Investigating the role of environmental enrichment initiated in adolescence against the detrimental effects of chronic unpredictable stress in adulthood: Sex-specific differences in behavioral and neuroendocrinological findings

Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis

(2020) Li Cai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chronic unpredictable intermittent restraint stress disrupts spatial memory in male, but not female rats

(2020) Dylan N. Peay et al.   BEHAVIOURAL BRAIN RESEARCH

Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway

(2020) Ahmed M. Mohamed et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enriched Environment Rearing from Birth Reduced Anxiety, Improved Learning and Memory, and Promoted Social Interactions in Adult Male Mice

(2020) Jing-Jing Zheng et al.   NEUROSCIENCE

Effects of exposure to enriched environment during adolescence on passive avoidance memory, nociception, and prefrontal BDNF level in adult male and female rats

(2020) Farshid Sadegzadeh et al.   NEUROSCIENCE LETTERS

Impact of enriched environment during adolescence on adult social behavior, hippocampal synaptic density and dopamine D2 receptor expression in rats

(2020) Paul Gabriel et al.   PHYSIOLOGY & BEHAVIOR

Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) - Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission

(2020) Wankupar Wankhar et al.   BEHAVIOURAL BRAIN RESEARCH

Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive‐like behavior in male adolescent mice

(2020) Yu Mao et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Modulatory action of environmental enrichment on hormonal and behavioral responses induced by chronic stress in rats: Hypothalamic renin-angiotensin system components

(2020) Rafaela Costa et al.   BEHAVIOURAL BRAIN RESEARCH

The structural reorganization of the prefrontal cortex during adolescence as a framework for vulnerability to the environment

(2020) Carly M. Drzewiecki et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Repeated unpredictable stress and social isolation induce chronic HPA axis dysfunction and persistent abnormal fear memory

(2020) Moustafa Algamal et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Enriched environment modulates behavior, myelination and augments molecules governing the plasticity in the forebrain region of rats exposed to chronic immobilization stress

(2019) Gangadharan Thamizhoviya et al.   METABOLIC BRAIN DISEASE

The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1/miR-134 signaling pathway in hippocampus

(2019) Jun Shen et al.   JOURNAL OF AFFECTIVE DISORDERS

Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats

(2019) Zikai Hao et al.   PSYCHONEUROENDOCRINOLOGY

Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression

(2019) Qiaohui Lu et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of enriched environment and predictable chronic stress on spatial memory in adolescent rats: Predominant expression of BDNF, nNOS, and interestingly malondialdehyde in the right hippocampus

(2019) Zülal Kaptan et al.   BRAIN RESEARCH

Sex differences in anxiety-like behaviors in rats

(2019) Jamie L. Scholl et al.   PHYSIOLOGY & BEHAVIOR

Environmental enrichment decreases chronic psychosocial stress-impaired extinction and reinstatement of ethanol conditioned place preference in C57BL/6 male mice

(2019) Amine Bahi et al.   PSYCHOPHARMACOLOGY

Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats

(2019) A. Sequeira-Cordero et al.   Scientific Reports

Amygdalar corticotropin-releasing factor mediates stress-induced anxiety

(2019) Ana Paula Ventura-Silva et al.   BRAIN RESEARCH

Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1/miR-134 signalling pathway regulates CREB/BDNF expression in hippocampus in vivo and in vitro

(2018) Jun Shen et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring

(2018) Jessica E. Sparling et al.   BEHAVIOURAL BRAIN RESEARCH

Beneficial effects of environmental enrichment on behavior, stress reactivity and synaptophysin/BDNF expression in hippocampus following early life stress

(2018) Εvgenia Dandi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons

(2018) S.M. Ohline et al.   NEUROPHARMACOLOGY

Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats

(2018) Jonas O. Vieira et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Sex-dependent changes in neuroactive steroid concentrations in the rat brain following acute swim stress

(2018) Ying Sze et al.   JOURNAL OF NEUROENDOCRINOLOGY

Effect of enriched environment during adolescence on spatial learning and memory, and voluntary consumption of morphine in maternally separated rats in adulthood

(2018) Javad Mohammadian et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Assessment of spatial learning and memory in the Barnes maze task in rodents—methodological consideration

(2018) Kinga Gawel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Deficits in cognitive flexibility induced by chronic unpredictable stress are associated with impaired glutamate neurotransmission in the rat medial prefrontal cortex

(2017) Julianne D. Jett et al.   NEUROSCIENCE

Sex differences in chronic stress effects on cognition in rodents

(2017) Victoria Luine et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress

(2017) Congli Hu et al.   PLoS One

Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains

(2017) Michiel van Boxelaere et al.   PLoS One

Environmental enrichment ameliorates chronic immobilisation stress-induced spatial learning deficits and restores the expression of BDNF, VEGF, GFAP and glucocorticoid receptors

(2017) BM Shilpa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Adolescent environmental enrichment prevents behavioral and physiological sequelae of adolescent chronic stress in female (but not male) rats

(2017) Brittany L. Smith et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Exposure to an enriched environment up to middle age allows preservation of spatial memory capabilities in old age

(2016) Fanny Fuchs et al.   BEHAVIOURAL BRAIN RESEARCH

The neurogenic effects of an enriched environment and its protection against the behavioral consequences of chronic mild stress persistent after enrichment cessation in six-month-old female Balb/C mice

(2016) Nelly Maritza Vega-Rivera et al.   BEHAVIOURAL BRAIN RESEARCH

The impact of early postnatal environmental enrichment on maternal care and offspring behaviour following weaning

(2016) Ki Angel Li et al.   BEHAVIOURAL PROCESSES

Short-term exposure to enriched environment rescues chronic stress-induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits

(2016) Venkanna Rao Bhagya et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Estradiol: Mediator of memories, spine density and cognitive resilience to stress in female rodents

(2016) Victoria Luine   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Environmental enrichment as a method to improve cognitive function. What can we learn from animal models?

(2016) Andre Fischer   NEUROIMAGE

Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders

(2016) Ryan Shepard et al.   NEUROSCIENCE

Early environmental enrichment affects neurobehavioral development and prevents brain damage in rats submitted to neonatal hypoxia-ischemia

(2016) Clarissa Pedrini Schuch et al.   NEUROSCIENCE LETTERS

Corticosterone levels and behavioral changes induced by simultaneous exposure to chronic social stress and enriched environments in NMRI male mice

(2016) Patricia Mesa-Gresa et al.   PHYSIOLOGY & BEHAVIOR

Adolescent chronic stress causes hypothalamo–pituitary–adrenocortical hypo-responsiveness and depression-like behavior in adult female rats

(2016) Aynara C. Wulsin et al.   PSYCHONEUROENDOCRINOLOGY

Environmental enrichment does not reverse the effects of maternal deprivation on NMDAR and Balb/c mice behaviors

(2015) Kubra Akillioglu et al.   BRAIN RESEARCH

Enriched environment improves synaptic plasticity and cognitive deficiency in chronic cerebral hypoperfused rats

(2015) Mahnaz Bayat et al.   BRAIN RESEARCH BULLETIN

Environmental enrichment: Evidence for an unexpected therapeutic influence

(2015) Robert J. Kotloski et al.   EXPERIMENTAL NEUROLOGY

Post-weaning environmental enrichment improves BDNF response of adult male rats

(2015) Belal Mosaferi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Local N-methyl-d-aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats

(2015) M.N. Locklear et al.   NEUROSCIENCE

Inoculation stress hypothesis of environmental enrichment

(2015) Elizabeth J. Crofton et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Environmental enrichment and cafeteria diet attenuate the response to chronic variable stress in rats

(2015) N. Zeeni et al.   PHYSIOLOGY & BEHAVIOR

Enduring effects of post-weaning rearing condition on depressive- and anxiety-like behaviors and motor activity in male rats

(2015) Belal Mosaferi et al.   PHYSIOLOGY & BEHAVIOR

Environmental Enrichment Increases Glucocorticoid Receptors and Decreases GluA2 and Protein Kinase M Zeta (PKMζ) Trafficking During Chronic Stress: A Protective Mechanism?

(2015) Roseanna M. Zanca et al.   Frontiers in Behavioral Neuroscience

Brain plasticity and cognitive functions after ethanol consumption in C57BL/6J mice

(2015) E Stragier et al.   Translational Psychiatry

Sex differences in the chronic mild stress model of depression

(2014) Anthony Franceschelli et al.   BEHAVIOURAL PHARMACOLOGY

Stress-induced neuroplasticity: (Mal)adaptation to adverse life events in patients with PTSD – A critical overview

(2014) S. Deppermann et al.   NEUROSCIENCE

Adolescence as a vulnerable period to alter rodent behavior

(2013) Miriam Schneider   CELL AND TISSUE RESEARCH

Effects of environmental enrichment on nicotine-induced sensitization and cross-sensitization to d-amphetamine in rats

(2013) Emily Adams et al.   DRUG AND ALCOHOL DEPENDENCE

Behavioral effects of combined environmental enrichment and chronic nicotine administration in male NMRI mice

(2013) Patricia Mesa-Gresa et al.   PHYSIOLOGY & BEHAVIOR

Sex differences in the effects of social and physical environment on novelty-induced exploratory behavior and cocaine-stimulated locomotor activity in adolescent rats

(2012) Elena Zakharova et al.   BEHAVIOURAL BRAIN RESEARCH

Environmental enrichment protects against the effects of chronic stress on cognitive and morphological measures of hippocampal integrity

(2012) Katie M. Hutchinson et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The impact of environmental enrichment on sex-specific neurochemical circuitries – Effects on brain-derived neurotrophic factor and the serotonergic system

(2012) S. Chourbaji et al.   NEUROSCIENCE

The consequences of adolescent chronic unpredictable stress exposure on brain and behavior

(2012) F. Hollis et al.   NEUROSCIENCE

Anxiolytic effects of environmental enrichment attenuate sex-related anxiogenic effects of scopolamine in rats

(2012) Robert N. Hughes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Hippocampal GluR1 associates with behavior in the elevated plus maze and shows sex differences

(2011) Xiaojun Xiang et al.   BEHAVIOURAL BRAIN RESEARCH

Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior

(2011) Thu N. Huynh et al.   BEHAVIOURAL BRAIN RESEARCH

The impact of environmental enrichment in laboratory rats—Behavioural and neurochemical aspects

(2011) Joy Simpson et al.   BEHAVIOURAL BRAIN RESEARCH

Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan

(2011) T. Freret et al.   NEUROBIOLOGY OF AGING

Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity

(2011) Nikolaos Kokras et al.   NEUROPHARMACOLOGY

Environmental Enrichment Preceding Early Adulthood Methylphenidate Treatment Leads to Long Term Increase of Corticosterone and Testosterone in the Rat

(2011) Avi Avital et al.   PLoS One

Environmental enrichment exerts sex-specific effects on emotionality in C57BL/6J mice

(2010) En-Ju D. Lin et al.   BEHAVIOURAL BRAIN RESEARCH

Stress Vulnerability during Adolescent Development in Rats

(2010) Ryan Jankord et al.   ENDOCRINOLOGY

Stress-related changes in the activity of cocaine- and amphetamine-regulated transcript and nesfatin neurons in the midbrain non-preganglionic Edinger–Westphal nucleus in the rat

(2010) L. Xu et al.   NEUROSCIENCE

Sex-dependent effects of chronic unpredictable stress in the water maze

(2010) L.M. McFadden et al.   PHYSIOLOGY & BEHAVIOR

Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats

(2009) Christian G. Reich et al.   BEHAVIOURAL BRAIN RESEARCH

Attention and memory in aged rats: Impact of lifelong environmental enrichment

(2009) Hayat Harati et al.   NEUROBIOLOGY OF AGING

Sex differences in oxidant/antioxidant balance under a chronic mild stress regime

(2009) E.F. Kamper et al.   PHYSIOLOGY & BEHAVIOR

Sex differences in stress responses: Focus on ovarian hormones

(2009) Gert J. Ter Horst et al.   PHYSIOLOGY & BEHAVIOR

Sex-dependent changes in anxiety, memory, and monoamines following one week of stress

(2009) R.E. Bowman et al.   PHYSIOLOGY & BEHAVIOR

Enriched Environment Experience Overcomes Learning Deficits and Depressive-Like Behavior Induced by Juvenile Stress

(2009) Yana Ilin et al.   PLoS One

A critical review of chronic stress effects on spatial learning and memory

(2009) Cheryl D. Conrad   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Context and strain-dependent behavioral response to stress

(2008) Katarzyna Nosek et al.   Behavioral and Brain Functions

Open field locomotor activity and anxiety-related behaviors in mucopolysaccharidosis type IIIA mice

(2008) Adeline A. Lau et al.   BEHAVIOURAL BRAIN RESEARCH

Enriched environment prevents chronic stress-induced spatial learning and memory deficits

(2007) Ryan L. Wright et al.   BEHAVIOURAL BRAIN RESEARCH

Sex differences in the effects of two stress paradigms on dopaminergic neurotransmission

(2007) C. Dalla et al.   PHYSIOLOGY & BEHAVIOR