Review
Biochemistry & Molecular Biology
Alvaro Gutierrez, Hannah Demond, Priscilla Brebi, Carmen Gloria Ili
Summary: Colorectal cancer is the third most common cancer globally, and biomarkers play a crucial role in diagnosis and predicting metastasis. Key signaling pathways associated with cancer progression include the MAPK pathway, p53 pathway, and TGF-beta pathway.
Article
Multidisciplinary Sciences
Laura Sole, Teresa Lobo-Jarne, Daniel Alvarez-Villanueva, Josune Alonso-Maranon, Yolanda Guillen, Marta Guix, Irene Sangrador, Catalina Rozalen, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel Garcia-Romero, Marta Garrido, Jessica Gonzalez, Maria Martinez-Iniesta, Erika Lopez-Arribillaga, Ramon Salazar, Clara Montagut, Ferran Torres, Mar Iglesias, Toni Celia-Terrassa, Alberto Munoz, Alberto Villanueva, Anna Bigas, Lluis Espinosa
Summary: This study reveals that sub-lethal dose of chemotherapy induces a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state in wild-type p53 colorectal cancers, which is associated with higher metastatic activity and poor prognosis in patients.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Farah J. Nassar, Zahraa S. Msheik, Rihab R. Nasr, Sally N. Temraz
Summary: Colorectal cancer is a deadly disease with a high mortality rate worldwide; early detection is crucial for improving survival outcomes; traditional CRC diagnostic tests have limitations, and methylated circulating tumor DNA shows promise as a potential biomarker worth further investigation.
CLINICAL EPIGENETICS
(2021)
Article
Medicine, Research & Experimental
Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang, Huichuan Yu
Summary: This study found that the NTRK3 gene promoter was more frequently methylated in CRC, leading to suppressed gene expression. It was confirmed that NTRK3 promoter methylation was associated with survival outcome in CRC and a nomogram predicting survival outcome was developed. Moreover, NTRK3 promoter methylation also predicted survival outcomes in other tumors.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Bo Xiao, Liyan Liu, Zhuoyuan Chen, Aoyu Li, Yu Xia, Pingxiao Wang, Cheng Xiang, Yi Zeng, Hui Li
Summary: This study identified a novel prognostic marker based on stem cell-related genes for osteosarcoma patients, independent of other clinical traits. The marker was validated to be significant in predicting survival rate and providing potential therapeutic targets. The research suggests that the expression level of stem cell-related genes could serve as valuable prognostic markers and therapeutic targets for osteosarcoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yu Kyeong Han, Ha Young Park, Sae-Gwang Park, Jae Joon Hwang, Hae Ryoun Park, Joo Mi Yi
Summary: Growing evidence suggests that genetic and epigenetic factors, including environmental factors, contribute to the development of oral squamous cell carcinoma (OSCC). This study investigated the transcriptional silencing and promoter methylation of CD24, CD44, CD133, and CD147 genes in OSCC cell lines, and found that CD133 and CD147 methylation status is associated with poor survival in OSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Hao Jiang, Hongquan Zhang, Xuegong Zhang
Summary: A method to analyze tissue differentiation spectrum in colorectal cancer was developed, identifying three major CRC subtypes with distinct tissue differentiation patterns. It was observed that differentiation states are closely correlated with anti-tumor immune response and patient outcomes in CRC.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Oncology
Maria C. Heinz, Niek A. Peters, Koen C. Oost, Rik G. H. Lindeboom, Lisa van Voorthuijsen, Arianna Fumagalli, Mirjam C. van der Net, Gustavo de Medeiros, Joris H. Hageman, Ingrid Verlaan-Klink, Inne H. M. Borel Rinkes, Prisca Liberali, Martijn Gloerich, Jacco van Rheenen, Michiel Vermeulen, Onno Kranenburg, Hugo J. G. Snippert
Summary: Study on early colorectal cancer liver metastases reveals that micrometastatic lesions lack cancer stem cells (CSC), but the development of overt metastases involves the emergence of de novo CSCs through cellular plasticity at a multicellular stage. Cellular heterogeneity is crucial for continuous growth.
Article
Oncology
Hao-Zhe Cao, Wen-Ting Yang, Peng-Sheng Zheng
Summary: The study found that the disulfiram/copper complex has strong cytotoxicity against cervical cancer cells, disrupting the S phase, inhibiting the expression of stemness markers, and reducing the number of cancer stem cell-like LGR5(+) cells, thereby enhancing the anti-tumor effect.
Article
Biochemistry & Molecular Biology
Manar AbdelMageed, Hager Tarek H. Ismail, Lina Olsson, Gudrun Lindmark, Marie-Louise Hammarstrom, Sten Hammarstrom, Basel Sitohy
Summary: The study demonstrates the utility of measuring mRNA expression levels of CSC markers in predicting survival outcome and recurrence risk in colon cancer patients. LGR5 is identified as a particularly useful prognostic biomarker, and combining it with other biomarkers can enhance the accuracy of prediction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Pratyusha Bala, Jonathan P. Rennhack, Daulet Aitymbayev, Clare Morris, Sydney M. Moyer, Gina N. Duronio, Paul Doan, Zhixin Li, Xiaoyan Liang, Jason L. Hornick, Matthew B. Yurgelun, William C. Hahn, Nilay S. Sethi
Summary: Cell state plasticity is regulated in adult epithelia to prevent cancer, but its expansion in neoplasia is poorly understood. Mouse models and patient samples revealed that impaired differentiation precedes cancer development, with aberrant transcriptional state marked by Ly6a and reactivation of fetal genes. Genetic inactivation of Sox9 prevents adenoma formation and restores multilineage differentiation. These findings indicate that unabated regenerative activity and developmental reprogramming contribute to the aberrant cell state plasticity preceding cancer development.
Review
Oncology
Dedrick Kok Hong Chan, Simon James Alexander Buczacki
Summary: Colorectal cancer is a global burden, characterized by an initial explosion of genetic diversity followed by neutral dynamics. Understanding the interplay between clonal populations during neutral evolution provides insights into the roles of driver genes in the progression from normal colonic epithelium to adenoma and carcinoma. Recent advances have focused on genetic, transcriptomic, and proteomic factors, as well as the ecological and evolutionary processes that contribute to cancer development.
Article
Biochemistry & Molecular Biology
Christopher J. Bergin, Aicha Zouggar, Joshua R. Haebe, Angelique N. Masibag, Francois M. Desrochers, Simon Y. Reilley, Gautam Agrawal, Yannick D. Benoit
Summary: Colorectal tumors are governed by populations of self-renewing cancer stem cells, and the emergence of cancer stemness phenotype is influenced by epigenetic reprogramming. The histone methyltransferase G9a plays a crucial role in colorectal cancer, impacting self-renewal, tumorigenicity, and undifferentiated state. Inhibitors of G9a function show potential in inducing differentiation and restricting tumor-initiating activity in colorectal cancer stem cells.
Article
Medicine, General & Internal
Shaobo Mo, Weixing Dai, Hui Wang, Xiaoliang Lan, Chengcheng Ma, Zhixi Su, Wenqiang Xiang, Lingyu Han, Wenqin Luo, Long Zhang, Renjie Wang, Yaodong Zhang, Wenming Zhang, Lin Yang, Renquan Lu, Lin Guo, Ying Zheng, Mingzhu Huang, Ye Xu, Li Liang, Sanjun Cai, Guoxiang Cai
Summary: This study developed a noninvasive detection method for early detection and prognosis prediction of colorectal cancer based on circulating tumor DNA (ctDNA) methylation haplotype patterns. The analysis of plasma samples from 1138 individuals revealed the accuracy of ctDNA methylation patterns in distinguishing healthy individuals, advanced adenoma patients, and colorectal cancer patients. The method showed high accuracy and sensitivity, and high methylation levels were associated with poor prognosis.
Article
Engineering, Multidisciplinary
Shuai Zhang, Zhongqiu Wang, Jianhua Yang
Summary: The paper studies the dynamic response of a Duffing system from self-induced resonance to system resonance. Numerical simulation shows that the system response gradually transitions from self-induced resonance to system resonance with the increase of the pulse amplitude of the signal. To describe this process, the quality factor of the system response is defined. A novel method is developed to evaluate the severity of rolling bearing early damage based on the evolution from self-induced resonance to system resonance.
ASCE-ASME JOURNAL OF RISK AND UNCERTAINTY IN ENGINEERING SYSTEMS PART B-MECHANICAL ENGINEERING
(2023)
Article
Acoustics
Zhen Shan, Zhongqiu Wang, Jianhua Yang, Dengji Zhou, Houguang Liu
Summary: In this paper, a novel general time-varying scale transformation aperiodic stochastic resonance method is proposed to extract and enhance weak non-stationary signals under strong noise background. The method has stronger noise robustness and can provide output with higher signal-to-noise ratio and cross-correlation coefficient.
JOURNAL OF VIBRATION AND CONTROL
(2023)
Article
Oncology
Rui Zhao, Shuai Ren, Changyin Li, Kai Guo, Zipeng Lu, Lei Tian, Jian He, Kai Zhang, Yingying Cao, Shijia Liu, Donghui Li, Zhongqiu Wang
Summary: This study identified metabolic features of pancreatic ductal adenocarcinoma (PDAC) and discovered potential early detection biomarkers for PDAC through tissue and serum metabolomics analysis. The identified biomarker panel showed promising performance in distinguishing PDAC from benign pancreatic neoplasms and healthy controls, especially when combined with carbohydrate antigen 19-9 (CA19-9).
Article
Environmental Sciences
You Lu, Jing Cheng, Qixing Mao, Zhongqiu Wang, Qiang Wei
Summary: This study reveals the regulatory role of long non-coding RNA TDRG1 in the stemness of lung cancer cells. It was found that TDRG1 directly binds to Sox2 mRNA, a critical stemness regulator, and enhances its stability, thereby promoting the stemness of lung cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Kai Guo, Dong Chen, Shuai Ren, Muhammad Rizwan Younis, Zhaogang Teng, Longjiang Zhang, Zhongqiu Wang, Ying Tian
Summary: Immune checkpoint blockade therapy and photothermal therapy have great potential in cancer treatment. Using MK-8628 and HPDA@MK as non-antibody methods, both PD-L1 and CD47 can be simultaneously suppressed, immune response can be activated, and the combined therapeutic effect can be enhanced, providing a feasible approach for the treatment of other solid tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Oncology
Cheng Wang, Tingting Lin, Xin Chen, Wenjing Cui, Chuangen Guo, Zhongqiu Wang, Xiao Chen
Summary: This study aimed to investigate the association between pain and the grade of pancreatic neuroendocrine neoplasms (PNENs). The results showed that 30.6% of the patients experienced pain, which was associated with vascular invasion and higher grade PNENs. The researchers developed a nomogram model to predict the grade of PNENs, which showed good diagnostic performance.
Article
Chemistry, Multidisciplinary
Ying Tian, Muhammad Rizwan Younis, Yatong Zhao, Kai Guo, Jiayingzi Wu, Longjiang Zhang, Peng Huang, Zhongqiu Wang
Summary: Researchers have developed a nanomodulator based on mesoporous polydopamine nanoparticles for combinational photothermal-immunotherapy. This nanomodulator improves immunotherapy outcomes by restoring immune suppression and providing thermal therapy for tumor treatment. The nanomodulator has excellent biocompatibility, water solubility, and imaging abilities. It can precisely deliver and release immune inhibitors at tumor sites, effectively reversing immune suppression and enhancing therapeutic efficacy.
Article
Physics, Multidisciplinary
Zhongqi Xu, Zhongqiu Wang, Jianhua Yang, Miguel A. F. Sanjuan, Bowen Sun, Shengping Huang
Summary: We investigated aperiodic stochastic resonance (ASR) in a biased monostable system subjected to weak aperiodic pulse signals and strong noise. Compared with the bistable system, the biased monostable system has a unique advantage in processing weak aperiodic pulse signals. The effects of noise, system parameters, and iteration step on ASR were examined in detail. The results showed that ASR induced by a certain noise intensity was more pronounced, and there were optimal system parameters and iterative steps to achieve the best ASR output. The shape and potential well height of the biased monostable system can be fine-tuned from multiple angles to achieve optimal output. An application study on weak damage signals of wire rope in a noise background verified the importance of ASR in the biased monostable system.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Environmental Sciences
Xinan Yue, Fanyu Liu, Junyi Wang, Yonghui Wang, Yihui Cai, Feng Ding, Baiqi Ning, Mingyuan Li, Ning Zhang, Zhongqiu Wang, Su Xu
Summary: In this study, ion line calibration was conducted based on experiments with the newly built SYISR. The calibration factor was obtained by simultaneous measurements of plasma line and ion line electron density, and it significantly improved the agreement between ion line f(o)F(2) and ionosonde results. The deviations after calibration might be caused by uncertainties in the calibration factor or ionosonde measurements. The plasma line calibration technique is expected to be enhanced with the upcoming completion of the SYISR Tristatic System.
Article
Oncology
Wenli Qiu, Hui Xie, Haibin Chen, Hongli Zhou, Zhongqiu Wang, Hongguang Zhou
Summary: This study evaluates the effect of Xiaoai Jiedu recipe (XJR) on colorectal cancer (CRC) and investigates its underlying mechanism. Both in vitro and in vivo experiments demonstrate the anti-CRC effect of XJR. It affects the gut microbiota and serum metabolic profiles, with beneficial bacteria increasing and aggressive bacteria decreasing. The study provides insights into the mechanism of XJR and its potential clinical application.
FRONTIERS IN ONCOLOGY
(2023)
Article
Materials Science, Characterization & Testing
Chen Yang, Zhongqiu Wang, Tao Gong, Jianhua Yang
Summary: A new diagnosis method for bearing unknown faults is proposed in this study, which can adaptively diagnose faults in single or multiple parts of the bearing. The method utilizes ensemble empirical mode decomposition and sample entropy index to select the target frequency band containing potential fault features. The advantages of sample entropy in anti-noise interference are also analyzed. The proposed approach is validated using both simulated and experimental signals.
RUSSIAN JOURNAL OF NONDESTRUCTIVE TESTING
(2023)
Article
Astronomy & Astrophysics
Xu Zhou, Xinan Yue, Junyi Wang, Yihui Cai, Feng Ding, Baiqi Ning, Yuyan Jin, Mingyuan Li, Yonghui Wang, Ning Zhang, Zhongqiu Wang, Junhao Luo
Summary: A new incoherent scattering radar in Sanya has allowed for direct measurements of the ionospheric E-F valley. It has revealed a fascinating phenomenon called ionospheric drizzle, which manifests as weak plasma streaks that detach from the F-layer base and extend downward to the sporadic E (Es) layer during pre-dawn hours. The frequently observed ionospheric drizzle provides additional plasma to enhance the Es layer, making it crucial for communication and navigation.
JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS
(2023)
Article
Acoustics
Darius Petermann, Gordon Wichern, Aswin Shanmugam Subramanian, Zhong-Qiu Wang, Jonathan Le Roux
Summary: Emulating the human ability to focus on a source of interest in a complex acoustic scene, this paper addresses the cocktail fork problem by separating an audio mixture into speech, music, and sound effects categories. Deep learning-based source separation models are evaluated using objective measures and metrics that correlate with human perception. The impact of source separation on downstream transcription tasks is thoroughly evaluated, and the remixing of separated source stems is investigated to reduce artifacts and improve transcription performance.
IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING
(2023)
Article
Health Care Sciences & Services
Ying-Ying Cao, Kai Guo, Rui Zhao, Yuan Li, Xiao-Jing Lv, Zi-Peng Lu, Lei Tian, Shuai Ren, Zhong-Qiu Wang
Summary: This study developed a potential biomarker model for the detection of resectable pancreatic ductal adenocarcinoma (PDAC) using tissue and serum metabolomics. The panel of three metabolites, including 16-hydroxypalmitic acid, phenylalanine, and norleucine, showed promising potential in distinguishing resectable PDAC from healthy controls.
Article
Oncology
Huifeng Zhang, Yingying Cao, Shuai Ren, Kai Guo, Yaping Zhang, Tingting Lin, Yaohui Wang, Xiao Chen, Zhongqiu Wang
Summary: This study explored independent risk factors and determined the threshold value of the main pancreatic duct (MPD) diameter in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). The results showed that MPD diameter and mural nodule were independent associated factors with high-risk IPMNs. A cutoff value of 0.77 cm MPD diameter may be a threshold in identifying malignant IPMNs or undergoing surgical resection.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)