Article
Medical Laboratory Technology
Lu Zhou, Huirong Li, Jiangtao Hu, Junping Meng, Honghong Lv, Feng Yang, Mengqiu Wang, Rui Liu, Wei Wu, Donghua Hou, Hongbao Liu
Summary: This study analyzed the oxidative lipidomics of plasma from patients with sepsis-associated acute kidney injury (SA-AKI) and identified potential biomarkers and pathophysiological mechanisms involved in SA-AKI.
CLINICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Masayoshi Saito, Satoshi Horie, Hidenori Yasuhara, Akane Kashimura, Eiji Sugiyama, Takeaki Saijo, Hajime Mizuno, Hiroshi Kitajima, Kenichiro Todoroki
Summary: Extracellular vesicles (EVs) are lipid bilayer particles released by cells that can serve as a noninvasive snapshot of cell status and potential liquid biopsy-based biomarkers. Metabolome analysis of urine EVs in rats with drug-induced kidney injury identified potential biomarkers reflecting the type and extent of injury. Pathway analysis indicated that these metabolites may provide insights into cellular changes during kidney injury, suggesting the utility of urinary EVs metabolomics as an informative tool.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Urology & Nephrology
Yumeng Wen, Heather Thiessen-Philbrook, Dennis G. Moledina, James S. Kaufman, W. Brian Reeves, Nasrollah Ghahramani, T. Alp Ikizler, Alan S. Go, Kathleen D. Liu, Eddie D. Siew, Jonathan Himmelfarb, Paul L. Kimmel, Chi-yuan Hsu, Chirag R. Parikh
Summary: This study evaluated the impact of using urine creatinine or urine osmolarity as indices to control for urine concentration on the association between biomarkers and the development of chronic kidney disease (CKD) in patients with acute kidney injury (AKI). The results showed that indexing or adjusting for urine concentration can strengthen the associations and improve the predictions for CKD for some biomarkers, but not for others. Therefore, the incorporation of urinary concentration should be individualized for each biomarker in research and clinical applications.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Jonathan G. Amatruda, Michelle M. Estrella, Amit X. Garg, Heather Thiessen-Philbrook, Eric McArthur, Steven G. Coca, Chirag R. Parikh, Michael G. Shlipak
Summary: Preoperative U alpha 1m concentrations may identify patients at high risk of AKI and other adverse events after cardiac surgery, but postoperative U alpha 1m concentrations do not appear to be informative in predicting adverse outcomes.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
Ibrahim Sandokji, Jason H. Greenberg
Summary: Serum creatinine and proteinuria, traditional biomarkers of chronic kidney disease (CKD) progression, do not fully explain the variability of glomerular filtration rate decline and are late markers. Recent studies have identified novel plasma and urine biomarkers at higher levels in children with CKD, independently associated with CKD progression, even after adjustment for serum creatinine and proteinuria.
SEMINARS IN NEPHROLOGY
(2021)
Article
Critical Care Medicine
Tianlong Li, Jiahao Zhang, Minghui Long, Xiaofang Jiang, Cheng Yang, Fengqin Wang, Lianjiu Su, Zhiyong Peng
Summary: This study found that serum MIF level might serve as a biomarker for predicting the occurrence, development, and outcomes of septic AKI.
Review
Medical Laboratory Technology
Yumeng Wen, Chirag R. Parikh
Summary: Biomarkers play a crucial role in the diagnosis, treatment, and prognosis of acute kidney injury (AKI), with potential clinical implications. Different biomarkers are involved in distinct pathophysiological processes after kidney injury.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2021)
Review
Endocrinology & Metabolism
Ning Gao, Hui-Qing Lu, Ting-Ting Zou, Li -Ping Ren, Ke Cai, Yue Li, Xue-Hua Pu, Ji-Lu Ye
Summary: Acute kidney injury (AKI) can be caused by various factors and early diagnosis and timely treatment are crucial. Subclinical AKI refers to the diagnosis of AKI based solely on elevated markers. In recent years, there have been many studies on biomarkers for early diagnosis of AKI, resulting in the emergence of several novel biomarkers.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Genetics & Heredity
Nicholas Kueng, Severine Arcioni, Fanny Sandberg, Christian Kuhn, Vanessa Banz, Carlo R. Largiader, Daniel Sidler, Ursula Amstutz
Summary: Liquid biopsy using quantification of donor-derived cell-free DNA (dd-cfDNA) in plasma has become a novel approach for allograft monitoring in solid organ transplant recipients. This study compared different dd-cfDNA quantification methods and found that the presented high-throughput sequencing method showed strong correlation with existing methods. Absolute levels of dd-cfDNA in urine may be required for allograft surveillance in stable kidney recipients due to extensive variability of relative amounts.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, Research & Experimental
Lili Yue, Yulu Gu, Juntian Xu, Tongqiang Liu
Summary: Septic acute kidney injury (SAKI) is a common and life-threatening complication of sepsis, with unclear pathogenesis and unsatisfactory treatment options. This review summarizes the involvement of noncoding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, in SAKI. The roles, expression patterns, functions, and molecular mechanisms of ncRNAs in SAKI are elaborated, and their potential as diagnostic and prognostic biomarkers and therapeutic targets are discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medical Laboratory Technology
Ahram Yi, Chang-Hoon Lee, Yeo-Min Yun, Hanah Kim, Hee-Won Moon, Mina Hur
Summary: The study suggests that PNGAL may be a useful biomarker for predicting AKI in high-risk patients, however UNGAL may be more effective in predicting AKI in patients with CKD.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Biology
Sahra Pajenda, Ludwig Wagner, Daniela Gerges, Harald Herkner, Tamar Tevdoradze, Karl Mechtler, Alice Schmidt, Wolfgang Winnicki
Summary: Acute kidney injury (AKI) is a leading complication in hospitalized patients, and urinary collectrin may serve as a biomarker for early detection of AKI.
Review
Critical Care Medicine
Li-Chun Lin, Min-Hsiang Chuan, Jung-Hua Liu, Hung-Wei Liao, Leong L. Ng, Martin Magnusson, Amra Jujic, Heng-Chih Pan, Vin-Cent Wu, Lui G. Forni
Summary: Our meta-analysis of 11 observational studies with 3969 patients showed that proenkephalin A 119-159 (PENK) has significant potential as a biomarker for early detection of acute kidney injury (AKI), with a cutoff value of 57.3 pmol/L. The overall sensitivity and specificity of PENK in identifying AKI were 0.69 (95% CI 0.62-0.75) and 0.76 (95% CI 0.68-0.82), respectively. The combined positive likelihood ratio (LR) was 2.83 (95% CI 2.06-3.88), and the negative LR was 0.41 (95% CI 0.33-0.52). The summary receiver operating characteristic (SROC) curve demonstrated a pooled diagnostic accuracy of 0.77 (95% CI 0.73-0.81). Interestingly, patients with a history of hypertension or heart failure showed lower specificity of PENK in correlating with the development of AKI.
Article
Critical Care Medicine
L. Boutin, M. Legrand, M. Sadoune, A. Mebazaa, E. Gayat, C. E. Chadjichristos, F. Depret
Summary: Plasma levels of Gal-3 are strongly associated with renal function, with an increased risk of MAKE and death after ICU admission.
Article
Medical Laboratory Technology
Zhimin Huang, Lin Wu, Ming Zeng, Buyun Wu, Xueqiang Xu, Huijuan Mao, Yanggang Yuan, Changying Xing
Summary: This study aimed to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) in differentiating acute kidney injury (AKI) from chronic kidney disease (CKD). The results showed that urinary NGAL (uNGAL) levels were significantly higher in the AKI group compared to the CKD group, while serum NGAL (sNGAL) levels were not significantly different. Furthermore, the u/s NGAL ratio and fractional excretion of NGAL (Fe NGAL) were able to effectively distinguish AKI from CKD. Further confirmatory studies are still necessary.
CLINICA CHIMICA ACTA
(2022)
Article
Genetics & Heredity
Andre Kraus, Gunnar Schley, Karl Kunzelmann, Rainer Schreiber, Dorien J. M. Peters, Ruth Stadler, Kai-Uwe Eckardt, Bjoern Buchholz
JOURNAL OF MOLECULAR MEDICINE-JMM
(2016)
Article
Urology & Nephrology
Gunnar Schley, Holger Scholz, Andre Kraus, Thomas Hackenbeck, Bernd Klanke, Carsten Willam, Michael S. Wiesener, Eva Heinze, Nicolai Burzlaff, Kai-Uwe Eckardt, Bjoern Buchholz
KIDNEY INTERNATIONAL
(2015)
Article
Physiology
Melanie Vogler, Anke Zieseniss, Amke R. Hesse, Elif Levent, Malte Tiburcy, Eva Heinze, Nicolai Burzlaff, Gunnar Schley, Kai Uwe Eckardt, Carsten Willam, Doerthe M. Katschinski
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2015)
Article
Cell Biology
Isabel Siegert, Johannes Schoedel, Manfred Nairz, Valentin Schatz, Katja Dettmer, Christopher Dick, Joanna Kalucka, Kristin Franke, Martin Ehrenschwender, Gunnar Schley, Angelika Beneke, Joerg Sutter, Matthias Moll, Claus Hellerbrand, Ben Wielockx, Doerthe M. Katschinski, Roland Lang, Bruno Galy, Matthias W. Hentze, Peppi Koivunen, Peter J. Oefner, Christian Bogdan, Guenter Weiss, Carsten Willam, Jonathan Jantsch
Review
Urology & Nephrology
Bjoern Buchholz, Gunnar Schley, Kai-Uwe Eckardt
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2016)
Article
Immunology
Valentin Schatz, Yannic Strussmann, Alexander Mahnke, Gunnar Schley, Maximilian Waldner, Uwe Ritter, Jens Wild, Carsten Willam, Nathalie Dehne, Bernhard Brune, Jennifer M. McNiff, Oscar R. Colegio, Christian Bogdan, Jonathan Jantsch
JOURNAL OF IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Andre Kraus, Steffen Grampp, Margarete Goppelt-Struebe, Rainer Schreiber, Karl Kunzelmann, Dorien J. M. Peters, Jens Leipziger, Gunnar Schley, Johannes Schoedel, Kai-Uwe Eckardt, Bjoern Buchholz
Purinergic Signalling
(2016)
Article
Multidisciplinary Sciences
Gunnar Schley, Jutta Jordan, Stephan Ellmann, Seymour Rosen, Kai-Uwe Eckardt, Michael Uder, Carsten Willam, Tobias Baeuerle
Article
Urology & Nephrology
Andre Kraus, Dorien J. M. Peters, Bernd Klanke, Alexander Weidemann, Carsten Willam, Gunnar Schley, Karl Kunzelmann, Kai-Uwe Eckardt, Bjoern Buchholz
KIDNEY INTERNATIONAL
(2018)
Article
Chemistry, Medicinal
Marleen Mayer, Kerstin Fey, Eva Heinze, Christian R. Wick, Martine I. Abboud, Tzu-Lan Yeh, Anthony Tumber, Nicole Orth, Gunnar Schley, Bjoern Buchholz, Timothy Clark, Christopher J. Schofield, Carsten Willam, Nicolai Burzlaff
Article
Urology & Nephrology
Rainer Schreiber, Bjoern Buchholz, Andre Kraus, Gunnar Schley, Julia Scholz, Jiraporn Ousingsawat, Karl Kunzelmann
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Cell Biology
Gunnar Schley, Steffen Grampp, Margarete Goppelt-Struebe
CELL AND TISSUE RESEARCH
(2020)
Article
Neurosciences
Katharina A. E. Broeker, Michaela A. A. Fuchs, Julia Schrankl, Claudia Lehrmann, Gunnar Schley, Vladimir T. Todorov, Christian Hugo, Charlotte Wagner, Armin Kurtz
Summary: Renal renin-expressing cells can be divided into two subgroups, with interstitial renin(+) cells belonging to the pool of native EPO-producing cells and showing a fast response to acute hypoxia. Deletion of both PHD2 and PHD3 is necessary for inducing EPO expression in juxtaglomerular renin(+) cells.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Urology & Nephrology
Kei Schulz, Yohannes Hagos, Gerhard Burckhardt, Gunnar Schley, Nikolai Burzlaff, Carsten Willam, Birgitta C. Burckhardt