Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

A Small Molecule Inhibitor of ATPase Activity of HSP70 Induces Apoptosis and Has Antitumor Activities

(2015) Sung-Kyun Ko et al.   CHEMISTRY & BIOLOGY

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Chemical biology approaches to target validation in cancer

(2014) Julian Blagg et al.   CURRENT OPINION IN PHARMACOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Learning from our mistakes: The ‘unknown knowns’ in fragment screening

(2013) Ben J. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stay on target

(2013)   Nature Chemical Biology

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Correction: Functional Analysis of Hsp70 Inhibitors

(2013) Rainer Schlecht et al.   PLoS One

Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture

(2012) Shawn C. Owen et al.   ACS Chemical Biology

Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

(2011) Marissa V. Powers et al.   CELL CYCLE

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

A Small Molecule That Binds to an ATPase Domain of Hsc70 Promotes Membrane Trafficking of Mutant Cystic Fibrosis Transmembrane Conductance Regulator

(2011) Hyungseoph J. Cho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

Probing the Probes: Fitness Factors For Small Molecule Tools

(2010) Paul Workman et al.   CHEMISTRY & BIOLOGY

ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90

(2010) Andrew J. Massey   JOURNAL OF MEDICINAL CHEMISTRY

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

(2010) Christopher G. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Identification of Hsp70 modulators through modeling of the substrate binding domain

(2009) Conor M. Haney et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of molecular chaperones in human misfolding diseases

(2009) Sarah A. Broadley et al.   FEBS LETTERS

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design†

(2009) Douglas S. Williamson et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

An Apoptosis-Inducing Small Molecule That Binds to Heat Shock Protein 70

(2008) Darren R. Williams et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of a fluorescence polarization assay platform for the study of human Hsp70

(2008) Yanlong Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

(2008) Laura Trinkle-Mulcahy et al.   JOURNAL OF CELL BIOLOGY

From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery

(2008) Eirini Meimaridou et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK

(2007) Lyra Chang et al.   ANALYTICAL BIOCHEMISTRY