Review
Biochemistry & Molecular Biology
Davide Allegrini, Raffaele Raimondi, Alfredo Borgia, Tania Sorrentino, Giovanni Montesano, Panos Tsoutsanis, Giuseppe Cancian, Yash Verma, Francesco Paolo De Rosa, Mario R. Romano
Summary: Recent evidence suggests that curcumin may be effective in treating retinal diseases by modulating gene transcription, reducing cell apoptosis, and improving vascular function. However, its limited bioavailability has hindered its use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yijing Yang, Ying Wang, Ying Deng, Jing Lu, Li Xiao, Jie Li, Yasha Zhou, Fujiao Nie, Xiangdong Chen, Jun Peng, Hanyu Tan, Yuhui Qin, Qinghua Peng
Summary: This study assessed the impact of Fructus Lycii and Salvia miltiorrhiza Bunge extract (FSE) on retinitis pigmentosa (RP) and explored the mechanism by which FSE can prevent oxidative stress-induced photoreceptor ferroptosis in RP via the P53/SLC7A11 pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Faith A. A. Kwa, Bang V. Bui, Bruce R. Thompson, Lauren N. Ayton
Summary: Vision loss has a significant impact on individuals and communities, both financially and emotionally. Age-related macular degeneration, diabetic retinopathy, glaucoma, and retinitis pigmentosa are common causes of vision loss. As the global population grows and ages, it is crucial to develop therapies that can prevent early pathological events. This review outlines the preclinical research on sulforaphane, a compound derived from broccoli, in ocular diseases and discusses its potential for future clinical testing.
DRUG DISCOVERY TODAY
(2023)
Article
Plant Sciences
Chen Ou, Pengfei Jiang, Ye Tian, Zhen Yao, Yijing Yang, Jun Peng, Meiyan Zeng, Houpan Song, Qinghua Peng
Summary: The study demonstrated that the combination of Fructus Lycii and Salvia miltiorrhiza Bunge extract has protective effects on retinitis pigmentosa, potentially through regulating the Nrf2/HO-1 pathway to inhibit oxidative stress.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biology
Xing Li, Shichang Cai, Zhiming He, James Reilly, Zhihong Zeng, Niall Strang, Xinhua Shu
Summary: Retinal diseases, leading to visual loss and blindness, have a significant negative impact on the quality of life worldwide. Developing more effective screening strategies and diagnostic biomarkers is crucial for improving outcomes. Metabolomics shows promise in addressing these challenges by discovering biomarkers and understanding disease pathogenesis.
Review
Biochemistry & Molecular Biology
Yingwei Wang, Junwen Wang, Yi Jiang, Di Zhu, Jiamin Ouyang, Zhen Yi, Shiqiang Li, Xiaoyun Jia, Xueshan Xiao, Wenmin Sun, Panfeng Wang, Qingjiong Zhang
Summary: Variants in PRPH2 were analyzed in this study using online prediction tools and large datasets. Ten pathogenic or likely pathogenic variants were identified in 14 families, with p.G305Afs*19 being the most frequent variant. The study proposed novel insights into the genotype-phenotype correlation of PRPH2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Cheng Cao, Yunqing Lu, Bing Li, Yang Chen, Pan Xu, Mengqiu Liu, Ziqiang Zhu, Lei Yuan, Sheng Guo, Hongjie Kang, Jin-ao Duan, Yue Zhu
Summary: This study found that Lycii Fructus extracts have antioxidant effects and can attenuate oxidative damage and cell apoptosis in a mouse retinal injury model. The extracts also increase the expression of glutamine synthetase, a biomarker for Muller cells, indicating their protection against oxidative injury. In Muller cell cultures, the extract inhibits cellular apoptosis through the Nrf2/HO-1 signaling pathway, with aqueous extracts demonstrating better activity than ethanol extracts.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Jacek Dziedziak, Kaja Kasarello, Agnieszka Cudnoch-Jedrzejewska
Summary: Age-related macular degeneration (AMD) and glaucoma, both involving oxidative stress, are major causes of irreversible vision loss worldwide. Antioxidants play a crucial role in preventing these eye diseases, especially in individuals with diets rich in antioxidants. Numerous preclinical studies have demonstrated the efficacy of dietary antioxidants in combating neurodegeneration associated with AMD and glaucoma.
Review
Cell Biology
Rachele Marino, Rebecca Sappington, Marco Feligioni
Summary: Retinal dysfunction is a common cause of vision loss in various retinal disorders. The prevalence of these pathologies is increasing globally due to factors such as molecular changes, environmental factors, and genetic predisposition. Current treatments focus on alleviating clinical features but are not curative. However, advancements in investigation methods, including gene therapy and metabolomics, hold promise for tailored treatments and precision medicine approaches.
NEURAL REGENERATION RESEARCH
(2023)
Review
Cell Biology
Geetika Kaur, Nikhlesh K. Singh
Summary: Vision depends on the precise structure and functioning of the retina, and any stress or injury can disrupt it, leading to vision impairment, loss, and blindness. Inflammation plays a crucial role in the development of retinal disorders, such as glaucoma, macular degeneration, diabetic retinopathy, and retinitis pigmentosa. This review provides evidence on the role of inflammation in these disorders and suggests potential therapeutic targets.
NEURAL REGENERATION RESEARCH
(2023)
Review
Medicine, General & Internal
Abinaya Thenappan, Arjun Nanda, Chang Sup Lee, Sun Young Lee
Summary: Timely recognition and differentiation of pseudo-RP cases is crucial due to the treatable nature of many such conditions. This review provides examples of pseudo-RP cases and an in-depth overview of RP masquerades, emphasizing the importance of accurate diagnoses for effective interventions. It also discusses the role of genetic testing in RP patients and highlights the necessity of a precise clinical assessment for diagnosis and management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Ophthalmology
Priya R. Chandrasekaran, V. G. Madanagopalan
Summary: This study reviews the role of curcumin in retinal diseases, the modification of the molecule to improve bioavailability in the COVID era, and its future prospects. Curcumin has shown pleiotropic effects in experimental models, exhibiting potential in the treatment of retinal diseases such as diabetic retinopathy, age-related macular degeneration, and retinitis pigmentosa. It also displays anti-inflammatory, antioxidant, and anti-proliferative properties in proliferative vitreoretinopathy, retinal ischemia reperfusion injury, and retinoblastoma.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Yuhong Chen, Jieqiong Chen, Hong Wang, Yang Yu, Wenqiu Wang, Wenjia Liu, Suqin Yu, Yuanyuan Gong, Huixun Jia, Tong Li, Xiaodong Sun
Summary: The prevalence of outer retinal tubulation (ORT) varies among different inherited retinal diseases (IRDs) phenotypes, with the highest prevalence in Bietti crystalline corneoretinal dystrophy (BCD). The presence of choroidal atrophy and inner nuclear layer (INL) cysts may be associated with an increased risk of ORT formation in patients with IRD.
Article
Biochemistry & Molecular Biology
Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin, Chia-Yu Chang, Ching- Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Chin-San Liu, Yan-Ting Chen, Hong-Lin Su
Summary: Research found that mitochondrial transplantation can moderately attenuate the degeneration of retinal layers in RCS rats. This result was confirmed through histological examination and OCT measurement of retina thickness. VEP analysis showed that the transmission time of electrical signals after mitochondrial transplantation was similar to the normal value. The results suggest that mitochondrial transplantation can improve the degeneration of photoreceptors in RCS rats and have potential for clinical application.
Review
Chemistry, Medicinal
Yali Niu, Guoheng Zhang, Xiaojia Sun, Shikun He, Guorui Dou
Summary: Oxidative stress caused by imbalanced production of reactive species and reduced antioxidant activity can lead to ocular diseases. Lycium barbarum polysaccharides (LBPs) are complex polysaccharides extracted from the fruit of L. barbarum, which have remarkable antioxidant effects and are relatively safe. Recent research has focused on the antioxidant mechanisms of LBPs and their potential applications in various ocular diseases.
Article
Medicine, General & Internal
Thilagaratnam Shyamala, Sweet Fun Wong, Akila Andiappan, Kah Guan Au Eong, Anu Birla Bakshi, Debbie Boey, Tsung Wei Chong, Hui Ping Eng, Noor Hafizah Ismail, Tang Ching Lau, Wei-Yen Lim, Hsin Wei Wendy Lim, Lydia Seong, Wei Chin Wong, Kai Zhen Yap, Sri Yudah
SINGAPORE MEDICAL JOURNAL
(2015)
Article
Medicine, General & Internal
Jyh Haur Woo, Wei Di Ng, Maaz Mohammad Salah, Kumari Neelam, Kah-Guan Au Eong, Chandra Mohan Kumar
SINGAPORE MEDICAL JOURNAL
(2016)
Letter
Ophthalmology
Denise T. M. Au Eong, David Z. Chen, Kah-Guan Au Eong
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2014)
Letter
Endocrinology & Metabolism
Srinivasan Sanjay, You Chuen Chin, Yan Sun, Ee Lin Ong, Kah Guan Au Eong
Article
Ophthalmology
K. G. Au Eong, E. W. Chan, N. Luo, S. H. Wong, N. W. H. Tan, T. H. Lim, A. M. Wagle
Article
Ophthalmology
Srinivasan Sanjay, You Chuen Chin, Hui Ting Teo, Shu Xuan Ong, Serene Hui Fang Toh, Ming Hui Khong, Anna C. H. Yeo, Kah-Guan Au Eong
OPHTHALMIC EPIDEMIOLOGY
(2014)
Article
Ophthalmology
Hui Yee Neo, Kumari Neelam, Chee Chew Yip, Hui Min Quah, Kah-Guan Au Eong
INTERNATIONAL OPHTHALMOLOGY
(2013)
Letter
Medicine, General & Internal
Paul Toon Lim Chiam, Yean Teng Lim, Cheng Kang Ong, Kah-Guan Au
SINGAPORE MEDICAL JOURNAL
(2021)
Letter
Medicine, General & Internal
Srinivasan Sanjay, Ajeet Madhav Wagle, Adam Hahn, Kah-Guan Au Eong
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2021)
Article
Ophthalmology
Srinivasan Sanjay, Seo Wei Leo, Kah - Guan Au Eong, Gitalisa Andayani Adriono, Kenneth C. S. Fong, Kartik Anand, Rumita S. Kadarisman, David B. Granet, Padmamalini Mahendradas, Rohit Shetty, Sharon D. Souza, Swaminathan P. Iyer
Summary: Global ophthalmologists have experienced significant changes in practice patterns during the COVID-19 pandemic, with a precipitous drop in surgical procedures. 41% of ophthalmologists are considering resuming elective surgeries after evaluating the situation. More than 2/3 of respondents prioritize physical distancing, mask-wearing, and hand disinfection for patient protection.
OPHTHALMIC EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Ryan L. J. Chiew, Denise T. M. Au Eong, Kah Guan Au Eong
Summary: Mucus fishing syndrome is a chronic inflammatory ocular surface condition that involves self-extraction of mucous strands from the eye. Patients with this condition experience symptoms such as ocular redness, itch, irritation, tearing, and sticky mucoid discharge. Mechanical removal of mucus from the eyes leads to conjunctival damage. The condition can be relieved by discontinuing mucus removal and receiving topical medication.
Letter
Medicine, General & Internal
Yong Seng Tam, Chandra M. Kumar, Kah Guan Au Eong, Chee Chew Yip, Jason Cheng
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2018)
Review
Ophthalmology
Kumari Neelam, Catherina J. Goenadi, Katherine Lun, Chee Chew Yip, Kah-Guan Au Eong
BRITISH JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Kumari Neelam, Henrietta Ho, Chee Chew Yip, Wenyun Li, Kah-Guan Au Eong
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)