Badescu, Katie Teng, Nobuko Yamanaka, Maxime Bouchard, Jiannis Ragoussis, Yojiro Yamanaka
Summary: Research shows that there are transcriptionally distinct populations of cells in the distal and proximal regions of the oviduct, which are specified early in development and maintained separately, aiding in the understanding of epithelial development, homeostasis, and disease initiation from the oviduct.
Article
Biochemistry & Molecular Biology
Xiao Chun Li, Rumana Hassan, Ana Paula O. Leite, Akemi Katsurada, Courtney Dugas, Ryosuke Sato, Jia Long Zhuo
Summary: This study explored the role of the proximal tubule Ang II/AT(1) (AT(1a))/NHE3 axis in the development of 2K1C Goldblatt hypertension using novel mouse models with proximal tubule-specific deletion of AT(1a) receptors or NHE3. The results showed that the deletion of AT(1a) receptors or NHE3 in the proximal tubules attenuated the development of 2K1C hypertension, indicating the significance of this pathway in hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Sarah M. Nwia, Xiao Chun Li, Ana Paula de Oliveira Leite, Rumana Hassan, Jia Long Zhuo
Summary: The sodium/hydrogen exchanger 3 (NHE3) is a vital antiporter involved in Na+/H+ exchange in the small intestines and proximal tubules. It plays key roles in intracellular pH regulation and acid-base balance. Recent studies have shown that NHE3 is responsible for absorbing external Na+ and excreting intracellular H+, contributing to salt and fluid balance, blood pressure homeostasis, and the development of hypertension.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Sukanya Raghavan, Nataliya Tovbis-Shifrin, Christina Kochel, Anandi Sawant, Marielle Mello, Manjiri Sathe, Wendy Blumenschein, Eric S. Muise, Alissa Chackerian, Elaine M. Pinheiro, Thomas W. Rosahl, Herve Luche, Rene de Waal Malefyt
Summary: The study investigated the cellular and molecular events following inhibition of PD-1 signaling in a colon carcinoma model, revealing that PD-1 suppression plays a key role in inhibiting CD8 T-cell responses in tumor immunity. Extensive immune phenotypic analysis identified 20 different T cell subsets, with 5 CD8 positive subsets expanding after PD-1 blockade in all models, expressing granzyme B and interferon gamma. Gene expression analysis showed upregulation of pathways related to T-cell activation and non-T-cell processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Peripheral Vascular Disease
Zhong-Xiuzi Gao, Qi-Chao Wei, Ting-Ting Shu, Shu-Ting Li, Rui Zhou, Ming-Yan Li, Zi-Hui Mao, Dong-Wei Liu, Zhang-Suo Liu, Peng Wu
Summary: This study found that high salt intake in early streptozotocin-induced diabetes leads to imbalanced Na+/K+ ratio, increased blood pressure, and enhanced NCC activity. These effects are associated with increased expression and activity of Kir4.1 in the distal convoluted tubule (DCT). Additionally, the study suggests that Kir4.1 deletion prevents the upregulation of NCC and the development of salt-sensitive hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Samuel Shin, Eugenia Awuah Boadi, Bidhan C. Bandyopadhyay
Summary: This study found that the reduced activities of HCO3-, PO43-, and C2O42- transporters in PT cells of TRPC3(-/-) mice may contribute to the formation of CaP crystals.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Urology & Nephrology
Wanting Shi, Weibo Le, Qiaoli Tang, Shaolin Shi, Jingsong Shi
Summary: Diabetic kidney disease (DKD), the most common complication of diabetes mellitus and a leading cause of kidney failure, remains poorly understood in terms of its mechanisms underlying early kidney damage. In this study, gene regulatory networks were constructed using single nucleus RNA-seq in the kidney cortex of patients with early DKD, revealing cell type-specific changes in genetic regulation associated with diabetic status. The upregulation of FXR (NR1H4) and CREB5 in kidney proximal convoluted tubule epithelial cells (PCTs) was validated in DKD patients, and in vitro experiments showed their protective effects on cells. These findings suggest that FXR and CREB5 may be potential targets for early intervention in DKD.
Article
Medicine, Research & Experimental
Zhousheng Xiao, Jerome Baudry, Li Cao, Jinsong Huang, Hao Chen, Charles R. Yates, Wei Li, Brittany Dong, Christopher M. Waters, Jeremy C. Smith, L. Darryl Quarles
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Urology & Nephrology
Xiaobin Han, Jed Ross, Ganesh Kolumam, Min Pi, Junichiro Sonoda, Gwendalyn King, L. Darryl Quarles
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Review
Endocrinology & Metabolism
Min Pi, Satoru Kenneth Nishimoto, L. Darryl Quarles
MOLECULAR METABOLISM
(2017)
Article
Food Science & Technology
Min Pi, Karan Kapoor, Ruisong Ye, Jeremy C. Smith, Jerome Baudry, Leigh D. Quarles
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Article
Multidisciplinary Sciences
Min Pi, Karan Kapoor, Ruisong Ye, Dong-Jin Hwang, Duane D. Miller, Jeremy C. Smith, Jerome Baudry, L. Darryl Quarles
Review
Endocrinology & Metabolism
Elizabeth A. Fitzpatrick, Xiaobin Han, Zhousheng Xiao, L. Darryl Quarles
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Multidisciplinary Sciences
Min Pi, Ruisong Ye, Xiaobin Han, Benjamin Armstrong, Xue Liu, Yuanjian Chen, Yao Sun, L. Darryl Quarles
SCIENTIFIC REPORTS
(2018)
Review
Urology & Nephrology
L. Darryl Quarles
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2019)
Article
Pharmacology & Pharmacy
Ruisong Ye, Min Pi, Mohammed M. Nooh, Suleiman W. Bahout, L. Darryl Quarles
MOLECULAR PHARMACOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Hanxuan Li, Zhousheng Xiao, L. Darryl Quarles, Wei Li
Summary: Osteoporosis is a pathological condition characterized by a loss of bone mass due to an imbalance in bone remodeling. Current treatments include anti-resorptive agents and anabolic drugs, but severe side effects and loss of efficacy may limit long term usage. Sequential and combinational use of current drugs, as well as development of novel drugs against new targets, offer alternative approaches for osteoporosis treatment.
CURRENT MEDICINAL CHEMISTRY
(2021)
Editorial Material
Pharmacology & Pharmacy
Shih-Hsien Liu, Zhousheng Xiao, Jeremy C. Smith, Darryl Quarles
Summary: Chen et al. have obtained cryo-EM structures of signaling complexes involving FGF23 and its receptor, α-Klotho, and heparin sulfate. These structures, with their asymmetric features, raise questions about their in vivo function and may aid in the development of drugs targeting FGF23 signaling.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Cell & Tissue Engineering
Zhousheng Xiao, Li Cao, Micholas Dean Smith, Hanxuan Li, Wei Li, Jeremy C. Smith, Leigh Darryl Quarles
Summary: This study demonstrates the interaction between polycystin-1 and Wwtr1 in osteoblasts and their role in mechanosensing and bone formation. The loss of both proteins results in greater reductions in bone mass and impaired mechanical loading responses. The findings suggest that PC1 and Wwtr1 form an anabolic mechanotransduction signaling complex and could be a potential therapeutic target for osteoporosis.
Letter
Endocrinology & Metabolism
Xiaobin Han, L. Darryl Quarles
Article
Urology & Nephrology
Csaba P. Kovesdy, Jun Ling Lu, Barry M. Wall, Geeta Gyamlani, Adnan Naseer, Angela Wallick, Zhongji Han, Fridtjof Thomas, L. Darryl Quarles, Nabil Jarmukli
KIDNEY INTERNATIONAL REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Hector A. Velazquez, Demian Riccardi, Zhousheng Xiao, Leigh Darryl Quarles, Charless Ryan Yates, Jerome Baudry, Jeremy C. Smith
CHEMICAL BIOLOGY & DRUG DESIGN
(2018)