Review
Nutrition & Dietetics
Kumari Neelam, Sonali Dey, Ralene Sim, Jason Lee, Kah-Guan Au Eong
Summary: Fructus lycii, an exotic berry-type fruit of the plant Lycium barbarum, is known for its high antioxidant potential and has been used in traditional Chinese home cooking and medicine for centuries. Despite its wide range of biological activities like antioxidant, anti-inflammatory effects, its role in clinical management of retinal diseases is yet to be established.
Article
Food Science & Technology
Deepak Kumar Koli, Shalini Gaur Rudra, Arpan Bhowmik, Sunil Pabbi
Summary: Incorporating spirulina powder into pasta increases its nutritional content and functional properties without affecting its texture and sensory attributes. The enriched pasta contains higher levels of gamma-linolenic acid, docosahexaenoic acid, phenolics, flavonoids, and antioxidants compared to regular pasta. Pasta enriched with 12.5% spirulina is highly liked and has a high purchase intention.
Article
Biochemistry & Molecular Biology
Wenyi Tang, Jingli Guo, Wei Liu, Jun Ma, Gezhi Xu
Summary: The study revealed that light exposure induced pro-ferroptotic changes in photoreceptor cells, suggesting the involvement of ferroptosis in light-induced retinal degeneration. Treatment with ferrostatin-1 alleviated the effects of light-induced ferroptosis and protected the retina from damage, indicating its potential as a novel therapeutic target for preventing retinal degeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Hanhan Wu, Beijing Zhu, Daijin Li, Jing Xu, Jie Chang, Xiaoye Du, Jingang Cui, Ning Zhang, Teng Zhang, Yu Chen
Summary: This study demonstrates for the first time that Cuscuta chinensis Lam. (CCL) has protective effects on photoreceptors, alleviating the damage caused by photooxidative stress to retinal structure and function, and maintaining immune homeostasis. These findings provide novel evidence supporting the clinical application of CCL in the prevention and treatment of photoreceptor degenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li, Lili Gong
Summary: This study demonstrates that targeted degradation of BET by dBET6 exerts neuroprotective effects by inhibiting cGAS-STING in reactive retinal macrophages/microglia, and it is expected to become a new strategy for the treatment of retinal degeneration.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Biancamaria Longoni, Gian Carlo Demontis
Summary: The retina is vulnerable to oxidative stress due to its high content of polyunsaturated lipids, exposure to blue light, and abundant oxygen supply. Lipid peroxidation and inflammation caused by reactive species are associated with retinal degeneration. This review summarizes recent evidence that shows how retinal polyunsaturated lipids can counteract the inflammatory response triggered by blue light-activated carotenoid derivatives, enabling the retina to function properly despite the prooxidant environment. Tight control of polyunsaturated lipid synthesis in retinal cells is crucial to balance their protective actions against lipid peroxidation induced by oxidative stress. Different transcriptional control mechanisms regulate polyunsaturated lipid synthesis throughout the lifespan of the retina. Additionally, the role of antioxidant nutrients like xanthophylls and carotenoids in enhancing retinal cells' antioxidant responses and protecting against prooxidant stimuli is discussed.
Article
Plant Sciences
Jia-Hao Feng, Xiao-Wei Dong, Hao-Li Yu, Wei Shen, Xian-Yu Lv, Rong Wang, Xue-Xiang Cheng, Fei Xiong, Xiao-Long Hu, Hao Wang
Summary: This study demonstrated that cynaroside can reduce blue light-induced A2E-laden ARPE-19 cell damage and oxidative stress, and protect against blue light-induced retinal degeneration by modulating autophagy and decreasing the NLRP3 inflammasome.
Article
Biochemistry & Molecular Biology
Guang-Ping Zou, Tao Wang, Jin-Xing Xiao, Xiao-Yu Wang, Li-Ping Jiang, Fang-Fang Tou, Zhi-Ping Chen, Xin-Hui Qu, Xiao-Jian Han
Summary: Age-related macular degeneration, a common cause of blindness in the elderly, is primarily attributed to oxidative stress and dysregulated autophagy in retinal pigment epithelium cells. Lactate has been found to act as a signaling molecule that protects against oxidative stress. This study aimed to investigate the protective effect of lactate against oxidative stress-induced retinal degeneration. The results showed that lactate alleviated oxidative stress-induced cell death and retinal degeneration by activating autophagy and preserving mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Nutrition & Dietetics
Lidia Ciccone, Susanna Nencetti, Armando Rossello, Lucia Barlettani, Nicolo Tonali, Paola Nieri, Elisabetta Orlandini
Summary: EPA and DHA, two omega-3 polyunsaturated fatty acids, are safe dietary supplements derived from fish oil that contribute to human health. Studies show that these fatty acids have a role in counteracting neurodegenerative processes related to amyloidogenic proteins. The research found that EPA and DHA can directly interact with TTR and contribute to stabilizing the TTR tetramer.
Review
Biochemistry & Molecular Biology
Jacek Dziedziak, Kaja Kasarello, Agnieszka Cudnoch-Jedrzejewska
Summary: Age-related macular degeneration (AMD) and glaucoma, both involving oxidative stress, are major causes of irreversible vision loss worldwide. Antioxidants play a crucial role in preventing these eye diseases, especially in individuals with diets rich in antioxidants. Numerous preclinical studies have demonstrated the efficacy of dietary antioxidants in combating neurodegeneration associated with AMD and glaucoma.
Article
Multidisciplinary Sciences
Ze-Hua Xu, Hang Zhang, Chang-Jun Zhang, Si-Jian Yu, Jing Yuan, Kangxin Jin, Zi-Bing Jin
Summary: With the increasing use of artificial light and optoelectronic products, light damage (LD) to the human retina has become a global issue. This study investigated the mechanism of how blue light leads to photoreceptor death and found that regenerating islet-derived 1 alpha (REG1A) prevents LD-induced apoptosis in photoreceptor cells by increasing the expression of the anti-apoptotic gene Bcl2 and decreasing the expression of the pro-apoptotic gene Bax. REG1A restores mitochondrial function and cell apoptosis after LD-induced damage, suggesting its potential application in the prevention and treatment of retinal vision loss.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hideyuki Shimizu, Kei Takayama, Kazuhisa Yamada, Ayana Suzumura, Tomohito Sato, Yoshiaki Nishio, Masataka Ito, Hiroaki Ushida, Koji M. Nishiguchi, Masaru Takeuchi, Hiroki Kaneko
Summary: The study aims to investigate the protective effect of dimethyl fumarate (DMF) against blue-light (BL) exposure in retinal pigment epithelial (RPE) cells. The results demonstrate that DMF can reduce reactive oxygen species (ROS) generation, decrease cell death rate and apoptosis in RPE cells induced by BL exposure. Additionally, DMF inhibits inflammation through activation of the NRF2 signaling pathway induced by BL exposure. Therefore, DMF has a protective effect on RPE cells against BL exposure.
Article
Nutrition & Dietetics
Thu Nguyen Minh Pham, Chae-Young Shin, Seo Hyun Park, Taek Hwan Lee, Hyeon Yeol Ryu, Sung-Bae Kim, Kwang Auh, Kwang Won Jeong
Summary: The study showed that an extract from Solanum melongena L. (eggplant) protected against blue light-induced cell death and inflammation in A2E-laden cells, potentially through the degradation of A2E. Chlorogenic acid isolated from the eggplant extract also exerted protective effects. In vivo, administration of the extract reduced retinal damage in a blue light-induced retinal damage model in mice, suggesting a potential role in AMD treatment.
Review
Chemistry, Medicinal
Shivani Khattar, Sauban Ahmed Khan, Syed Amir Azam Zaidi, Mahdi Darvishikolour, Uzma Farooq, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kurunian, Mohammed Zaafar Khan, Athar Shamim, Mohd Masih Uzzaman Khan, Zeenat Iqbal, Mohd Aamir Mirza
Summary: Resveratrol is a well-known phytochemical that is widely used in dietary supplements and botanical products. It has a wide range of pharmacological effects, including antioxidant, anti-cancer, and anti-inflammatory activities, and can be used to treat multiple diseases. Establishing safety, efficacy profile, and physicochemical characterization are the major requirements for its development as a phyto-pharmaceutical.
Article
Biochemistry & Molecular Biology
Kathy Beirne, Thomas J. Freeman, Malgorzata Rozanowska, Marcela Votruba
Summary: The study utilized aged mice models to investigate the therapeutic potential of photobiomodulation (PBM) for retinal ganglion cell (RGC) degeneration. Results showed that in vivo 670 nm light pretreatment inhibited RGC dendropathy, indicating the potential of PBM as a treatment for diseases involving RGC degeneration. Additionally, the study revealed a potential molecular mechanism priming the retina to resist future oxidative insult, suggesting a promising direction for further research and treatment development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Hayfa Medfai, Alia Khalil, Alexandre Rousseau, Vincent Nuyens, Martina Paumann-Page, Benjamin Sevcnikar, Paul G. Furtmueller, Christian Obinger, Nicole Moguilevsky, Olivier Peulen, Michael Herfs, Vincent Castronovo, Mohamed Amri, Pierre Van Antwerpen, Luc Vanhamme, Karim Zouaoui Boudjeltia
CARDIOVASCULAR RESEARCH
(2019)
Article
Neurosciences
Olfa Rebai, Mohamed Amri
NEUROTOXICITY RESEARCH
(2018)
Article
Reproductive Biology
Rym Belhareth, Soraya Mezouar, Amira Ben Amara, Celine Chartier, Eya Ben Azzouz, Eric Chabriere, Mohamed Amri, Jean-Louis Mege
REPRODUCTIVE TOXICOLOGY
(2018)
Article
Clinical Neurology
Sami Aboudhiaf, Georges Alves, Sandrine Parrott, Mohamed Amri, Megane M. Simonnet, Yael Grosjean, Gerard Maniere, Laurent Seugnet
Article
Neurosciences
Olivier Perche, Chloe Felgerolle, Maryvonne Ardourel, Audrey Bazinet, Arnaud Paris, Rafaelle Rossignol, Geraldine Meyer-Dilhet, Anne-Laure Mausset-Bonnefont, Betty Hebert, David Laurenceau, Celine Montecot-Dubourg, Arnaud Menuet, Jean-Charles Bizot, Jacques Pichon, Isabelle Ranchon-Cole, Sylvain Briault
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Clinical Neurology
Sami Aboudhiaf, Georges Alves, Sandrine Parrott, Mohamed Amri, Megane M. Simonnet, Yael Grosjean, Gerard Maniere, Laurent Seugnet
Article
Biochemistry & Molecular Biology
Hadhemi Kaddour, Yosra Hamdi, Fatma Amri, Seyma Bahdoudi, Ibtissem Bouannee, Jerome Leprince, Sami Zekri, Hubert Vaudry, Marie-Christine Tonon, David Vaudry, Mohamed Amri, Sana Mezghani, Olfa Masmoudi-Kouki
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Sarah Ben Youssef, Guillaume Brisson, Helene Doucet-Beaupre, Anne-Marie Castonguay, Charles Gora, Mohamed Amri, Martin Levesque
Summary: The study demonstrated the neuroprotective effect of GSSE on midbrain dopaminergic neurons in both in vitro and in vivo models of Parkinson's disease. GSSE effectively protected dopamine neurons from 6-OHDA toxicity by reducing apoptosis, ROS levels, and inflammation, ultimately improving neuronal loss and motor function in a PD model.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Samia Bouzghaya, Mohamed Amri, Fabrice Homble
JOURNAL OF MEDICINAL FOOD
(2020)
Article
Sport Sciences
Ghazi Racil, Mohamed C. Jlid, Mohamed S. Bouzid, Rime Sioud, Riadh Khalifa, Mohamed Amri, Sabri Gaied, Jeremy Coquart
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2020)
Article
Nutrition & Dietetics
Ingrid Munia, Laurent Gafray, Marie-Agnes Bringer, Pablo Goldschmidt, Lil Proukhnitzky, Nathalie Jacquemot, Christine Cercy, Khaoula Ramchani Ben Otman, Marie Helene Errera, Isabelle Ranchon-Cole
Article
Food Science & Technology
Mohamed Nizar Zourgui, Mbarka Hfaiedh, Dalel Brahmi, Wissal Affi, Neji Gharsallah, Lazhar Zourgui, Mohamed Amri
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2020)
Article
Biochemistry & Molecular Biology
Wafaa Laabbar, Abdellatif Abbaoui, Abdeljalil Elgot, Meherzia Mokni, Mohamed Amri, Olfa Masmoudi-Kouki, Halima Gamrani
Summary: Aluminum is a potent neurotoxic metal that induces oxidative stress and neuronal cell death, while curcumin acts as a multi-functional drug with antioxidant activity that can protect against aluminum toxicity in astrocytes. The protective effect of curcumin is initiated by stimulating the endogenous antioxidant system.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Nutrition & Dietetics
Maryvonne Ardourel, Chloe Felgerolle, Arnaud Paris, Niyazi Acar, Khaoula Ramchani Ben Othman, Natsuko Ueda, Rafaelle Rossignol, Audrey Bazinet, Betty Hebert, Sylvain Briault, Isabelle Ranchon-Cole, Olivier Perche
Summary: This study found that ocular dietary supplements can protect the retina from oxidative damage by promoting glutamine synthesis in vitro, which may be a key factor in providing benefits in vivo.
Article
Pharmacology & Pharmacy
Heyfa Hadriche-Jarraya, Ferid Limam, Ezzedine Aouani, Mohamed Amri, Meherzia Mokni
Summary: Garlic, also known as Allium sativum (As), has been shown to modulate vascular activity by increasing blood vessel permeability and inducing vasodilation. The active component responsible for these effects appears to be a low molecular weight peptide, different from DAS and DADS.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)