Article
Behavioral Sciences
M. M. Hyer, A. J. Wegener, I. Targett, S. K. Dyer, G. N. Neigh
Summary: Prolonged stress during adolescence can disrupt the neuroendocrine system and prime the neuroimmune system to inflammation in adulthood. In a study with male and female rats, males with a history of adolescent stress were more susceptible to the peripheral effects of lipopolysaccharide (LPS), while females experienced similar effects regardless of stress history. Learning and memory were impacted differently by LPS depending on the stress history and sex. Adolescent stress led to deficits in initial learning in males, while females showed a slight impairment during reversal learning. Both stressed males and females exhibited memory impairment during probe assessments. These findings highlight the long-term influence of adolescent stress on the neuroimmune system and its impact on cognitive performance in both sexes.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Barbara D. Fontana, Alistair J. Gibbon, Madeleine Cleal, William H. J. Norton, Matthew O. Parker
Summary: The study found that the 7-day chronic unpredictable early-life stress (CUELS) protocol decreased anxiety in both young and adult zebrafish, while exposure to 14 days of CUELS led to an opposite anxious phenotype. However, memory and cognition, social behavior, and cortisol levels did not show significant changes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biotechnology & Applied Microbiology
Chen Meng, Chen Dong, Hong Liu
Summary: This study demonstrated that metronidazole and ciprofloxacin had differential effects on CUMS-induced changes in the microbiota of the colon, cecum, and ileum.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Behavioral Sciences
Hector Miguel Mancha-Gutierrez, Erika Estrada-Camarena, Lilian Mayagoitia-Novales, Elena Lopez-Pacheco, Carolina Lopez-Rubalcava
Summary: Chronic social defeat during early adolescence leads to depression-like behaviors, cognitive deficits, and neuroendocrine abnormalities, with long-term effects causing persistent psychological and physiological impacts.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychology, Biological
Evgenia Dandi, Evangelia Spandou, Despina A. Tata
Summary: This study investigates the effects of environmental enrichment and chronic unpredictable stress on emotional behavior, cognitive function, and neuroendocrine markers. The findings indicate that environmental enrichment in adolescence can protect against the negative effects of chronic stress in adulthood, with sex-specific differences observed. It highlights the importance of including both sexes in animal studies.
BEHAVIOURAL PROCESSES
(2022)
Article
Clinical Neurology
Laura Sanchez-Marin, Maria Flores-Lopez, Antoni Pastor, Ana Luisa Gavito, Juan Suarez, Rafael de la Torre, Francisco Javier Pavon, Fernando Rodriguez de Fonseca, Antonia Serrano
Summary: Early restraint stress and alcohol exposure during adolescence induced anxiety-like behaviors in young adult rats, affecting the expression of signaling systems associated with emotional behaviors in both blood and amygdala. There were significant interaction effects between stress and alcohol exposure, but no potentiation of effects by their combination was observed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Hannah G. Sexton, Nathan A. Olszewski, Mary-Louise Risher
Summary: Adolescence is a period characterized by increased social behavior, risk taking, and novelty seeking. Exposure to chronic adolescent unpredictable stress can lead to maladaptive behaviors and increase susceptibility to alcohol and substance abuse. The PPAR gamma agonist rosiglitazone may be an effective therapeutic for attenuating certain risk taking and novelty seeking behaviors in females.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Federica Somma, Paolo Bartolomeo, Federica Vallone, Antonietta Argiuolo, Antonio Cerrato, Orazio Miglino, Laura Mandolesi, Maria Clelia Zurlo, Onofrio Gigliotta
Summary: This study investigated the impact of the COVID-19 pandemic on spatial cognition tasks, particularly regarding spatial exploration and pseudoneglect. Results showed an increase in leftward bias and pseudoneglect among participants during the lockdown, which was positively correlated with perceived stress and negatively correlated with positive coping strategies.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Nathan Wofford, Natalie Ceballos, Gary Elkins, Carmen E. Westerberg
Summary: This study found that a brief nap can reduce negative affect to a greater extent than taking a break, suggesting that it may be a useful way to improve mood while experiencing acute stress. However, a nap did not confer additional benefits for perceived stress or working memory beyond taking a break.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Neurosciences
Erin P. Harris, Francisca Villalobos-Manriquez, Thieza G. Melo, Gerard Clarke, Olivia F. O'Leary
Summary: Psychiatric disorders, especially major depression, are more prevalent in women than in men. This study investigated the role of stress during puberty in the sex difference in depression vulnerability. The results showed that pubertal stress had sex-specific effects on depressive-like behavior and anhedonia, possibly through discrete neurotransmitter systems.
NEUROBIOLOGY OF STRESS
(2022)
Article
Neurosciences
Linling Xu, Huimin Sun, Chujie Qu, Jun Shen, Changhua Qu, Hao Song, Tian Li, Jiaxin Zheng, Junjian Zhang
Summary: This study demonstrates that environmental enrichment (EE) can have neuroprotective effects on depression and cognitive impairment by inducing autophagy-mediated inflammation inhibition. Autophagy-mediated inflammation inhibition reduces the release of proinflammatory cytokines, thereby improving depressive-like behaviors and cognitive decline.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Shir Shlomi, Roni Toledano, Keren Nitzan, Sigal Dror Shahaf, Emanuela P. Break, Dan Frenkel, Ravid Doron
Summary: Stressful and unpredictable life events are associated with numerous diseases, with adolescence being a sensitive period in brain development. Research shows that exposure to unpredictable chronic mild stress during adolescence can have long-term effects on cognition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jiahui Liu, Yi Zhang, Jiang Qiu, Dongtao Wei
Summary: This study analyzed non-imaging and structural brain variables in 497 healthy participants and found that the transition from late adolescence to early adulthood is characterized by a surge of life changes and brain reorganization influenced by negative affect, personality, and social conditions. Sparse canonical correlation analysis revealed modes with maximum covariation between structural brain changes and non-imaging features.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Nutrition & Dietetics
Sosorburam Batsukh, Seyeon Oh, Kyoungmin Rheu, Bae-Jin Lee, Chang Hu Choi, Kuk Hui Son, Kyunghee Byun
Summary: Chronic stress leads to muscle atrophy by increasing cortisol levels, while rice germ supplemented with γ-aminobutyric acid (RG) attenuates muscle atrophy in an animal model of chronic unpredictable mild stress (CUMS). RG reversed the effects of CUMS on adrenal gland weight, serum adrenocorticotropic hormone (ACTH), cortisol levels, GC receptor (GR) expression, and muscle degradation-related signaling pathways, while enhancing muscle synthesis-related signaling pathways, reducing oxidative stress and increasing cell proliferation in the gastrocnemius muscle.
Article
Cell Biology
Marcia Spoelder, Yami Bright, Martine C. Morrison, Veerle van Kempen, Lilian de Groodt, Malvina Begalli, Nikita Schuijt, Eva Kruiger, Ronald Bulthuis, Gabriele Gross, Robert Kleemann, Janna A. van Diepen, Judith R. Homberg, Giovanni Cirillo
Summary: Increased insulin levels may contribute to the development of neural circuits involved in cognition, while chronic mild inflammation may lead to cognitive impairment. This study investigated whether cognition is affected during adolescence in a genetic rat model for obesity and type 2 diabetes. The results showed that adolescent obese rats displayed enhanced cognition despite their early diabetic profile.
Article
Behavioral Sciences
Lauren E. Chaby, Michael J. Sheriff, Amy M. Hirrlinger, Victoria A. Braithwaite
Article
Behavioral Sciences
L. E. Chaby, S. A. Cavigelli, A. M. Hirrlinger, M. J. Caruso, V. A. Braithwaite
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Psychology, Biological
Lauren E. Chaby, Michael J. Sheriff, Sonia A. Cavigelli, Amy M. Hirrlinger, James Lim, Victoria A. Braithwaite
Review
Psychology, Biological
Lauren E. Chaby
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Multidisciplinary Sciences
M. J. Caruso, L. R. Seemiller, T. B. Fetherston, C. N. Miller, D. E. Reiss, S. A. Cavigelli, H. M. Kamens
SCIENTIFIC REPORTS
(2018)
Article
Zoology
Marco Del Giudice, C. Loren Buck, Lauren E. Chaby, Brenna M. Gormally, Conor C. Taff, Christopher J. Thawley, Maren N. Vitousek, Haruka Wada
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2018)
Article
Behavioral Sciences
Chieh Chen, Lauren E. Chaby, Sahana Nazeer, Israel Liberzon
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Behavioral Sciences
Lauren E. Chaby, Klevis Karavidha, Michael J. Lisieski, Shane A. Perrine, Israel Liberzon
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Lauren E. Chaby, Nareen Sadik, Nicole A. Burson, Scott Lloyd, Kelly O'Donnel, Jesse Winters, Alana C. Conti, Israel Liberzon, Shane A. Perrine
SCIENTIFIC REPORTS
(2020)
Article
Behavioral Sciences
Jesse J. Winters, Larry W. Hardy, Jenna M. Sullivan, Noel A. Powell, Mohammed Qutaish, Surabhi Nair, Jack Heimann, Ali Ghayoor, Ildiko Polyak, Lauren Chaby, Elizabeth Rodriguez, Dima Chaar, Jon Oscherwitz, Israel Liberzon
Summary: The study revealed that male rats subjected to single-prolonged stress exhibited significant deficits in fear extinction recall, accompanied by abnormal persisting activity in the hippocampal region during the process. This abnormal activity may lead to persistent fear overgeneralization, affecting the ability to discriminate between different contexts. Therefore, further research is needed to identify therapeutic targets for stress-induced deficits in fear extinction recall.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Lauren E. Chaby, Heather C. Lasseter, Charles Geier, Andreas Jeromin
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2020)
Review
Behavioral Sciences
Chantelle Ferland-Beckham, Lauren E. Chaby, Nikolaos P. Daskalakis, Dayan Knox, Israel Liberzon, Miranda M. Lim, Christa McIntyre, Shane A. Perrine, Victoria B. Risbrough, Esther L. Sabban, Andreas Jeromin, Magali Haas
Summary: Posttraumatic stress disorder (PTSD) is a mental health condition triggered by experiencing a terrifying event, leading to lifelong burden and increased mortality. Animal models are crucial for studying new treatments, though discrepancies between human clinical trials and preclinical animal studies have raised questions about research methods.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lauren E. Chaby, Heather C. Lasseter, Kevin Contrepois, Reza M. Salek, Christoph W. Turck, Andrew Thompson, Timothy Vaughan, Magali Haas, Andreas Jeromin
Summary: The performance of metabolomics platforms varies across metabolite classes, but is comparable between targeted and untargeted approaches. Precision and accuracy range from 0.9-63.2% and 0.6-99.1% respectively, with high inter-assay variance in certain metabolite classes. Platform-specific coverage ranges from 16-70% of PTSD-associated metabolites, presenting challenges in dataset integration.
Article
Psychiatry
Meghan E. Pierce, Jasmeet Hayes, Bertrand Russell Huber, Andreas Jeromin, Catherine B. Fortier, Jennifer R. Fonda, Heather Lasseter, Lauren Chaby, Regina McGlinchey, William Milberg
Summary: This study explored the relationships between plasma biomarkers, clinical, and medical comorbidities in a sample of post-9/11 veterans. The findings suggest that close blast exposure is associated with increased inflammation and decreased GFAP levels, which may be related to deployment-related psychopathology.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Behavioral Sciences
Lauren E. Chaby, Li Zhang, Israel Liberzon
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2017)