Resistance of Human Immunodeficiency Virus Type 1 to a Third-Generation Fusion Inhibitor Requires Multiple Mutations in gp41 and Is Accompanied by a Dramatic Loss of gp41 Function

Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41

(2011) Cleo G. Anastassopoulou et al.   VIROLOGY

Inhibition of HIV-1 by Fusion Inhibitors

(2010) Dirk Eggink et al.   CURRENT PHARMACEUTICAL DESIGN

In VitroSelection and Characterization of HIV-1 Variants with Increased Resistance to Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

(2010) Zhonghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

(2010) Andrés Finzi et al.   MOLECULAR CELL

Detailed Mechanistic Insights into HIV-1 Sensitivity to Three Generations of Fusion Inhibitors

(2009) Dirk Eggink et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Amphiphilicity and Negative Charge in Glycoprotein 41 Interactions in the Hydrophobic Pocket

(2009) Miriam Gochin et al.   JOURNAL OF MEDICINAL CHEMISTRY

X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution

(2009) Tsuyoshi Watabe et al.   JOURNAL OF MOLECULAR BIOLOGY

The Heptad Repeat 2 Domain Is a Major Determinant for Enhanced Human Immunodeficiency Virus Type 1 (HIV-1) Fusion and Pathogenicity of a Highly Pathogenic HIV-1 Env

(2009) V. Sivaraman et al.   JOURNAL OF VIROLOGY

HR-2 Mutations in Human Immunodeficiency Virus Type 1 gp41 Restore Fusion Kinetics Delayed by HR-1 Mutations That Cause Clinical Resistance to Enfuvirtide

(2009) N. Ray et al.   JOURNAL OF VIROLOGY

Matrix and Envelope Coevolution Revealed in a Patient Monitored since Primary Infection with Human Immunodeficiency Virus Type 1

(2009) E. Beaumont et al.   JOURNAL OF VIROLOGY

Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41

(2009) C. G. Anastassopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry

(2009) Reem Berro et al.   PLoS Pathogens

SC29EK, a Peptide Fusion Inhibitor with Enhanced  -Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide

(2008) T. Naito et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design and Evaluation of Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

(2008) Yuxian He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Enfuvirtide‐Associated Mutational Pathways in HIV‐1 Gp41 Are Significantly Correlated With an Increase in CD4+Cell Count, Despite Virological Failure

(2008) Valentina Svicher et al.   JOURNAL OF INFECTIOUS DISEASES

Design of a Novel HIV-1 Fusion Inhibitor That Displays a Minimal Interface for Binding Affinity

(2008) Shinya Oishi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic Studies of a T20-Dependent Human Immunodeficiency Virus Type 1 Variant

(2008) C. Baldwin et al.   JOURNAL OF VIROLOGY

Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution

(2008) I. Bontjer et al.   JOURNAL OF VIROLOGY

Selection of T1249-Resistant Human Immunodeficiency Virus Type 1 Variants

(2008) D. Eggink et al.   JOURNAL OF VIROLOGY

Conserved Salt Bridge between the N- and C-Terminal Heptad Repeat Regions of the Human Immunodeficiency Virus Type 1 gp41 Core Structure Is Critical for Virus Entry and Inhibition

(2008) Y. He et al.   JOURNAL OF VIROLOGY

Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase

(2008) Marleen CDG Huigen et al.   Retrovirology

Peptide Mimic of the HIV Envelope gp120–gp41 Interface

(2007) Sunghwan Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

T-20 and T-1249 HIV fusion inhibitors' structure and conformation in solution: a molecular dynamics study

(2007) António M. T. Martins Do Canto et al.   JOURNAL OF PEPTIDE SCIENCE