Article
Oncology
Linyan Yu, Zhaozhong Wang, Yuan Hu, Yanan Wang, Nan Lu, Cai Zhang
Summary: Gamma delta T-cells recognize infected or transformed cells and are associated with antitumor immune response. This study found that tumor-infiltrating gamma delta T-cells exhibit functional exhaustion in colorectal cancer (CRC) and identified three distinct exhausted subsets of gamma delta T-cells. The transcription factor c-Maf was shown to play a key role in gamma delta T-cell exhaustion. These findings provide insights into the mechanisms and association of gamma delta T-cell exhaustion with tumor development and pathogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Immunology
Ming Zheng, Yi-Ming Li, Zhen-Yu Liu, Xin Zhang, Yinghui Zhou, Jian-Li Jiang, Ping Zhu, Xiang-Min Yang, Juan Tang, Zhi-Nan Chen
Summary: Immunotherapy targeting tumor-infiltrating lymphocytes has shown promising potential as a treatment for various cancers, but its efficacy varies across different cancer types and patients. The distribution of TIL-T and TIL-B cells and their interactions with the tumor microenvironment play a crucial role in determining the clinical outcomes. Understanding the prognostic significance of these factors can have important implications for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zeev Elkoshi
Summary: Tumor-infiltrating lymphocytes, particularly the frequencies of regulatory T cells (Tregs) and CD8+ T cells, are important prognostic markers in cancer. The correlation between intra-tumoral Tregs and survival can vary depending on the type of cancer. This study suggests using the frequency ratio of lymphocytes as the preferred marker in most cancer types, as it shows a direct correlation with survival and is less variable compared to individual lymphocyte frequencies. However, if the frequency of one lymphocyte is highly variable, it may be beneficial to focus on the lymphocyte with a less variable frequency to improve the correlation with survival, especially when the intra-tumoral frequencies of the two species are inversely correlated. The marker selected using this approach may also be a good predictor of checkpoint inhibitor therapy success.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ben Yi, Shuai Zhang, Suying Yan, Yanfei Liu, Zhiqiang Feng, Tianhao Chu, Jun Liu, Wei Wang, Jun Xue, Chunze Zhang, Yijia Wang
Summary: The study found that Marsdenia tenacissima extract (MTE) can inhibit the expression of TGF-beta 1 and PD-L1 in colorectal cancer cells. In both in vitro and in vivo experiments, MTE also increased the density of CD3+/CD8+ tumor-infiltrating T cells and exhibited significant tumor-suppressive effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sara Valpione, Piyushkumar A. Mundra, Elena Galvani, Luca G. Campana, Paul Lorigan, Francesco De Rosa, Avinash Gupta, John Weightman, Sarah Mills, Nathalie Dhomen, Richard Marais
Summary: High baseline T cell receptor diversity is predictive of favorable prognosis in multiple cancer types, while monoclonal expansion of T cells pre-treatment correlates with good response to immune checkpoint blockade therapy in metastatic melanoma patients.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Sonia Aristin Revilla, Onno Kranenburg, Paul J. Coffer
Summary: Colorectal cancer is a heterogeneous disease with a high incidence and mortality rate worldwide. Tumor-infiltrating lymphocytes (TILs), particularly regulatory T (Treg) cells, play an important role in anti-tumor immunity. Increased numbers of Treg cells in colorectal tumors are associated with tumor development, immunotherapy failure, and a poorer prognosis. Targeting Treg cells is a potential strategy to improve cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
A. Reum Kim, Kyu Sung Choi, Min-Sung Kim, Kyung-Min Kim, Ho Kang, Sojin Kim, Tamrin Chowdhury, Hyeon Jong Yu, Chae Eun Lee, Joo Ho Lee, Soon-Tae Lee, Jae Kyung Won, Jin Wook Kim, Yong-Hwy Kim, Tae Min Kim, Sung-Hye Park, Seung Hong Choi, Eui-Cheol Shin, Chul-Kee Park
Summary: Quantifying tumor-infiltrating immune cells helps understand the heterogeneity of the immune microenvironment in HGG, which has prognostic implications. Radiomic signatures can predict this immune microenvironment non-invasively.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Wei Shi, Mackenzie Fijardo, Jeff P. Bruce, Jie Su, Wei Xu, Rachel Bell, Pierre-Antoine Bissey, Angela B. Y. Hui, John Waldron, Trevor J. Pugh, Kenneth W. Yip, Fei-Fei Liu
Summary: This study reveals the prognostic significance of CD8+ tumor-infiltrating lymphocytes (TILs) in naso-pharyngeal cancer (NPC) and suggests the potential of utilizing CD8+ lymphocytes for immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Yifan Xie, Feng Xie, Lei Zhang, Xiaoxue Zhou, Jun Huang, Fangwei Wang, Jin Jin, Long Zhang, Linghui Zeng, Fangfang Zhou
Summary: In the tumor microenvironment, immune cells such as T cells and B cells play crucial roles in anti-tumor immunotherapy. Understanding the functions of these cells can lead to novel therapies that induce specific anti-tumor immune responses, benefiting certain groups of patients. Various anti-tumor therapy approaches based on different immune cells are being explored for future applications in cancer treatment.
Article
Biochemistry & Molecular Biology
Jesus Machuca-Aguado, Antonio Felix Conde-Martin, Alejandro Alvarez-Munoz, Enrique Rodriguez-Zarco, Alfredo Polo-Velasco, Antonio Rueda-Ramos, Rosa Rendon-Garcia, Juan Jose Rios-Martin, Miguel A. Idoate, Apostolos Zaravinos
Summary: This study utilized a machine learning system to classify and quantify tumor-infiltrating lymphocytes in high-grade serous ovarian carcinoma (HGSOC) patients, and correlated the results with patient survival. The results showed that intense colonization of tumor cords by TILs was associated with a better prognosis. Furthermore, the concentration of intraepithelial TILs was found to be an independent prognostic factor for overall survival and progression-free survival. Additionally, a synergistic effect was observed between complete surgical cytoreduction and high levels of intraepithelial TILs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yingcheng Zhang, You Liu, Xiaomei Qiu, Bing Yan
Summary: In colorectal cancer, tumor budding, tumor infiltrating pattern, and preoperative lymphocyte-to-monocyte ratio have been proven to be important prognostic markers for predicting patient survival, with the preoperative lymphocyte-to-monocyte ratio potentially being the most significant independent prognostic factor.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Immunology
Xi Yang, Quan Qi, Yuefen Pan, Qing Zhou, Yinhang Wu, Jing Zhuang, Jiamin Xu, Mingyue Pan, Shuwen Han
Summary: This study characterized tumor-infiltrating T cell populations in colorectal cancer using single-cell RNA sequencing data, revealing distinct T cell subgroups in tumor tissue and peripheral blood. Differences in tumor-infiltrating T cell populations between colon cancer and rectal cancer were identified, with changes in gene expression patterns observed in both cancer types.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Paris M. M. Kollis, Lisa M. M. Ebert, John Toubia, Cameron R. R. Bastow, Rebecca J. J. Ormsby, Santosh I. I. Poonnoose, Sakthi Lenin, Melinda N. N. Tea, Stuart M. M. Pitson, Guillermo A. A. Gomez, Michael P. P. Brown, Tessa Gargett
Summary: This study characterized the chemokine receptor and integrin expression profiles of endogenous glioblastoma-infiltrating T cells and identified potential homing receptor-ligand pairs that could enhance the tumour-homing properties of future T-cell immunotherapies for glioblastoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qi Zou, Xiaolin Wang, Donglin Ren, Bang Hu, Guannan Tang, Yu Zhang, Meijin Huang, Rish K. Pai, Daniel D. Buchanan, Aung Ko Win, Polly A. Newcomb, William M. Grady, Huichuan Yu, Yanxin Luo
Summary: This study developed a DNA methylation-based signature for CD8+ TILs in colorectal cancer, which showed a strong association with prognosis and immune markers. The QASM assay developed for CD8+ MeTIL markers provided a quantitative and accurate measurement of CD8+ TILs distribution in tumor tissues, indicating potential as a biomarker for therapeutic approaches, including immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Shirin Tavana, Zahra Mokhtari, Mohammad Hossein Sanei, Zahra Heidari, Amir-Reza Dehghanian, Zahra Faghih, Marzieh Rezaei
Summary: This study investigated the presence of CD45RO+, LAG3+, CD3+, and CD8+ lymphocytes in colorectal cancer (CRC) tumor tissues and their association with clinicopathological parameters and patient survival. The results showed that CD45RO+ and CD3+ cells were the most frequent infiltrating lymphocytes in colon tumor tissues, while LAG3+ lymphocytes were the least frequent subset. The frequency of CD45RO+ TILs was positively associated with advanced TNM stages, and high scores of CD45RO+ TILs in the invasive margin were associated with better overall survival.
CANCER CELL INTERNATIONAL
(2023)
