The Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal Applications

Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012

(2015) Katharine J. Looker et al.   PLoS One

Herpes simplex virus drug-resistance

(2013) Graciela Andrei et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents

(2013) M. I. Petrova et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications

(2013) Geoffrey Férir et al.   PLoS One

Role of the Carbohydrate-Binding Sites of Griffithsin in the Prevention of DC-SIGN-Mediated Capture and Transmission of HIV-1

(2013) Bart Hoorelbeke et al.   PLoS One

Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

(2012) Geoffrey Férir et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Systemic and Topical Drugs for the Prevention of HIV Infection: Antiretroviral Pre-exposure Prophylaxis

(2012) Jared Baeten et al.   Annual Review of Medicine

Herpes simplex virus and HIV: genital infection synergy and novel approaches to dual prevention

(2012) A R Thurman et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Herpes Simplex Virus 2 (HSV-2) Prevents Dendritic Cell Maturation, Induces Apoptosis, and Triggers Release of Proinflammatory Cytokines: Potential Links to HSV-HIV Synergy

(2012) Martha Stefanidou et al.   JOURNAL OF VIROLOGY

Lignosulfonic Acid Exhibits Broadly Anti-HIV-1 Activity – Potential as a Microbicide Candidate for the Prevention of HIV-1 Sexual Transmission

(2012) Min Qiu et al.   PLoS One

Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120

(2012) Geoffrey Férir et al.   VIROLOGY

Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1

(2012) Vanessa Pirrone et al.   Virology Journal

Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women

(2011) Salim S Abdool Karim et al.   AIDS

The rise and fall of polyanionic inhibitors of the human immunodeficiency virus type 1

(2011) Vanessa Pirrone et al.   ANTIVIRAL RESEARCH

Topical Tenofovir, a Microbicide Effective against HIV, Inhibits Herpes Simplex Virus-2 Replication

(2011) Graciela Andrei et al.   Cell Host & Microbe

Consistent Inhibition of HIV-1 Replication in CD4+ T Cells by Acyclovir without Detection of Human Herpesviruses

(2011) M. A. McMahon et al.   JOURNAL OF VIROLOGY

Resistance of Human Immunodeficiency Virus Type 1 to a Third-Generation Fusion Inhibitor Requires Multiple Mutations in gp41 and Is Accompanied by a Dramatic Loss of gp41 Function

(2011) D. Eggink et al.   JOURNAL OF VIROLOGY

A time-of–drug addition approach to target identification of antiviral compounds

(2011) Dirk Daelemans et al.   Nature Protocols

Bridging the Gap between Preclinical and Clinical Microbicide Trials: Blind Evaluation of Candidate Gels in Murine Models of Efficacy and Safety

(2011) Theodore J. Segarra et al.   PLoS One

Myeloid dendritic cells in HIV-1 infection

(2011) Nina Derby et al.   Current Opinion in HIV and AIDS

HSV-2 Infection of Dendritic Cells Amplifies a Highly Susceptible HIV-1 Cell Target

(2011) Elena Martinelli et al.   PLoS Pathogens

Synthesis, antiviral and contraceptive activities of nucleoside–sodium cellulose sulfate acetate and succinate conjugates

(2010) Hitesh K. Agarwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1

(2009) Dana Huskens et al.   ANTIVIRAL RESEARCH

Entry inhibitors in the treatment of HIV-1 infection

(2009) John C. Tilton et al.   ANTIVIRAL RESEARCH

Disruption of Tight Junctions by Cellulose Sulfate Facilitates HIV Infection: Model of Microbicide Safety

(2009) Pedro M. M. Mesquita et al.   JOURNAL OF INFECTIOUS DISEASES

Mechanism of Human Immunodeficiency Virus Type 1 Resistance to Monoclonal Antibody b12 That Effectively Targets the Site of CD4 Attachment

(2009) X. Wu et al.   JOURNAL OF VIROLOGY

Acyclovir Is Activated into a HIV-1 Reverse Transcriptase Inhibitor in Herpesvirus-Infected Human Tissues

(2008) Andrea Lisco et al.   Cell Host & Microbe

Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN

(2008) M. A. W. P. de Jong et al.   JOURNAL OF GENERAL VIROLOGY

Acyclovir‐Resistant Corneal HSV‐1 Isolates from Patients with Herpetic Keratitis

(2008) Rui Duan et al.   JOURNAL OF INFECTIOUS DISEASES

Avoiding the void: cell-to-cell spread of human viruses

(2008) Quentin Sattentau   NATURE REVIEWS MICROBIOLOGY

Genital Herpes Has Played a More Important Role than Any Other Sexually Transmitted Infection in Driving HIV Prevalence in Africa

(2008) Laith J. Abu-Raddad et al.   PLoS One

Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains

(2008) Y. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA